SARS-CoV-2 immunity in animal models

作     者：Zhao Chen Yaochang Yuan Qingtao Hu Airu Zhu Fenghua Chen Shu Li Xin Guan Chao Lv Tian Tang Yiyun He Jinling Cheng Jie Zheng Xiaoyu Hu Jingxian Zhao Jincun Zhao Jing Sun 

作者机构：State Key Laboratory of Respiratory DiseaseNational Clinical Research Centre for Respiratory DiseaseNational Centre for Respiratory MedicineGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China GMU-GIBH Joint School of Life SciencesGuangzhou Medical UniversityGuangzhou 510000China Guangzhou National LaboratoryGuangzhouGuangdong 510005China Shanghai Institute for Advanced Immunochemical StudiesSchool of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China Institute for HepatologyNational Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518005China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2024年第21卷第2期

页      面：119-133页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by a grant from the National Key R&D Program of China(No.2021YFC2301700 JS,2022YFC2604102 JS) Major Project of Guangzhou National Laboratory(GZNL2023A01003) the National Natural Science Foundation of China(82025001 JCZ,81971500 JXZ,2022YFC2303700 ARZ) the Guangdong Basic and Applied Basic Research Foundation(2022B1515020059 JS,2021B15150005 JXZ) the State Key Laboratory of Respiratory Disease(SKLRD-Z-202304,QTH) the ZHONGNANSHAN MEDICAIFOUNDATION OF GUANGDONG PROVINCE(No.ZNSA2020013 JCZ) 

主　　题：COVID-19 SARS-CoV-2 animal models immune response 

摘      要：The COVID-19 pandemic,which was caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a worldwide health crisis due to its ***-CoV-2 infection results in severe respiratory illness and can lead to significant complications in affected *** complications encompass symptoms such as coughing,respiratory distress,fever,infectious shock,acute respiratory distress syndrome(ARDS),and even multiple-organ *** models serve as crucial tools for investigating pathogenic mechanisms,immune responses,immune escape mechanisms,antiviral drug development,and vaccines against ***,various animal models for SARS-CoV-2 infection,such as nonhuman primates(NHPs),ferrets,hamsters,and many different mouse models,have been *** model possesses distinctive features and *** this review,we elucidate the immune response elicited by SARS-CoV-2 infection in patients and provide an overview of the characteristics of various animal models mainly used for SARS-CoV-2 infection,as well as the corresponding immune responses and applications of these models.A comparative analysis of transcriptomic alterations in the lungs from different animal models revealed that the K18-hACE2 and mouse-adapted virus mouse models exhibited the highest similarity with the deceased COVID-19 ***,we highlighted the current gaps in related research between animal model studies and clinical investigations,underscoring lingering scientific questions that demand further clarification.