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J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery

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Chinese Chemical Letters 2024年第1期35卷 271-274页

作者： Yun Qu Wenjuan Jin Yichen Wan Zhichao pei yuxin pei College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China

Drug loading capacity is very important in the construction of targeted drug delivery systems(TDDSs)for the improvement of drug delivery ***,the drug-loading capacity of most nanomaterials is non-idealistic,and developing the high drug-loading TDDSs is still a critical *** this work,an ultrahigh loading system(denoted as HMPB_(2))was prepared via J-aggregation of an aza-boron dipyrromethene derivative(Bod)by using hollow MnO_(2)modified with glucosamine pillar[5]arene as a carrier,which was demonstrated to have typical J-aggregate absorption of Bod,specific cancer cells targeting ability,negligible dark cytotoxicity,and potent *** work provides a successful example to construct an ultrahigh drug-loading system via J-aggregation for targeted delivery.

关键词： J-aggregate Ultrahigh drug-loading Aza-BODIPY Hollow MnO_(2) Phototherapy Pillar[n]arene

Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang yuxin pei Zhichao pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

Regioselective Acylation of 2＇- or 3＇-Hydroxyl Group in Salicin： Hemisynthesis of Acylated Salicins

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Chemical Research in Chinese Universities 2014年第5期30卷 774-777页

作者： SHAO Chen pei yuxin BORG-KARLSON Anna-Karin pei Zhichao College of Science Northwest A&F University Yangling 712100 P. R. China KTH Royal Institute of Technology Department of Chemistry Stockholm S-10044 Sweden

Salicin-based phenolic glycosides（PGs） are important defensive substances against herbivore feeding and have good bioactivities. In this work, a novel approach for the synthesis of salicin-based PGs has been developed, by which PGs of 2＇-O-acetylsaliein（5a）, 3＇-O-acetylsalicin（gb） and 3＇-O-benzoylsalicin（Sd） were hemisynthesized. The effects of acylation reagent, solvent and temperature on the regioselective acylation of 2＇- or 3＇-hydroxyl groups of salicin mediated by dibutyltin oxide were investigated. The optimal conditions under which the best regioselectivity reached for 5a-5d were discovered, respectively. Moreover, a tentative tin-oxygen coordination mechanism was put forward to explain the different regioselectivities shown under different conditions.

关键词： Regioselective acylation Salicin Phenolic glycoside Tin-oxygen coordination Hemisynthesis

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“拼贴式婚礼”:城市青年的婚礼实践

当代青年研究 2024年第3期 1-12页

作者：裴谕新方颖李凤娟中山大学社会学与人类学学院中山大学

文章通过观察、深度访谈与网络民族志等质性研究方法,对广州市18对青年初婚夫妻的婚礼实践展开研究。研究发现,面对营造新家庭的经济压力和浪漫想象,城市青年成为积极的生活项目实践主体。在婚礼策划和实践中,他们兼具经济理性与造梦能... 详细信息

文章通过观察、深度访谈与网络民族志等质性研究方法,对广州市18对青年初婚夫妻的婚礼实践展开研究。研究发现,面对营造新家庭的经济压力和浪漫想象,城市青年成为积极的生活项目实践主体。在婚礼策划和实践中,他们兼具经济理性与造梦能力,以自我体验和自我表达为核心,利用婚礼表达城市认同,重视婚礼社会网络中的情感投资作用。同时,他们保持着经济理性的头脑,将数字时代的媒介文化资源当作重要的拼贴素材来源。城市青年充满主体性的改造让婚礼变得简约化、个性化、精致化,推动了“高价婚礼”模式向“拼贴式婚礼”模式的转变。

关键词：城市青年婚礼变迁拼贴主义拼贴式婚礼

GaR视角下海洋产业结构升级、科技创新与海洋经济高质量发展

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海洋开发与管理 2024年第3期41卷 143-152页

作者：任仙玲孙丽萍裴雨欣中国海洋大学经济学院青岛266100

海洋产业结构升级是实现海洋经济高质量发展的关键,其能否促进海洋经济增长是海洋产业结构高质量转型的着力点。文章从在险增长视角,以我国沿海11个省(自治区、直辖市)为样本,通过构建面板分位数回归模型,研究海洋产业结构升级对GOP分... 详细信息

海洋产业结构升级是实现海洋经济高质量发展的关键,其能否促进海洋经济增长是海洋产业结构高质量转型的着力点。文章从在险增长视角,以我国沿海11个省(自治区、直辖市)为样本,通过构建面板分位数回归模型,研究海洋产业结构升级对GOP分布的影响,着重分析海洋经济下行风险和上升潜力的变化趋势。实证结果显示:海洋产业结构升级与短、中、长期海洋经济增长正相关,显著促进海洋经济高质量发展,且不同经济增长水平下,该促进作用具有异质性。而科技创新能够正向调节海洋产业结构升级与海洋经济增长的关系,助力海洋产业结构升级,降低中、短期海洋经济下行风险,并提高中、长期海洋经济上升潜力,发挥出海洋产业升级对海洋GaR的正向促进作用。因此,有关部门应完善海洋科技创新体系,加快推进海洋产业结构升级,对海洋经济高质量发展具有重要的意义。

关键词：海洋产业结构升级海洋经济增长海洋在险增长科技创新

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pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group

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Chinese Chemical Letters 2022年第10期33卷 4563-4566页

作者： Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao yuxin pei Zhichao pei Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China

Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug ***,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced ***,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery ***,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic *** amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug *** experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor *** experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer *** present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.

关键词： Pillararene Sodium xanthate Host-guest interaction pH-and H_(2)O_(2)-dual responsive Controllable drug delivery

Facile fabrication of branched-chain carbohydrate chips for studying carbohydrate-protein interactions by QCM biosensor

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Chinese Chemical Letters 2018年第1期29卷 65-68页

作者： Yuchao Lu Siyu Song Chenxi Hou Shuang Pang Xueming Li Xiaowen Wu Chen Shao yuxin pei Zhichao pei Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry and Pharmacy Northwest A & F University Attana

A novel approach for fabricating branched-chain （BC） carbohydrate chips to study carbohydrate-protein interactions using Quartz Crystal Microbalance （QCM） biosensor was developed. This approach utilizes functional alkynyl-branch molecule modified chip surfaces, which through the terminal alkynyl group for covalent linking of unprotected azide-carbohydrates. The unprotected azide-carbohydrates were syhthesized in one-step using 2-azido-l,B-dimethylqmidazolinium as catalyst, avoiding complex chemical modifications. Additionally, the branch surface modified with the carbohydrates not only supplies more specific binding site but also reveals significant cluster effect. To exemplify the sugar cluster effect on BC carbohydrate chips, BC Galactose and Mannose chips prepared in this work were used to determine carbohydrate-lectin interactions using QCM biosensor. The results clearly showed that BC chip significantly improves the detection sensitivity compared with the straight-chain （SC） chip. More importantly, the BC galactose chip sensitivity was enhanced 40% compared with the SC galactose chip.

关键词： MultivalentBrach carbohydrate chipO CMCarbohydrate-protein interactions

Investigation of the degradation and stability of acrylamide-based polymers in acid solution: Functional monomer modified polyacrylamide

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Petroleum 2016年第4期2卷 399-407页

作者： yuxin pei Liqiang Zhao Guangyan Du Nianyin Li Kun Xu Hanjie Yang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500People's Republic of China Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province Southwest Petroleum UniversityChengdu 610500People's Republic of China Shu'nan Gas Field Petrochina Southwest Oil&Gas Field CompanyLuzhou 646000People's Republic of China

Acrylamide copolymers are often used as acidizing diverting and thickening agents for their advantageous thickening,flocculation,adhesion and resistance reduction *** results indicate that the acid concentration greatly affects the properties of acrylamide polymers,which varies from results reported by other *** the theoretical and field application value of the present study,four comparable acrylamide-based polymers were synthesized,and their macro-and micro-changes as well as the related changes in viscosity and molecular weight were studied in high-concentration hydrochloric acid.A proposed mechanism of acrylamide copolymer stability and degradation is provided,and further suggestions are made for the modification of acrylamide copolymers.

关键词： Acrylamide-based polymer Acidizing Degradation Stability Thickening

A harmonic-wave bio-thermal method for continuous monitoring skin thermal conductivity and capillary perfusion rate

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Nano Research 2024年第5期17卷 4420-4427页

作者： yuxin Ouyang Jie Lin Jiajing pei Rui Sui Di Liu Yanhui Feng Lin Qiu School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China

The revelation of thermal energy exchange mechanism of human body is challenging yet worthwhile,because it can clearly explain the changes in human symptoms and health ***,the heat transfer of the skin is significant because the skin is the foremost organ for the energy exchange between the human body and the *** order to diagnose the physiological conditions of human skin without causing any damage,it is necessary to use a non-invasive measurement technique by means of a conformal flexible *** harmonic method can minimize the thermal-induced injury to the skin due to its low heat generating properties.A novel type of computational theory assessing skin thermal conductivity,blood perfusion rate of capillaries in the dermis,and superficial subcutaneous tissues was formed by combining the multi-medium thermal diffusion model and the bio-thermal model(Pennes equation).The skins of the hand back of six healthy subjects were *** was found that the results revealed no consistent changes in thermal conductivity were observed across genders and *** measured blood perfusion rates were within the range of human capillary *** was found that female subjects had a higher perfusion rate range(0.0058-0.0061 s^(-1))than male subjects(0.0032-0.0049 s^(-1)),which is consistent with invasive medical studies about the gender difference in blood flow rates and stimulated effects in relaxation situations.

关键词： thermal conductivity blood perfusion rate harmonic method Pennes equation