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Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu wU Rui zHANG Sheng YUAN zhong-Xing CAI Chang-Dong guan Tong-Qiang zOU Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P w χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P w-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

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Oncology Research 2024年第4期32卷 659-678页

作者： XIAOFENG GAO JUANJUAN GE XUzHENG GAO NA MEI YANTING SU SHIGANG SHAN wENBIN QIAN JIANGHENG guan zHENwANG zHANG LONG wANG Hubei Provincial Key Laboratory of Diabetic Cardiovascular Diseases Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Basic Medical Sciences Xianning Medical CollegeHubei University of Science and TechnologyHubei University of Science and TechnologyXianning437100China School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China Department of Neurosurgery The General Hospital of Chinese PLA Central Theater CommandWuhan430070China

Background:IQGAP3 plays a crucial role in regulating cell proliferation,division,and cytoskeletal *** expression of IQGAP3 has been linked to various tumors,but its function in glioma is not well ***:Various methods,including genetic differential analysis,single-cell analysis,ROC curve analysis,Cox regression,Kaplan-Meier analysis,and enrichment analysis,were employed to analyze the expression patterns,diagnostic potential,prognostic implications,and biological processes involving IQGAP3 in normal and tumor *** impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using ***,the cBioPortal database was used to analyze copy number variations and mutation sites of *** validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying ***:High IQGAP3 expression in gliomas is associated with an unfavorable prognosis,particularly in wild-type IDH and 1p/19q non-codeleted *** analysis revealed that IQGAP3 is involved in regulating the cell cycle,PI3K/AKT signaling,p53 signaling,and PLK1-related ***,IQGAP3 expression may be closely related to the immunosuppressive microenvironment of ***-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma *** vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells,with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma ***:IQGAP3 shows promise as a valuable biomarker for diagnosis,prognosis,and immunotherapeutic strategies in gliomas.

关键词： IQGAP3 Tumor immune infiltration Prognosis Glioma Biomarker

异质金属激光增材制造研究及应用进展(特邀)

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中国激光 2024年第10期51卷 48-69页

作者：马毅管迎春北京航空航天大学机械工程与自动化学院北京100083 北京航空航天大学大型金属构件增材制造国家工程实验室北京100191

极端服役环境对空天等核心构件可靠性和集成性提出了严峻挑战。传统单一材料体系和制造工艺难以满足复杂性能需求。激光增材制造技术是实现异质金属结构-功能一体化的有效途径,但异质材料兼容问题(易诱发缺陷、加工参数响应不一等)限制... 详细信息

极端服役环境对空天等核心构件可靠性和集成性提出了严峻挑战。传统单一材料体系和制造工艺难以满足复杂性能需求。激光增材制造技术是实现异质金属结构-功能一体化的有效途径,但异质材料兼容问题(易诱发缺陷、加工参数响应不一等)限制了高质量异质界面的形成,这对制造装备与连接工艺提出了更高挑战。本文基于异质金属激光增材制造的最新研究进展,聚焦异质金属成型的关键问题及解决方案,回顾了近年来异质金属体系的发展及空天领域应用,从送粉方式、复合制造等方面介绍了激光增材装备的改进策略,总结了近年来激光增材技术在连接方式、参数调控、监测预测和前后端处理方面的研究进展,并针对这一技术的共性及难点问题给出了展望与思考。

关键词：激光技术异质金属空天应用增材装备增材制造工艺

Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

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world Journal of Gastrointestinal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang Liu Hao wang Bo Gao Ting-Ting Xu Qing-Gang Yuan Shi-zhen zhou Chao Ding Ji Miao wen-Xian guan Department of General Surgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional status(CONUT)score effectively reflects a patient’s nutritional status,which is closely related to cancer *** study invest-igated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer,and compared the predictive ability of the CONUT score with other *** To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative *** This retrospective analysis included 217 patients with newly diagnosed *** CONUT score was calculated based on the serum albumin level,total lymphocyte count,and total cholesterol *** cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic *** associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression *** Using the cutoff value of the CONUT score,patients were stratified into CONUT low(n=189)and CONUT high groups(n=28).The CONUT high group had worse overall survival(OS)(P=0.013)and relapse-free survival(RFS)(P=0.015).The predictive performance of CONUT was superior to the modified Glasgow prognostic score,the prognostic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances of CONUT+tumor node metastasis(TNM)stage for 3-year OS[area under the receiver operating characteristics curve(AUC)=0.803]and 3-year RFS(AUC=0.752)were no less than skeletal muscle mass index(SMI)+TNM *** CONUT score was negatively correlated with SMI(Pwas superior to other *** correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.

关键词： Controlling nutritional status Colorectal cancer Prognostic marker Sarcopenia Skeletal muscle

SiO_(2) Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model

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Biomedical and Environmental Sciences 2024年第6期37卷 617-627页

作者： Yongheng wang Ning Li Yi guan Tong LI Yuxiu zhang Hong Cao zhihua Yu zhiheng Li Shuoyan Li Jiahao Hu wenxin zhou Sisi Qin Shuang Li Sanqiao Yao School of Public Health North China University of Science and TechnologyTangshan 063210HebeiChina Hebei Key Laboratory of Occupational Health and Safety for Coal Industry North China University of Science and TechnologyTangshan 063210HebeiChina Occupational Disease Prevention and Control Institute of Jinneng Holding Coal Industry Group Co. LtdDatong 037001ShanxiChina China Pingmei Shenma Group Occupational Disease Prevention and Control Hospital Pingdingshan 467000HenanChina School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina

Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO_(2)-induced cardiac injury using a mouse *** Male C57BL/6 mice were intratracheally instilled with SiO_(2) to create a silicosis ***-1(Fer-1)and deferoxamine(DFO)were used to suppress *** biomarkers,oxidative stress markers,histopathology,iron content,and the expression of ferroptosis-related proteins were *** SiO_(2) altered serum cardiac injury biomarkers,oxidative stress,iron accumulation,and ferroptosis markers in myocardial ***-1 and DFO reduced lipid peroxidation and iron overload,and alleviated SiO_(2)-induced mitochondrial damage and myocardial ***_(2) inhibited Nuclear factor erythroid 2-related factor 2(Nrf2)and its downstream antioxidant genes,while Fer-1 more potently reactivated Nrf2 compared to *** Iron overload-induced ferroptosis contributes to SiO_(2)-induced cardiac *** ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO_(2) cardiotoxicity,potentially via modulation of the Nrf2 pathway.

关键词： SiO_(2) exposure Iron overload Ferroptosis Cardiac injury Nrf2

Development of 400-μw cryogen-free dilution refrigerators for quantum experiments

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Chinese Physics B 2024年第7期33卷 28-35页

作者：关翔樊洁边勇波程智刚姬忠庆 Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

we have successfully developed cryogen-free dilution refrigerators with medium cooling power that can be applied to quantum experiments. Breakthroughs have been made in some key technologies and components of heat switches and dilution units. Our prototype has been running continuously and stably for more than 100 hours below 10 m K, with a minimum temperature of 7.6 m K and a cooling power of 450 μw at 100 m K. At the same time, we have also made progress in the application of dilution refrigerators, such as quantum computing, low-temperature detector, and magnet integration. These indicators and test results indicate good prospects for application in physics, astronomy, and quantum information.

关键词： cryogen-free dilution refrigerator quantum computing low-temperature detector superconducting magnet

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi wang Yuning Li Yakun Gu wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

SARS-CoV-2 immunity in animal models

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Cellular & Molecular Immunology 2024年第2期21卷 119-133页

作者： zhao Chen Yaochang Yuan Qingtao Hu Airu zhu Fenghua Chen Shu Li Xin guan Chao Lv Tian Tang Yiyun He Jinling Cheng Jie zheng Xiaoyu Hu Jingxian zhao Jincun zhao Jing Sun State Key Laboratory of Respiratory Disease National Clinical Research Centre for Respiratory DiseaseNational Centre for Respiratory MedicineGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510000China guangzhou National Laboratory GuangzhouGuangdong 510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518005China

The COVID-19 pandemic,which was caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a worldwide health crisis due to its ***-CoV-2 infection results in severe respiratory illness and can lead to significant complications in affected *** complications encompass symptoms such as coughing,respiratory distress,fever,infectious shock,acute respiratory distress syndrome(ARDS),and even multiple-organ *** models serve as crucial tools for investigating pathogenic mechanisms,immune responses,immune escape mechanisms,antiviral drug development,and vaccines against ***,various animal models for SARS-CoV-2 infection,such as nonhuman primates(NHPs),ferrets,hamsters,and many different mouse models,have been *** model possesses distinctive features and *** this review,we elucidate the immune response elicited by SARS-CoV-2 infection in patients and provide an overview of the characteristics of various animal models mainly used for SARS-CoV-2 infection,as well as the corresponding immune responses and applications of these models.A comparative analysis of transcriptomic alterations in the lungs from different animal models revealed that the K18-hACE2 and mouse-adapted virus mouse models exhibited the highest similarity with the deceased COVID-19 ***,we highlighted the current gaps in related research between animal model studies and clinical investigations,underscoring lingering scientific questions that demand further clarification.

关键词： COVID-19 SARS-CoV-2 animal models immune response

BOUNDARY ELEMENT APPROXIMATION OF STEKLOV EIGENVALUE PROBLEM FOR HELMHOLTz EQUATION

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Journal of Computational Mathematics 1998年第2期16卷 165-178页

作者： Tang, wJ guan, z Han, HD Inst Appl Phys & Computat Math Lab Computat Phys Beijing 100088 Peoples R China Tsing Hua Univ Dept Appl Math Beijing 100084 Peoples R China

Steklov eigenvalue problem of Helmholtz equation is considered in the present paper. Steklov eigenvalue problem is reduced to a new variational formula on the boundary of a given domain, in which the self-adjoint property of the original differential operator is kept and the calculating of hyper-singular integral is avoided. A numerical example showing the efficiency of this method and an optimal error estimate are given.

关键词： Steklov eigenvalue problem differential operator error estimate boundary element approximation