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The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro

BIOCELL 2023年第4期47卷 891-904页

作者： zeinab klaab AZIZA HASSAN JAWAHER ALBAQAMI FAIZAH A.ALMALKI Department of Biology Taif UniversityTaif21944Saudi Arabia Department of Biotechnology Taif UniversityTaif21944Saudi Arabia

Cancer remains to be one of the most severe sicknesses *** have kept rising over the *** cancer(BC),which is among the leading types of cancers and predominantly affects women,is the second leading cause of cancer *** have developed interventions over the years;however,the BC survival rate has not improved since the *** has created the need for novel drug interventions that would manage and treat BC more *** study focused on using a combination of natural product extracts such as phytoestrogen(Ziziphus jujube)and Tannin nanoparticles(NP99)together,which we have referred to as(***99)and tamoxifen(Tam)as one of the leading BC drugs since the 70s,in treating *** effectiveness of Tam if used alone in the treatment and if combined with ***99 was evaluated using MCF-7 cells in *** findings showed that the combination treatment of ***99 affected the proliferation and viability of MCF-7 cells more than Tam at a 10μg/mL ***,***99 with Tam stimulated the maximum reduction of MCF-7 proliferation and viability in a time-dependent ***,Tam and ***99 augmented the DNA fragmentation percentage combined with the upregulation of the apoptotic ***,the results showed that the apoptotic impact of ***99 and Tam on MCF-7 cells may be intermediated by down-regulating some genes such as Claudin-1 followed by down-regulating mRNA expression of MMP-9,VEGF,and BCL-2 genes of treated *** Tam with ***99 considerably enhanced the effectiveness of conventional *** a result,this study suggested that the ***99 was ideal for developing effective natural treatments that would improve BC outcomes.

关键词： Breast cancer DNA fragmentation Apoptosis

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Tannin Nanoparticles(NP99)Enhances the Anticancer Effect of Tamoxifen on ER+Breast Cancer Cells

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Journal of Renewable Materials 2021年第12期9卷 2077-2092页

作者： Faizah A.AlMalki Aziza M.Hassan zeinab M.klaab Soliman Abdulla Antonio Pizzi Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biotechnology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Physics Faculty of ScienceAlexandria UniversityAlexandriaEgypt ENSTIB-LERMAB University of LorraineEpinal88051France

Recently,natural substances in the form of nanoparticles are increasingly being used in different field,particularly in medicines to enhance their beneficial effects in treatment and *** cells of the breast(MCF-7)have been chosen to be examined and treated in vitro with conventional drug Tamoxifen(Tam)and tannin nanoparticles extract(NP99)individually or in *** reagent has been applied to assess the cell viability and propagation percentage,DNA fragmentation and mRNA relative expression of apoptotic genes to study the cell death *** results showed that Tam and tannin NP99 triggered cytotoxic activity towards the MCF7 *** reduce the viability and induced high potent repressive activity on cell proliferation percentage and induced apoptosis as indicated by rising the percentage in DNA *** of NP99 extract exhibited its effect in a dose and *** combined treatment of Tam and NP99 were much more efficient than individual *** could be concluded that NP99 is considered a promising natural anticancer agent as a new tool in therapeutic strategies.

关键词： Condensed tannin nanoparticles tamoxifen MCF-7 cells anticancer

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