检索结果-南通市图书馆

Synthesis of Fluorene-Bridged Arylene Vinylene Fluorophores： Effects of End-Capping Groups on the Optical Properties, Aggregation Induced Emission

引用

Chinese Journal of Chemistry 2015年第8期33卷 939-947页

作者： Guo-Feng Zhang Tao chen ze-qiang chen Matthew P. Aldred Xianggao Meng Ming-qiang Zhu Wuhan National Laboratory for Optoelectronics School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan Hubei 430074 China Department of Chemistry Durham University South Road Durham DH1 3LE UK Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of Chemistry Central China Normal University Wuhan Hubei 430079 China

We have synthesized a series of fluorene-based fluorophores, in which a central fluorene core has been modified with different peripheral arylene vinylene substituents that are able to activate aggregation-induced emission （AIE） characteristics. 9,9-Dioctylfluorene doubly end-capped at the 2,7-positions with triphenylethene groups, such as 4-（2,2-diphenylvinyl）phenyl （F1-（2,2）-HTPE） and 4-（1,2-dipbenylvinyl）phenyl （F1-（1,2）-HTPE） were synthesized and compared to the tetraphenylethene analogue （F1-TPE）. Both FI-（2,2）-HTPE and F1-（1,2）-HTPE glow with a deep blue fluorescence in THF solution with emission maxima （λem） of 426 and 403 nm, respectively. The λem slightly red-shifts in the solid-state to 458 nm for F 1-（2,2）-HTPE and 437 nm for F 1-（1,2）-HTPE. The fluorescence quantum yields （ΦF） of F1-（2,2）-HTPE （ΦF=35.1%） and FI-（1,2）-HTPE （ΦF=26.2%） were found to be higher in solution compared to the near quenching of F 1-TPE （ΦF = 0.1%）. Consequently, this results in weaker AIE-stability of F1-（2,2）-HTPE （αAIE= 1.5） and F1-（1,2）-HTPE （αAIE=1.9） compared to F1-TPE （αAIE=125）, suggesting that four phenyl groups are necessary for efficient AIE-activity of these fluorene bridged arylene vinylene type materials In addition, decreasing the steric hindrance around the arylene vinylene moiety by removal of a phenyl ring is an- other method to decrease the AIE characteristics, in a similar manner to the commonly known ＂phenyl-locking＂. Non-polar triphenylethenes are poorer AlE materials than their tetraphenylethene analogues. Replacing the hydro- gen atom of F1-（2,2）-HTPE with a cyano group affords fluorene end-capped with 2,3,3-triphenylacrylonitrile （F1-TPAN）, which boosts the AIE-effect to αAIE=90.5 and red-shifts the solid-state emission （λem=528 nm） with near quenching in THF solution （ΦF= 0.12%）. X-ray crystallographic analysis of F1-TPAN indicates that the intro- duction of cyano groups can not only diminish the intramolecular steric hindrance in comparison of F1-TPE, but

关键词： aggregation-induced emission fluorene triphenylethene tetraphenylethene 2,3,3-triphenylacrylonitrile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geminal Cross Coupling (GCC) Reaction for AIE Materials

引用

Chinese Journal of Polymer Science 2019年第4期37卷 327-339,I0005页

作者： Qi Yu Ya-Long Wang ze-qiang chen Peng-Ju Zhao cheng Fan Chong Li Ming-qiang Zhu Wuhan National Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and Technology

Tetraphenylethylene(TPE) derivatives are typical aggregation-induced emission(AIE) molecules, which have been widely investigated and applicated. The Rathore's procedures and McMurry reaction are the two frequently used methods for synthesizing the TPE derivatives. The complex processes and low tolerance of active function groups make the TPE with limited structures and properties in some degree. Very recently, a novel strategy, named geminal cross coupling(GCC) reaction, is developed for designing and synthesizing various topological small molecules and polymers with rich optical properties beyond simple TPE compounds, and becomes a powerful synthesis method to AIE materials. This review overviews the current progresses of AIE molecules and polymers prepared by GCC as well as their applications. We believe that GCC reaction will have a bright future in the development of the next generation of tetraarylethylene(TAE)-kind AIE materials.

关键词： GCC reaction AIE Tetraarylethylene Conjugated polymer Imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

引用

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging progress: photochemical transformation of nitroso compounds

引用

Science China Chemistry 2025年第1期 118-133页

作者： ze-Le chen qiang-qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

结合模糊C均值聚类和曲线演化的心脏MRI图像分割

引用

系统仿真学报 2005年第1期17卷 129-133页

作者：周则明陈强王平安夏德深南京理工大学计算机系南京210094 香港中文大学计算机科学与工程系

提出了结合模糊C均值聚类和曲线演化的MRT图像分割算法。由于心脏的变形和血液的流动,MRI图像中出现了弱边界、局部梯度极大值区域、伪影等现象。分析了使用水平集方法分割此类图像时出现的问题,提出了两阶段分割算法:结合先验知识和直... 详细信息

提出了结合模糊C均值聚类和曲线演化的MRT图像分割算法。由于心脏的变形和血液的流动,MRI图像中出现了弱边界、局部梯度极大值区域、伪影等现象。分析了使用水平集方法分割此类图像时出现的问题,提出了两阶段分割算法:结合先验知识和直方图,对心脏MRI图像进行模糊C均值聚类,再根据聚类的结果定义窄带中像素点的速度函数,通过曲线演化获取左心室的粗边界;然后使用梯度向量流构造另一速度函数对边界进行细化。心脏MRI图像的分割实验证明了算法的有效性。

关键词：曲线演化模糊C均值聚类水平集方法梯度向量流 MRI图像分割

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

引用

NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-ze Wang, Yu-Chang Liu, Ting-Ting Zhao, Quan-Liang Li, chen-Sha Cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

引用

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

引用

Science China Life Sciences 2025年第1期 300-302页

作者： ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Thieno[3,4-b]pyrazine-based Alternating Conjugated Polymers via Direct Arylation for Near-infrared OLED Applications

引用

Chinese Journal of Polymer Science 2022年第2期40卷 138-146页

作者： ze-Wang He qiang Zhang chen-Xi Li Hong-Ting Han Yan Lu School of Materials Science&Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials&Photoelectric DevicesMinistry of EducationTianjin University of TechnologyTianjin 300384China College of Chemistry Nankai UniversityTianjin 300071China

Three alternating conjugated polymers,namely PFTP,PCz TP,and PSi TP,which combine a thieno[3,4-b]pyrazine(TP)unit with different benzene-based donor units such as 9,9-dioctylfluorene,9-heptadecyl-9H-carbazole and 5,5-dioctyl-5H-dibenzo[b,d]silole,were synthesized in good yield(>85%)and high molecular weight up to Mn=5.82×10^(4) via direct arylation polymerization(DAr P).All the resultant polymers exhibit moderate bandgap of about 1.80 e V and strong deep red/near-infrared emitting in the solid *** them,the PSi TP-based electroluminescence(EL)devices with an architecture of ITO/PEDOT:PSS/PTAA/emitting layer/TPBi/Li F/Al give the best performance with a maximum luminance of 2543 cd/m^(2) at 478 m A/cm^(2).This work expands the application scope of high-performance conjugated polymers which can be synthesized by DAr P.

关键词： Thieno[3 4-b]pyrazine Alternating D-A structure Direct arylation polymerization Conjugated polymer Organic light-emitting diodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

宋代“鞫谳分司”制下司法参军的司法实践——以毛滂的“检法”实例为视角

引用

河北大学学报（哲学社会科学版） 2025年第1期50卷 44-52页

作者：柴荣陈泽北京师范大学法学院北京100875

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家... 详细信息

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家的毛滂,深受当时社会环境和家庭的影响,养成了较高的法律素养。分析毛滂在司法参军任上的“检法”实例,可以看出他在遵守法律的前提下,对“止杀”“仁民”“爱物”等司法活动多重价值的权衡取舍。结合具体的司法实践,可以更加深入地认识宋代重视法律的历史背景和“鞫谳分司”的运行机制,以及其与司法官员之间相互影响、相互作用的紧密关系。

关键词：重视法律 “鞫谳分司” 司法参军改易风俗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：