pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group

作     者：Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao Yuxin Pei Zhichao Pei Ziyan Shen;Ning Ma;Feng Wang;Jiaming Ren;Chenxi Hou;Shuang Chao;Yuxin Pei;Zhichao Pei

作者机构：Shaanxi Key Laboratory of Natural Products&Chemical BiologyCollege of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第10期

页      面：4563-4566页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.21877088.22171230) China Postdoctoral Science Foundation(No.2016M602861) 

主　　题：Pillararene Sodium xanthate Host-guest interaction pH-and H_(2)O_(2)-dual responsive Controllable drug delivery 

摘      要：Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug ***,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced ***,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery ***,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic *** amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug *** experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor *** experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer *** present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.