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Chinese Journal of Integrative Medicine 2021年第10期27卷 767-773页

作者： MO Ji-hao XIE Han-kun zhou ye-mian Ng Sihan-benjamin LI Shao-xia WANG Lei Department of Medical Laboratory Luoyang Orthopedic Hospital of Henan ProvinceOrthopedic Institute of Henan ProvinceLuoyangHenan Province(471002)China Miller School of Medicine University of Miami(33136)MiamiFLUSA Institute of Technical Biology&Agriculture Engineering Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei(230031)China Eatobe Pte.Limited(573969) Singapore

Objective:To elucidate the active compounds and the molecular mechanism of Cyathula Off/c/na//s as a drug treatment for rheumatoid arthritis(RA).Methods:The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese *** protein-protein interaction between the target genes were analyzed using STRING and *** transcriptome of RA patients compared to healthy people(GSE121894)were analyzed using R program package *** relative expression of the target genes was obtained from the RNA-seq *** molecular docking analyses were processed based on the molecular model of estrogen receptor 1(ESR1)binding with estradiol(PDB ID:1A52).The binding details were analyzed by ***:Inokosterone,ecdysterone,and cyaterone were the 3 active ingredients from Cyathula Officinalis that bind to target *** all the significantly changed genes from RA patients,ESR1,ADORA1,and ANXA1 were significantly increased in mRNA samples of RA ***:ESR1,the transcription factor that binds inokosterone in the molecular binding analysis,is the target protein of Cyathula Officinalis.

关键词： rheumatoid arthritis estrogen receptor 1 inokosterone Cyathula Officinalis Chinese medicine

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En zhou Yilin Li Xiaoming Lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan zhou Hongdong Zhao ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting Yang Ya Yu Kang zhou Xiaoyang ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang zhou Ru ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Saturated super-twisting sliding mode missile guidance

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Chinese Journal of Aeronautics 2022年第10期35卷 292-300页

作者： mian GONG Di zhou Xinguang ZOU School of Astronautics Harbin Institute of TechnologyHarbin 150001China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China

This paper concentrates on developing a missile terminal guidance law against a highly maneuvering target whose maneuvering acceleration is very close to that of the missile or even exceeds the missile normal acceleration in a finite period of time.A new saturated super-twisting algorithm is proposed and applied to the design of missile guidance *** proposed algorithm has the advantages of simple structure,easy parameter tuning rules and a full utilization of the limit control *** designed saturated super-twisting sliding mode guidance law is then employed in a missile guidance *** and its superior performance against strong maneuvering targets is demonstrated.

关键词： Highly maneuvering target Input saturation Missile guidance control Robust control Sliding mode control Super-twisting algorithm

How the radial gap affects the runner’s hydrodynamic damping characteristic of a pump-turbine:A physical experiment on a rotating disc

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Journal of Hydrodynamics 2023年第4期35卷 736-745页

作者： Yong-shun Zeng Xin Qi mian-mian Bai Ling-jiu zhou Zhi-feng Yao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China BAPTEEC LTD Beijing100176China Shanxi Province Institute of Water Resources and Electric Power Investigation and Design Xi’an710001China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing100083China

Clarifying how radial gap affects the vibration characteristic of a disc-like structure is of importance in engineering applications,such as in evaluating the operational stability of a runner of a pump *** the present investigation,the runner is simplified as a disc,and a physical experiment is designed on it with variable radial gaps to measure the vibration characteristics,especially by considering *** frequency peaks for the diametrical mode are generated due to the rotation,and those with lower and higher frequencies are defined as positive and negative modes,*** frequency difference between positive and negative modes increases linearly with the increasing rotating speed,and a linear function is captured to describe the relationship between natural frequency and rotating *** the radial gap,its increase causes a slight increase in the natural frequencies but results in a significant reduction in the hydrodynamic damping *** in the smaller radial gap conditions,such as when the relative radial gap increases from 0.67%to 3.3%,the reduction in hydrodynamic damping ratio reaches 31.52%.From the perspective of suppressing the resonance amplitude,reducing the radial gap of a runner is recommended due to the mechanism of increasing hydrodynamic damping.

关键词： Rotating disc radial gap rotating speed natural frequency hydrodynamic damping

Inverse-square-root-acceleration method for predicting the failure time of landslides

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Science China(Technological Sciences) 2021年第5期64卷 1127-1136页

作者： zhou XiaoPing ye Teng School of Civil Engineering Chongqing UniversityChongqing 400045China

Predicting the failure time of unstable slopes is one of the most pivotal issues. In this paper, the inverse square root acceleration(INSRA) method was proposed to estimate the time-of-failure(TOF) of landslides. Four collapsed slopes were presented in the three open-pit mines, two of them were probed by ground-based radar, and two of them were obtained from previous scientific papers. The inverse velocity(INV) method and INSRA method were adopted to analyze these four landslides and one slope which had great deformation but did not reach failure. Compared with the traditional INV method, the INSRA method can promote the forecasting effectiveness and has the advantage of higher accuracy.

关键词： failure time of landslide inverse square root of acceleration traditional inverse velocity method

Fermi polarons in a driven-dissipative background medium

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Science China(Physics,Mechanics & Astronomy) 2022年第11期65卷 97-106页

作者： ye Cao Jing zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Department of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China

The study of the polaron of an open quantum system plays an important role in verifying the effectiveness of an approximate many-body theory and predicting novel quantum phenomena in open quantum systems. In a pioneering work, Piazza et al.(2021) proposed a Fermi-polaron scheme with a lossy impurity, which exhibits a novel long-lived attractive polaron branch in the quantum Zeno limit. However, we have encountered a counterpart problem in which an impurity interacting with an open quantum bath scatters exciting polarons, which is what we focus on. In this work, we determine through analytical research the molecular state under the two limits of vanishingly small and infinitely large dissipation intensities as well as the reason why the dissipation range leads to a decrease in the gap between the molecular state and the molecule-hole continuum in the former *** spectrum functions of molecular and polaron states with different dissipation ranges and loss rates are investigated. We find the spectral signals of molecular and polaron states will first diffuse and then revive as the dissipation increases. Moreover, we show that the attractive and repulsive polarons respond differently to an increasing dissipation range in our model. Finally, we exhibit the polaron energy, residue, effective mass, and two-body decay for mass-balanced and imbalanced systems. Our results might be useful for cold-atom experiments on open quantum systems.

关键词： quantum Zeno dynamics open systems quantum statistical methods decoherence

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In-depth insights into critical role of aromatic C(sp^(2))-H on Li^(+)storage

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Rare Metals 2024年第10期43卷 5449-5452页

作者： Ling Qin ye zhou China-UK Low Carbon College Shanghai Jiao Tong UniversityShanghai 200120China

The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors(LIBs/LICs).Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be a promising candidate due to its facile synthesis and high capacity for Li^(+)***,conclusive data are still lacking to elucidate the fundamental function of the hydrogen-terminated groups(C-H configuration)in Li^(+)*** and his co-workers have utilized an ion-catalyzed self-template method to synthesize the hydrogen-rich carbon nanoribbon(HCNR)with high specific and rate capacity.

关键词： aromatic insight critical