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Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model

Asian Pacific Journal of Tropical Biomedicine 2018年第2期8卷 120-129页

作者： zahra sabahi Fatemeh Soltani Mahmoodreza Moein Medicinal Plants Processing Research Center Shiraz University of Medical Sciences Biotechnology Research Center Institute of Pharmaceutical Technology Mashhad University of Medical Sciences Department of Pharmacognosy School of Pharmacy Shiraz University of Medical Sciences

DNA damage is one of the most important consequences of oxidative stress in the cells. If DNA repair is unable to modify these inducible DNA damages, genomic instability may lead to mutation, cancer, aging and many other diseases. Single cell gel electrophoresis or comet assay is a common and versatile method to quantify these types of DNA damages. DNA damages induced by hydrogen peroxide(H_2O_2) are one of the proper models for measurement of protective ability of different compounds. So the main aim of this review is to provide an overview about protection ability of medicinal plants and their potential mechanism against H_2O_2 induced DNA damages. In this review, relevant researches on the effect of medicinal plants on DNA damages induced by H_2O_2 and possible molecular mechanisms are *** seems that, medicinal plants are considered as therapeutic key factors to protect DNA from consequences caused by oxidative stress. Sufficient in vitro evidences introduce them as DNA protective agents through different mechanisms including antioxidant activity and some other cellular mechanisms. Moreover, in order to correlate the antigenotoxicity effects with their potential antioxidant property, most of medicinal plants were evaluated in term of antioxidant activity using standard methods. This review highlights the preventive effects of herbal medicine against oxidative DNA damages as well as provides rational possibility to engage them in animal studies and future clinical investigations.

关键词： Herbal medicine DNA damage Comet assay Hydrogen peroxide Single cell gel electrophoresis

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Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 111-119页

作者： zahra sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi zahra GhasempourFarsani Hoda Mogholi Gerashi Marzieh Rashedinia Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazFarsIran Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Research Center Yasuj University of Medical SciencesYasujIran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazIran

Objective:To determine the effects of syringic acid on hepatic damage in diabetic ***:Diabetes was induced by *** rats were given syringic acid at doses of 25,50 and 100 mg/kg by oral gavage for 6 *** acid effects on the liver were evaluated by examination of plasma biochemical parameters,and pathological *** addition,biomarkers of lipid peroxidation and antioxidant status of liver tissues were *** time-PCR was performed to investigate the m RNA expression levels of mitochondrial biogenesis indices in different ***:Syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic ***,syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic *** was no difference between the glutathione content of the treated and untreated *** findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic *** acid also significantly upregulated the hepatic m RNA expression of PGC-1α,NRF-1,and NRF-2 and increased the mtD NA/nD NA ratio in diabetic ***:Syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic ***,it has the potential of targeting hepatic mitochondria in diabetes.

关键词： Syringic acid Diabetic Liver Oxidative stress Mitochondrial biogenesis Rats

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Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 270-278页

作者： Marzieh Rashedinia Azita Nasrollahi Marzieh Shafaghat Shahrzad Momeni Forough Iranpak Jamileh Saberzadeh Rita Arabsolghar zahra sabahi Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology and Toxicology Faculty of PharmacyShiraz University of Medical SciencesShirazIran Diagnostic Laboratory Sciences and Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShirazIran Department of Biochemistry Islamic Azad University of ShirazShirazIran Department of Medical Laboratory Sciences School of Paramedical SciencesShiraz University of Medical SciencesShirazIran

Objective:To investigate the effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)***:The antiproliferative effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions were examined by MTT ***,colony-forming,reactive oxidative species(ROS)generation,apoptosis induction,autophagy,mitochondrial membrane potential,and mitochondrial mass were ***:At 24 and 72 h,no significant differences were observed in the viability of HepG2 cells between the control and syringic acid+Fe(Ⅱ)***,exposure of HepG2 cells to syringic acid+Cu(Ⅱ)for 72 h reduced the cell viability ***,ROS formation,induction of apoptosis,and autophagic vacuoles were significantly increased in HepG2 cells without marked changes in mitochondrial membrane potential and mitochondrial ***,syringic acid+Cu(Ⅱ)reduced the plating efficiency and surviving fraction ***:The combination of syringic acid with Cu(Ⅱ)was toxic to cancer cells and showed pro-oxidant *** addition,this combination induced autophagy in cancer cells with less cytotoxic effects on normal cells,which is a potential candidate for the development of novel therapeutics towards cancer.

关键词： Syringic acid Copper Iron Cancer cell Pro-oxidant Autophagy

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Seismic performance evaluation of hybrid coupled shear wall system with shear and flexural fuse-type steel coupling beams

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 691-712页

作者： zahra Ramezandoust Abbas Tajaddini Panam Zarfam Department of Civil Engineering Science and Research branchIslamic Azad UniversityTehran 14778-93855Iran Department of Civil Engineering Karaj BranchIslamic Azad UniversityKaraj 31485-313Iran

Replaceable flexural and shear fuse-type coupling beams are used in hybrid coupled shear wall(HCSW)systems,enabling concrete buildings to be promptly recovered after severe *** study aimed to analytically evaluate the seismic behavior of flexural and shear fuse beams situated in short-,medium-and high-rise RC buildings that have *** building groups hypothetically located in a high seismic hazard zone were studied.A series of 2D nonlinear time history analyses was accomplished in OpenSees,using the ground motion records scaled at the design basis earthquake *** was found that the effectiveness of fuses in HCSWs depends on various factors such as size and scale of the building,allowable rotation value,inter-story drift ratio,residual drift quantity,energy dissipation value of the fuses,*** results show that shear fuses better meet the requirements of rotations and *** contrast,flexural fuses dissipate more energy,but their sectional stiffness should increase to meet other *** was concluded that adoption of proper fuses depends on the overall scale of the building and on how associated factors are considered.

关键词： hybrid coupled shear wall steel fuse coupling beam shear and flexural fuse nonlinear dynamic analysis seismic performance

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Integrating flood and earthquake resilience: a framework for assessing urban community resilience against multiple hazards

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JOURNAL OF SAFETY SCIENCE AND RESILIENCE 2024年第3期5卷 330-343页

作者： Ahmadi, zahra Ghasemi, Mahdi Khavarian-Garmsir, Amir Reza Ahmadi, Mohammad Yazd Univ Fac Art & Architecture Urbanism Dept Yazd Iran Yazd Univ Fac Art & Architecture Dept Architecture Yazd Iran Univ Isfahan Fac Geog Sci & Planning Dept Geog & Urban Planning Esfahan Iran Islamic Azad Univ Dept Civil Engn Tabriz Branch Tabriz Iran

Floods and earthquakes are the most common natural disasters, causing significant damage and casualties in urban communities. Although academic research has focused on assessing cities' ability to withstand these natural disasters, there is a lack of established frameworks for evaluating resilience against multiple hazards. This research integrates the earthquake and flood resilience indicators to create a comprehensive resilience assessment framework. This study integrated seismic and flood resilience indicators and categorized them into 27 clusters. It also used the DEMATEL (Decision-Making Trial and Evaluation Laboratory) method to determine the significance of clusters and prioritize them. This research identified 13 cause clusters and 14 effect clusters of indicators for seismic and flood resilience. The 'response capacity' cluster has the most impact on seismic and flood resilience, while the 'transportation and accessibility' cluster is the most affected cluster. This article presents a framework for evaluating flood and seismic resilience and makes suggestions for future research.

关键词： Resilience Flood Earthquake Dematel Resilience assessment Multiple Hazards DEMATEL MAP

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Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 406-415页

作者： zahra Shafieizadeh Zohreh Shafieizadeh Maryam Davoudi Reza Afrisham Xiaolei Miao Department of Medical Laboratory Sciences School of Allied Medical SciencesTehran University of Medical SciencesTehranIran School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianningHubeiChina

Partial hepatectomy is a first-line treatment for hepatocellular *** 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver ***,residual microtumors may also exploit these pathways to reappear and *** targeting molecules that are differentially regulated between normal cells and malignancies,such as fibrinogen-like protein 1(FGL1),appears to be an effective *** potential functions of FGL1 in both regenerative and malignant cells are discussed within the ambit of this *** FGL1 is normally elevated in regenerative hepatocytes,it is normally downregulated in malignant *** does indeed upregulate FGL1 by increasing the release of transcription factors that promote FGL1,including HNF-1α and STAT3,and inflammatory effectors,such as TGF-β and ***,in turn,stimulates certain proliferative pathways,including EGFR/Src/*** alters the phase transition of highly differentiated hepatocytes from G0 to G1,thereby transforming susceptible cells into cancerous *** of the PI3K/Akt/mTOR pathway by FGL1 allele loss on chromosome 8,a tumor suppressor area,may also cause hepatocellular ***,FGL1 is specifically expressed in the liver via HNF-1α histone acetylase activity,which triggers lipid metabolic reprogramming in ***1 might also be involved in other carcinogenesis processes such as hypoxia,epithelial-mesenchymal transition,immunosuppression,and sorafenib-mediated drug *** study highlights a research gap in these disciplines and the necessity for additional research on FGL1 function in the described processes.

关键词： Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration Hepatectomy Lipogenesis Recurrence

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Application of Plant-Based Coagulants and Their Mechanisms in Water Treatment:A Review

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Journal of Renewable Materials 2024年第4期12卷 667-698页

作者： Abderrezzaq Benalia Kerroum Derbal zahra Amrouci Ouiem Baatache Amel Khalfaoui Antonio Pizzi Higher Normal School of Constantine Ali Mendjeli Nouvelle VilleConstantine25000Algeria Laboratory of Process Engineering for Sustainable Development and Health Products(GPDDPS) Department of Process EngineeringNational Polytechnic School of ConstantineConstantine25000Algeria Department of Environmental Engineering Laboratoire de Recherche sur le Médicament et le Développement Durable(ReMeDD)University of Salah Boubnider Constantine 3El Khroub25012Algeria Laboratory LIPE Faculty Process EngineeringUniversity of Constantine 3Ali Mendjeli Nouvelle VilleConstantine25000Algeria Laboratoire d’Etude et Recherche sur le Matériau Bois(LERMAB).Ecole Nationale Supérieure des Technologies et Industries du Bois(ENSTIB)—University of Lorraine Epinal88000France

This review describes the mechanisms of natural *** provides a good understanding of the two key processes of coagulation-flocculation:adsorption and charge neutralization,as well as adsorption and *** factors have influence the coagulation/flocculation process,including the effect of pH,coagulant dosage,coagulant type,temperature,initial turbidity,coagulation speed,flocculation speed,coagulation and flocculation time,settling time,colloidal particles,zeta potential,the effects of humic acids,and extraction density are *** bio-coagulants derived from plants are *** impact of organic coagulants on water quality,focusing on their effects on the physicochemical parameters of water,heavy metals removal,and bacteriological water quality,is *** methods of extraction and purification of plant-based coagulants,highlighting techniques such as solvent extraction and ultrasonic extraction,are *** also examines the parameters that influence these *** methods and principles of purification of coagulating agents,including dialysis,freeze-drying,ion exchange,electrophoresis,filtration,and centrifugation,are ***,it evaluates the sustainability of natural coagulants,focusing on the environmental,technical,and economic aspects of their *** the end of this review,the readers should have a comprehensive understanding of the mechanisms,selection,extraction,purification,and sustainability of plant-based natural coagulants in water treatment.

关键词： Bio-coagulants coagulating agents extraction water treatment

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Enhancing Hyper-Spectral Image Classification with Reinforcement Learning and Advanced Multi-Objective Binary Grey Wolf Optimization

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Computers, Materials & Continua 2024年第6期79卷 3469-3493页

作者： Mehrdad Shoeibi Mohammad Mehdi Sharifi Nevisi Reza Salehi Diego Martín zahra Halimi Sahba Baniasadi TheWPI Business School Worcester Polytechnic InstituteWorcesterMassachusetts01609-2280USA Department of Industrial Engineering Iran University of Science and TechnologyNarmakTehran16846-13114Iran ETSI de Telecomunicación Universidad Politécnica de MadridAv.Complutense 30Madrid28040Spain Department of Civil and Environmental Engineering University of MarylandCollege ParkMaryland20742USA Department of Industrial Engineering College of EngineeringUniversity of HoustonHoustonTexas77204USA

Hyperspectral(HS)image classification plays a crucial role in numerous areas including remote sensing(RS),agriculture,and the monitoring of the *** band selection in HS images is crucial for improving the efficiency and accuracy of image *** process involves selecting the most informative spectral bands,which leads to a reduction in data *** on these key bands also enhances the accuracy of classification algorithms,as redundant or irrelevant bands,which can introduce noise and lower model performance,are *** this paper,we propose an approach for HS image classification using deep Q learning(DQL)and a novel multi-objective binary grey wolf optimizer(MOBGWO).We investigate the MOBGWO for optimal band selection to further enhance the accuracy of HS image *** the suggested MOBGWO,a new sigmoid function is introduced as a transfer function to modify the wolves’*** primary objective of this classification is to reduce the number of bands while maximizing classification *** evaluate the effectiveness of our approach,we conducted experiments on publicly available HS image datasets,including Pavia University,Washington Mall,and Indian Pines *** compared the performance of our proposed method with several state-of-the-art deep learning(DL)and machine learning(ML)algorithms,including long short-term memory(LSTM),deep neural network(DNN),recurrent neural network(RNN),support vector machine(SVM),and random forest(RF).Our experimental results demonstrate that the Hybrid MOBGWO-DQL significantly improves classification accuracy compared to traditional optimization and DL ***-DQL shows greater accuracy in classifying most categories in both datasets *** the Indian Pine dataset,the MOBGWO-DQL architecture achieved a kappa coefficient(KC)of 97.68%and an overall accuracy(OA)of 94.32%.This was accompanied by the lowest root mean square error(RMSE)of 0.94,indicating very precise

关键词： Hyperspectral image classification reinforcement learning multi-objective binary grey wolf optimizer band selection

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Exploring the impact of weak measurements on exciton–exciton interactions

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Communications in Theoretical Physics 2024年第11期 44-49页

作者： Fatima-zahra Siyouri Olivier Giraud Yassine Hassouni équipe Sciences de la Matiére et du Rayonnement (ESMaR) Département de Physique Faculté des Sciences Université Mohammed V—Agdal Laboratoire de Physique Théorique et Modéles Statistiques (LPTMS) Faculté des sciencesUniversité paris saclay

In our study of super quantum discord between two excitonic qubits inside a coupled semiconductor quantum dots system, our primary focus is to uncover the impact of weak measurement on its quantum characteristics. To achieve this, we analyze how varying the measurement strength x, affects this super quantum correlation in the presence of thermal ***, we assess the effect of this variation on the system's evolution against its associated quantum parameters; external electric fields, exciton–exciton dipole interaction energy and F?rster interaction. Our findings indicate that adjusting x to smaller values effectively enhances the super quantum correlation, making weak measurements act as a catalyst. This adjustment ensures its robustness against thermal effects while preserving the non-classical attributes of the ***, our study unveils that the effect of weak measurements on this latter surpasses the quantum effects associated with the system. Indeed, manipulating the parameter x allows the weak measurement to function as a versatile tool for modulating quantum characteristics and controlling exciton–exciton interactions within the coupled semiconductor quantum dots system.

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Safety of tranexamic acid in surgically treated isolated spine trauma

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World Journal of Orthopedics 2024年第4期15卷 346-354页

作者： Wajiha zahra Sandeep Krishan Nayar Ashwin Bhadresha Vinay Jasani Syed Aftab Trauma and Orthopedics Department University Hospital of North Midlands NHS TrustStoke-on-Trent ST46QGUnited Kingdom Trauma and Orthopedics Department Royal London HospitalBarts Health InstituteLondon E11BBUnited Kingdom Craniospinal Services University Hospital of North Midlands NHS TrustStokeon-Trent ST46QGUnited Kingdom Spine Department Royal London HospitalBarts Health InstituteLondon E11BBUnited Kingdom

BACKGROUND Tranexamic acid(TXA),a synthetic antifibrinolytic drug,effectively reduces blood loss by inhibiting plasmin-induced fibrin *** is the first study in the United Kingdom to investigate the effectiveness of TXA in the surgical management of isolated spine *** To assess the safety of TXA in isolated spine *** primary and secondary outcomes are to assess the rate of thromboembolic events and to evaluate blood loss and the incidence of blood transfusion,*** This prospective observational study included patients aged≥17 years with isolated spine trauma requiring surgical intervention over a 6-month period at two major trauma centers in the United *** We identified 67 patients:26(39%)and 41(61%)received and did not receive TXA,*** groups were matched in terms of age,gender,American Society of Anesthesiologists grade,and mechanism of injury.A higher proportion of patients who received TXA had a subaxial cervical spine injury classification or thoracolumbar injury classification score>4(74%vs 56%).All patients in the TXA group underwent an open approach with a mean of 5 spinal levels involved and an average operative time of 203 min,compared with 24 patients(58%)in the non TXA group who underwent an open approach with an average of 3 spinal levels involved and a mean operative time of 159 *** patients who received TXA,blood loss was<150 and 150–300 mL in 8(31%)and 15(58%)patients,*** were no cases of thromboembolic events in any patient who received *** Our study demonstrated that TXA is safe for isolated spine *** is challenging to determine whether TXA effectively reduces blood loss because most surgeons prefer TXA for open or multilevel ***,larger studies are necessary to explore the rate,dosage,and mode of administration of TXA.

关键词： Tranexamic acid Infection Trauma Thromboembolic disease Minimally invasive Percutaneous

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