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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing dong huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo Beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

Spatial interfacial heat transfer and surface characteristics during gravity casting of A356 alloy

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Transactions of Nonferrous Metals Society of China 2019年第1期29卷 43-50页

作者： Jia-hua LIN Hai-dong ZHAO Jia-min huaNG National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of Technology Guangzhou 510641 China

As one of the key boundary conditions during casting solidification process, the interfacial heat transfer coefficient (IHTC) affects the temperature variation and distribution. Based on the improved nonlinear estimation method (NEM), thermal measurements near both bottom and lateral metal-mold interfaces throughout A356 gravity casting process were carried out and applied to solving the inverse heat conduction problem (IHCP). Finite element method (FEM) is employed for modeling transient thermal fields implementing a developed NEM interface program to quantify transient IHTCs. It is found that IHTCs at the lateral interface become stable after the volumetric shrinkage of casting while those of the bottom interface reach the steady period once a surface layer has solidified. The stable value of bottom IHTCs is 750 W/(m^2·℃), which is approximately 3 times that at the lateral interface. Further analysis of the interplay between spatial IHTCs and observed surface morphology reveals that spatial heat transfer across casting-mold interfaces is the direct result of different interface evolution during solidification process.

关键词： A356 alloy solidification interfacial heat transfer coefficient inverse heat conduction problem surface characteristics

基于高效液相色谱-高分辨串联质谱的他克莫司软膏杂质谱研究

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中国药学杂志 2024年第1期59卷 78-87页

作者：布仁周刚盛华莲花曹慧敏朱召贞白文明内蒙古医科大学药学院呼和浩特010110 内蒙古自治区药品检验研究院呼和浩特010020 山东瑞安药业有限公司济南250013

目的研究他克莫司软膏的杂质谱,为仿制药质量标准制定提供依据。方法采用高效液相色谱-高分辨串联质谱联用技术分析强制破坏后的他克莫司软膏杂质,根据一级、二级质谱数据结合杂质的质谱裂解方式,推测各杂质的来源和分子结构。结果他克... 详细信息

目的研究他克莫司软膏的杂质谱,为仿制药质量标准制定提供依据。方法采用高效液相色谱-高分辨串联质谱联用技术分析强制破坏后的他克莫司软膏杂质,根据一级、二级质谱数据结合杂质的质谱裂解方式,推测各杂质的来源和分子结构。结果他克莫司软膏强制破坏后,共产生10个杂质,其中包括3组同分异构体。结论本研究建立的杂质谱分析方法为他克莫司软膏的质量控制和工艺优化提供了参考依据。

关键词：他克莫司软膏杂质谱裂解方式高效液相色谱-高分辨串联色谱

利用ATR-FTIR定量测定聚氨酯预聚体的异氰酸酯基含量

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应用化工 2024年第8期53卷 1989-1991,2002页

作者：张栋孙峤昳孔德婷董阳北京低碳清洁能源研究院北京102211

对于多苯基多亚甲基多异氰酸酯与聚醚多元醇制备的聚氨酯预聚体系列样品进行衰减全反射傅里叶变换红外(ATR-FTIR)测试,分别用异氰酸酯基团(-NCO)的红外特征峰(~2245 cm^(-1))的吸光度A和校正峰面积S与电位滴定法得到的-NCO含量进行线性... 详细信息

对于多苯基多亚甲基多异氰酸酯与聚醚多元醇制备的聚氨酯预聚体系列样品进行衰减全反射傅里叶变换红外(ATR-FTIR)测试,分别用异氰酸酯基团(-NCO)的红外特征峰(~2245 cm^(-1))的吸光度A和校正峰面积S与电位滴定法得到的-NCO含量进行线性拟合。结果表明,后者的线性关系优于前者,相关系数R 2分别为0.9967和0.9856。依据校正峰面积S对-NCO含量之间的工作曲线,测定了新制备预聚体的-NCO含量,与电位滴定法相比,相对误差均<0.2%,相对标准偏差均<0.5%,表明测试准确度良好,方法可靠。利用ATR-FTIR测定聚氨酯预聚体的-NCO含量,样品无需任何前处理且用量少,不产生废液、环境友好,测试结果可靠;便于在工业生产现场进行操作和应用。

关键词：傅里叶变换红外光谱聚氨酯预聚体异氰酸酯基线性拟合定量测定

采用NaA型分子筛膜反应器合成奥拉西坦的研究

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化学工程师 2024年第5期38卷 107-110页

作者：李阳郑秋红盛春光吴巍臧毅华中海油天津化工研究设计院有限公司天津300131

为了解决奥拉西坦合成工艺复杂、产品收率低的技术难题,本文采用NaA型分子筛膜反应器通过蒸汽渗透技术与环合反应耦合制备奥拉西坦,考察了工艺条件对处理效果的影响。结果表明,在NaA分子筛膜渗透侧真空度为0.02~0.05MPa、反应温度为85... 详细信息

为了解决奥拉西坦合成工艺复杂、产品收率低的技术难题,本文采用NaA型分子筛膜反应器通过蒸汽渗透技术与环合反应耦合制备奥拉西坦,考察了工艺条件对处理效果的影响。结果表明,在NaA分子筛膜渗透侧真空度为0.02~0.05MPa、反应温度为85℃、反应时间为24h的条件下,奥拉西坦的产品收率达到80.5%;在NaA分子筛膜污染后经过再生,渗透通量恢复率达到99.1%。

关键词：奥拉西坦 NaA型分子筛膜蒸汽渗透

Sensitivity study of anomalous HZZ couplings at a future Higgs factory

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Chinese Physics C 2019年第10期43卷 1-6页

作者： hua-dong Li Cai-Dian Lü Lian-You Shan Institute of High Energy Physics CASBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China

We study the sensitivity of constraining the model independent HZZ coupling based on the effective theory up to dimension-6 operators at a future Higgs factory. Using the current conceptual design parameters of the Circular Electron Positron Collider, we give the experimental limits for the model independent operators given by the total Higgsstrahlung cross-section and the angular distribution of Z boson decays. In particular, we give the very small sensitivity limit for the CP violation parameter g, which will be a clear window to test the Standard Model and look for new physics signals.

关键词： Higgs new physics effective field theory CEPC

基于PSW-DID模型的最严格水资源管理政策评估效应

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数理统计与管理 2024年第2期43卷 223-237页

作者：韩爱华高子桓罗一方韩素华中南财经政法大学湖北武汉430073 武汉学院湖北武汉430212

水利是农业的命脉,农业节水灌溉是突破农业粮食生产的水资源瓶颈,2011年建立了最严格水资源管理制度。基于此,本文以塔里木河流域5个地州42个县市和兵团4个师为样本,使用倾向得分加权双重差分(PSW-DID)方法,从最严格水资源管理对扩大耕... 详细信息

水利是农业的命脉,农业节水灌溉是突破农业粮食生产的水资源瓶颈,2011年建立了最严格水资源管理制度。基于此,本文以塔里木河流域5个地州42个县市和兵团4个师为样本,使用倾向得分加权双重差分(PSW-DID)方法,从最严格水资源管理对扩大耕地灌溉面积以及促进农业发展两个方面,客观评价最严格水资源管理政策的实施效果。研究发现:(1)PSW-DID模型不仅解决了内生性问题,消除了样本选择性偏差,而且采用重叠权重实现了处理组与控制组之间的平衡,避免了PSM-DID模型中控制组样本损失,提升了估计的效率与稳健性;(2)最严格水资源管理红线的划定对耕地灌溉面积扩大有正向促进作用,政策实施效果因灌区类型、耕地类型不同而产生差异;(3)耕地灌溉面积扩大可以为最严格水资源管理政策在推动农业发展方面提供重要保障,在中型灌区实施该政策对农业生产总值的促进效果更加显著。

关键词：最严格水资源政策节水灌溉农业发展双重差分倾向得分加权

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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甲苯催化氧化的研究进展

现代化工 2024年第8期44卷 48-53页

作者：彭秀德徐怀钰何德东罗永明曹小华昆明理工大学化学工程学院云南昆明650500

以贵金属、过渡金属、钙钛矿、尖晶石和MOFs基催化剂为例,综述了不同类型的催化剂在甲苯催化氧化领域中取得的研究进展,并对其催化氧化甲苯的反应路径和机理进行了总结。最后提出了甲苯催化氧化所存在的技术难点,并对该方法未来发展方... 详细信息

以贵金属、过渡金属、钙钛矿、尖晶石和MOFs基催化剂为例,综述了不同类型的催化剂在甲苯催化氧化领域中取得的研究进展,并对其催化氧化甲苯的反应路径和机理进行了总结。最后提出了甲苯催化氧化所存在的技术难点,并对该方法未来发展方向进行了展望。

关键词：甲苯催化氧化催化性能反应机理

智能制造时代下圆竹家具的艺术传承和消费启迪

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林产工业 2024年第5期61卷 87-92页

作者：李言宋莎莎费本华王雪花北京林业大学木质材料科学与应用教育部重点实验室北京100083 北京林业大学木材科学与工程北京市重点实验室北京100083 国际竹藤中心国家林业和草原局/北京市共建竹藤科学与技术重点实验室北京100102 南京林业大学家居与工业设计学院江苏南京210037

圆竹家具是中国传统文化的重要载体,为了推广圆竹家具,营造传统文化生活环境,本文梳理了传统圆竹家具的文化传承和发展脉络,分析归纳了圆竹家具设计的原则和共性,总结出传统圆竹家具的艺术传承和文化特质。同时,探讨了圆竹家具中的文化... 详细信息

圆竹家具是中国传统文化的重要载体,为了推广圆竹家具,营造传统文化生活环境,本文梳理了传统圆竹家具的文化传承和发展脉络,分析归纳了圆竹家具设计的原则和共性,总结出传统圆竹家具的艺术传承和文化特质。同时,探讨了圆竹家具中的文化现象,对圆竹家具的文化符号进行了挖掘。在此基础上,分析了现代圆竹家具的消费倾向,得出了文化导向、环保导向、设计导向、工艺导向共同作用影响消费者决策的结论。此外,对现代圆竹家具的智造创新进行了分析,提出了生产标准化、连接方式五金化、部件模块化的圆竹家具智能制造发展路径。最后,从设计、制造、管理、服务四个角度阐述了圆竹家具智能制造的发展前景。

关键词：圆竹家具传统技艺艺术传承文化特质文化符号