检索结果-南通市图书馆

晚明灾疫应对中的基层政府运作——对万历十五年至十七年徽州府的考察

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

古代文明（中英文） 2025年第1期19卷 128-141,M0007页

作者：葛俊超安徽师范大学历史学院安徽芜湖241000

地方政府的灾疫应对为观察基层治理结构的特殊案例。审视万历十五年至十七年南直隶徽州府灾疫:储备缺失与仓政废弛造成灾害破坏的持续释放,进而引发基层秩序紊乱。围绕资源的配置和获取,该府及所辖诸县积极与上级部门及周边地区政府进... 详细信息

地方政府的灾疫应对为观察基层治理结构的特殊案例。审视万历十五年至十七年南直隶徽州府灾疫:储备缺失与仓政废弛造成灾害破坏的持续释放,进而引发基层秩序紊乱。围绕资源的配置和获取,该府及所辖诸县积极与上级部门及周边地区政府进行互动。在自救无力、他救无望时,该府转而对域内社会力量进行全面动员,直接引导了基层社会的自我修复。该府的灾疫应对行为说明,在明朝晚期,基层政府仍在社会治理中扮演了主要角色。从灾疫处置视角切入基层社会,有助于走出“士绅社会”的定式思维,进一步丰富对帝制中国基层治理结构的认识。

关键词：晚明灾疫基层政府万历徽州

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Recent Advances in Fibrous Materials for Hydroelectricity generation

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Well-posed problem of nonlinear singular distributed parameter systems and nonlinear ge-semigroup

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2013年第12期56卷 267-280页

作者： ge ZhaoQiang FENG DeXing Department of Applied Mathematics Xi’an Jiaotong University Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Science

According to the well-posed problem of nonlinear singular distributed parameter systems,frst of all,the nonlinear ge-semigroup induced by a continuous(possibly nonlinear)operator is introduced in Banach space,which is a generalization of ge-semigroup(i.e.,generalized operator semigroup),and the properties of nonlinear ge-semigroup are discussed;and then the existence,uniqueness and constructive expression for the strong solution of nonlinear singular distributed parameter system are discussed by nonlinear ge-semigroup;at last,the exponential stability of nonlinear singular distributed parameter system is studied by using nonlinear ge-semigroup,functional analysis and operator theory in Banach space.

关键词： nonlinear ge-semigroup nonlinear singular distributed parameter systems well-posed problem exponential stability Banach space

创意写作的概念、原理及建制化发展——创意本体论创意写作学的基本主张及其建制实践

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

当代文坛 2025年第1期 110-117页

作者：葛红兵马兵上海大学中国创意写作研究院

创意写作是一种创造性精神活动,以文字表达为实现形式,它遵循普遍的创意和表达规律,通过文化创意产业和事业来实现社会价值,助力“文化强国”和“创意国家”建设,依此而形成三大原理和创意生成叙事论、创意生成抒情论。中文创意写作学... 详细信息

创意写作是一种创造性精神活动,以文字表达为实现形式,它遵循普遍的创意和表达规律,通过文化创意产业和事业来实现社会价值,助力“文化强国”和“创意国家”建设,依此而形成三大原理和创意生成叙事论、创意生成抒情论。中文创意写作学的发展进入建制化时期,需要在基本概念和三大原理指引下,理论联系实际,平衡传承与创新、改革与接续的关系,自觉地承担中文学科改革者、探索者的角色,从培养目标、培养内容、培养方法等各个方面,改革中文学科旧制,走新建制主义之路。中文创意写作学科的工作者需要与种种错误的见解和窄化的庸见作斗争,突破传统中国汉语言文学学科的陈腐陋见。

关键词：创意写作叙事叙事生成-转换语法生成叙事转换叙事

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

煤矿井下水泵房巡检机器人系统设计与应用

煤矿现代化 2025年第1期34卷 117-122页

作者：孙歌山西煤炭运销集团蒲县昊锦塬煤业有限公司山西临汾041206

针对煤矿井下水泵房传统工人巡检存在劳动强度大、巡检耗时较长、成本较高、检测结果不准确等问题,本文对煤矿井下水泵房智能巡检机器人系统进行研究,采用模块化和轻量化设计思想,在分析水泵房巡检内容和要求的基础上,提出了一种履带式... 详细信息

针对煤矿井下水泵房传统工人巡检存在劳动强度大、巡检耗时较长、成本较高、检测结果不准确等问题,本文对煤矿井下水泵房智能巡检机器人系统进行研究,采用模块化和轻量化设计思想,在分析水泵房巡检内容和要求的基础上,提出了一种履带式水泵房智能巡检机器人系统,实时采集井下水泵房现场被参数信息,代替工人完成井下水泵房的巡检任务。完成了智能巡检机器人硬件系统设计,利用模块化思想编写了控制系统程序,并且编写了巡检轨迹程序,可根据设定的轨迹自主巡检。经在山西某煤矿进行现场调试和试运行表明,井下水泵房智能巡检机器人系统可代替4~6名工人实施巡检,降低了工人劳动强度,巡检周期从单日1次增加到单日3次,巡检效率大大提高,机器人本体移动定位误差≤5 cm,能准确获取设备运行异常特征并报警。

关键词：煤矿水泵房智能巡检机器人远程运维路径规划

中国儿童道德情感发展的动态演变及生态系统模型建构——基于三轮大样本实证调查

在线全文

学校读者我要写书评

暂无评论

华东师范大学学报（教育科学版） 2025年第1期43卷 96-112页

作者：孙彩平葛丹丹南京师范大学道德教育研究所南京210024 南京工程学院学生工作处南京211167

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现... 详细信息

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现需要关注;(2)水平随年龄的增高呈现先增高后降低的发展趋势,10岁为儿童道德情感发展的关键点;(3)存在性别和城乡区域的结构差异;(4)按因素影响强度呈现独特的生态系统逻辑,从高到低排列为“个体-学校-社会支持-家庭”;生活满意度、了解儿童的人、学校和家庭心理环境是高影响因素;不同因素对不同性别和学段儿童的道德情感发展影响存在差异。由上发现提出,中国儿童道德情感培育要重视道德情感类型的发展失衡、群体发展的差异和关键影响因素,优化儿童道德情感发展的生态系统,抓住发展的关键期,进一步明确教育的侧重点,提升针对性和时效性。

关键词：中国儿童道德情感发展动态影响因素生态系统

复杂主动脉疾病中分支与开窗型腔内支架的创新进展与应用

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中华外科杂志 2025年第1期63卷 45-50页

作者：曹龙葛阳阳郭伟解放军总医院第一医学中心血管外科北京

近年来, 主动脉腔内修复技术治疗累及重要分支的复杂主动脉疾病(如主动脉弓和复杂腹主动脉瘤等), 取得了明显进展。分支、开窗型支架的快速发展, 为无法耐受开放手术的复杂主动脉疾病患者, 提供了安全、有效的微创治疗选择。初步临床证... 详细信息

近年来, 主动脉腔内修复技术治疗累及重要分支的复杂主动脉疾病(如主动脉弓和复杂腹主动脉瘤等), 取得了明显进展。分支、开窗型支架的快速发展, 为无法耐受开放手术的复杂主动脉疾病患者, 提供了安全、有效的微创治疗选择。初步临床证据表明, 分支、开窗型支架的技术成功率和手术效果均较好, 逐渐成为复杂主动脉疾病腔内修复技术创新与发展的重要方向。但不可否认, 分支、开窗型支架在复杂主动脉疾病的腔内治疗中尚处于早期经验积累阶段, 未来还需要一系列高质量研究验证其治疗效果, 并完善其与开放手术及不同腔内技术间的疗效比较。

关键词：主动脉疾病主动脉瘤主动脉弓分支与开窗型腔内支架