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进展期大肠癌的单克隆抗体治疗进展(英文)

进展期大肠癌的单克隆抗体治疗进展(英文)

中国医师协会内镜医师分会成立大会、中国第十四届内镜医学学术大会、《中国内镜杂志》创刊十周年学术讨论会、恩德思奖（Endoscopics Award）颁奖大会

作者： David z.chang University of Texas MD Anderson Cancer Center MD PhD

关键词：大肠癌单克隆抗体治疗进展

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软X射线皮秒变象管扫描相机

高速摄影与光子学 1989年第2期18卷 117-130页

作者：张小秋龚美霞常增虎雷志远杨斌州宋宗贤宋克昌中科院西安光机所

软X射线皮秒变象管扫描相机技术是一种用变象管扫描相机测量X射线脉冲而能达到皮秒时间分辨率和一维微米级空间分辨率的技术。X射线扫描相机是研究伴有X射线辐射的一切高速瞬变过程的极为重要的测量工具。例如在激光核聚变的研究中,加... 详细信息

软X射线皮秒变象管扫描相机技术是一种用变象管扫描相机测量X射线脉冲而能达到皮秒时间分辨率和一维微米级空间分辨率的技术。X射线扫描相机是研究伴有X射线辐射的一切高速瞬变过程的极为重要的测量工具。例如在激光核聚变的研究中,加热压缩期间靶球发生内爆过程中高温高密度等离子体的光谱辐射主要为软X射线,对这些软X射线的研究,可以获得有关等离子体的电子温度、电子能量分布、各种不稳定性的形态及这些参量随时间变化的资料。然而,产生X射线辐射的整个过程只在皮秒数量级。

关键词：相机扫描分辨率变象管软X射线

Dedicated SiPM array for GRD of GECAM

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Radiation Detection Technology and Methods 2022年第1期6卷 63-69页

作者： D.L.zhang X.L.Sun z.H.An X.Q.Li X.Y.Wen K.Gong C.Cai z.chang G.Chen C.Chen Y.Y.Du M.Gao R.Gao D.Y.Guo J.J.He D.J.Hou Y.G.Li C.Y.Li G.Li L.Li X.F.Li M.S.Li X.H.Liang X.J.Liu Y.Q.Liu F.J.Lu H.Lu B.Meng W.X.Peng F.Shi H.Wang J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao S.L.Xiong Y.B.Xu Y.P.Xu S.Yang1 X.zhou J.W.Yang Fan zhang S.N.zhang C.Y.zhang C.M.zhang Fei zhang X.Y.zhao Institute of High Energy Physics CASBeijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China

Purpose The discovery of gravitational waves and gamma-ray bursts heralds the era of multi-messenger *** the adoption of two small satellites to achieve the all-sky monitoring of gamma-ray bursts,the gravitational wave highenergy electromagnetic counterpart all-sky monitor(GECAM)possesses a quasi-real-time early warning ability and plays an important role in positioning the sources of gravitational waves and in subsequent *** satellite of GECAM was fitted with 253-inch-diameter gamma-ray detectors(GRD),covering an energy range of 8–2 *** have adopted silicon photomultiplier tubes(SiPM)in lieu of photomultiplier tubes(PMT)to adapt to the dimensional limitations of *** A unique 3-inch circular SiPM array was *** this design,646×6 mm chips were arranged evenly in a circular manner with the seams filled with reflecting films,thus achieving satisfactory uniformity of light *** integrated pre-amplifier circuit on the back of the SiPM array adopted two-level grouping and summing;further,it achieved a satisfactory signal-to-noise *** high-gain and low-gain channels were adopted to achieve a large dynamic range,and two independent power supply units were used,where each unit can be closed separately,thus improving *** Performance studies show that this SiPM array meets the requirements of *** A 3-inch SiPM array have been developed that uses grouped summation,reflective films,a circular arrangement,two groups of independent power supplies,high-and low-gain signals,differential signal output technologies,*** solution can be used not only for GECAM,but also as a general solution for SiPM-based scintillation detectors.

关键词： SiPM GECAM Gamma-ray Signal-to-noise ratio Reflecting film Pre-amplifier

The design and performance of charged particle detector onboard the GECAM mission

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Radiation Detection Technology and Methods 2022年第1期6卷 53-62页

作者： Y.B.Xu X.Q.Li X.L.Sun S.Yang H.Wang W.X.Peng X.H.Liang K.Gong Y.Q.Liu D.Y.Guo X.Y.zhao C.Y.Li z.H.An J.J.He X.J.Liu X.Y.Wen S.L.Xiong Fan zhang D.L.zhang C.Y.zhang C.Cai z.chang G.Chen C.Chen Y.Y.Du M.Gao R.Gao D.J.Hou Y.G.Li G.Li L.Li X.F.Li M.S.Li F.J.Lu H.Lu B.Meng F.Shi J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao Y.P.Xu J.W.Yang Q.B.Yi S.N.zhang C.M.zhang F.zhang Y.zhao X.zhou Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Background The Gravitational wave highly energetic Electromagnetic Counterpart All-sky Monitor(GECAM)is dedicated to detecting gravitational wave gamma-ray *** is capable of all-sky monitoring over and discovering gamma-ray bursts and new radiation *** consists of two microsatellites,each equipped with 8 charged particle detectors(CPDs)and 25 gamma-ray detectors(GRDs).Purpose The CPD is used to measure charged particles in the space environment,monitor energy and flow intensity changes,and identify between gamma-ray bursts and space charged particle events in conjunction with *** CPD uses plastic scintillator as the sensitive material for detection,silicon photomultiplier array as the optically readable device,and the inlaid Am-241 radioactive source as the onboard calibration *** In this paper,we will present the working principle,physical design,functional implementation and preliminary performance test results of the *** a result,the energy range of electron,gamma-ray detection efficiency and dead time are tested to be better than the indexes required through the ground calibration experiment.

关键词： GECAM CPD SiPM

The data acquisition algorithm designed for the SiPM-based detectors of GECAM satellite

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Radiation Detection Technology and Methods 2022年第1期6卷 70-77页

作者： Y.Q.Liu K.Gong X.Q.Li X.Y.Wen z.H.An C.Cai z.chang G.Chen C.Chen Y.Y.Du M.Gao R.Gao D.Y.Guo J.J.He D.J.Hou Y.G.Li C.Y.Li G.Li L.Li X.F.Li M.S.Li X.H.Liang X.J.Liu F.J.Lu H.Lu B.Meng W.X.Peng F.Shi X.L.Sun H.Wang J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao S.L.Xiong Y.B.Xu Y.P.Xu S.Yang J.W.Yang Q.B.Yi Fan zhang D.L.zhang S.N.zhang C.Y.zhang C.M.zhang Fei zhang X.Y.zhao Y.zhao X.zhou Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Physics and Space Science College China West Normal UniversityNanchong 637002China

Background The Gravitational Wave High-energy Electromagnetic Counterpart All-sky Monitor(GECAM)consists of 2 microsatellites,each of which contains 25 GRD(LaBr3)detectors and 8 CPD(plastic scintillator)*** silicon photomultiplier(SiPM)array is used to read each *** output signal of these detectors with SiPM array is very special and challenging to *** this study,a novel data acquisition(DAQ)algorithm for these detectors is designed and implemented,and the content of the output event packet is *** and Conclusion The performances,including the event acquisition efficiency of this DAQ algorithm,are extensively verified through experimental *** the on-ground and in-flight tests,this algorithm has excellent performance despite the very limited resources and short development time of GECAM mission.

关键词： Silicon photomultiplier Digital waveform processing Data acquisition

Quality assurance test and failure analysis of SiPM arrays of GECAM satellites

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Radiation Detection Technology and Methods 2022年第1期6卷 35-42页

作者： D.L.zhang M.Gao X.L.Sun X.Q.Li z.H.An X.Y.Wen C.Cai z.chang G.Chen C.Chen Y.Y.Du R.Gao K.Gong D.Y.Guo J.J.He D.J.Hou Y.G.Li C.Y.Li G.Li L.Li X.F.Li M.S.Li X.H.Liang X.J.Liu Y.Q.Liu F.J.Lu H.Lu B.Meng W.X.Peng F.Shi H.Wang J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao S.L.Xiong Y.B.Xu Y.P.Xu S.Yang J.W.Yang Fan.zhang S.N.zhang C.Y.zhang C.M.zhang Fei zhang X.Y.zhao X.zhou Institute of High Energy Physics CASBeijing 100049People’s Republic of China

Background The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)satellite developed a SiPM-based gamma-ray detector to monitor the gravitational wave-related GRBs and guide subsequent observations in other wavelengths of *** As all the available SiPM devices belong to commercial grade,quality assurance tests need to be performed in accordance with the aerospace *** In the SiPM application of GECAM,quality assurance experiments were *** mechanism of the failure of SiPM devices was analyzed during the development *** Based on the quality assurance test results,the fnal pass rate of SiPM array was 95%.Based on the failure analysis,it was found that a piece of SiPM had a leakage channel after longtime operation due to device *** According to the accumulated experience,in the reliability test of SiPM,it is necessary to pay special attention to test the impedance of each pin of SiPM to ground and confrm that the power switch state of SiPM is controllable.

关键词： Gravitational waves Gamma-ray detectors Silicon photomultipliers Quality assurance test Failure analysis

The technology for detection of gamma-ray burst with GECAM satellite

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Radiation Detection Technology and Methods 2022年第1期6卷 12-25页

作者： X.Q.Li X.Y.Wen z.H.An C.Cai z.chang G.Chen C.Chen Y.Y.Du M.Gao R.Gao K.Gong D.Y.Guo J.J.He D.J.Hou Y.G.Li C.Y.Li G.Li L.Li X.F.Li M.S.Li X.H.Liang X.J.Liu Y.Q.Liu F.J.Lu H.Lu B.Meng W.X.Peng F.Shi X.L.Sun H.Wang J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao S.L.Xiong Y.B.Xu Y.P.Xu S.Yang J.W.Yang Q.B.Yi D.L.zhang Fan zhang S.N.zhang C.Y.zhang C.M.zhang Fei zhang X.Y.zhao Y.zhao X.zhou C.S.zhang J.P.Yu L.chang K.K.zhang J.Huang Y.M.Chen X.B.Han Institute of High Energy Physics CASBeijing 100049China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 110875China Beijing Glass Research Institute Beijing 101100China Innovation Academy for Microsatellites of CAS Shanghai 201204China

Introduction The main physical objective of the GECAM satellite is to detect gamma-ray bursts,which is related to gravitational waves of double compact object *** GECAM satellite also detects and investigates various bursts of high-energy celestial *** and methods In this study,we designed,developed and calibrated the payload and launched it into orbit with GECAM *** payload consists of the gamma ray detector(GRD,for detecting 4 keV–4 MeV X/γray),the charged particle detector(CPD,for detecting 150 keV–5 MeV charged particle),and the electronic box(EBOX).The all-sky field coverage is achieved via two 229-degree large-area satellites positioned 180 degrees apart and are on opposite sides of the *** satellite is equipped with 25 GRDs and 8 CPDs;thus,the satellite can identify charged particle bursts in ***-ray detectors adopt lanthanum bromide crystal technology combined with silicon *** is the first time that this technology was used massively in space *** The GECAM satellite can quickly determine the direction of gamma-ray bursts(positioning)via indexing and fitting method,while the transmit variability,energy spectrum and direction of the gamma-ray bursts guide subsequent observations through the Beidou-3 RDSS in quasi-real *** will play an important role in the study of high energy celestial bursts.

关键词： GECAM Gamma-ray burst Lanthanum bromide crystal Silicon photomultiplier Beidou short message

The design and performance of GRD onboard the GECAM satellite

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Radiation Detection Technology and Methods 2022年第1期6卷 43-52页

作者： z.H.An X.L.Sun D.L.zhang S.Yang X.Q.Li X.Y.Wen K.Gong X.H.Liang X.J.Liu Y.Q.Liu Y.G.Li S.L.Xiong Y.B.Xu Fan zhang X.Y.zhao C.Cai z.chang G.Chen C.Chen Y.Y.Du P.Y.Feng M.Gao R.Gao D.Y.Guo J.J.He D.J.Hou C.Y.Li G.Li L.Li X.F.Li M.S.Li F.J.Lu H.Lu B.Meng W.X.Peng F.Shi H.Wang J.z.Wang Y.S.Wang H.z.Wang X.Wen S.Xiao Y.P.Xu J.W.Yang Q.B.Yi S.N.zhang C.Y.zhang C.M.zhang Fei zhang Y.zhao X.zhou CAS Institute of High Energy PhysicsBeijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China 3 Xiangtan UniversityXiangtan 411105China 4 Beijing Normal UniversityBeijing 110875China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 110875China

Background Each GECAM satellite payload contains 25 gamma-ray detectors(GRDs),which can detect gamma-rays and particles and can roughly localize the Gamma-Ray Bursts(GRBs).GRD was designed using lanthanum bromide(LaBr3)crystal as the sensitive material with the rear end coupled with silicon photomultiplier(SiPM)array for *** In aerospace engineering design of GRD,there are many key points to be *** this paper,we present the specific design scheme of GRD,the assembly and the performance test results of *** Based on Monte Carlo simulation and experimental test results,the specific schematic design and assembling process of GRD were *** being fully assembled,the GRDs were conducted performance tests by using radioactive source and also conducted random vibration *** and conclusion The test results show that all satellite-borne GRDs have energy resolution<16%at 59.5 keV,meeting requirements of satellite in scientific *** random vibration test shows that GRD can maintain in a stable performance,which meets the requirement of spatial application.

关键词： Lanthanum bromide scintillator SiPM array GECAM Gamma-ray detector Energy resolution

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑ze Wang Yu‑chang Wang Ting‑Ting Liu Quan‑Liang zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator