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Protein & Cell 2022年第9期13卷 683-688页

作者： Li Yang Jin Chen Jianqing Liang yufeng zhang Qingzhe Wang Xiaojun Ren Jinsong Wei Qianchun Gong Jiting zhang Ning Jiang Xinhua Lin Jin Li Bing Zhao State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China bioGenous Biotechnology Inc.Hangzhou 311231China Obstetrics and Gynecology Hospital of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesFudan UniversityShanghai 200011China

Dear Editor,Hepatoblastoma(HB)is a predominant hepatic neoplasm that develops in children from 0 to 4 years of age at the rate of 2.16 per 1,000,*** originates from abnormal differentiation of hepatocyte precursors(hepatoblasts)during embryogenesis(Sumazin et al.,2017).Approximately 20%of children with HB have metastasis in lung at diagnosis,which indicates poor prognosis(Angelico et al.,2019).While surgery in combination of chemotherapy and/or metastasectomy is the most popular therapy,relapse happens in a significant portion of HB patients(zhang et al.,2021).Therefore,novel and less aggressive therapies targeting the pathogenesis of HB should be explored to prolong patients’s disease-free survival as well as to improve their quality of life.

关键词： fetal diagnosis chemotherapy

Diffusion and reaction mechanism of limestone and quartz in fluxed iron ore pellet roasting process

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 485-497页

作者： yufeng Guo Jinlai zhang Shuai Wang Jianjun Fan Haokun Li Feng Chen Kuo Liu Lingzhi Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Technology Center Taiyuan Iron Steel(Group)Co.Ltd.(TISCO)Taiyuan 030003China

The increase to the proportion of fluxed pellets in the blast furnace burden is a useful way to reduce the carbon emissions in the ironmaking *** this study,the interaction between calcium carbonate and iron ore powder and the mineralization mechanism of fluxed iron ore pellet in the roasting process were investigated through diffusion couple *** electron microscopy with energy dispersive spectroscopy was used to study the elements’diffusion and phase transformation during the roasting *** results indicated that limestone decomposed into calcium oxide,and magnetite was oxidized to hematite at the early stage of *** the increase in roasting temperature,the diffusion rate of Fe and Ca was obviously accelerated,while the diffusion rate of Si was relatively *** order of magnitude of interdiffusion coefficient of Fe_(2)O_(3)-CaO diffusion couple was 10^(−10) m^(2)·s^(−1) at a roasting temperature of 1200℃for 9 ***_(2)Fe_(2)O_(5) was the initial product in the Fe_(2)O_(3)-CaO-SiO_(2) diffusion interface,and then Ca_(2)Fe_(2)O_(5) continued to react with Fe_(2)O_(3) to form CaFe_(2)O_(4).With the expansion of the diffusion region,the sillico-ferrite of calcium liquid phase was produced due to the melting of SiO_(2) into CaFe_(2)O_(4),which can strengthen the consolidation of fluxed ***,andradite would be formed around a small part of quartz particles,which is also conducive to the consolidation of fluxed *** addition,the principle diagram of limestone and quartz diffusion reaction in the process of fluxed pellet roasting was discussed.

关键词： fluxed iron ore pellet limestone hematite quartz diffusion reaction

F-doped orthorhombic Nb_(2)O_(5) exposed with 97% (100) facet for fast reversible Liþ-Intercalation

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Green Energy & Environment 2024年第4期9卷 723-731页

作者： Xiaodi Liu yufeng Tang Dan zhang Guangyin Liu Xinwei Luo Yi Shang Xiu Li Jianmin Ma College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang473061China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

Orthorhombic Nb_(2)O_(5)(T-Nb_(2)O_(5))is attractive for fast-charging Li-ion batteries,but it is still hard to realize rapid charge transfer kinetics for Li-ion ***,F-doped T-Nb_(2)O_(5) microﬂowers(F-Nb_(2)O_(5))are rationally synthesized through topotactic ***,F-Nb_(2)O_(5) are assembled by single-crystal nanoﬂakes with nearly 97%exposed(100)facet,which maximizes the exposure of the feasible Li^(+)transport pathways along loosely packed 4g atomic layers to the electrolytes,thus effectively enhancing the Li^(+)-intercalation ***,the band gap of F-Nb_(2)O_(5) is reduced to 2.87 eV due to the doping of F atoms,leading to enhanced electrical *** synergetic effects between tailored exposed crystal facets,F-doping,and ultrathin building blocks,speed up the Li^(+)/electron transfer kinetics and improve the pseudocapacitive properties of F-Nb_(2)O_(5).Therefore,F-Nb_(2)O_(5) exhibit superior rate capability(210.8 and 164.9 mAh g^(-1) at 1 and 10 C,respectively)and good long-term 10 C cycling performance(132.7 mAh g^(-1) after 1500 cycles).

关键词： Exposed facets Orthorhombic Nb_(2)O_(5) F-doping Pseudocapacitive intercalation anode Li-ion storage

Artificial intelligence optimization and controllable slow-release iron sulfide realizes efficient separation of copper and arsenic in strongly acidic wastewater

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Journal of Environmental Sciences 2024年第5期139卷 293-307页

作者： Xingfei zhang Chenglong Lu Jia Tian Liqiang Zeng yufeng Wang Wei Sun Haisheng Han Jianhua Kang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Centre for Mined Land Rehabilitation Sustainable Minerals InstituteThe University of QueenslandBrisbane 4072Australia

Iron sulfide(FeS)is a promising material for separating copper and arsenic from strongly acidic wastewater due to its S^(2-)slow-release ***,uncertainties arise because of the constant changes in wastewater composition,affecting the selection of operating parameters and FeS *** this study,the aging method was first used to prepare various controllable FeS nanoparticles to weaken the arsenic removal ability without affecting the copper *** experiments were conducted,and the results identified the Cu/As ratio,H_(2)SO_(4) concentration,and FeS dosage as the three main factors influencing the separation *** backpropagation artificial neural network(BP-ANN)model was established to determine the relationship between the influencing factors and the separation *** correlation coefficient(R)of overall model was 0.9923 after optimizing using genetic algorithm(GA).The BP-GA model was also solved using GA under specific constraints,predicting the best solution for the separation process in *** predicted results show that the high temperature and long aging time of FeS were necessary to gain high separation efficiency,and the maximum separation factor can reached 1,*** study provides a suitable sulfurizing material and a set of methods and models with robust flexibility that can successfully predict the separation efficiency of copper and arsenic from highly acidic environments.

关键词： FeS nanoparticles Aging Sulfide precipitation Orthogonal experiment Artificial neural network Prediction

中医药文化融入中小学文化育人工作实践与探索

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亚太传统医药 2024年第6期20卷 251-255页

作者：赵寒王小嘉张玉峰叶坤英李琦李西云河南中医药大学第一附属医院河南郑州450000 河南中医药大学第二临床医学院河南郑州450000 河南省中医院河南郑州450000 郑州高新技术产业开发区复新实验中学河南郑州450001

中医药文化是中华文化中一颗璀璨的明珠,蕴含着宝贵的精神财富和重要的价值内涵。将中医药文化融入中小学文化育人工作中,对于中小学生的全面发展具有重要意义。选择郑州高新区复新实验中学为试点,以文化育人为视角,以中医药文化为切入... 详细信息

中医药文化是中华文化中一颗璀璨的明珠,蕴含着宝贵的精神财富和重要的价值内涵。将中医药文化融入中小学文化育人工作中,对于中小学生的全面发展具有重要意义。选择郑州高新区复新实验中学为试点,以文化育人为视角,以中医药文化为切入点,从国家政策、现状分析、核心价值、创新活动及长效融合机制等方面探讨,明确中医药文化在中小学育人工作的现实意义,为深入推进中医药文化工作提供思路和方法,并最终实践和探索出中医药文化融入中小学文化育人工作的有效路径。

关键词：中小学文化育人中医药文化实践与探索

CD301b^(+) macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis

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Bioactive Materials 2022年第9期7卷 446-455页

作者： Jiaolong Wang Qin Zhao Liangliang Fu Shihang Zheng Can Wang Litian Han Zijian Gong Ziming Wang Hua Tang yufeng zhang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of EducationSchool&Hospital of StomatologyWuhan UniversityWuhan430079HubeiPR China Institute of Infection and Immunity Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan250000ShandongPR China Medical Research Institute School of MedicineWuhan UniversityWuhan430071HubeiPR China

Calcium phosphate(CaP)bioceramics are important for tissue regeneration and immune response,yet how CaP bioceramics influence these biological processes remains ***,the role of immune cells in biomaterial-mediated regeneration,especially macrophages,has been well ***301b^(+)macrophages were a new subset of macrophages we have discovered,which were required for bioceramics-mediated bone ***,the impact of CD301b^(+)macrophages on angiogenesis,which is a vital prerequisite to bone formation is yet ***,we found that CD301b^(+)macrophages were closely correlated to angiogenesis of CaP ***,depletion of CD301b^(+)macrophages led to the failure of *** showed that store-operated Ca^(2+)entry and calcineurin signals regulated the VEGF expression of CD301b^(+)macrophages via the NFATc1/VEGF *** of calcineurin effectively impaired angiogenesis via decreasing the infiltration of CD301b^(+)*** findings provided a potential immunomodulatory strategy to optimize the integration of angiogenesis and bone tissue engineering scaffold materials.

关键词： Calcium phosphate ceramics Macrophage Angiogenesis CD301b Calcineurin

How temperature and hydrostatic pressure impact organic room temperature phosphorescence from H-aggregation of planar triarylboranes and the application in bioimaging

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Science China Chemistry 2023年第3期66卷 816-825页

作者： Liangjing Tu Yuanyuan Fan Changjiang Bi Leyi Xiao Yonggang Li Aisen Li Weilong Che Yujun Xie yufeng zhang Shuping Xu Weiqing Xu Qianqian Li Zhen Li Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072 China Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials Department of ChemistryWuhan UniversityWuhan 430072China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China School and Hospital of Stomatology Wuhan UniversityWuhan 430079China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New CityFuzhou 350027China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Tianjin UniversityTianjin 300072China

Highly efficient persistent organic room temperature phosphorescence(RTP) has attracted increasing attention because of promising applications in fields of chemical sensors, optoelectronic devices, information security, and bioimaging, etc. Wherein,the crystal engineering of H-aggregation offers stabilization for long-lived triplet exciton for RTP, but the related research is rare because of the scarcity of ideal phosphorescent H-aggregate. Herein, we designed planar tricoordinate organoboron derivatives with molecular arrangement in ideal H-aggregation. The integration of Br atom can largely enhance RTP efficiency through increasing SOC effect, while the antiparallel molecular arrangement causes annihilation of triplet exciton. Thanks to good selfassembly property, their RTP can even be observed in PMMA matrix with doping ratio of merely 1 wt%. We further found that the cryogenic temperature contributes to stabilizing triplet exciton in H-aggregation, leading to red-shifted phosphorescence. By applying high hydrostatic pressure, the phosphorescence was largely enhanced and redshifted, demonstrating the crucial role of H-aggregation on RTP property. In phosphorescent tissue imaging of live mouse, nanoparticles of BrBA exhibited high contrast image via eliminating the interference of autofluorescence.

关键词： room temperature phosphorescence H-aggregation planar triarylboranes bioimaging

Highly Porous Yet Transparent Mechanically Flexible Aerogels Realizing Solar-Thermal Regulatory Cooling

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Nano-Micro Letters 2024年第7期16卷 231-243页

作者： Meng Lian Wei Ding Song Liu yufeng Wang Tianyi Zhu Yue-EMiao Chao zhang Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People’s Republic of China

The demand for highly porous yet transparent aerogels with mechanical flexibility and solar-thermal dual-regulation for energy-saving windows is significant but ***,a delaminated aerogel film(DAF)is fabricated through filtration-induced delaminated gelation and ambient *** delaminated gelation process involves the assembly of fluorinated cellulose nanofiber(FCNF)at the solid-liquid interface between the filter and the filtrate during filtration,resulting in the formation of lamellar FCNF hydrogels with strong intra-plane and weak interlayer hydrogen *** exchanging the solvents from water to hexane,the hydrogen bonding in the FCNF hydrogel is further enhanced,enabling the formation of the DAF with intra-layer mesopores upon ambient *** resulting aerogel film is lightweight and ultra-flexible,which pos-sesses desirable properties of high visible-light transmittance(91.0%),low thermal conductivity(33 mW m^(-1) K^(-1)),and high atmospheric-window emissivity(90.1%).Furthermore,the DAF exhibits reduced surface energy and exceptional hydrophobicity due to the presence of fluorine-containing groups,enhancing its durability and UV ***,the DAF has demonstrated its potential as solar-thermal regulatory cooling window materials capable of simultaneously providing indoor lighting,thermal insulation,and daytime radiative cooling under direct ***,the enclosed space protected by the DAF exhibits a temperature reduction of 2.6℃ compared to that shielded by conventional architectural glass.

关键词： Transparent aerogel Cellulose nanofiber aerogel Delaminated gelation Thermal insulation Passive daytime radiative cooling

Exponential Stability of a Robot with Safety System

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Journal of Systems Science and Information 2009年第3期7卷 201-214页

作者： Lihua Jin Aidong Jin yufeng zhang Department of Mathematics Science College Yanbian University Yanji 133002 China Teachers college Yanbian University Yanji 133002 China

This paper presents the analysis of exponential stability of a system consisting of a robot and its associated safety mechanism. The system have various modes of failures and is repairable. The paper investigates the nonnegative stead-state solution of system,the existence of strictly dominant eigenvalue and restriction of essential spectrum growth bound of the system operator. The essential spectral radius of the system operator is also discussed before and after perturbation. The results show that the dynamic solution of the system is exponential stab＇flity and converges to the steady-state solution.

关键词： repairable system nonnegative solution simple eigenvalue strictly domi- nant eigenvalue essential spectrum perturbation exponential stability

Thermally activated flux flow,vortex-glass phase transition and the mixed-state Hall effect in 112-type iron pnictide superconductors

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Science China(Physics,Mechanics & Astronomy) 2018年第12期61卷 45-52页

作者： XiangZhuo Xing ZhanFeng Li XiaoLei Yi JiaJia Feng ChunQiang Xu Nan Zhou Yan Meng yufeng zhang YongQiang Pan LingYao Qin Wei Zhou HaiJun Zhao ZhiXiang Shi School of Physics and Key Laboratory of MEMS of the Ministry of Education Southeast UniversityNanjing 211189China Advanced Functional Materials Lab and Department of Physics Changshu Institute of TechnologyChangshu 215500China

The transport properties in the mixed state of high-quality Ca_(0.8)La_(0.2)Fe_(0.98)Co_(0.02)As_2single crystal,a newly discovered 112-type iron pnictide superconductor,are comprehensively studied by magneto-resistivity *** field-dependent activation energy,U_0,is derived in the framework of thermally activated flux flow(TAFF)theory,yielding a power law dependence U_0～H~αwith a crossover at a magnetic field around 2 T in both H⊥ab and H//ab,which is ascribed to the different pinning ***,we have clearly observed the vortex phase transition from vortex-glass to vortex-liquid according to the vortex-glass model,and vortex phase diagrams are constructed for both H⊥ab and H//***,the results of mixed-state Hall effect show that no sign reversal of transverse resistivityρ_(xy)(H)is detected,indicating that the Hall component arising from the vortex flow is in theories or experiments previously reported on some high-T_ccuprates.

关键词： thermally activated flux flow vortex-glass transition mixed-state Hall effect 112-type iron pnictide superconductors