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CRMPs对神经元突起生长的调控

暨南大学学报（自然科学与医学版） 2011年第6期32卷 557-561页

作者：郭国庆张吉凤纪志盛暨南大学医学院解剖学教研室广东广州510632

神经元突起是建立神经网络的物质基础,其生长为生长信号启动胞内信号促使神经元不断极化的过程。作为Rho GTPases的下游信号,CRMPs富集于神经系统,参与神经元的发育过程,可作为不同信号通路的共同受体后分子,通过改变细胞骨架的运动调... 详细信息

神经元突起是建立神经网络的物质基础,其生长为生长信号启动胞内信号促使神经元不断极化的过程。作为Rho GTPases的下游信号,CRMPs富集于神经系统,参与神经元的发育过程,可作为不同信号通路的共同受体后分子,通过改变细胞骨架的运动调控突起生长。其不同亚基的功能分化、不同亲和性特点显示其具有突起生长调控的分子开关特征,有效地控制突起的生长不仅是发育神经生物学的基本问题,也为重建因神经损伤和退行性疾病受到破坏的神经网络提供可行的作用靶点。

关键词：坍塌反应调节蛋白神经元细胞骨架突起生长

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应用瑞利—里滋法分析储箱内液体晃动模态

哈尔滨工程大学学报 2007年第1期28卷 31-34页

作者：潘利剑武湛君张博明章继峰杜善义哈尔滨工业大学复合材料与结构研究所黑龙江哈尔滨150001

将瑞利—里滋法进一步拓展到储箱内液体晃动的模态分析中,结合瑞利商给出储箱内带自由液面液体晃动基频的计算方程,使得瑞利—里滋计算模态的方法得到进一步的扩展,同时对液体晃动基频计算提出更为有效的计算方法.此外,应用有限元程序AD... 详细信息

将瑞利—里滋法进一步拓展到储箱内液体晃动的模态分析中,结合瑞利商给出储箱内带自由液面液体晃动基频的计算方程,使得瑞利—里滋计算模态的方法得到进一步的扩展,同时对液体晃动基频计算提出更为有效的计算方法.此外,应用有限元程序ADINA,对圆柱形储箱内带自由液面的晃动频率和模态进行数值模拟.研究了液面半径和深度对液体晃动固有频率和模态的影响.模拟得出的结论与瑞利商和里滋法的计算结论基本相符,从而验证了所提出的瑞利—里滋法解析解的有效性.所给出的解析方法适合任意储箱内液体晃动的模态分析.

关键词：储箱自由液面模态分析瑞利-里滋法 ADINA

化肥减量配施有机液体肥对加工番茄生长及土壤酶活性的影响

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中国土壤与肥料 2021年第2期 53-60页

作者：桑文赵亚光张霁峰张凤华石河子大学/新疆绿洲生态农业兵团重点实验室新疆石河子832003

通过研究不同化肥减量配施有机液体肥对加工番茄生长及土壤酶活性的影响,为化肥减量配施有机液体肥的可行性及作物种植中的减肥增效提供理论依据和技术支撑。采用微区控制试验,设置了5个处理,空白对照NF、单施化肥CF100、化肥全量配施... 详细信息

通过研究不同化肥减量配施有机液体肥对加工番茄生长及土壤酶活性的影响,为化肥减量配施有机液体肥的可行性及作物种植中的减肥增效提供理论依据和技术支撑。采用微区控制试验,设置了5个处理,空白对照NF、单施化肥CF100、化肥全量配施有机液体肥CF100SW、化肥减量10%配施有机液体肥CF90SW、化肥减量20%配施有机液体肥CF80SW;分析其对番茄养分吸收、产量、品质和土壤酶活性的影响。结果表明:CF100SW、CF90SW、CF80SW处理较CF100处理显著促进番茄对氮、磷养分的吸收及提高氮磷肥利用率,其中CF80SW处理较CF100处理单株氮、磷素吸收量分别增加25.15%、11.59%,氮、磷肥利用率达34.00%、15.89%;CF100SW处理产量最高,较CF100处理增加12.34%,CF90SW处理次之,增加4.23%。施用有机液体肥的各处理(CF100SW、CF90SW、CF80SW)较CF100处理均能增加番茄Vc和番茄红素的含量;显著提高土壤蛋白酶、转化酶、纤维素酶、碱性磷酸酶、β-葡萄糖苷酶的活性;其中纤维素酶和转化酶增加最为显著,CF100SW、CF90SW、CF80SW处理纤维素酶活性分别较CF100处理增高35.59%、43.64%、29.98%;转化酶活性较CF100处理分别增高28.68%、58.44%、45.49%。综上所述,有机无机结合的施肥方式能够促进加工番茄养分吸收,提高肥料利用率,增产提质,营造良好的土壤微环境;且从产量、养分吸收和肥料利用率的综合角度考虑,适量减少10%~20%的化肥配施有机液体肥更为适宜。

关键词：减量施肥养分吸收产量品质酶活性液体有机肥

Study of low molecualr weight sulfated hyaluronic acid on the secretion of TNF-α、IL-1β from ALI/ARDS rats

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Study of low molecualr weight sulfated hyaluronic acid on th...

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

中国药学会全国多糖类药物研究与应用研讨会

作者： zhang Yun-feng ji Sheng-li QU Lei (Institute of Biochemical and Biotechnological Drug,Schoolof Pharmacy,Shandong University,jinan 250012)

＜正＞Objective Acute lunginjury （ALI） and acute respiratory distress syndrome （ARDS） represent inflammatory processes that are initiated by diverse systemic and/or pulmonary insults,resulting in a clinical syndrome of severe respiratory distress and refractory *** and ARDS are common,life-threatening causes of acute respiratory failure that arise from a variety of local and systemic *** some improvement in mortality with a lung-protective ventilator strategy,both morbidity and mortality remain high. According to the ALI and ARDS pathogenesis studies,anti-inflammatory and anti-coagulation therapies have become important treat *** is reported that glyeosaminoglycans （GAGs） has anti-inflammatory and anti-coagulation effect in recent *** molecular weight sulfated hyaluronie acid （LMWSHA） was selected as a new anti-acute lung injury material in our *** of LMWSHA on the sectretion of TNF-α、IL-1βfrom ALI/ARDS *** LMWSHA with different molecular weights （Mr） ranges were *** tested the effects of different compositions on TNF-αand IL-1βsecreted by lung alveolus macrophage,selected the most effective *** we studied its therapeutic effects on ARDS rats,and investigated its effects on mRNA transcription of TNF-α,IL-1βin the ARDS inflammatory *** The concentration of Rat TNF-αand Rat IL-βin the supernatant of cell culture was respectively 174.88±8.84 pg/mL and 148.55±3.30 pg/mL,obviously higher than the negative control group（15.50±2.98 pg/mL,21.22±1.65 pg/mL）（P＜0.05）.Among them compositions L-1-1,B-1-1 and B-2 were the most effective *** optical density values of group L-1-1,group B-1-1 and group B-2 were found to be lower than that of the model group,and the optical density value of group L-1-1 was found to be the lowest,demonstrating that three compositions of LMWSHA have inhibitive effect on the transcription of Rat lung alveolus macrophage TNF-α,RatIL-1βmRNA,with L-1-1 being the m

关键词： Low molecular weight sulfated hyaluronic acid Acute lung injury/acute respiratory distress syndrome Preparation Structure analysis Tumor necrosis factor-α Interleukin-1β mRNA

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu Lu Liu Yu zhang feng Tian jiao jiao Li jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

带p⁃Laplace算子的分数阶Langevin型方程对偶反周期边值问题解的存在唯一性

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山东大学学报（理学版） 2022年第9期57卷 91-100页

作者：张纪凤张伟韦慧倪晋波安徽理工大学数学与大数据学院安徽淮南232001

研究了一类新的分数阶Langevin型方程反周期边值问题。该方程带p⁃Laplace算子,边值条件由两对反周期边值条件构成(对偶反周期边值条件)。通过利用Krasnoselskii不动点定理以及Banach压缩映射定理分别得到了解的存在性与唯一性准则,并举... 详细信息

研究了一类新的分数阶Langevin型方程反周期边值问题。该方程带p⁃Laplace算子,边值条件由两对反周期边值条件构成(对偶反周期边值条件)。通过利用Krasnoselskii不动点定理以及Banach压缩映射定理分别得到了解的存在性与唯一性准则,并举例说明了主要结论,所得结果丰富了已有文献的相关工作。

关键词：分数阶Langevin型方程对偶反周期边值条件 p⁃Laplace算子解存在唯一性不动点定理

A coordinated planning strategy of energy storage allocation and line upgrading to increase photovoltaic consumption with lowest planning cost

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Science China Technological Sciences 2025年

作者： Bo zhang Yuqi ji Lu zhang Wei TANG Xiaohui zhang Liang WANG Haoran DING Hanchen MAO College of Information and Electrical Engineering China Agricultural University State Grid Heilongjiang Electric Power Research Institute State Grid Heilongjiang Electric Power Company Limited School of Electrical and Information Engineering Zhengzhou University of Light Industry

Random integration of massive distributed photovoltaic (PV) generation poses serious challenges to distribution networks. Voltage violations, line overloads, increased peak–valley differences, and power-flow reversals can occur at different locations, times, and severities. Traditional planning methods such as energy storage (ES) allocation and upgrading of lines may result in poor economics and low equipment utilization. This study proposes a distribution-network planning strategy that coordinates three planning mechanisms:ES allocation to substations and to feeders, and line upgrading. The proposed strategy achieved the lowest annual cost, considering the distribution network problems at different locations, times, and severities. A net load curve description method was first proposed considering economic planning and the uncertain distribution of loads and PVs. Second, a multistage optimization model for ES allocation and line upgrading was established based on the net load curves. Finally, an improved IEEE33 node system was used in the case study. The planning results show that the proposed coordinated planning strategy can address the problems caused by the random integration of massive distributed PVs, improve equipment utilization, and obtain the lowest total annual planning cost.

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“众创”法律服务供需矛盾及解决方案

重庆与世界(学术版) 2016年第4期 58-60页

作者：张稷锋中共重庆市江北区委党校

大众创业、万众创新上升至国家战略,各地实施"双创"战略成效显著,大量"众创空间"及创业园(社)区的发展呈"井喷"趋势。然而,"众创"配套服务体系中,法律服务解决企业治理架构、风险控制等重大问题,不容忽视。为此,以解决"众创"法律服务需... 详细信息

大众创业、万众创新上升至国家战略,各地实施"双创"战略成效显著,大量"众创空间"及创业园(社)区的发展呈"井喷"趋势。然而,"众创"配套服务体系中,法律服务解决企业治理架构、风险控制等重大问题,不容忽视。为此,以解决"众创"法律服务需求为切入点,从政府引导、政策支持、市场运作等方面提出解决思路。

关键词：众创法律服务供需矛盾

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中国现代企业制度回顾与展望

天津电大学报 2004年第1期8卷 45-48页

作者：张稷锋中共广东省委党校广州510053

1993年中共十四届三中全会提出建立现代企业制度,并以之作为国有企业改革的方向。历经十年艰辛历程,伴随中国由传统计划经济向现代市场经济转轨,现代企业制度不断完善,国有企业改革取得了世人瞩目的成就,但仍存在诸多问题。文章回顾了... 详细信息

1993年中共十四届三中全会提出建立现代企业制度,并以之作为国有企业改革的方向。历经十年艰辛历程,伴随中国由传统计划经济向现代市场经济转轨,现代企业制度不断完善,国有企业改革取得了世人瞩目的成就,但仍存在诸多问题。文章回顾了中国现代企业制度及以之作为方向的国有企业改革的发展道路,同时结合当前实际,总结出这一历程对我国国有企业改革所带来的启示,找出了现存问题并提出改革的进一步措施。

关键词：中国现代企业制度企业管理国有企业市场经济