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Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO_(2) as gatekeeper

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regenerative Biomaterials 2023年第1期10卷 1566-1576页

作者： zhaoyang Wang zekai Li Yuehua Shi Leyong zeng Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Chemical Biology Key Laboratory of Hebei ProvinceState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding 071002P.R.China

The non-specific leakage of drugs from nanocarriers seriously weakened the safety and efficacy of chemotherapy,and it was very critical of constructing tumor microenvironment(TME)-responsive delivery nanocarriers,achieving the modulation release of ***,using manganese dioxide(MnO_(2))as gatekeeper,an intelligent nanoplatform based on mesoporous polydopamine(MPDA)was developed to deliver doxorubicin(DOX),by which the DOX release was precisely controlled,and simultaneously the photothermal therapy(PTT)and chemodynamic therapy(CDT)were *** normal physiological environment,the stable MnO_(2)shell effectively avoided the leakage of ***,in TME,the overexpressed glutathione(GSH)degraded MnO_(2)shell,which caused the DOX ***,the photothermal effect of MPDA and the Fenton-like reaction of the generated Mn^(2+)further accelerated the cell ***,the developed MPDA-DOX@MnO_(2)nanoplatform can intelligently modulate the release of DOX,and the combined CDT/PTT/chemotherapy possessed high-safety and high-efficacy against tumors.

关键词： mesoporous polydopamine MnO_(2)gatekeeper chemotherapy photothermal therapy chemodynamic therapy

Analysis of seasonal signals and long-term trends in the height time series of IGS sites in China

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Science China Earth Sciences 2016年第6期59卷 1283-1291页

作者： MING Feng YANG YuanXi zeng AnMin JING YiFan Institute of Geospatial Information Information Engineering University National Key Laboratory of Geo-information Engineering Xi'an Institute of Surveying and Mapping Institute of Navigation and Aerospace Engineering Information Engineering University

The seasonal signal and long-term trend in the height time series of 10 IGS sites in China are investigated in this paper. The offset detection and outlier removal as well as the removal of common mode error are performed on the raw GPS time-series data developed by the Scripps Orbit and Permanent Array Center(SOPAC). The seasonal-trend decomposition procedure based on LOESS(STL) is utilized to extract precise seasonal signals, followed by an estimation of the long-term trend with the application of maximum likelihood estimation(MLE) to the seasonally adjusted time series. The Up-compo- nents of all sites are featured by obvious seasonal variations, with significant phase and amplitude modulation on some sites. After Kendall's tau test, a significant trend(99% confidence interval) for all sites is achieved. Furthermore, the trends at sites TCMS and TNML have significant changes at epochs 2009.5384 and 2009.1493(95% confidence interval), respectively, using the Breaks For Additive Seasonal and Trend test. Finally, the velocities and their uncertainties for all sites are estimated using MLE with the white noise plus flicker noise model. And the results are analyzed and compared with those announced by SOPAC. The results obtained in this paper have a higher precision than the SOPAC results.

关键词： GPS Height time series Seasonal signal Long-term trend STL filter Colored noise

Visible light promoted synthesis of N-aroylsulfoximines by oxidative C–H acylation of NH-sulfoximines

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Science China Chemistry 2019年第9期62卷 1213-1220页

作者： Wenlong Jiang Youming Huang Lihong zhou Qingle zeng State Key Laboratory of Geohazard Prevention and Geoenvironment Protection College of Materials Chemistry & Chemical Engineering Chengdu University of Technology Chengdu 610059 China College of Environment and Ecology Chengdu University of Technology Chengdu 610059 China

The visible light-promoted synthesis of N-aroylsulfoximines has been accomplished via an oxidative dehydrogenative coupling at room temperature under air without the addition of a photosensitizer, metal catalyst, or base. This process exhibits good functional group tolerance, allows facile isolation and purification, and affords N-aroylsulfoximines with high efficiency. The efficiency of the newly developed protocol is described in detail with 27 examples with yields ranging from 80% to 96%.Furthermore, the chirality of the NH-sulfoximine is completely maintained in the desired N-aroylsulfoximine product(>99% ee).

关键词： visible light aldehyde sulfoximines acylation oxidative dehydrogenative coupling

The record-breaking Mei-yu in 2020 and Associated Atmospheric Circulation and Tropical SST Anomalies

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Advances in Atmospheric Sciences 2021年第12期38卷 1980-1993页

作者： Yihui DING Yunyun LIU zeng-zhen HU National Climate Center China Meteorological AdministrationBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Climate Prediction Center NCEP/NOAACollege ParkMD 20740USA

The record-breaking mei-yu in the Yangtze-Huaihe river valley(YHrV)in 2020 was characterized by an early onset,a delayed retreat,a long duration,a wide meridional rainbelt,abundant precipitation,and frequent heavy rainstorm *** is noted that the East Asian monsoon circulation system presented a significant quasi-biweekly oscillation(QBWO)during the mei-yu season of 2020 that was associated with the onset and retreat of mei-yu,a northward shift and stagnation of the rainbelt,and the occurrence and persistence of heavy rainstorm ***,during the mei-yu season,the monsoon circulation subsystems,including the western Pacific subtropical high(WPSH),the upper-level East Asian westerly jet,and the low-level southwesterly jet,experienced periodic oscillations linked with the *** notably,the repeated establishment of a large southerly center,with relatively stable latitude,led to moisture convergence and ascent which was observed to develop *** was accompanied by a long-term duration of the mei-yu rainfall in the YHrV and frequent occurrences of rainstorm ***,two blocking highs were present in the middle to high latitudes over Eurasia,and a trough along the East Asian coast was also active,which allowed cold air intrusions to move southward through the northwestern and/or northeastern *** cold air frequently merged with the warm and moist air from the low latitudes resulting in low-level convergence over the *** persistent warming in the tropical Indian Ocean is found to be an important external contributor to an EAP/PJ-like teleconnection pattern over East Asia along with an intensified and southerly displaced WPSH,which was observed to be favorable for excessive rainfall over YHrV.

关键词： record-breaking mei-yu western Pacific subtropical high quasi-biweekly oscillation Tropical Indian Ocean warming low-level southwesterly jet blocking high

Mechanism study on flotation separation of molybdenite from chalcocite using thioglycollic acid as depressant

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International Journal of Mining Science and Technology 2017年第6期27卷 1043-1049页

作者： Qin Wenqing Wu Jiajia Jiao Fen zeng Jinming School of Minerals Processing and Bioengineering Central South University Changsha 410083 China

Effects of collectors(butyl xanthate(BX), O-isopropyl-N-sulfur ethyl carbamate(z-200) and emulsified kerosene), dereagent(sodium sulfide) and depressant thioglycollic acid(TGA) on the flotation of chalcocite and molybdenite were investigated through flotation. The first principle theory was adopted to understand the difference of their surfaces and reaction between minerals and reagents. results of flotation tests revealed that selectivity of emulsified kerosene is the best of three collectors in separation of chalcocite and molybdenite, though the others also display excellent collecting properties. Sodium sulfide can effectively remove collectors adsorbed on chalcocite surface, and TGA is an effective depressant of chalcocite at pH 8-9. Through first principle study, molybdenite displays relatively stronger covalence property while bonding interaction between copper atoms in chalcocite enhanced its ionicity. Bonding interaction is weaker in reaction of TGA and molybdenite, so it shows higher hydrophobicity and better flotability. Therefore, TGA is an effective inhibitor in the separation.

关键词： Chalcocite Molybdenite Thioglycollic acid Flotation First-principles study

Decentralized Adaptive Strategies for Synchronization of Fractional-order Complex Networks

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 543-550页

作者： Quan Xu Shengxian zhuang Yingfeng zeng Jian Xiao School of Electrical Engineering Southwest Jiaotong University School of Technology Xihua University

This paper focuses on synchronization of fractionalorder complex dynamical networks with decentralized adaptive *** on local information among neighboring nodes,two fractional-order decentralized adaptive strategies are designed to tune all or only a small fraction of the coupling gains *** constructing quadratic Lyapunov functions and utilizing fractional inequality techniques,Mittag-Leffler function,and Laplace transform,two sufficient conditions are derived for reaching network synchronization by using the proposed adaptive ***,two numerical examples are given to verify the theoretical results.

关键词： Decentralized adaptive control fractional-order complex networks quadratic Lyapunov functions synchronization

Bifurcation behaviors of catalytic combustion in a micro-channel

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Journal of Thermal Science 2008年第1期17卷 84-89页

作者： Wen zeng Maozhao Xie Hongan Ma Wei Xu School of Aero-engine and Energy Engineering Shenyang Institute of Aeronautical Engineering Shenyang 110034China School of Energy and Power Engineering Dalian University of Technology Dalian 116024 China

Bifurcation analysis of ignition and extinction of catalytic combustion in a short micro-channel is carded out with the laminar flow model incorporated as the flow model. The square of transverse Thiele modulus and the residence time are used as bifurcation parameters. The influences of different parameters on ignition and extinction behavior are investigated. It is shown that all these parameters have great effects on the bifurcation behaviors of ignition and extinction in the short micro-channel. The effects of flow models on bifurcation behaviors of combustion are also analyzed. The results show that in comparison with the flat velocity profile model, for the case of the laminar flow model, the temperatures of ignition and extinction of combustion are higher and the unsteady multiple solution region is larger.

关键词： catalytic combustion bifurcation theory short monolith

Establishment of the Constitutive relationship for MP159 Alloy

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Journal of Materials Science & Technology 1999年第3期15卷 239-244页

作者： Lu, SQ Shang, Bz Luo, zJ zeng, FC Nanchang Inst Aeronaut Technol Dept Mat Engn Nanchang 330034 Peoples R China Northwestern Polytech Univ Coll Mat Sci & Engn Xian 710072 Peoples R China Aviat Ind Corp Beijing 100034 Peoples R China

The constitutive relationship for MP159 alloy, a kind of high strength cobalt-base superalloy, was studied based on the experimental results of compression tests carried out in the THErMECMASTEr-z hot work simulating test machine. The constitutive relationship model using zener-Hollomon parameter as primary variable is proposed, and the constitutive equation for MP159 alloy is firstly formulized. This equation well represents the relationship of flow stress with thermomechanical,parameters, i.e. strain, strain rate and temperature, in a large deformation (a true strain of 1.10) and a wide range of deformation temperatures and strain rates, it can be used for the finite element simulation of plastic forming process and the dissipative structure theory and dynamic material modeling.

关键词： Superalloys

Aerodynamics Design of Two-stage Vane-less Counter-rotating Turbinec

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Journal of Thermal Science 2011年第5期20卷 406-412页

作者： Yang zhou Huoxing Liu Wei Li Jun zeng National Key Lab. on Aero-Engines Aero-Engines Simulation Research Center Beijing Univ. of Aero. ＆ Astro. Beijing 100191 China zhuzhou Aviation Powerplant research Institute Zhuzhou 412002 China China Gas Turbine Establishment Chengdu 610500 China

It is one of the most efficient ways to greatly improve aero-engines' performance by utilizing vaneless counterrotating turbine(VCrT) *** supply sufficient power,VCrT turns to be high Mach number,large flow angle at high-pressure turbine(HPT) rotor exit,and low blade camber angle,which increase difficulties to turbine *** the axial velocity ratio of HPT rotor is much larger than the conventional ones,the optimal selection of VCrT velocity triangles based on theoretical analysis is developed,and how the efficiency varied by HPT stator/rotor exit flow angle is also figured *** key points to design a high efficient practicable VCrT are to select velocity triangles that are characterized by low flow coefficient,high outlet flow angle and large axial velocity ratio of HPT ***,performance comparison between convergent blade and convergent-divergent blade shows the latter is more appropriate for VCrT.

关键词： counter-rotating turbine vaneless velocity triangle aerodynamic design