Micro RNAs and clinical implications in hepatocellular carcinoma
Micro RNAs and clinical implications in hepatocellular carcinoma作者机构:Biochemistry DepartmentNational Hepatology and Tropical Medicine Research Institute Department of Internal MedicineFaculty of MedicineAin Shams University Department of Internal MedicineFacultyof MedicineTanta University Department of Tropical MedicineFaculty of MedicineCairo University Department of Tropical MedicineFaculty of MedicineAin Shams University
出 版 物:《World Journal of Hepatology》 (世界肝病学杂志(英文版)(电子版))
年 卷 期:2017年第9卷第23期
页 面:1001-1007页
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Hepatocellular 癌 MicroRNA 肝肝硬化 MiR-23a
摘 要:AIM To assess the role of some circulating miRNAs(miR-23a, miR-203, miR338, miR-34, and miR-16) as tumor markers for diagnosis of hepatocellular carcinoma(HCC).METHODS One hundred and seventy-one subjects were enrolled, 57 patients with HCC, 57 patients with liver cirrhosis(LC) and 57 healthy subjects as control group. Severity of liver disease was assessed by Child Pugh score. Tumor staging was done using Okuda staging system. Quantification of Micro RNA(miR-23a, miR-203, miR338, miR-34, and miR-16) was performed.RESULTS All studied miRNA showed significant difference between HCC and cirrhotic patients in comparison tohealthy control. miR-23a showed statistically significant difference between HCC and cirrhotic patients being higher in HCC group than cirrhotic. miR-23a is significantly higher in HCC patients with focal lesion size equal or more than 5cm, patients with multiple focal lesions and Okuda stage Ⅲ. At cutoff value ≥ 210, miR-23a showed accuracy 79.3% to diagnose HCC patients with sensitivity 89.47% and specificity about 64.91%. At cut off level ≥ 200 ng/mL, serum alpha fetoprotein had 73.68% sensitivity, 52.63% specificity, 43.75% PPV, 80% NPV for diagnosis of HCC.CONCLUSION MicroR NA 23a can be used as a screening test for early detection of HCC. Also, it is related to larger size of tumour, late Okuda staging and multiple hepatic focal lesions, so it might be a prognostic biomarker.