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An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood

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Microsystems & Nanoengineering 2024年第3期10卷 293-303页

作者： Zhehan Ma Jianping Xia Neil Upreti Emeraghi David Joseph Rufo yuyang gu Kaichun Yang Shujie Yang Xiangchen Xu Jean Kwun Eileen Chambers Tony Jun Huang Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Pediatrics Duke UniversityDurhamNCUSA Duke Transplant Center Department of SurgeryDuke University School of MedicineDurhamNCUSA

Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research,medical diagnostics,and therapeutic *** protocols for plasma isolation require multiple centrifugation steps or multiunit microfluidic processing to sequentially remove large red blood cells(RBCs)and white blood cells(WBCs),followed by the removal of small ***,we present an acoustofluidic platform capable of efficiently removing RBCs,WBCs,and platelets from whole blood in a single *** leveraging differences in the acoustic impedances of fluids,our device generates significantly greater forces on suspended particles than conventional microfluidic approaches,enabling the removal of both large blood cells and smaller platelets in a single *** a result,undiluted human whole blood can be processed by our device to remove both blood cells and platelets(>90%)at low voltages(25 Vpp).The ability to successfully remove blood cells and platelets from plasma without altering the properties of the proteins and antibodies present creates numerous potential applications for our platform in biomedical research,as well as plasma-based diagnostics and ***,the microfluidic nature of our device offers advantages such as portability,cost efficiency,and the ability to process small-volume samples.

关键词： remove separation removing

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang yuyang gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

Mastering lanthanide energy states for next-gen photonic innovation

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中国科学:化学英文版 2023年第9期66卷 2460-2479页

作者： yuyang gu Chang gu Yuxiang Zhang Zhen Mu Xiaogang Liu Department of Chemistry National University of SingaporeSingapore 117543Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and ResearchSingapore 138634Singapore

Lanthanide-based photonic materials have been extensively explored for use in laser crystals,lighting,fiber-optic communications,bioimaging,diagnostics,and many other *** recent years,they have enabled numerous breakthroughs in areas such as single-particle spectroscopy,super-resolution imaging,micro-lasing,lifetime multiplexing,and ***,we summarize recent advances in lanthanide photonic materials from an energy state perspective,focusing on the interplay between energy state manipulation and advanced photonic *** then discuss the challenges and prospects for controlling energy states at the single-particle *** wish to highlight the importance of quantifying and understanding the energy states of lanthanides for future innovations.

关键词： lanthanide nanomaterials super-resolution lifetime lasing

Recent Development of Integrated Systems of Microsupercapacitors

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Energy Material Advances 2022年第1期2022卷 132-146页

作者： Chang Gao yuyang gu Yang Zhao Liangti Qu Key Laboratory of Cluster Science Ministry of Education of ChinaBeijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

Development of wearable and portable electronics promotes the miniaturization of energy storage ***(MSC)featuring in fast charging and discharging rates,long cycle life,and high-power density stands out from miniaturized energy storage devices,particularly for its small size and adjustable structure which is easily processed to integrate with other on-chip *** this review,we systematically analyzed the MSC integration with other electronics from the perspective of structures and *** the beginning,we briefly introduced typical MSCs with unique ***,applications and integrations of MSCs with energy-consuming or energy-generating electronics were ***,compatible materials and designed structure of the all-in-one device were also ***,challenges and future development of MSC-integrated systems were put forward.

关键词： consuming generating electronics

Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation

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Microsystems & Nanoengineering 2022年第2期8卷 149-159页

作者： Zeyu Wang Joseph Rich Nanjing Hao yuyang gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side ***,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading ***,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome *** synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is *** final product consists of drug-loaded silica nanocarriers that are encased within an exosomal *** drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the ***,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of *** exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell *** utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications.

关键词： exosome loading simultaneous

Luminescence interference-free lifetime nanothermometry pinpoints in vivo temperature

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Science China Chemistry 2021年第6期64卷 974-984页

作者： Mengya Kong yuyang gu Yingjie Chai Jiaming Ke Yulai Liu Xincheng Xu Zhanxian Li Wei Feng Fuyou Li Department of Chemistry Institutes of Biomedical SciencesState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Luminescence nanothermometry makes non-invasive and real-time temperature readings possible in living ***,the spectral fluctuation in tissues and fluids,as well as the interaction between fluorophores and environment hinders accuracy of the ***,we report a luminescence lifetime-based nanothermometry which specifically addresses this problem.A temporal based calibration(lifetime sensing)in the NIR range,an endogenous thermal response as well as a polymer encapsulation evading environmental factors,altogether help to pinpoint temperature in *** to the highly condensed NdYb ions in a well-protected tiny core-shell nanocrystal(overall 11 nm),a temperature sensitivity about 2.07%K^(-1)(with 5%Yb^(3+)doped nanoparticles)and an accuracy of 0.27 K(with 25%Yb^(3+)doped nanoparticles)in biological fluids are ***,combining thermally activated energy transfer nanothermometer with anti-interference lifetime thermometry would provide a more accurate temperature measurement for biological and preclinical studies.

关键词： luminescence nanothermometry NIR lifetime imaging lanthanide-doped nanocrystals thermal sensing

NaYF4:Nd^(3+),Yb^(3+)纳米粒子用于生物体系温度测量

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中国稀土学报 2021年第1期39卷 181-187页

作者：徐心成顾昱飏孔梦涯冯玮李富友复旦大学化学系上海200438

采用溶剂热法制备了Nd^(3+)敏化Yb^(3+)的近红外纳米探针NaYF_(4):Nd^(3+),Yb^(3+),观察到材料在980与865 nm两处发光峰的强度比值随温度的升高而降低。通过对探针中Nd^(3+)/Yb^(3+)比例的调节,综合考虑材料的发光强度与温敏效率,确定了... 详细信息

采用溶剂热法制备了Nd^(3+)敏化Yb^(3+)的近红外纳米探针NaYF_(4):Nd^(3+),Yb^(3+),观察到材料在980与865 nm两处发光峰的强度比值随温度的升高而降低。通过对探针中Nd^(3+)/Yb^(3+)比例的调节,综合考虑材料的发光强度与温敏效率,确定了NaYF4:2%Nd, 20%Yb为所测条件下适用于测量生物体系温度的较优组成。材料转水相前后温敏效率均随着Yb^(3+)离子掺杂增加而提高,环己烷中最高可达1.9%·K^(-1),水相中最高为0.46%·K^(-1)。通过盖肉片模拟及激光加热活体成像实验,研究了温敏材料在生物环境中发光随温度的变化情况,以及组织遮挡前后荧光比值未发生明显变化的结果,初步验证了使用该探针测量生物体系温度的可行性。

关键词：稀土纳米晶温度探针活体成像

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调频超声激励造影剂微气泡的次谐波响应研究

中国介入影像与治疗学 2016年第8期13卷 505-509页

作者：吕道文章东固宇旸张拥军欧阳君蚌埠医学院公共课程部安徽蚌埠233000 南京大学声学研究所近代声学教育部重点实验室江苏南京210093

目的研究利用调频超声激励微气泡群产生的次谐波进行血压测量的有效性。方法选用参数相同的调频波和正弦波,通过模拟计算和实验研究比较两种激励下次谐波的幅度与激励声压之间的关系,分析次谐波幅度对过压变化的敏感度;同时探讨调频... 详细信息

目的研究利用调频超声激励微气泡群产生的次谐波进行血压测量的有效性。方法选用参数相同的调频波和正弦波,通过模拟计算和实验研究比较两种激励下次谐波的幅度与激励声压之间的关系,分析次谐波幅度对过压变化的敏感度;同时探讨调频波的带宽和循环数对次谐波幅度所产生的影响。结果调频波可以提高次谐波的幅度5~10dB,过压测量的敏感度提高3.4dB。结论适当地增大调频信号的带宽或循环数,可以提高次谐波对过压的敏感程度。

关键词：超声检查造影剂血压

实验室模拟村镇小型分散式垃圾焚烧炉渣中氯存在特性及影响机制

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环境科学学报 2024年第2期44卷 255-260页

作者：沈东升石宏杰龙於洋古佛全浙江工商大学环境科学与工程学院浙江省固体废物处理与资源化重点实验室有色金属废弃物资源化浙江省工程研究中心杭州310012

垃圾焚烧炉渣中的氯是影响其资源化利用的关键因素,然而,目前对焚烧过程炉渣中氯存在特性及影响机制尚无明确认识.本研究聚焦垃圾焚烧过程,通过实验室小型焚烧炉模拟村镇可燃垃圾分散式焚烧,研究了不同焚烧工况下,焚烧炉渣样品形态及粒... 详细信息

垃圾焚烧炉渣中的氯是影响其资源化利用的关键因素,然而,目前对焚烧过程炉渣中氯存在特性及影响机制尚无明确认识.本研究聚焦垃圾焚烧过程,通过实验室小型焚烧炉模拟村镇可燃垃圾分散式焚烧,研究了不同焚烧工况下,焚烧炉渣样品形态及粒度分布、氯迁移行为以及氯存在特性.结果表明,提高入炉垃圾中塑料、木竹及焚烧温度有助于炉渣中氯向非水溶性氯的转变,而纸类、织物的添加对炉渣中水溶性氯和非水溶性氯占比的影响不明显.本研究可为炉渣中氯污染的源头调控奠定理论基础.

关键词：垃圾焚烧炉渣氯非水溶性氯