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Micro RNAs and clinical implications in hepatocellular carcinoma

World Journal of Hepatology 2017年第23期9卷 1001-1007页

作者： Amal Ahmed Mohamed zainab A ali-eldin Tamer A Elbedewy Magdy El-Serafy Fatma A ali-eldin Hossameldin Abdel Aziz Biochemistry Department National Hepatology and Tropical Medicine Research Institute Department of Internal Medicine Faculty of MedicineAin Shams University Department of Internal Medicine Facultyof MedicineTanta University Department of Tropical Medicine Faculty of MedicineCairo University Department of Tropical Medicine Faculty of MedicineAin Shams University

To assess the role of some circulating miRNAs (miR-23a, miR-203, miR338, miR-34, and miR-16) as tumor markers for diagnosis of hepatocellular carcinoma (HCC). METHODSOne hundred and seventy-one subjects were enrolled, 57 patients with HCC, 57 patients with liver cirrhosis (LC) and 57 healthy subjects as control group. Severity of liver disease was assessed by Child Pugh score. Tumor staging was done using Okuda staging system. Quantification of Micro RNA (miR-23a, miR-203, miR338, miR-34, and miR-16) was performed. RESULTSAll studied miRNA showed significant difference between HCC and cirrhotic patients in comparison to healthy control. miR-23a showed statistically significant difference between HCC and cirrhotic patients being higher in HCC group than cirrhotic. miR-23a is significantly higher in HCC patients with focal lesion size equal or more than 5 cm, patients with multiple focal lesions and Okuda stage III. At cutoff value ≥ 210, miR-23a showed accuracy 79.3% to diagnose HCC patients with sensitivity 89.47% and specificity about 64.91%. At cut off level ≥ 200 ng/mL, serum alpha fetoprotein had 73.68% sensitivity, 52.63% specificity, 43.75% PPV, 80% NPV for diagnosis of HCC. CONCLUSIONMicroRNA 23a can be used as a screening test for early detection of HCC. Also, it is related to larger size of tumour, late Okuda staging and multiple hepatic focal lesions, so it might be a prognostic biomarker.

关键词： Hepatocellular carcinoma MicroRNA Liver cirrhosis MiR-23a

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Colorectal cancer in Arab world:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1791-1798页

作者： Nahed A Makhlouf Muhammad Abdel-Gawad Aya M Mahros Sameh A Lashen Mariam Zaghloul Ahmed Eliwa Eman E Elshemy zainab ali-eldin Doaa Abdeltawab Fathiya El-Raey Dalia Omran Marwa Khalaf Nancy Fanous Ahmed Shawkat Abdelmohsen Ahmed Abu-Elfatth Mohamed Abdelghani Mahmoud Farouk Mohamed Abdelaziz Mohamed Alboraie Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroenterologyand Infectious DiseasesAl-Azhar UniversityAssiut 71631Egypt Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafrelsheikh 33656Egypt Department of Internal Medicine Alexandria UniversityAlexandria 21521Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Hepatogastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt Department of Internal Medicine Ain Shams UniversityCairo 11646Egypt Department of Hepatogastroenterology and Infectious diseases Faculty of MedicineAl-Azhar UniversityDamietta 34511CairoEgypt Department of Endemic Medicine Cairo UniversityCairo 12613Egypt Department of Tropical Medicine and Gastroenterology Assiut Liver CenterAssiut 71511Egypt Department of Gastroenterology Hepatology and EndoscopyPolice Authority HospitalCairo 12654Egypt Department of Clinical Oncology and Nuclear Medicine Al-Azhar UniversityCairo 11824Egypt

BACKGROUND The incidence of colorectal cancer(CRC)is increasing among young individuals in the Arab world as well as in other regions of the *** To explore the incidence and prevalence of CRC in the Arab *** The PubMed,Scopus,Web of Science,EBSCO and Wiley databases were searched to retrieve relevant articles irrespective of the language or the publication *** search terms were("colon OR rectum OR sigmoid OR rectal OR colonic OR colorectal")AND("cancer OR malignancy OR malignant OR neoplasm")AND("Jordan"OR"United Arab Emirates"OR"Bahrain"OR"Tunisia"OR"Algeria"OR"Djibouti"OR"Saudi Arabia"OR"Sudan"OR"Syria"OR"Somalia"OR"Iraq"OR"Oman"OR"Palestine"OR"Qatar"OR"Comoros"OR"Kuwait"OR"Lebanon"OR"Libya"OR"Egypt"OR"Morocco"OR"Mauritania"OR"Yemen").Reviews,metaanalyses,and articles containing nonoriginal data were *** articles were screened,and relevant data were *** statistics were used for data *** Nine studies were *** of the studies provided information regarding the prevalence of *** prevalence of CRC was 0.72% in Saudi Arabia and 0.78% in the United Arab Emirate,while in Egypt,it ranged from 0.4% to 14%.Four studies showed information regarding the *** annual incidence rate of CRC in Qatar was 7.5/100000/*** Egypt,the crude incidence rate(CIR)in males was 3.1 for colon cancer and 1 for rectal cancer,while in females,it was 2.3 for colon cancer and 0.8 for rectal *** age-standardized rate for CRC incidence in 2003 was 36.90 for males,26.50 for females,and 30.49 for both sexes in Saudi *** 2016,the CIRs in Saudi Arabia were 3.6 and 2.1 in females for colon cancer and rectal cancer,respectively,while in males,it was 3.3 and 2.8 for colon cancer and rectal cancer,*** study in Egypt revealed that 25% of CRC cases occurred among individuals younger than 40 years *** There is a considerable prevalence of CRC in some Arab *** studies are n

关键词： Colorectal cancer Incidence Prevalence Arab world

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Perception beyond sight:Investigating the cognitive maps of congenitally blind individuals in urban environments

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Frontiers of Architectural Research 2024年第4期13卷 809-821页

作者： Anwar Ibrahim Hikmat Hali zainab Mahmoud College of Architecture and Design Jordan University of Science and TechnologyIrbidJordan College of Engineering and Architecture Al Yamamah UniversityRiyadhKSA

This study explores the challenges faced by congenitally blind individuals in navigating urban ***,this research investigates the factors that contribute to the construction of city mental mapping for individuals who are born ***-one congenitally blind individuals from the University of Jordan were asked to define and describe specific elements of the city based on their personal experiences and ***,participants were guided through two urban paths:familiar and *** participants were asked to complete a survey regarding their experiences during the *** collected data was analyzed by using thematic *** results revealed that congenitally blind individuals construct their mental image of the city by using their three senses of touching,hearing,and smelling,as well as their safety and *** mental image consists of five key elements:links,reference points,areas,separators,and *** the small size of the study sample and the specificity of the context,the results of this study will tremendously help planners in designing highly inclusive urban *** characteristics that can be recognized by the blinds will enhance their accessibility of urban spaces,encourage independent mobility,increase the quality of life and social inclusion for them.

关键词： Mental map City image Congenital blind Cognitive mapping Environmental perception

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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： Hasan M Isa Fatema A Alkharsi Jawad K Khamis Sawsan A Hasan zainab A Naser zainab N Mohamed Afaf M Mohamed Shaikha A Altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and Medical Departments of Salmaniya Medical Complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,Ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and Mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-Meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis C

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Acute Transverse Myelitis in Pregnancy—A Case Report and a Literature Review

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1512-1521页

作者： Huda Abbas ali Isa Fatema Hasan zainab Mohd Al Aswad Naeema Ahmed Abdulkareem Salmaniya Medical Complex Manama Bahrain Ob Gyn Faculty Arabian Gulf University Manama Bahrain

Purpose: This case report highlights a rare instance of a 26-week pregnant woman presenting with limb numbness, diagnosed with acute transverse myelitis (ATM) following COVID-19 vaccination. Notably, she tested positive for neuromyelitis optica (NMO) but did not exhibit the typical symptoms of blurred vision. Methods: Data were collected from I Seha in governmental hospitals in Bahrain, providing a comprehensive overview of the patient’s clinical journey. Results: The patient was treated with carbamazepine, steroids, and clexane, leading to the successful delivery of a healthy baby at 34 weeks. However, two years postpartum, she reported new episodes of blurred vision and numbness. Subsequent treatment with Rituximab resulted in significant improvement, with a diagnosis of Devic’s disease established. Conclusion: Acute transverse myelitis is a rare condition, particularly during pregnancy, and in this case, symptoms of Devic’s disease were masked by the absence of blurred vision. This condition predominantly affects females in their 20s during childbearing years and can lead to complications such as premature delivery. Effective management includes steroids and antiepileptic drugs, with clexane playing a crucial role in preventing embolisms. A delivery mode may vary based on obstetric factors, and MRI remains the gold standard for diagnosis. Close follow-up is essential for optimal patient outcomes.

关键词： Acute Transverse Myelitis (ATM) COVID-19 Devic’s Syndrome Neuromyelitis Optica (NMO) Obstetric Management of ATM

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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

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Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-Chaves zainab Maastor Carlos Spuch José Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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Predictive modelling of volumetric and Marshall properties of asphalt mixtures modified with waste tire-derived char:A statistical neural network approach

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Journal of Road Engineering 2024年第3期4卷 318-333页

作者： Nura Shehu aliyu Yaro Muslich Hartadi Sutanto Noor zainab Habib aliyu Usman Abiola Adebanjo Surajo Abubakar Wada Ahmad Hussaini Jagaba Department of Civil and Environmental Engineering Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Civil Engineering Ahmadu Bello UniversityZaria 810107Nigeria Institute of Infrastructure and Environment Heriot-Watt UniversityDubai 294345United Arab Emirates School of Civil Engineering Central South UniversityChangsha 410075China Interdisciplinary Research Centre for Membranes and Water Security King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

The goals of this study are to assess the viability of waste tire-derived char(WTDC)as a sustainable,low-cost fine aggregate surrogate material for asphalt mixtures and to develop the statistically coupled neural network(SCNN)model for predicting volumetric and Marshall properties of asphalt mixtures modified with *** study is based on experimental data acquired from laboratory volumetric and Marshall properties testing on WTDCmodified asphalt mixtures(WTDC-MAM).The input variables comprised waste tire char content and asphalt binder *** output variables comprised mixture unit weight,total voids,voids filled with asphalt,Marshall stability,and *** coupled neural networks were utilized to predict the volumetric and Marshall properties of asphalt *** predictive modeling,the SCNN model is employed,incorporating a three-layer neural network and preprocessing techniques to enhance accuracy and *** optimal network architecture,using the collected dataset,was a 2:6:5 structure,and the neural network was trained with 60%of the data,whereas the other 20%was used for cross-validation and testing *** network employed a hyperbolic tangent(tanh)activation function and a feed-forward *** to the results,the network model could accurately predict the volumetric and Marshall *** predicted accuracy of SCNN was found to be as high value>98%and low prediction errors for both volumetric and Marshall *** study demonstrates WTDC's potential as a low-cost,sustainable aggregate *** SCNN-based predictive model proves its efficiency and versatility and promotes sustainable practices.

关键词： Waste tire Neural network Sustainable practices Asphalt mixtures Predictive model

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Exploring the impact of tacrolimus on kidney transplant recipients:insights into immunological outcomes

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Journal of Chinese Pharmaceutical Sciences 2024年第8期33卷 737-750页

作者： zainab A Abbood Ahmed Hamza AL-Shammari Eman M.Jasim Amjad I.Oraibi Department of Pharmacy Kut University CollegeAlkutWasitIraq52001 AL-Manara College For Medical Science/Department of Pharmacy MisanIraq62001

To minimize graft rejection,it is crucial to reduce *** the present study,we investigated immunological markers in the blood of transplant patients who did not receive *** also assessed alloreactive CD4+CD25+FoxP3+ Tregs both before transplantation and after tacrolimus *** comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 *** reducing tacrolimus,rejectors exhibited elevated levels of memory CD8+T cells compared to Tregs,while non-rejectors displayed a lower ratio of memory CD4+T cells to *** tacrolimus removal,rejectors showed an increase in naïve T cells and a decrease in effector T *** transplantation,CD4+Treg levels declined,but their anti-donor regulatory function remained consistent in both rejectors and *** correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T *** indicators identified individuals whose immunosuppression could be safely reduced.

关键词： Tacrolimus Kidney Transplant Immune system Rejection

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Subconjunctival hemorrhage after wet cupping therapy: a case report

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Clinical Research Communications 2024年第2期7卷 27-29页

作者： zainab AlMusleh Ahmad Alrawashdeh Tamer Aboushanab Department of Academic Tabibi Poly ClinicDoha 212100Qatar Hearing&Balance Disorders Hamad Medical CorporationDoha 3050Qatar Department of Therapeutic Ministry of Health and PopulationCairo 11467Egypt.

Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of *** therapy is reported to be a relatively safe practice especially if performed by qualified *** hemorrhage(SCH)is a common cause of eye redness and can be classified into traumatic and *** presentation:This case report discussed an adverse event related to wet cupping *** patient developed SCH one day after performing cupping *** was completely recovered after 2 *** case report should increase the knowledge of cupping therapists regarding increasing safety of patient when performing wet cupping therapy on specific body parts especially,head,neck and cervical ***,it highlighted the importance of conducting research regarding the mechanical and physiological effects of cupping ***:Adverse events related to cupping therapy should be reported with every *** therapists should be aware of this possible mild adverse *** the best of our knowledge,this is the first published adult case of SCH related to wet cupping therapy *** studies are critically needed for evaluation of cupping therapy effects and adverse events especially when performed on head and neck.

关键词： cupping therapy wet cupping Hijama subconjunctival hemorrhage adverse event

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Postpartum Quality of Life in Primiparous Women after Normal Vaginal Delivery versus Caesarean Section

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1027-1045页

作者： Bayan Ahmed Basma Alsayegh Fatema Ahmed zainab Aljufari Department of Obstetrics and Gynecology Salmaniya Medical Complex Manama Kingdom of Bahrain

Background: Studies on either postnatal quality of life in general or studies that compare quality of life in new mothers after different mode of delivery are limited. An investigation on health related quality of life measures in women after different type of delivery showed that women who had vaginal delivery had better health related quality of life compared to those who had caesarean section. However, the best method of delivery, vaginal or caesarean for postpartum quality of life is a difficult question as it is a matter of controversy both from professional’s perspectives and from women’s experience during childbirth. Objective: To compare postpartum quality of life in primiparous women after vaginal delivery versus caesarean section. Methods: Prospective cross-sectional study was conducted at the department of Obstetrics and Gynecology, Salmaniya medical complex in Kingdom of Bahrain. 500 primiparous women who gave birth either vaginally or by cesarean section answered a questionnaire designed to include general information, questions from short form health survey questionnaire (SF-36) and specific questions regarding postnatal related symptoms. Results: Body pain, fatigue, wound pain, headache and backache were significantly higher in cesarean section group as compared to vaginal delivery group (p-value Conclusion: Cesarean delivery has negatively affected the quality of life (QOL) of primiparous women. More studies with larger sample sizes should be conducted to examine the effects of cesarean delivery on QOL in both primiparous and multiparas within a shorter period after delivery. .

关键词： Quality of Life Primiparous Vaginal Delivery Caesarean Section

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