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TcPO2 changes are more pronounced than SpO2 changes during simulated altitude changes in a hy.obaric oxy.en chamber: a nonrandomiz.d controlled trial

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Emergency.and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Li y. Chen L. Fu z. Wang z. Sun S. Luan X. Ma D. Hu T. School of Nursing and Rehabilitation Shandong University Shandong Jinan China Department of Emergency.and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pulmonary.and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency.Management Center of State Grid Shandong Electric Power Company Shandong Jinan China School of Nursing and Rehabilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School of Mechanical Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hy.oxia is a significant risk factor of hy.ertension. However, no studies have used transcutaneous tissue partial pressure of oxy.en (TcPO2) and partial pressure of carbon dioxide (TcPCO2) monitors to measure the respective partial pressures in healthy.individuals. Oxy.en saturation (SpO2) is often used for traditional monitoring of vital signs. This study.investigated the changes in TcPO2 and SpO2 values during rapid changes in altitude. The trial was registered at *** (registration no. NCT06076057). Methods: Healthy.adult volunteers were instructed to sit vertically.in a hy.obaric oxy.en chamber, which ascended from 0 m to 2500 m at a uniform speed within 10 min. The Danish Radiometer TCM4 was used to measure TcPO2 and TcPCO2 with the ventral side of the upper arm as the measurement site. The Shenz.en Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO2, with values recorded once every.500 m. Results: Altogether, 49 healthy.volunteers were recruited between March 2023 and August 2023. With increasing altitude, TcPO2 and SpO2 decreased significantly.(P y.at 500 m (P y.at 1000 m (P y.significant changes in TcPO2 and SpO2 (P 500 m, statistical significance was identified between TcPO2 in both sexes (P y.changing low-pressure hy.oxic environments, TcPO2 changed more dramatically.than SpO2 © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Altitude change Low-pressure oxy.en chamber Transcutaneous oxy.en saturation Transcutaneous partial pressure of oxy.en

Decellularised extracellular matrix-based injectable hy.rogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-y. Wang W.-H. Xu P.-y. Kankala R.K. Chen A.-z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian Provincial Key.Laboratory.of Biochemical Technology.(Huaqiao University. Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its exceptional biocompatibility.and malleability.attributes. These advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity. the injectable hy.rogels can be administered in a liquid state and subsequently.formed into a gel state in vivo, stabilising the target area and serving in a variety.of way., such as support, repair, and drug release functions. Thus, dECM-based injectable hy.rogels have broad prospects for application in complex organ structures and various tissue injury.models. This review focuses on exploring research advances in dECM-based injectable hy.rogels, primarily.focusing on the applications and prospects of dECM hy.rogels in tissue engineering. Initially. the recent developments of the dECM-based injectable hy.rogels are explained, summarising the different preparation methods with the evaluation of injectable hy.rogel properties. Furthermore, some specific examples of the applicability.of dECM-based injectable hy.rogels are presented. Finally. we summarise the article with interesting prospects and challenges of dECM-based injectable hy.rogels, providing insights into the development of these composites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hy.rogels tissue engineering

Preliminary.Application of High-Frequency.Ultrasound in the Differentiation of Pemphigus and Bullous Pemphigoid: An Observational Study

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International Journal of Dermatology.and Venereology 2024年第3期7卷 155-159页

作者： Liu y.-A. Cao R. Da M.-H. Dong z.-B. Wang F. Department of Dermatology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Department of Dermatology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Department of Dermatology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultrasonography.is a diagnostic imaging technique used to visualiz. subcutaneous body.structures for identification of possible pathologies. In this study. we aimed to explore the clinical significance of high-frequency.ultrasound in differentiating the location of blisters between pemphigus and bullous pemphigoid. Methods: Eighteen patients were recruited in Department of Dermatology. z.ongda Hospital from 2020 to 2021 and divided into a pemphigus group (n = 8) and a bullous pemphigoid group (n = 10) according to the diagnostic criteria for each. Ultrasonographic images were collected using a 50-MHz.high-frequency.ultrasound sy.tem. The indexes of ultrasonic evaluation were the lay.r (epidermis or dermis), siz., shape, internal echo, and boundary.of the blister. Categorical variables are expressed as n (%), and differences were compared using Fisher's exact test. Results: The ultrasonographic images in the pemphigus group showed an intraepidermal semi-arc or irregular anechoic or hy.oechoic areas. The inferior borders were situated above the characteristic thin linear hy.erechoic bands of the epidermis. A linear hy.oechoic band was present at the dermoepidermal junction in some cases. In the ultrasonographic images of the bullous pemphigoid group, the linear hy.erechoic bands of the epidermis were continuous and intact. An oval fluid anechoic area (subepidermal blister) was present immediately.below the bands. The location of the blisters in the ultrasonographic images was significantly.different between the 2 groups (P y.ultrasound can be used as an auxiliary.means to differentiate the location of blisters between pemphigus and bullous pemphigoid. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, published by.Wolters Kluwer, Inc.

关键词： bullous pemphigoid high-frequency.ultrasound pemphigus

Membrane-coated nanoparticles as a biomimetic targeted delivery.sy.tem for tumour therapy

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Biomaterials Translational 2024年第1期5卷 33-45页

作者： Guo H. Guo M. xia z. Shao z. Department of Orthopaedic Beijing Jishuitan Hospital Capital Medical University Beijing China Department of Orthopaedic Beijing Jishuitan Hospital Fourth Medical College of Peking University Beijing China National Center for Orthopaedics Beijing China Department of Orthopaedics Affiliated Hospital of NCO School of Army Medical University Hebei Province Shijiazhuang China Centre for Nanohealth ILS2 Medical School Swansea University Swansea United Kingdom Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Province Wuhan China

Drug therapy.towards tumours often causes adverse effects because of their non-specific nature. Membrane-coated technology.and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery. By.camouflaging the nanoparticles with natural derived or artificially.modified cell membranes, the nano-pay.oads are bestowed with properties from cell membranes such as longer circulation, tumour or inflammation-targeting, immune stimulation, augmenting the performance of traditional therapeutics. In this review, we review the development of membrane coating technology. and summarise the technical details, phy.icochemical properties, and research status of membrane-coated nanoparticles from different sources in tumour treatment. Finally. we also look forward to the prospects and challenges of transforming membrane coating technology.from experiment into clinical use. Taken together, membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： biomimetic targeted delivery.sy.tem membrane-coated nanoparticles membrane-coated technology tumour therapy

On power series statistical convergence and new uniform integrability.of double sequences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 519-532页

作者： Sevda y.ld■z.Kamil Demirci Sinop University Department of MathematicsSinopTurkey

In the present paper,we mostly.focus on P_(p)^(2)-statistical *** will look into the uniform integrability.via the power series method and its characteriz.tions for double ***,the notions of P_(p)^(2)-statistically.Cauchy.sequence,P_(p)^(2)-statistical boundedness and core for double sequences will be described in addition to these findings.

关键词： power series methods statistical convergence uniform integrability double sequences

Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocataly.ic hy.rogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.Huang z.y.ng S.y.y.ng z.H.Dai y.J.Liu J.H.Liao G.y.z.ong z.J.Xie y.P.Fang S.S.z.ang Key.Laboratory.for Biobased Materials and Energy.of Ministry.of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Phy.ics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy.Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity.of semiconductors to visible and infrared light is a key.constraint on the utiliz.tion of light energy.in photocataly.ic *** photocataly.ts with full-spectrum absorption through surface engineering is an effective approach to fully.harnessing light energy.in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction cataly.t is obtained by.in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-aly.ic hy.rogen evolution capability.upon the heterogeneous *** unique 2D/2D structure effectively.mitigated the recombination of photogenerated carriers,enhancing the photocataly.ic performance of the ***,the composite cataly.t exhibits a significantly.higher surface temperature of 80.4℃under visible light irradiation at an intensity.of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite cataly.t with photothermal ef-fect demonstrates a remarkable hy.rogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study.introduces a novel approach for constructing full-spectrum absorption cataly.ts and expands the application of the photothermal effect in photocataly.ic hy.rogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocataly.t Hy.rogen evolution

Genoty.es and Phenoty.es of Uy.ur Children with Xeroderma Pigmentosum: A Case Study.in Xinjiang, China

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International Journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： Qiu y. Wang W.-J. Liang J.-Q. y.key. B. Wang P. z.ang J.-z. Kang X.-J. Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Laboratory.of Dermatology.Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by.genetic defects of DNA repair. This study.was performed to detect and analy.0} the genes of 2 Uy.ur patients with XP and their families and assess the patients' phenoty.es, which may.enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family.members. The patients' DNA was sequenced and detected by.Sanger sequencing, and gene mutations were screened. Results: The proband in family.1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary.to a facial rash. The proband had a homoz.gous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family. both parents were heteroz.gous, and no similar mutation detected in the sister. In family.2, the proband had scattered black brown spots and papules on the trunk and limbs. and his y.unger sister was also a patient. The proband and his y.unger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain sy.thesis prematurely. All the normal individuals in the two families were heteroz.gotes, and homoz.gous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uy.ur population. This study.expanded the mutation spectrum of XP and provided a basis for early.diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, published by.Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

Effect of Al_(2)O_(3)on the Mechanical Properties of(B_(4)C+Al_(2)O_(3))/Al Neutron Absorbing Materials

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： J.X.Cai B.M.Shi N.Li y.Liu z.G.z.ang y.N.z.n Q.z.Wang B.L.xiao z.y.Ma Shi‑Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key.Laboratory.of Nuclear Materials and Safety.Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Department of Materials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

B_(4)C/Al composites are widely.utiliz.d as neutron absorbing materials for the storage and transportation of spent nuclear *** order to improve the high-temperature mechanical properties of B_(4)C/Al composites,in-situ nano-Al_(2)O_(3)was introduced utiliz.ng oxide on Al powder *** this study.the Al_(2)O_(3)content was adjusted by.utiliz.ng spheroid Al powder with vary.ng diameters,thereby.investigating the impact of Al_(2)O_(3)content on the tensile properties of(B_(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain boundaries could hinder the recovery.of dislocations and lead to dislocation accumulation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain siz.,the high-temperature strength of the composites increased *** finest Al powder used in this investigation had a diameter of 1.4μm,whereas the resultant composite exhibited a maximum strength of 251 MPa at room temperature and 133 MPa at 350℃,surpassing that of traditional B_(4)C/Al composites.

关键词： Al matrix composites Neutron absorbing materials (B_(4)C+Al_(2)O_(3))/Al composites High-temperature strength

Rational design of AgGaS/z.S/z.S quantum dots with a near-unity.photoluminescence quantum y.eld via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu z.z.Fu y.y.Chen H.Q.Dai z.Hu W.L.z.ang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China y.wu Research Institute of Fudan University YiwuZhejiang 322000China z.ongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study.a two-step method was used to sy.thesiz. highly.luminescent AgGaS/z.S/z.S quantum dots(QDs).In the first step,an inner z.S shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer z.S shell,thereby.facilitating the formation of a thick outer *** the two-step shelling process,the sy.thesiz.d AgGaS/z.S/z.S QDs showed an excellent photoluminescence quantum y.eld(PLQy.of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQy.reported thus far for AgGaS ***,the effect of halogen ions in z. precursors on the shelling process was *** was proposed that the capacity.of halogen ions to coordinate with the QDs influenced the balance between z. cation diffusion and z.S shelling ***,the z.S shelling reaction was dominant when z.Cl_(2)was employ.d,while z. cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the z.S shelling and offers a clear map for the tailored sy.thesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloy.d core/shell interface