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多系统萎缩患者睡眠质量与焦虑、抑郁及精神病性症状相关性研究

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阿尔茨海默病及相关病杂志 2024年第1期7卷 25-29页

作者：李萌萌黄钰媛黄胜燕复旦大学附属华山医院神经内科上海200040

目的:探讨多系统萎缩(multiple system atrophy,MSA)患者睡眠质量与焦虑、抑郁及精神病性症状的相关性。方法:选取185例MSA患者,按照匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)评分分为MSA伴睡眠障碍组(MSA patients... 详细信息

目的:探讨多系统萎缩(multiple system atrophy,MSA)患者睡眠质量与焦虑、抑郁及精神病性症状的相关性。方法:选取185例MSA患者,按照匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)评分分为MSA伴睡眠障碍组(MSA patients with sleep disorders,MSA-SD组,PSQI>5分)和MSA不伴睡眠障碍组(MSA patients without sleep disorders,MSA-NSD组,PSQI≤5分)。采用简易智能状态检查量表(mini-mental state examination,MMSE)、额叶功能评定量表(frontal Assessment Battery, FAB)、汉密尔顿焦虑量表(hamilton Anxiety Scale,HAMA)、汉密尔顿抑郁量表(hamilton Depression Scale,HAMD)、神经精神量表(neuropsychiatric Inventory, NPI),轻度行为障碍清单(mild Behavioral Impairment Checklist, MBI-C)分别评估患者的整体认知功能、执行功能、焦虑和抑郁情绪以及精神行为状况,分析MSA患者睡眠质量与认知功能、焦虑和抑郁情绪及异常精神行为的相关性。结果:MSA患者睡眠障碍发生率为48.11%,MSA合并睡眠障碍者的整体认知功能、执行功能比不合并睡眠障碍者差,焦虑和抑郁情绪、精神行为症状比不合并睡眠障碍者严重。单因素分析结果显示,PSQI总评分与年龄、MMSE、FAB均无显著关联,而与NPI总评分、HAMA评分、HAMD、MBI评分呈正相关。多重线性回归分析结果表明,抑郁和异常精神行为是MSA相关睡眠障碍的独立危险因素。结论:睡眠质量下降、焦虑和抑郁、精神行为异常是MSA患者常见的非运动症状,患者的抑郁情绪及精神病性症状是影响其睡眠质量的重要因素。

关键词：多系统萎缩睡眠质量焦虑抑郁精神病性症状

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后皮质萎缩患者神经心理及影像学特征的研究

中华神经科杂志 2024年第7期57卷 738-745页

作者：董丽华李加梅陈科良雷小晶陈淑芬黄钰媛郁金泰复旦大学附属华山医院神经内科、国家神经疾病医学中心上海200040 山东省日照市人民医院神经内科日照276800 潍坊医学院临床医学院潍坊261000

目的探讨后皮质萎缩(PCA)患者的神经心理学特征以及影像学特征。方法收集2019年9月27日至2021年9月24日于复旦大学附属华山医院认知障碍病房诊断的PCA患者、路易体痴呆(DLB)患者、典型阿尔茨海默病(t-AD)患者及同期在华山医院及日照市... 详细信息

目的探讨后皮质萎缩(PCA)患者的神经心理学特征以及影像学特征。方法收集2019年9月27日至2021年9月24日于复旦大学附属华山医院认知障碍病房诊断的PCA患者、路易体痴呆(DLB)患者、典型阿尔茨海默病(t-AD)患者及同期在华山医院及日照市人民医院门诊及体检中心就诊的正常对照者,采集4组受试者的神经心理评估、头颅磁共振成像(MRI)和正电子发射体层摄影(PET)/CT资料,比较4组受试者神经心理学表现的差异,并总结PCA患者的影像学特征。结果最终共纳入11例PCA患者、17例DLB患者、31例t-AD患者及11名正常对照参与本研究。PCA组患者的认知功能[简易精神状态检查量表(MMSE)评分(13.52±1.81)分;蒙特利尔认知评估量表(MoCA)评分(7.06±1.72)分]较正常对照组显著受损[MMSE评分(27.85±1.75)分,t=-6.561,P<0.001;MoCA评分(23.60±1.59)分,t=-7.968,P<0.001],但与DLB组、t-AD组相比差异无统计学意义。PCA组患者的注意力、执行和语言功能损害[连线测试A评分(298.86±16.16)分,连线测试B评分(305.51±18.89)分,波士顿命名测试评分(8.67±1.53)分]较DLB组[(110.07±18.62)分,t=9.980,P<0.001;(230.34±23.59)分,t=2.865,P=0.024;(15.66±1.56)分,t=-2.682,P=0.013]和t-AD组[(148.91±12.77)分,t=7.071,P<0.001;(200.78±19.34)分,t=3.789,P=0.004;(15.15±1.05)分,t=-2.544,P=0.016]严重。PCA组的视空间及视知觉得分均显著低于正常对照组[1(0,1)分比3(3,3)分,Z=-4.023,P<0.001;0(0,1)分比35(34,36)分,Z=-3.704,P<0.001]。PCA患者的头颅MRI表现为顶枕叶萎缩,颞叶内侧萎缩不明显,可与t-AD相鉴别。PCA患者18氟-氟代脱氧葡萄糖PET/CT表现为双侧顶叶、枕叶、后扣带回葡萄糖代谢相对减低,18氟-florbetapir PET/CT表现为双侧额叶、顶叶、颞叶、扣带回的淀粉样蛋白沉积。结论PCA患者神经心理特征表现为视空间功能障碍,并在多个认知领域如记忆力、注意力和执行功能方面存在损害,其MRI典型特点为顶枕叶萎缩,PET/CT结果常符合AD的代谢改变。

关键词：阿尔茨海默病萎缩认知障碍神经心理测验正电子发射断层显像术磁共振成像

Novel pegiviruses infecting wild birds and rodents

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Virologica Sinica 2022年第2期37卷 208-214页

作者： Wentao Zhu Jing Yang Shan Lu yuyuan huang Dong Jin Ji Pua Liyun Liu Zhenjun Li Mang Shi Jianguo Xu State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508China Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing100730China School of Medicine Sun Yat-sen UniversityShenzhen510006China Research Institute of Public Heath Nankai UniversityTianjin300071China

Pegivirus(family Flaviviridae)is a genus of small enveloped RNA viruses that mainly causes blood infections in various mammals including ***,we carried out an extensive survey of pegiviruses from a wide range of wild animals mainly sampled in the Qinghai-Tibet Plateau of *** novel pegiviruses,namely Passer montanus pegivirus,Leucosticte brandti pegivirus and Montifringilla taczanowskii pegivirus,were identified from different wild birds,and one new rodent pegivirus,namely Phaiomys leucurus pegivirus,was identified from Blyth's ***,the pegiviruses of non-mammalian origin discovered in this study substantially broaden the host range of Pegivirus to avian ***-evolutionary analysis showed virus-host co-divergence over long evolutionary timescales,and indicated that pegiviruses largely followed a virus-host co-divergence ***,this work extends the biodiversity of the Pegivirus genus to those infecting wild birds and hence revises the host range and evolutionary history of genus Pegivirus.

关键词： Bird Rat Pegivirus Evolution Qinghai-Tibet Plateau

A novel bat coronavirus with a polybasic furin-like cleavage site

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Virologica Sinica 2023年第3期38卷 344-350页

作者： Wentao Zhu yuyuan huang Jian Gong Lingzhi Dong Xiaojie Yu Haiyun Chen Dandan Li Libo Zhou Jing Yang Shan Lu Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing100020China State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Hainan Provincial Center for Disease Control and Prevention Haikou570203China Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing100730China

The current pandemic of COVID-19 caused by a novel coronavirus,severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),threatens human health around the *** particular concern is that bats are recognized as one of the most potential natural hosts of SARS-CoV-2;however,coronavirus ecology in bats is still ***,we performed a degenerate primer screening and next-generation sequencing analysis of 112 bats,collected from Hainan Province,*** coronaviruses,namely bat betacoronavirus(Bat CoV)CD35,Bat CoV CD36 and bat alpha-coronavirus CD30 were *** CoV CD35 genome had 99.5%identity with Bat CoV CD36,both sharing the highest nucleotide identity with Bat Hp-betacoronavirus Zhejiang2013(71.4%),followed by SARS-CoV-2(54.0%).Phylogenetic analysis indicated that Bat CoV CD35 formed a distinct clade,and together with Bat Hp-betacoronavirus Zhejiang2013,was basal to the lineage of SARS-CoV-1 and ***,Bat CoV CD35 harbored a canonical furin-like S1/S2 cleavage site that resembles the corresponding sites of *** furin cleavage sites between CD35 and CD36 are *** addition,the receptor-binding domain of Bat CoV CD35 showed a highly similar structure to that of SARS-CoV-1 and SARS-CoV-2,especially in one binding *** conclusion,this study deepens our understanding of the diversity of coronaviruses and provides clues about the natural origin of the furin cleavage site of SARS-CoV-2.

关键词： Bat Coronavirus SARS-CoV-2 Betacoronavirus Furin Cleavage site

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深圳市坝光核坝路生态旅游植物资源分析

热带农业科学 2024年第4期44卷 89-95页

作者：杨志明蒋呈曦余华金黄玉源余欣繁李鑫泰仲恺农业工程学院园艺园林学院广东广州510225 深圳市大鹏新区建筑工务署广东深圳518120 深圳茂森生态科技有限公司广东深圳518120 广东大湾区区域生态环境变化与综合治理国家野外科学观测研究站/国家环境保护快速城市化地区生态环境科学观测研究站/广东省深圳生态环境监测中心站广东深圳518049

为了解深圳市大鹏新区核坝路植物资源状况,基于植物群落结构的调查数据,分析该区域植物资源和植物景观在发展生态旅游上的优势。结果表明,核坝路段共调查记录87科185属238种植物,占大鹏新区植物种类的17.35%,其中红树植物14种(乔木52种... 详细信息

为了解深圳市大鹏新区核坝路植物资源状况,基于植物群落结构的调查数据,分析该区域植物资源和植物景观在发展生态旅游上的优势。结果表明,核坝路段共调查记录87科185属238种植物,占大鹏新区植物种类的17.35%,其中红树植物14种(乔木52种,占所调查植物种类的21.85%;灌木128种,占53.78%;草本82种,占34.45%);植物群落的Simpson物种多样性指数为0.76~0.95,植物资源丰富,乔木层物种数与灌木层物种数呈显著正相关(p<0.01);记录有国家二级保护植物金毛狗、土沉香、润楠、樟,濒危物种银叶树以及二级保护动物香港瘰螈。自然植物群落丰富的生物资源构成了核坝路周边多样、丰富的自然景观,为坝光核坝路沿线发展生态旅游奠定了丰厚的基础。根据调查状况提出开展生态旅游可持续发展对策,在遵循自然规律的前提下,针对目前存在的问题提出保护当地植被和生态系统的改进建议,为实现经济、生态效益双赢的目标策略提供科学依据和理论参考。

关键词：生态旅游植物多样性植物资源生态景观

阿尔茨海默病靶向Aβ疾病修饰治疗:曙光初现

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中华神经科杂志 2023年第9期56卷 959-964页

作者：黄钰媛郁金泰复旦大学附属华山医院神经内科、国家神经疾病医学中心上海200040

阿尔茨海默病(AD)是老年期最常见的神经系统退行性疾病,目前临床对其发病机制认识仍较为局限、治疗药物研发滞后。β-淀粉样蛋白(Aβ)级联瀑布假说仍然是目前AD发病机制的主流学说,也是AD疾病修饰药物研发的重要理论基础。近年来,靶向A... 详细信息

阿尔茨海默病(AD)是老年期最常见的神经系统退行性疾病,目前临床对其发病机制认识仍较为局限、治疗药物研发滞后。β-淀粉样蛋白(Aβ)级联瀑布假说仍然是目前AD发病机制的主流学说,也是AD疾病修饰药物研发的重要理论基础。近年来,靶向Aβ的免疫治疗药物相继通过美国食品药品监督管理局批准上市或突破性疗法认定,为AD的疾病修饰治疗带来了曙光。文中评述了近年来靶向Aβ疾病修饰治疗临床试验的研究进展,分析总结了以往靶向Aβ疾病修饰治疗临床试验失败的原因。虽然目前靶向Aβ疾病修饰疗法不是十分成熟,但其俨然已成为极具前景的AD药物研发策略。

关键词：阿尔茨海默病 β淀粉样蛋白临床试验疾病修饰治疗

Studies on Tracheary Element of Several Native Cycad Species in Australia and Two American Plants

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American Journal of Plant Sciences 2022年第1期13卷 147-174页

作者： yuyuan huang Harvey Ottley Yolande Yep Sharon Wilson David Griffiths Nikeeta O’sullivan Yanhua Han Jane Hempel College of Life Sciences Zhongkai University of Agriculture and Engineering Guangzhou China Agricultural College Guangxi University Nanning China George Brown Darwin Botanic Gardens Darwin Australia Palm and Cycad Society of the Northern Territory Darwin Australia School of Environment Charles Darwin University Darwin Australia Research Institute for Environment & Livelihoods Charles Darwin University Darwin Australia

Cycas angulata, Cycas armstrongii and Cycas conferta that are native species of Australia were collected in Darwin city of tropical region, Zamia erosa and angiosperm Guaiacum officinale of Zygophyllaceae which are introduced collected in the Darwin Botanic Gardens, and were carried out light microscope and electron microscope observed research to tracheary element and parenchyma tissue cells of leaflet, rachis and stem. The results showed that there are more vessel elements in their xylems;the length of vessel element of Cycadaceae with Zamiaceae are not obvious difference, the length of vessel element of angiosperm Guaiacum officinale is shorter, but their diameter is smaller, we thought that the characteristics which the length of vessel element is longer and the diameter is bigger are more evolutionary, because thus vessel, their number which interconnected points of possessed perforations’ end walls of vessel element is fewer, and the passageway space is larger so that the conduction speed and quantity are faster and more in unit length range and unit time. These vessels are annular vessels, spiral vessels, scalariform vessels, reticular vessels, pitted vessels and scalariform-pitted vessels, etc. In the transverse section, the vessel elements of Cycadaceae and Zamiaceae are circular, polygonous, more similar to vessel characteristics of leaf and stem of some angiosperms;however, the number of circular vessel of Guaiacum officinale is more, about occupy 35%, others are polygonous. The diameter of vessel is that annular vessel, spiral vessel is least, scalariform vessel or scalariform-reticular vessel is medium, reticular vessel and pitted vessel are the biggest, the characteristic is same as angiosperm. In Cycas conferta, etc. plants often can see several large perforations in the

关键词： Cycad Evolution Vessel Native Species Structural Characteristics

中国盘腹蚁属二新种记述(膜翅目:蚁科:切叶蚁亚科)

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Entomotaxonomia 2023年第4期45卷 302-310页

作者：黄屿源钟迎吴川市第一中学广东吴川524500 深圳市建文外国语学校广东深圳518116

本文记述中国盘腹蚁属2新种。双色盘腹蚁新种*** ***.与雕刻盘腹蚁*** Wheeler,1921接近,但是新种前胸背板两侧具纵皱纹,中胸侧板和后胸侧板大部光滑,并胸腹节背面光滑,并胸腹节刺长约为其基部宽的1.2倍,身体二色;横纹盘腹蚁新种*** ***... 详细信息

本文记述中国盘腹蚁属2新种。双色盘腹蚁新种*** ***.与雕刻盘腹蚁*** Wheeler,1921接近,但是新种前胸背板两侧具纵皱纹,中胸侧板和后胸侧板大部光滑,并胸腹节背面光滑,并胸腹节刺长约为其基部宽的1.2倍,身体二色;横纹盘腹蚁新种*** ***.与小刺盘腹蚁*** Zhou,2001接近,但是新种头后部1/3和胸部具横皱纹,柄节具密集亚倾斜立毛和密集倾斜绒毛被,并胸腹节刺很长且弯向后方,身体黑色。

关键词：蚁总科蚂蚁分类

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明清时期岭南小说中的麻风病书写

玉溪师范学院学报 2022年第5期38卷 30-36页

作者：黄钰媛云南民族大学文学与传媒学院云南昆明650500

明清时期岭南地区进入小说家视野,在以岭南为背景、描写岭南习俗、反映明清岭南思想文化的岭南小说中,麻风病题材涌现。明清岭南小说中的麻风病有其独特的病因和病状,兼之“过癞”、毒蛇疗方等治疗习俗,体现出异乡人对岭南的奇异想象和... 详细信息

明清时期岭南地区进入小说家视野,在以岭南为背景、描写岭南习俗、反映明清岭南思想文化的岭南小说中,麻风病题材涌现。明清岭南小说中的麻风病有其独特的病因和病状,兼之“过癞”、毒蛇疗方等治疗习俗,体现出异乡人对岭南的奇异想象和对美好爱情向往的文学审美意蕴。同时,明清岭南小说中的麻风病书写还具有宣扬向善、劝贞奖节的现实意义。

关键词：明清岭南小说麻风病文学审美教化意义