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肝硬化肝性脑病患者脑灰质体积改变:Meta分析

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中国介入影像与治疗学 2024年第8期21卷 486-490页

作者：曾烨胡威赣南医学院第一附属医院医学影像科江西赣州341000 洪湖市人民医院医学影像科湖北荆州433200

目的采用meta分析系统分析肝硬化(LC)肝性脑病(HE)患者脑灰质体积(GMV)改变。方法检索自建库至2023年11月8日中国知网、维普数据库、万方医学网、PubMed、Embase、Web of Science及Scholar数据库中基于体素的形态学测量(VBM)分析LC HE患... 详细信息

目的采用meta分析系统分析肝硬化(LC)肝性脑病(HE)患者脑灰质体积(GMV)改变。方法检索自建库至2023年11月8日中国知网、维普数据库、万方医学网、PubMed、Embase、Web of Science及Scholar数据库中基于体素的形态学测量(VBM)分析LC HE患者(LC组)与健康对照(HC组)GMV差异的对照研究,根据纳入及排除标准进行筛选。采用标记差异映像(SDM)软件观察LC组GMV相比HC组的改变,并行亚组分析。结果最终纳入12篇文献,包括LC组401例[153例无HE(NHE亚组)、146例轻度HE(MHE亚组)及102例显性HE(OHE亚组)]和HC组289名。相比HC组,LC组左侧丘脑、右侧舌回及右侧海马旁回GMV均增加,左侧小脑、右侧前扣带及旁扣带回和右侧豆状核苍白球GMV均缩小(Pz>1,簇范围≥20个体素)。亚组分析显示,相比HC组,NHE、MHE及OHE亚组左侧丘脑、左侧距状裂周围皮层及右侧舌回GMV均增加,NHE及MHE亚组双侧基底核及小脑等脑区GMV均缩小(P均<0.05)。结论LC HE患者左侧丘脑、左侧距状裂周围皮层及右侧舌回、双侧基底核和左侧小脑等脑区存在GMV改变。

关键词：肝性脑病肝硬化灰质体积荟萃分析

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Multimedia model of atrazine in plant-soil-groundwater system with a fugacity approach

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Journal of Environmental Sciences 2001年第4期13卷 466-471页

作者： ye, C.-m. Lei, z.-f. Wang, X.-j. Gong, A.-j. zheng, H.-h. Res. Cntr. Eco-Environmental Sci. Chinese Academy of Sciences Beijing 100085 China

The application of atrazine in China during the last ten years has led to some environmental problems. In this paper, the multimedia model of atrazine in soil-plant-groundwater system at Baiyangdian Lake area in Northern China was established using a fugacity approach, and verified with observed values. The model involved 7 environmental compartments which are air, groundwater, soil, corn roots, corn stem, corn leaf and kernel of corn. The results showed that the relative errors between calculated and observed values have a mean value of 24.7%, the highest value is 48% and the lowest value is 1.4%. All these values indicated that this multimedia model can be used to simulate the environmental fate of atrazine. Both the calculated and observed values of concentrations of atrazine in plant compartments are in the following order: in corn roots > in corn stem > in kernel of corn > in corn leaf, it exhibited a good regularity. The prediction results indicated that concentrations of atrazine in the groundwater and kernel of corn will override the limitation of 3 μg/L and 0.05 mg/kg respectively.

关键词： Concentration (process) Error detection Groundwater Lakes Plants (botany) Soils

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棕榈油在鱼类配合饲料中应用的研究进展

中国饲料 2024年第13期 101-108页

作者：闭然叶继丹集美大学水产学院厦门市饲料检测与安全评价重点实验室福建厦门361021

以中国为代表的全球水产养殖业发展迅猛,拉动了鱼油的强劲消费,从而造成鱼油持续供给短缺和价格上涨的局面,因此,寻求鱼油替代品已成为水产饲料领域的重要课题之一。棕榈油是一种种植面积广、产量大的植物油,已广泛应用于饲料、食品、... 详细信息

以中国为代表的全球水产养殖业发展迅猛,拉动了鱼油的强劲消费,从而造成鱼油持续供给短缺和价格上涨的局面,因此,寻求鱼油替代品已成为水产饲料领域的重要课题之一。棕榈油是一种种植面积广、产量大的植物油,已广泛应用于饲料、食品、化工、医药、生物质能和其他领域。本文综述了棕榈油在鱼类配合饲料中应用的研究进展,为合理配制鱼类配合饲料提供有益参考。

关键词：棕榈油鱼油替代鱼类饲料

Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei zhang Wencai ye Minfeng Chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

China-Spain Friendship Gaining Ground--An Exclusive Interview with Wu Haitao,Chinese Ambassador to Spain

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China Today 2023年第5期72卷 44-48页

作者： MIAO ye MICHAEL zÁRATE 不详

MARCH 9,2023 marks the 50th anniversary of the establishment of diplomatic relations between China and *** gain more insight into the development of this relationship,China Today recently spoke to Wu Haitao,Chinese am... 详细信息

关键词： Spain planned Today

NUMERICAL SIMULATION OF HEATING AND QUENCHING PROCESSES FOR A 280 CONNECTING ROD OF 16V280zJ DIESEL LOCOMOTIVE

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Acta Metallurgica Sinica(English Letters) 2002年第6期15卷 561-568页

作者： J.S. ye, z.R. ye, A. Yang,and Y.LuaSchool of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China ziyang Internal-Combustion Factory of Sichuan, ziyang 641000, China Sch. of Mat. Sci. and Eng. Shanghai Jiaotong Univ. Shanghai 200030 China ziyang Internal-Combustion Factory Ziyang 641000 China

A modified temperature-phase transformation-stress coupled 3D non-linear mathematical model and a series of subroutines on the non-liner MARC (MARC Analysis Research Corporation) are developed. Then this modified model has been utilized to simulate the heat treatment processes of 280 connecting rod of 16 V280zJ diesel locomotive. The simulation results are basically in agreement with the experiments, which testify that the mathematical model and method are feasible. In addition, the simulation can not only obtain the transient temperature and micro structure of heat treatment process, but also provide a sound scientific basis for the heat treatment workers.

关键词： non-linear transient temperature phase transformation mathematical model

Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

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Chinese Medical Journal 2024年第9期137卷 1105-1114页

作者： Xinsheng Xie ye Yuan Yulong Huang Xiang Hong Shichai Hong Gang Chen Yihui Chen Yue Lin Weifeng Lu Weiguo Fu Lixin Wang Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Fudan UniversityShanghai 200032China

Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been *** study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this ***:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)*** expressed genes(DEGs)were identified using the"limma"package in *** absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker ***-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in ***:A total of 16 DEGs were *** enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related *** type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for *** expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall ***,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall ***-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T *** addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall ***:COL1A1 and SYTL2 may serve as diagnostic marker genes for *** upregulation of SYTL2 and COL1A1 may be involved in the inflammat

关键词： Bioinformatics Thoracic aortic aneurysm Immune response Single cell analysis Machine learning

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng ye Yunfei Deng Yue Gu Pengfei Liu Jie Luo Jiangqin Pu Jingyu Chen Yu Huang Nanping Wang Yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong zhou Li-Jian Fang Ya-Xing Wang ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu Shuo-Hua Chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination