The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro

作     者：ZEINAB KLAAB AZIZA HASSAN JAWAHER ALBAQAMI FAIZAH A.ALMALKI 

作者机构：Department of BiologyTaif UniversityTaif21944Saudi Arabia Department of BiotechnologyTaif UniversityTaif21944Saudi Arabia 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第4期

页      面：891-904页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Researchers Supporting Project No.TURSP-2020/274 Taif University Taif Saudi Arabia 

主　　题：Breast cancer DNA fragmentation Apoptosis 

摘      要：Cancer remains to be one of the most severe sicknesses *** have kept rising over the *** cancer(BC),which is among the leading types of cancers and predominantly affects women,is the second leading cause of cancer *** have developed interventions over the years;however,the BC survival rate has not improved since the *** has created the need for novel drug interventions that would manage and treat BC more *** study focused on using a combination of natural product extracts such as phytoestrogen(Ziziphus jujube)and Tannin nanoparticles(NP99)together,which we have referred to as(***99)and tamoxifen(Tam)as one of the leading BC drugs since the 70s,in treating *** effectiveness of Tam if used alone in the treatment and if combined with ***99 was evaluated using MCF-7 cells in *** findings showed that the combination treatment of ***99 affected the proliferation and viability of MCF-7 cells more than Tam at a 10μg/mL ***,***99 with Tam stimulated the maximum reduction of MCF-7 proliferation and viability in a time-dependent ***,Tam and ***99 augmented the DNA fragmentation percentage combined with the upregulation of the apoptotic ***,the results showed that the apoptotic impact of ***99 and Tam on MCF-7 cells may be intermediated by down-regulating some genes such as Claudin-1 followed by down-regulating mRNA expression of MMP-9,VEGF,and BCL-2 genes of treated *** Tam with ***99 considerably enhanced the effectiveness of conventional *** a result,this study suggested that the ***99 was ideal for developing effective natural treatments that would improve BC outcomes.