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Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU Shi-hao SHI Wei-qi li Yu-hang liU Ru-hui HU Da-yi zheng li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, Plinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, Pline(all Plimitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

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一种应用于卫星中红外遥感的辐射传输简化计算方案

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红外与毫米波学报 2024年第3期43卷 375-390页

作者：姚前许华樊程李莉王思恒郑杨徐文斌侯伟真徐敬海庄齐枫周鹏张灏陈震霆李正强中国科学院空天信息创新研究院国家环境保护卫星遥感重点实验室北京100101 中国科学院大学北京100049 中国空间技术研究院遥感卫星总体部北京100094 北京环境特性研究所光学辐射重点实验室北京100854 南京工业大学测绘科学与技术学院江苏南京211816 昆明学院信息技术学院云南昆明650214

作为可见光-近红外和热红外的连接谱段,中红外(MIR)兼具短波辐射的反射特性和长波辐射的发射特性,对于温度探测、目标识别等应用场景有十分重要的意义。目前,MIR谱段辐射传输(RT)计算仍然面临背景参数输入多且不易获取的问题。基于此,... 详细信息

作为可见光-近红外和热红外的连接谱段,中红外(MIR)兼具短波辐射的反射特性和长波辐射的发射特性,对于温度探测、目标识别等应用场景有十分重要的意义。目前,MIR谱段辐射传输(RT)计算仍然面临背景参数输入多且不易获取的问题。基于此,提出了一种应用于卫星MIR遥感的RT简化计算方案。使用MODTRAN模型(MM),对MIR白天RT过程中所涉及的背景地表和大气参数定量模拟分析,得到影响RT的关键参数,据此形成一套基于MM的参数简化方案(SS)。在MODIS 6个MIR通道的中心波长处,对SS和MM计算的总辐亮度做对比验证,RMSE均小于0.004399,具有较高精度。SS仅依赖于表面温度、表面发射率、大气廓线类型、水汽和云光学厚度,不需要输入气溶胶、CO_(2)和O_(3)数据。相比MM,SS将输入参数从8类降低到5类,计算的时间效率提升了9.02%。在有限的计算资源下,本文所提的SS能够为MIR图像快速处理、大场景遥感仿真等应用领域提供支撑。

关键词：中红外(MIR)谱段辐射传输(RT)计算背景参数简化方案(SS)

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Bovine Serum Albumin Loaded Solid lipid Nanoparticles Prepared by Double Emulsion Method

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Chemical Research in Chinese Universities 2010年第1期26卷 136-141页

作者： li Zhen li Xin-wei zheng li-qiang liN Xiao-hong GENG Fei YU li Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan 250100 P. R. China

Solid lipid nanoparticles loaded with bovine serum albumin（BSA） were prepared by a double emulsion method. As the mass fraction of the model drug BSA increased from 0 to 15%, the particle size gradually increased. The physical stability of the nanoparticles was investigated by zeta potential measurement and they were shown to be quite stable. Fluorescence spectroscopy confirmed that the loaded position of BSA was on the interface between the inner aqueous phase and the solid lipid phase. Both Fourier-transform infrared spectroscopy and circular dichroism spectra indicate that BSA in the nanoparticles was not destroyed, but the secondary structure was disrupted slightly.

关键词： Solid lipid nanoparticle Double emulsion Bovine serum albumin Drug model

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Effects of Siqi Decoction on Concentration of Nitric Oxide and Activity of Nitric Oxide Synthase in Blood Serum of Rats with Myocardial Ischemia

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Chemical Research in Chinese Universities 2008年第1期24卷 65-68页

作者： SU Yan-bin li zheng-qiang SU Yan-wen ZHANG Fen-rong School of Chemical and Pharmaceutical Engineering Jilin Institute of Chemical Technology Jilin 132022 P. R. China Key Laboratory of Molecular Etymology and Engineering Ministry of Education Jilin University Changchun 130021 P. R. China Jilin Provincial Institute for Drug and Food Control Changchun 130033 P. R. China

To study the effects of Siqi decoction on rats with Myocardial Ischemia, the model of Myocardium Ischemia was made for the Wistar rats cured with posterior pituitary injection through vein in tail. Siqi decoction, Diaoxinxuekang（DK） and Fufangdanshenpian（FD）, the latter two drugs of which were effective TCM drugs of anti-Myocardial Ischemia at present, were administrated to the rats with Myocardium Ischemia for 5 days to compare the effect of anti-Myocardium Ischemia as reference drugs by measuring the changes of NO concentration and activity of NOS in the rat blood serum with Myocardial Ischemia. There was a remarkable increase in the NO concentration and activity of NOS in serum in Siqi decoction groups compared with those in control group（p〈0.05）. The results of the prevention group in experiment of Siqi decoction are better than those of the cure group. Siqi decoction was really fit for Myocardium Ischemia via increasing NO concentration by stimulating the activity of NOS in serum. The effect of Siqi decoction against Myocardium Ischemia in preventive group is better than the curative that of Siqi decoction in the curative group.

关键词： Siqi decoction Myocardial Ischemia Posterior pituitary Nitric oxide(NO) Nitric oxide synthase(NOS)

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Studies on HEPES Stabilizing M Intermediate of Bacteriorhodopsin

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Chemical Research in Chinese Universities 1995年第3期11卷 215-218页

作者： Fu, Xue-qi li, zheng-qiang Wang, Jin-dui Wang, Bao-hui li, Bo-fu li, Tie-jin JIliN UNIV NATL KEY LAB ENZYME ENGNCHANGCHUN 130023PEOPLES R CHINA JIliN UNIV KEY LAB MOLEC SPECTRUM & MOLEC STRUCTCHANGCHUN 130023PEOPLES R CHINA JIliN UNIV DEPT CHEMCHANGCHUN 130023PEOPLES R CHINA

EPES has proved to stabilize M intermediate of Bacteriorhodopsin. Absorp-tion and Raman spectra showed that there was a more stable form of M intermedi-ate in BR-HEPES solution. It was found by SPS that there were two... 详细信息

关键词： Bacteriorhodopsin M intermediate HEPES

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Exploring Trade-offs in Thermal Interface Materials:The Impact of Polymer-Filler Interfaces on Thermal Conductivity and Thixotropy

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Chinese Journal of Polymer Science 2024年第7期42卷 916-925,I0006页

作者： Bin Zhang zheng-li Dou Yong-zheng Zhang qiang Fu Kai Wu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

Effective thermal transport across solid-solid interfaces which is essential in thermal interface materials(TIMs),necessitates both optimal thixotropy and high thermal *** role of filler surface modification,a fundamental aspect of TIM fabrication,in the influence of these properties is not fully *** study employs the use of a silane coupling agent(SCA)to modify alumina,integrating experimental approaches with molecular dynamics simulations,to elucidate the interface effects on thixotropy and thermal conductivity in polydimethylsiloxane(PDMS)-based *** findings reveal that the variations of SCAs modify both interface binding energy and transition layer *** interface binding energy restricts macromolecular segmental relaxation near the interface,hindering desirable thixotropy and bond line *** the contrary,the thickness of the transition layer at the interface positively influences thermal conductivity,facilitating the transport of phonons between the polymer and ***,selecting an optimal SCA allows a balance between traditionally conflicting goals of high thermal conductivity and minimal bond line thickness,achieving an impressively low interface thermal resistance of just 2.45-4.29 K·mm^(2)·W^(-1)at275.8 kPa.

关键词： Thermal interface material Surface modification Thermal conductivity Thixotropy Interface thermal resistance

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Structure Characteristic and Catalase Activity of Vitreoscilla Hemoglobin Bound with Membrane

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Chemical Research in Chinese Universities 2011年第3期27卷 450-454页

作者： ZHAO Hai-feng WU Lei LU Ming HU Yu-lin HAN Xiao li zheng-qiang Key Laboratory for Molecular Enzymology ＆ Engineering Ministry of Education Jilin University Changchun 130012 P. R. China Medical Department of liver Gall Pancreas the First Hospital of Jilin University Changchun 130021 P. R. China

lipid-bound [VHb（406）] and lipid-free [VHb（402）] wide type Vitreoscilla hemoglobin were separated from E. coli BL21（DE3）. The RZ is 3.30 for [VHb（406）] and 3.15 for [VHb（402）], respectively. VHb（406） shows a characteristic absorption band at 626 nm, while VHb（402） shows one at 644 nm, and it has more α-helix than VHb（402）. Data of Raman spectra experiment shows under the excitation wavelength 488 nm, υ4 vibration of both VHb（402） and VHb（406） had a pure and strong signal at 1375 cm-1, which proves that iron porphyrin of both the samples is at their trivalence oxidation state. And no matter lipid binds VHb or not, the vinyl of porphyrin is at cis state. The catalase activity of Vitreoscilla hemoglobin was explored with L-dopa and H2O2 as substrates. The results indicate that VHb（406） has more catalase activity than VHb（402）, VHb is a cell’s oxygen modulator and its catalase ability is modulated by the membrane.

关键词： Vitreoscilla hemoglobin Structure Function Membrane binding

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Parallel Vision ■ Image Synthesis/Augmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 782-784页

作者： Wenwen Zhang Wenbo zheng qiang li Fei-Yue Wang the School of Computer Science Shaanxi Normal UniversityXi’an 710119China the School of Computer Science and Technology Wuhan 430070China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,Scene understanding is an essential task in computer *** ultimate objective of scene understanding is to instruct computers to understand and reason about the scenes as humans *** vision is a research fram... 详细信息

关键词： instru explanation computer

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Ectomycorrhizal fungi and dark septate endophyte inoculation improve growth and tolerance of Pinus tabulaeformis under cadmium stress

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Pedosphere 2024年第2期34卷 473-483页

作者： Yong ZHOU Yanyan zheng Pengwei li lingjie XU qiang FU College of Landscape Architecture and Tourism Hebei Agricultural UniversityBaoding 071000China

Forest trees can establish symbiotic associations with dark septate endophytes(DSEs)and ectomycorrhizal fungi(ECMF)***,the combined effects of these two fungi on the growth and cadmium(Cd)tolerance of host plants remain largely *** address this knowledge gap,a pot experiment was conducted to examine the effects of the interaction between an ECMF strain(Suillus granulatus)and a DSE strain(Pseudopyrenochaeta sp.)on Pinus tabulaeformis under Cd stress,by assessing plant growth and physiological parameters,nutrient uptake,and soil ***,the colonization rates of both fungal strains were found to increase in response to Cd stress,with the extent of this increase being influenced by the specific fungal species and the Cd level in the *** to the non-inoculation treatment,single inoculation with fungal strain resulted in enhanced biomass,root development,and nutrient contents in *** seedlings under Cd ***,a synergistic effect was observed when these seedlings were co-inoculated with *** and Pseudopyrenochaeta sp.,as indicated by significantly greater measurements in various indicators compared to both the single and non-inoculation *** inoculation effectively regulated the antioxidant defense responses and photosynthesis of *** seedlings subjected to Cd stress,particularly in the co-inoculation *** addition,fungal inoculation facilitated the Cd accumulation in ***,suggesting a promising potential for the implementation of bioremediation strategies in the areas contaminated with heavy *** findings from this study indicate that the utilization of root symbiotic fungi obtained from stress environments could potentially enhance the growth performance and tolerance of *** towards heavy metals,and co-inoculation of both fungal groups may result in even more pronounced synergistic effects on the overall fitness of the plant.

关键词： antioxidant defense response colonization rate fungal inoculation heavy metal tolerance physiological parameter root symbiotic fungi soil property

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Mechanical parameter evolutions and deterioration constitutive model for ductile-brittle failure of surrounding rock in high-stress underground engineering

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Underground Space 2024年第2期15卷 131-152页

作者： Zhi zheng Ronghua li qiang Zhang Xiaohua Huang Wei Wang Shuling Huang State Key Laboratory of Featured Metal Materials and life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100038China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Key Laboratory of Geotechnical Mechanics and Engineering of Ministry of Water Resources Yangtze River Scientific Research InstituteWuhan 430010China

The deep surrounding rock is usually in the true triaxial stress state,and previous constitutive models based on the understanding of uniaxial and conventional triaxial test results have difficulty characterizing the degradation and fracture process of rock ductile–brittle failure under true triaxial stress ***,this study conducted a series of true triaxial tests to obtain the understanding of the ductile–brittle behaviour of rock,and then combined the test results and the Mogi–Coulomb strength criterion,and proposed calculation methods for the elastic modulus E,cohesion c and internal friction angle u and the evolution functions of E,c and u of rock under true triaxial *** the decreasing of the minimum principal stress r3 or increasing of the intermediate principal stress r2,the marble post-peak stress drop rate gradually increases,the ductility gradually weakens,and the brittleness significantly *** calculation method and evolution function of rock E,c and u under true triaxial stress were proposed.E decreased at first and then tended to remain stable with the increasing of equivalent plastic strain increment dep.c and u slowly increased at first and then rapidly *** a method of parameter degradation rate to realize post-peak stress drop rate to reflect the ductile–brittle characteristics,a new three-dimensional ductile–brittle deterioration mechanical model(3DBDM)was *** proposed model can accurately characterize the influence of r2 and r3 on mechanical parameters,the ductile–brittle behaviour of rock under true triaxial stresses,and the asymmetric failure characteristics of surrounding rock after excavation of deep underground *** proposed model can be reduced to elastic–perfectly plastic,elastic–brittle,cohesion weakening friction strengthening(CWFS),Mohr–Coulomb,and Drucker–Prager models.

关键词： True triaxial stress Post-peak characteristics 3D deterioration model Elastic modulus evolution Cohesion and friction angle evolution

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