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Science China Chemistry 2024年第9期67卷 2982-2988页

作者： En-He Huang Li-Gao Liu You-Wei Yin Hao-Xuan Dong ji-jia zhou Xin Lu Bo zhou Long-Wu ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on α-imino metal carbenes has not been developed to date. Herein, we disclose an enantioselective desymmetrizing C（sp2）–H functionalization of azide-ynamides via α-imino copper carbenes, leading to the efficient assembly of divergent chiral indoloazepines in generally moderate to excellent yields with high enantioselectivities. Notably, this reaction represents the first enantioselective desymmetrization based on α-imino metal carbenes. Further synthetic transformations and biological tests show the potential utility of this method. Moreover,computational studies are employed to elucidate the reaction mechanism and the origin of enantioselectivity.

关键词： enantioselective desymmetrization metal carbenes copper catalysis nitrene transfer alkynes

In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,zn alloying and polymer coating

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journal of Magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.Luňácková M.jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová j.Dušková E.Filová z.Sucharda M.Steinerová S.Habr K.Balík A.Singh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15zn,Mg-0.4zn and Mg-1zn was ***,Mg-0.4zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： Magnesium Resorbable Mg wire Mg-zn implant degradation Biocompatibility study zn grain boundary segregation

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Chlorantraniliprole exposure aggravates high-fat diet-induced metabolic disorders in mice by regulating gut microbiota and its metabolites

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Food Science and Human Wellness 2024年

作者： Ting Gu jie Lin jiani Yang William Mumby Quancai Sun ye Peng Faculty of Medicine Macau University of Science and Technology School of Food and Biological Engineering jiangsu University Department of Health Nutrition and Food Sciences Florida State University

Food contaminants， particularly insecticides， are important factors contributing to obesity and other adverse effects. As the most widely used diamide insecticide worldwide， chlorantraniliprole (CP) is ubiquitous in food and the environment. However， the influence of CP on obesity and the gut microbiota remains unknown. In this study， we administered CP/carboxymethyl cellulose sodium to C57BL/6j mice with a high-fat diet (HFD) via gavage for 13 weeks. The CP exposure induced significant increases in body weight gain， fat mass， serum total cholesterol (TC)， and low-density lipoprotein cholesterol (LDL-C). Moreover， CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria. Based on untargeted metabolomics analysis， CP was found to be involved in the regulation of pathways including ‘alanine， aspartate and glutamate metabolism’ and ‘arginine and proline metabolism’. Notably， CP exposure primarily induced alterations in microbial metabolites within these pathways， such as L-(+)-aspartic acid and L-glutamic acid. Additionally， individual metabolites， such as the lipid mediator (oleoyl ethanolamide)， also demonstrated alterations upon CP exposure. Furthermore， Spearman correlation analysis revealed several noteworthy associations between microbial alterations， metabolite changes， and phenotypes. The results of the study demonstrate a connection between microbiota， metabolites， and the effects of CP exposure on HFD-induced obesity， elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.

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PSRDP:A Parallel Processing Method for Pulsar Baseband Data

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Research in Astronomy and Astrophysics 2024年第1期24卷 300-310页

作者： Ya-zhou zhang Hai-Long zhang jie Wang Xin-Chen ye Shuang-Qiang Wang Xu Du Han Wu Ting zhang Shao-Cong Guo Meng zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

To address the problem of real-time processing of ultra-wide bandwidth pulsar baseband data,we designed and implemented a pulsar baseband data processing algorithm(PSRDP)based on GPU parallel computing *** can perform operations such as baseband data unpacking,channel separation,coherent dedispersion,Stokes detection,phase and folding period prediction,and folding integration in GPU *** tested the algorithm using the j0437-4715 pulsar baseband data generated by the CASPSR and Medusa backends of the Parkes,and the j0332+5434 pulsar baseband data generated by the self-developed backend of the Nan Shan Radio *** obtained the pulse profiles of each baseband *** experimental analysis,we have found that the pulse profiles generated by the PSRDP algorithm in this paper are essentially consistent with the processing results of Digital Signal Processing Software for Pulsar Astronomy(DSPSR),which verified the effectiveness of the PSRDP ***,using the same baseband data,we compared the processing speed of PSRDP with DSPSR,and the results showed that PSRDP was not slower than DSPSR in terms of *** theoretical and technical experience gained from the PSRDP algorithm research in this article lays a technical foundation for the real-time processing of QTT(Qi Tai radio Telescope)ultra-wide bandwidth pulsar baseband data.

关键词： (stars:)pulsars:general methods:data analysis techniques:miscellaneous

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Numerical Study of Flow Features Around Submerged Circular and Square Piles at Flat and Scoured Beds Using OpenFOAM

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journal of Ocean University of China 2024年第4期23卷 897-914页

作者： WANG Chaolin WU Guoxiang WANG Dianhe DU Shengtao zHANG zhiyong jIN Heng zHU David z. LIANG Bingchen Donghai Academy School of Civil&Environmental Engineering and Geography ScienceNingbo UniversityNingbo 315211China Key Laboratory of Estuary and Coast of zhejiang Province and Zhejiang Institute of Hydraulics and EstuaryHangzhou 310020China Shandong Provincial Key Laboratory of Ocean Engineering and College of EngineeringOcean University of ChinaQingdao 266100China Shandong Water Conservancy Vocational College Rizhao 276826China School of Mechanical and Energy Engineering Ningbotech UniversityNingbo 315211China

Elucidating the flow features around piles in local scouring processes is crucial for studies of local scouring mechanisms and scour depth *** study details the flow turbulence characteristics of two submerged piles that are determined by solving the Navier-Stokes equations with the improved delayed detached eddy simulation *** model is verified by comparing experimental and numerical results for hydrodynamic parameters with the literature for both square-crossing piles(SCPs)and circular-crossing piles(CCPs).Original topographies of flat and scoured beds(i.e.,the initial and equilibrium scouring stages)are based on experimental results obtained by the authors in the present *** and CCP flow features in the scouring process are *** results indicate that during the scouring process,the time-averaged drag coefficient and root mean square(rms)of the lift coefficient increase linearly in the CCP test,while the rms of the lift coefficient in the SCP test decreases ***,the minimum pressure coefficient is always located in the upstream corners in the SCP case but moves from 72.5°to 79.5°when the scour hole is completely developed in the CCP *** flow behind the pile,which is generated by separated boundary layers above the top face of the pile,can reach the sand bed and turn the separated shear layers into patches of small vortices in the near-wake ***,the high shear stress zones are mainly at the scour edges under scoured-bed conditions.

关键词： flat bed scoured bed local scour OpenFOAM bed shear stress

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Dear-DIA^(XMBD): Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics

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Research 2024年第1期6卷 707-720页

作者： Qingzu He Chuan-Qi zhong Xiang Li Huan Guo Yiming Li Mingxuan Gao Rongshan Yu Xianming Liu Fangfei zhang Donghui Guo Fangfu ye Tiannan Guo jianwei Shuai jiahuai Han Department of Physics and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)and Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China School of Life Sciences Xiamen UniversityXiamen 361102China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkXiamen 361102China Department of Computer Science Xiamen UniversityXiamen 361005China National Institute for Data Science in Health and Medicine School of MedicineXiamen UniversityXiamen 361102China Bruker(Beijing)Scientific Technology Co.Ltd. BeijingChina Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China Westlake Omics Ltd. Yunmeng Road 1HangzhouChina Department of Electronic Engineering Xiamen UniversityXiamen 361005China

Data-independent acquisition(DIA)technology for protein identification from mass spectrometry and related algorithms is developing *** spectrum-centric analysis of DIA data without the use of spectra library from data-dependent acquisition data represents a promising *** this paper,we proposed an untargeted analysis method,Dear-DIA^(XMBD),for direct analysis of DIA ***-DIA^(XMBD) first integrates the deep variational autoencoder and triplet loss to learn the representations of the extracted fragment ion chromatograms,then uses the k-means clustering algorithm to aggregate fragments with similar representations into the same classes,and finally establishes the inverted index tables to determine the precursors of fragment clusters between precursors and peptides and between fragments and *** show that Dear-DIA^(XMBD) performs superiorly with the highly complicated DIA data of different species obtained by different instrument platforms.

关键词： Deep Auto Independent

Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding

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Nano Research 2024年第7期17卷 6560-6566页

作者： Cheng-Xin Yu Yu-Feng Meng Bo Yang jun Pang Xiang-Sen Meng zi-ye zhao Qing-Yue Wang Li-Bo Mao zhi-Kun Wu Shu-Hong Yu Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Biological structural materials,despite consisting of limited kinds of compounds,display multifunctionalities due to their complex hierarchical *** some biomimetic strategies have been applied in artificial materials to enhance their mechanical stability,the simultaneous optimization of other functions along with the mechanical properties via biomimetic designs has not been thoroughly ***,iron oxide/carbon nanotube(CNT)-based artificial nacre with both improved mechanical and electromagnetic interference(EMI)shielding performance is fabricated via the mineralization of Fe_(3)O_(4)onto a CNTincorporated *** micro-and nano-structures of the artificial nacre are similar to those of natural nacre,which in turn improves its mechanical *** alternating electromagnetic wave-reflective CNT layers and the wave-absorptive iron oxide layers can improve the multiple reflections of the waves on the surfaces of the reflection layers,which then allows sufficient interactions between the waves and the absorption ***,compared with the reflection-dependent EMI-shielding of the non-structured material,the artificial nacre exhibits strong absorption-dependent shielding behavior even with a very low content of wave-absorptive *** to the high mechanical stability,the shielding effectiveness of the artificial nacre that deeply cut by a blade is still maintained at approximately 70%−96%depending on the incident wave *** present work provides a new way for designing structural materials with concurrently enhanced mechanical and functional properties,and a path to combine structural design and intrinsic properties of specific materials via a biomimetic strategy.

关键词： artificial nacre electromagnetic interference shielding biomineralization biomimetic material hierarchical structure

j-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

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General Psychiatry 2024年第1期37卷 44-52页

作者： Chengzhang Liu Qiguo Meng Yuanxiu Wei Xinyue Su Yuanyuan zhang Panpan He Chun zhou Mengyi Liu ziliang ye Xianhui Qin Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina institute of Biomedicine Anhui Medical UniversityHefeiAnhuiChina Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdongChina

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains *** To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese *** The study included a total of 3106 participants capable of completing repeated cognitive function *** nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment *** decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive *** The median follow-up duration was 5.9 *** was a j-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine *** the inflection point,thiamine intake was not significantly associated with cognitive *** the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all pj-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关键词： intake shaped cognitive

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： ye Cheng Lei zhang Xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao jie Bai Yaming Wang zeliang Hu Leiming Wang Qingtang Lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical ***,the molecular landscape underlying this difference remains *** analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and *** of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： ye-Qiang Han Yuan Xie jianyu zhang Shiyu Tan Haoke zhang Ben zhong Tang jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 zhejiang-Israel joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation