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Study on the efficacy of early treatment with pirfenidone on the lung function of patients with idiopathic pulmonary fibrosis

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World Journal of Clinical Cases 2024年第22期12卷 4913-4923页

作者： Ying Lei Jian-Hui Sheng Xu-Ru Jin Xian-Bing Liu Xiao-Yan Zheng Xiao-hua Xu Department of Pulmonary and Critical Care Medicine The Quzhou Affiliate Hospital of Wenzhou Medical UniversityQuzhou 324000Zhejiang ProvinceChina Department of Clinical Laboratory The Quzhou Affiliate Hospital of Wenzhou Medical UniversityQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Idiopathic pulmonary fibrosis(IPF)is classified under fibrotic interstitial pneumonia,characterized by a chronic and progressive *** predominant clinical features of IPF include dyspnea and pulmonary *** To assess the effects of pirfenidone in the early treatment of IPF on lung function in *** A retrospective analysis was performed on 113 patients with IPF who were treated in our hospital from November 2017 to January *** patients were divided into two groups:control group(n=53)and observation group(n=60).In the control group,patients received routine therapy in combination with methylprednisolone tablets,while those in the observation group received routine therapy together with *** applying these distinct treatment approaches to the two groups,we assessed several parameters,including the overall effectiveness of clinical therapy,the occurrence of adverse reactions(e.g.,nausea,vomiting,and anorexia),symptom severity scores,pulmonary function index levels,inflammatory marker levels,and the 6-min walk distance before and after treatment in both *** The observation group exhibited significantly higher rates than the control group after therapy,with a clear distinction(P<0.05).After treatment,the observation group experienced significantly fewer adverse reactions than the control group,with a noticeable difference(P<0.05).When analyzing the symptom severity scores between the two groups of patients after treatment,the observation group had significantly lower scores than the control group,with a distinct difference(P<0.05).When comparing the pulmonary function index levels between the two groups of patients after therapy,the observation group displayed significantly higher levels than the control group,with a noticeable difference(P<0.05).Evaluating the inflammatory marker data(C-reactive protein,interleukin-2[IL-2],and IL-8)between the two groups of patients after therapy,the observation group

关键词： Pirfenidone Early intervention Idiopathic pulmonary fibrosis Pulmonary function Effect evaluation

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Polyoxometalates based compounds for green synthesis of aldehydes and ketones

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中国化学快报:英文版 2023年第8期34卷 90-101页

作者： Kejie Qin Dejin zang Yongge Wei School of Pharmacy and Pharmaceutical Sciences&Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesNHC Key Laboratory of biotechnology drugs(Shandong Academy of Medical Sciences)Key Lab for Rare&Uncommon Diseases of Shandong ProvinceJi’nan 250117China Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

Molecular oxygen within Polyoxometalates(POMs)based compounds are ideal oxidants with high atom economy and its use results in the production of water as the only *** progress has been made in the development of catalytic methods for aerobic alcohol oxidation to have aldehydes and ketones with POMs based *** are alternative to the use of traditional hypervalent iodine catalyst systems which are with molecular oxygen as a terminal ***,POMs based catalysts can be applied to catalytic reactions with different modes of energization such as thermocatalysis,photocatalysis and *** review summarizes the frontier advances in polyoxometalates for catalytic alcohol selective oxidation in thermocatalytic,electrocatalytic,and photocatalytic *** three advantages of POM catalysts in terms of performance,economy,and environmental protection are *** include the use of sol-gel and electrostatic assembly methods to increase the reaction surface area,reduce the use of precious metals,and improve the stability of POMs *** field of selective alcohol oxidation is ***,the challenges of preparing more efficient and“green”catalysts are presented.

关键词： Polyoxometalates Alcohol oxidation Thermocatalysis Photocatalysis Electrocatalysis Aldehydes Ketones

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Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury

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Neural Regeneration Research 2016年第4期11卷 670-675页

作者： Ye-chen Lu Han-qiu Liu Xu-yun hua Yun-dong Shen Wen-dong Xu Jian-guang Xu Yu-dong Gu Department of Hand Surgery Huashan HospitalFudan University Department of Radiology Huashan HospitalFudan University State Key Laboratory of Medical Neuroscience Fudan University

Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve *** is believed that the capability of brain plasticity is crucial for the recovery of hand *** supplementary motor area may play a key role in brain remodeling after peripheral nerve *** this study,we explored the activation mode of the supplementary motor area during a motor imagery *** investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery *** from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor *** result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain *** of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.

关键词： nerve regeneration peripheral nerve injury brachial plexus injury neuronal plasticity supplementary motor area premotor area magnetic resonance imaging motor preparation motor imagery clinical restoration of hand function cortical remodeling block design neural regeneration

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高功率线偏振窄线宽光纤激光器TMI抑制

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激光与红外 2024年第5期54卷 692-696页

作者：崔国栋赵鸿张利明张大勇吕华昌中国电子科技集团公司第十一研究所北京100015

高功率线偏振窄线宽光纤激器在功率光谱合成、相干探测等方面具有广泛的应用前景。在高功率线偏振窄线宽光纤激光器中,模式不稳定(TMI)效应是限制其功率提升的主要因素之一。本文分析了TMI效应对高功率线偏振窄线宽光纤激光器输出功率... 详细信息

高功率线偏振窄线宽光纤激器在功率光谱合成、相干探测等方面具有广泛的应用前景。在高功率线偏振窄线宽光纤激光器中,模式不稳定(TMI)效应是限制其功率提升的主要因素之一。本文分析了TMI效应对高功率线偏振窄线宽光纤激光器输出功率的影响,提出了TMI效应的抑制方法。文章采用长波泵浦技术,输出功率100 mW的单频激光器作为种子源,相位调制器将种子源线宽展宽至25 GHz,经三级放大,最终实现了线宽25 GHz、功率2.2 kW、中心波长1064 nm、消光比98%的线偏振窄线宽激光输出,光束质量M_(x)^(2)=1.2、M_(y)^(2)=1.21。分析了泵浦波长对TMI效应的影响:由于光线芯径较小(20μm),增益光纤对泵浦光吸收系数较高(1.8 dB/m@976 nm),纤芯温度较高,加上泵浦光量子亏损引入的热,导致纤芯折射率发生变化,较低功率下发生TMI效应,当泵浦波长向长波偏移时,泵浦光的量子亏损降低,同时泵浦吸收系数也降低,无论在光纤全长、还是单位长度上的热分布均减小,增大了TMI阈值,提升了线偏振窄线宽光纤激光器的输出功率。

关键词：光纤激光器线偏振窄线宽模式不稳定

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Concomitant atypical knee gout and seronegative rheumatoid arthritis:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5245-5252页

作者： Zhou-Yi Chen Min-hua Ou-Yang Shao-Wei Li Rui Ou Zhi-huang Chen Song Wei Department of Chinese Medicine General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Gout Guangdong Hydropower HospitalGuangzhou 511340Guangdong ProvinceChina

BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently *** information is available regarding the clinical management and prognosis of these combined *** SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with *** initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the *** symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues *** invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee *** postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both *** This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.

关键词： Arthroscopic debridement Minimally invasive diagnostic techniques Seronegative rheumatoid arthritis Atypical knee gout Case report

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Combined transarterial chemoembolization and tislelizumab for patients with unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2829-2841页

作者： Bin-Bin Tan Ying Fu Ming-hua Shao Hai-Lei Chen Ping Liu Chao Fan Hui Zhang Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Jiangbei Area(The 958th Hospital of Chinese People's Liberation Army)Chongqing 400020China

BACKGROUND Hepatocellular carcinoma(HCC)often presents as unresectable,necessitating effective treatment *** transarterial chemoembolization(TACE)with immunotherapy and targeted therapy has shown promise,yet real-world evidence is *** To investigate effectiveness and safety of TACE with tislelizumab±targeted therapy for unresectable HCC in real-world *** This retrospective study included patients with unresectable HCC receiving combined treatment of TACE and *** clinical outcomes included progression-free survival(PFS),overall survival(OS),objective response rate(ORR),and disease control rate(DCR).All patients were evaluated according to the mRECIST *** adverse event(AE)was also *** In this study of 56 patients with median follow-up of 10.9 months,7 had previous *** was administered before TACE in 21(37.50%)and after in 35(62.50%)patients,with 91.07%receiving concurrent targeted *** PFS was 14.0(95%CI:7.0-18.00)months,and OS was 28(95%CI:2.94-53.05)*** with prior immunotherapy had shorter PFS(6 vs.18 months,P=0.006).Overall ORR and DCR were 82.14%and 87.50%.Grade≥3 treatment-related AEs included increased alanine aminotransferase(8.93%),aspartate aminotransferase(10.71%),and total bilirubin(3.57%).CONCLUSION The combination of TACE and tislelizumab,with or without targeted therapy,demonstrated promising efficacy and safety in unresectable HCC,especially in immunotherapy-naive patients,warranting further prospective validation studies.

关键词： Hepatocellular carcinoma Transarterial chemoembolization,Therapeutic Immunotherapy Prognosis

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Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-Hui Kuang Tao Hu Lu-Yong Zhang Yu-Feng Yao Ming-hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill

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枯草芽孢杆菌在动物生产中的应用与作用机制

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饲料研究 2024年第8期47卷 150-155页

作者：付雪张启航刘周靓臧荣鑫西北民族大学生命科学与工程学院甘肃兰州730124

枯草芽孢杆菌是目前应用较为广泛的益生菌之一,具有较强的稳定性,可在动物肠道内生存与繁殖。枯草芽孢杆菌与其他益生菌或益生元存在协同作用,是在微生物饲料添加剂中应用较为广泛的益生菌。枯草芽孢杆菌比乳酸菌和双歧杆菌在胃肠道内... 详细信息

枯草芽孢杆菌是目前应用较为广泛的益生菌之一,具有较强的稳定性,可在动物肠道内生存与繁殖。枯草芽孢杆菌与其他益生菌或益生元存在协同作用,是在微生物饲料添加剂中应用较为广泛的益生菌。枯草芽孢杆菌比乳酸菌和双歧杆菌在胃肠道内的生存能力更具优势。枯草芽孢杆菌可调节动物肠道菌群,改善生长性能,增强免疫力和肠道健康。文章以枯草芽孢杆菌的生理特征作为出发点,描述其在动物生产上的应用及其调控肠道健康、抑制氧化应激、增强机体免疫力等作用,旨在为枯草芽孢杆菌在动物生产中的相关应用提供参考。

关键词：枯草芽孢杆菌动物生产肠道健康氧化应激机体免疫力

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Understanding fundamentals of electrochemical reactions with tender X-rays:A new lab-based operando X-ray photoelectron spectroscopy method for probing liquid/solid and gas/solid interfaces across a variety of electrochemical systems

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Chinese Journal of Catalysis 2022年第11期43卷 2858-2870页

作者： Chiyan Liu Qiao dong Yong Han Yijing zang Hui Zhang Xiaoming Xie Yi Yu Zhi Liu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

Electrocatalysis is key to improving energy efficiency,reducing carbon emissions,and providing a sustainable way of meeting global energy ***,elucidating electrochemical reaction mechanisms at the electrolyte/electrode interfaces is essential for developing advanced renewable energy ***,the direct probing of real-time interfacial changes,i.e.,the surface intermediates,chemical environment,and electronic structure,under operating conditions is challenging and necessitates the use of in situ ***,we present a new lab-based instrument commissioned to perform in situ chemical analysis at liquid/solid interfaces using ambient pressure X-ray photoelectron spectroscopy(APXPS).This setup takes advantage of a chromium source of tender X-rays and is designed to study liquid/solid interfaces by the“dip and pull”*** of the main components was carefully described,and the results of performance tests are *** a three-electrode setup,the system can probe the intermediate species and potential shifts across the liquid electrolyte/solid electrode *** addition,we demonstrate how this system allows the study of interfacial changes at gas/solid interfaces using a case study:a sodium–oxygen model ***,the use of APXPS in electrochemical studies is still in the early stages,so we summarize the current challenges and some developmental *** the challenges,we expect that joint efforts to improve instruments and the electrochemical setup will enable us to obtain a better understanding of the composition–reactivity relationship at electrochemical interfaces under realistic reaction conditions.

关键词： Tender X-rays Ambient pressure X-ray photoelectron spectroscopy Electrocatalysis Liquid/solid interface Gas/solid interface

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微循环阻力指数联合左室舒张末期压力指数预测急性心肌梗死患者预后的价值

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吉林医学 2024年第9期45卷 2073-2077页

作者：刘启云李江华刘华东尹达罗林杰深圳市人民医院、暨南大学第二临床医学院、南方科技大学第一附属医院心内科、深圳市心血管微创医学工程技术研究开发中心广东深圳518020

目的:探讨急性ST段抬高型心肌梗死(STEMI)患者中联合测量微血管阻力指数(IMR)和左室舒张末期压力(LVEDP)对介入治疗(PCI)患者预后的价值。方法:选取2019年3月~2021年10月深圳市人民医院收治的STEMI患者73例,行急诊血运重建治疗。在直接... 详细信息

目的:探讨急性ST段抬高型心肌梗死(STEMI)患者中联合测量微血管阻力指数(IMR)和左室舒张末期压力(LVEDP)对介入治疗(PCI)患者预后的价值。方法:选取2019年3月~2021年10月深圳市人民医院收治的STEMI患者73例,行急诊血运重建治疗。在直接PCI结束时进行IMR和LVEDP测量,根据结果分为低LVEDP/低IMR组(n=24),高LVEDP/低IMR组(n=14),低LVEDP/高IMR组(n=19),高LVEDP/高IMR组(n=16)。对术后住院期间及术后3个月时的心脏功能指标、随访起病之后1年时主要不良心脏事件(MACE)进行统计学分析。结果:入选STEMI患者均成功行再灌注治疗,术后TIMI血流均为Ⅲ级。四组比较,运重建治疗之后住院期间EF值比较差异无统计学意义(P>0.05)。血运重建治疗之后3个月,高LVEDP/高IMR组EF值低于其他组,差异有统计学意义(P0.05);术后及术后3个月,高LVEDP/高IMR组NT-proBNP值均高于其他组,差异有统计学意义(P0.05)。1年随访MACE发生率,高LVEDP/高IMR组的发生率显著升高,与其他三组比较,差异有统计学意义(P<0.05)。结论:IMR联合LVEDP可以明显提高对STEMI患者直接经皮冠状动脉介入治疗预后的预测价值。

关键词：急性ST段抬高型心肌梗死微血管阻力指数左室舒张末期压力冠状动脉介入治疗预后

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