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Impacts of Different Dynamic Factors on the Saltwater Intrusion in the Northern Branch of the Yangtze Estuary

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China Ocean Engineering 2019年第6期33卷 673-684页

作者： WANG Jin-hua zhang De-bin zhang wei-sheng zhang Jin-shan State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

A 3-D baroclinic numerical model is established to study the temporal and spatial distribution of salinity in the Northern Branch(NB) of the Yangtze Estuary(YE) in response to river runoff, wind and currents. The idealized,process-oriented studies show that the lower river runoff in the dry season is the main driving factor for the spilling over from the NB to the Southern Branch(SB). The NB takes longer time to get in dynamic stable state compared with the SB, as the runoff transfers from the wet season to the dry season. The vertical stratification intensity of the NB has obvious periodic phenomena in the dry season, and the stratification strength is enhanced under the action of low runoff and north wind, which further weakens the vertical transport of water. Momentum balance analysis suggested that the landward net flux increases when considering the influence of the moderate north wind, and the landward flux will enhance if considering the boundary current during the spring tide. With the influence of the boundary current, increases the average salinity of the NB, as well as the intrusion degree from the NB to the *** indicates that the nearshore ocean current of the Yellow Sea is an important factor affecting the saltwater intrusion in the NB of the YE.

关键词： Yangtze Estuary saltwater intrusion ocean currents vertical stratification FVCOM

Impact of Wind on Tide-Induced Advective Salt Transport in A Well- Mixed Estuary

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China Ocean Engineering 2021年第1期35卷 107-122页

作者： CHEN wei-lun ZHU Yu-liang KONG Jun CHU Ao zhang wei-sheng State Key Laboratory of Hydrology Water Resources and Hydraulic EngineeringHohai UniversityNanjing 210098China Key Laboratory of Coastal Disaster and Defence of Ministry of Education Hohai UniversityNanjing 210098China College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Key Laboratory of the Pearl River Estuarine Dynamics and Associated Process Regulation Ministry of Water ResourcesGuangzhou 510610China Faculty of Civil Engineering and Geosciences Section of Hydraulic EngineeringDelft University of Technology2600 GA DelftThe Netherlands

The tide-induced net advective salt flux in well-mixed estuaries consists of five terms according to the method from *** term resulted from the vertical variation in salinity can be negligible in well-mixed estuaries with four tide-induced salt flux terms,known as F1−*** explore the effects of wind on these salt fluxes,the current-salinity analytical model combined with the perturbation analysis is extended by including *** expressions for the four salt fluxes are derived separately in the present *** the assumption that only the M_(2) tidal component is accounted for and the salt flux generated by diffusion is not studied,the tide-induced net advective salt flux Q_(sx) is in the seaward direction without the wind *** applying the Western Scheldt estuary case,the wind influence on the tidal advection salt flux(TASF)distribution in the F4 term was *** phase difference between zero-order velocity and first-order salinity(Δφ)at the surface layer of the estuary is larger than 90°and smaller than 90°at the bottom layer,which leads to landward TASF in the surface layer and seaward TASF in the bottom *** distribution ofΔφis not uniform in the horizontal direction with wind included,which differs from the result without *** the case of seaward wind with the speed of 18 m/s,the decrease in the zeroth-order velocity phase(φu)at the surface layer is larger than that of the first-order salinity phase(φs)downstream,which leads to an abnormal seaward TASF in this *** to the surface stress caused by wind,the Stokes compensation flow in the middle and lower reaches increases/decreases with the increase of the landward/seaward wind,while the upstream situation is ***,the first-order velocity in the middle and lower reaches increases/decreases with the increase of the landward/seaward wind,while the upstream situation is also *** first-order salinity also increases/decreases with the increase of la

关键词： tide-induced net advective salt flux analytical expression wind effect well-mixed estuary Western Scheldt Estuary

Hydrodynamic Characteristics of Three-Bucket Jacket Foundation for Offshore Wind Turbines During the Lowering Process

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China Ocean Engineering 2023年第1期37卷 73-84页

作者： zhang Pu-yang QI Xin wei Yu-mo zhang sheng-wei LE Cong-huan DING Hong-yan State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China

The three-bucket jacket foundation is a new type of foundation for offshore wind turbine that has the advantages of fast construction speed and suitability for deep water. The study of the hoisting and launching process is of great significance to ensure construction safety in actual projects. In this paper, a new launching technology is proposed that is based on the foundation of the three-bucket jacket for offshore wind turbine. A complete time domain simulation of the launching process of three-bucket jacket foundation is carried out by a theoretical analysis combined with hydrodynamic software Moses. At the same time, the effects of different initial air storage and sea conditions on the motion response of the structure and the hoisting cable tension are studied. The results show that the motion response of the structure is the highest when it is lowered to 1.5 times the bucket height. The natural period of each degree of freedom of the structure increases with the increase of the lowering depth. The structural motion response and the hoisting cable tension vary greatly in the early phases of Stages Ⅰ and Ⅲ, smaller in Stage Ⅱ, and gradually stabilize in the middle and late phases of Stage Ⅲ.

关键词： three-bucket jacket foundation time domain simulation hoisting construction motion response offshore wind turbine

Mitochondrial Proteomic Analysis of Cytoplasmic Male Sterility Line and Its Maintainer in Wheat (Triticum aestivum L.)

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Agricultural Sciences in China 2010年第6期9卷 771-782页

作者： CHEN Rui-hong LIU wei zhang Gai-sheng YE Jing-xiu Shaanxi Key Laboratory of Crop Heterosis/Northwest A＆F University Yangling 712100 t~R. China

To investigate the CMS mechanism of wheat on proteomic level and find the crucial proteins which related to fertility,mitochondria was isolated from young spike of wheat by differential centrifugation and Percoll density-gradient *** by marker enzyme assays and chlorophyll content,the mainly contaminants in the spike mitochondrial fraction were caused by peroxisomes,plastids and chloroplasts after the first discontinuous Percoll density gradient *** order to improve the purity of spike mitochondria,a second 28% Percoll self-forming density gradient centrifugation was further carried out,the result showed that the contaminants were decreased to negligible amount,meanwhile the integrity of mitochondria （88%） was improved to 90%.The spike mitochondria proteins extracted from uninucleate stage of （S）-1376A and （A）-1376B were separated by two-dimensional electrophoresis （2-DE）,and the silver stained gels were analyzed by PDQuest 2-DE software,about 326 protein spots could be visualized on the 2-DE maps,and also revealed a similar pattern between the male sterile line and its maintainer line,except 11 spots were differentially expressed.A total of five differentially expressed proteins were analyzed by matrix-assisted laser desorption ionization time of flight mass spectrometry （MALDI-TOF-MS）,three of them were identified as manganese superoxide dismutase and T5E216 following NCBInr database by the Mascot *** results may contribute to further understanding of the mechanisms of CMS in wheat.

关键词： mitochondria proteomics cytoplasmic male sterility two-dimensional electrophoresis MALDI-TOF-MS

Long term clinical outcomes in patients with moderate renal insufficiency undergoing stent based percutaneous coronary intervention

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Chinese Medical Journal 2006年第14期119卷 1176-1181页

作者： zhang Rui-yan NI Jing-wei zhang Jian-sheng HU Jian YANG Zhen-kun zhang Qi LUE An-kang SHEN wei-feng Department of Cardiology Shanghai Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025

Background Patients with end-stage renal disease have a high mortality from coronary artery disease, but the impact of moderate renal insufficiency on clinical outcomes after percutaneous coronary intervention （PCI） and the effect of drug-eluting stent implantation in these patients remain unclear. This study determined the long-term effect of moderate renal insufficiency on death and major adverse cardiac events （MACE） after stent based PCI and examined whether drug-eluting stent implantation could favourably influence clinical outcome. Methods Major adverse cardiac events and causes of mortality were determined for 1012 patients undergoing percutaneous intervention from January 1, 2002 to December 31, 2004 at Shanghai Ruijin Hospital. Based on estimated creatinine clearance levels, long term outcomes were compared between patients with estimated creatinine clearance 〈60 ml/min （renal insufficiency group; n=410） and those with estimated creatinine clearance ≥60 ml/min （control group; n=602）. Subgroup analysis was also made for patients with renal insufficiency between drug eluting stent （n=264） and bare metal stent implantation （n=146） during PCI. Results During follow-up （average 17 months） after successful PCI, all causes of death （7.1% vs 2.3%, P〈0.01） and cardiac death （3.4% vs 1.0%, all P〈0.01） were significantly higher in renal insufficiency group than in control group. For patients with moderate renal insufficiency, drug-eluting stent implantation reduced significantly all causes of death （5.3% vs 10.9%, P〈0.05） and occurrence of major cardiac adverse events （15.1% vs 24.6%, P〈0.05） compared with bare metal stents. Conclusions Moderate renal insufficiency is an important clinical factor influencing the mortality after PCI in patients with coronary artery disease and the use of drug-eluting stents should be the preferred therapy for the improvement of long-term outcomes in such patients.

关键词： long term outcome percutaneous coronary intervention renal insufficiency drug eluting stent

Anatomical study of the anterolateral and posteromedial bundles of the posterior cruciate ligament for double-bundle reconstruction using the quadruple bone-tunnel technique

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Chinese Medical Journal 2012年第22期125卷 3972-3976页

作者： LUO Hao AO Ying-fang zhang wei-guang LIU sheng-yong zhang Ji-ying YU Jia-kuo Peking Univ Hosp 3 Inst Sports Med Beijing 100191 Peoples R China Peking Univ Hlth Sci Ctr Dept Anat Beijing 100191 Peoples R China

Background Several techniques have been described for posterior cruciate ligament （PCL） reconstruction. However, double-bundle PCL reconstruction using the quadruple bone-tunnel technique has been seldom reported. The current study investigated this technique, focusing on the anatomy of the femoral and tibial insertions of the anterolateral （AL） and posteromedial （PM） bundles of the PCL. Methods Twenty-two fresh, healthy adult cadaveric knees were dissected and measured. The PCL was divided into the AL bundle and PM bundle at the insertion footprint. The insertion footprints of the AL and PM bundles, their location, size, and the clock positions were measured and described. Results On the femur, the clock position of the footprint of the AL bundle was 11：21＋0：23 （left） or 0：39＋0：23 （right）, and the PM bundle was 9：50＋0：18 （left） or 2：10＋0：18 （right）, with the knee flexed at 90 degrees. The distances from the center of the femoral insertions of the AL and PM bundles to the anterior cartilage margins of the medial femoral condyle were （7.79＋1.22） mm and （8.36＋1.63） mm, respectively. On the tibia, the vertical distances from the center of the tibial insertions of the AL and PM bundles to the tibial articular surface were （3.25＋1.20） mm and （6.91＋1.57） mm, respectively. Conclusions These results have led to a better definition of the anatomy of the AL and PM bundle footprint of the PCL. The technique of double-bundle PCL reconstruction using quadruple bone-tunnel is feasible. Application of these data during PCL reconstruction using the quadruple bone-tunnel technique may help optimize knee stability.

关键词： knee posterior cruciate ligament anatomy double-bundle reconstruction

新型HF-LPME-HPLC对蒙药荜茇生物碱含量测定研究

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药物生物技术 2024年第1期31卷 29-33页

作者：郭晶晶张俊清白云霞张胜巍包头医学院内蒙古包头014040 包头医学院第一附属医院内蒙古包头014010

研究建立一种新型中空纤维膜液相微萃取联合高效液相色谱(HF-LPME-HPLC)测定蒙药荜茇中生物碱含量,对影响HF-LPME萃取效率的各项参数进行优化分析。中空纤维膜材料为偏氟乙烯纤维膜(空隙率>50%),正辛醇为萃取剂,萃取温度为室温,振荡速度... 详细信息

研究建立一种新型中空纤维膜液相微萃取联合高效液相色谱(HF-LPME-HPLC)测定蒙药荜茇中生物碱含量,对影响HF-LPME萃取效率的各项参数进行优化分析。中空纤维膜材料为偏氟乙烯纤维膜(空隙率>50%),正辛醇为萃取剂,萃取温度为室温,振荡速度为200 r/min,萃取时间为128 min。建立了新型HF-LPME的萃取方法,对蒙药荜茇中胡椒碱的R>5,与传统萃取方法相比,富集倍数为40倍。线性范围分别为0.006~0.01 mg/mL,相关系数(r)为0.9999。相比于传统的萃取方法,该方法使用极少量的有机溶剂,可高效萃取并测定蒙药荜茇中生物碱的含量,打破了仅能在环境和食品中应用的限制,可以在各类化学基础实验中推广应用。

关键词：新型中空纤维膜液相微萃取高效液相色谱蒙药荜茇提取方法生物碱含量测定

放牧对不同类型草原植物多样性及其碳储量的影响

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环境科学 2024年第9期45卷 5395-5405页

作者：赵星宇韩国强张圣微赵鸿彬刘敏敏林汐王帅内蒙古农业大学水利与土木建筑工程学院呼和浩特010018 呼和浩特市生态环境局呼和浩特010018 内蒙古自治区水资源保护与利用重点实验室呼和浩特010018 黄河流域内蒙段水资源与水环境综合治理自治区协同创新中心呼和浩特010018 内蒙古农业大学生命科学学院呼和浩特010018

随着气候干暖化和不合理的放牧,内蒙古各类型草地出现不同程度的退化,而不同管理模式势必会影响土壤草地植物多样性和植被碳储量.为了明确不同管理模式下各类型草地植物多样性和碳储量的变化及其影响因素,基于横跨内蒙古3种不同类型草原... 详细信息

随着气候干暖化和不合理的放牧,内蒙古各类型草地出现不同程度的退化,而不同管理模式势必会影响土壤草地植物多样性和植被碳储量.为了明确不同管理模式下各类型草地植物多样性和碳储量的变化及其影响因素,基于横跨内蒙古3种不同类型草原的18个定点监测站点,对植物物种组成、地上生物量和植被全碳等指标进行分析.结果表明,放牧会导致典型草原和荒漠草原的优势度增加,而草甸草原为降低,均匀度指数和香农-维纳多样性指数在草甸草原和荒漠草原增加较小.放牧降低草甸草原和典型草原禾本科生物量,而在荒漠草原为上升.禁牧区地上植被、地下根系碳储量远高于放牧区,分别高出1.5倍和1.2倍,但长期禁牧站点的植被碳储量明显低于短期禁牧.同时结构方程表明,地理位置、气候因子和土壤因子对3种草原类型的生物量和植被碳储量的影响差异明显,研究结果可为草地生态可持续发展及管理模式优化提供参考.

关键词：草原类型不同管理模式植物多样性植被碳储量影响因素

同源异型盒基因A5、三结构域蛋白14与结直肠癌的关系

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海南医学 2024年第12期35卷 1673-1678页

作者：张胜威许召杰王东王华胜李晓洁屈海涛河南中医药大学郑州人民医院肛肠外科河南郑州450003 河南中医药大学第一附属医院肛肠病诊疗中心河南郑州450003

目的探讨结直肠癌组织同源异型盒基因A5(HOXA5)、三结构域蛋白14(TRIM14)蛋白表达水平与临床病理特征及患者预后的关系。方法回顾性收集整理2016年5月至2018年5月期间于河南中医药大学郑州人民医院确诊的120例结直肠癌患者癌组织及癌旁... 详细信息

目的探讨结直肠癌组织同源异型盒基因A5(HOXA5)、三结构域蛋白14(TRIM14)蛋白表达水平与临床病理特征及患者预后的关系。方法回顾性收集整理2016年5月至2018年5月期间于河南中医药大学郑州人民医院确诊的120例结直肠癌患者癌组织及癌旁组织标本及相关临床资料,采用免疫组化法检测组织HOXA5、TRIM14蛋白表达水平;分析HOXA5、TRIM14水平与结直肠癌患者临床病理特征及预后的关系;采用Kaplan-Meier法分析组织中HOXA5、TRIM14表达与结直肠癌5年生存率的关系;采用Cox比例风险回归模型分析结直肠癌5年预后影响因素。结果结直肠癌组织中TRIM14蛋白阳性率为73.33%,明显高于癌旁组织的10.00%,HOXA5蛋白阳性率为27.50%,明显低于癌旁组织的81.67%,差异均有统计学意义(P<0.05)。TRIM1蛋白阳性表达患者肿瘤低分化比例为42.05%,浸润深度T_(3)~T_(4)比例为72.73%,有淋巴结转移比例为47.73%,有远处转移比例为29.55%,明显高于TRIM1蛋白阴性表达的12.50%、37.50%、12.50%、6.25%,差异均有统计学意义(P<0.05);HOXA5蛋白阴性表达患者肿瘤低分化比例为41.38%,浸润深度T3~T4比例为77.01%,有淋巴结转移比例为48.28%,有远处转移比例为29.89%,明显高于HOXA5蛋白阳性表达的15.15%、27.27%、12.12%、6.06%,差异均有统计学意义(P<0.05)。结直肠癌组织中HOXA5阴性表达和TRIM14阳性表达患者的5年生存率分别为57.47%、59.09%,明显低于HOXA5阳性表达患者的90.91%和TRIM14阴性表达患者的87.50%,差异均有统计学意义(P<0.05)。死亡组患者有淋巴结转移比例为85.00%,有远处转移比例为55.00%,明显高于生存组的15.00%、7.50%,差异均有统计学意义(P<0.05)。经Cox比例风险回归模型分析结果显示,TRIM14是结直肠癌患者5年内死亡的独立危险因素,HOXA5是结直肠癌患者5年内死亡的保护因素(P<0.05)。结论结直肠癌组织中TRIM14呈高表达状态,HOXA5呈低表达状态,两者均与TNM分期、肿瘤分化程度、浸润深度等临床病理特征及预后相关,有作为预后标志物及治疗靶点的潜力。

关键词：结直肠癌同源异型盒基因A5 三结构域蛋白14 预后临床病理特征相关性