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Chinese Medical Journal 2024年第5期137卷 616-618页

作者： Eda Kaya yusuf yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochum 44892Germany Institute of Gastroenterology Marmara Universityİstanbul 34840Turkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRize 53100Turkey

To the Editor:The nomenclature for steatotic liver disease has been a topic of debate since *** conventional expression,non-alcoholic fatty liver disease(NAFLD),was introduced in 1980 to describe the occurrence of steatosis in the absence of other hepatic ***,in recent years,there has been a growing movement to phase out and retire this *** 2020,Eslam et al^([1])proposed a new definition—metabolic(dysfunction)associated fatty liver disease(MAFLD)—redefining the disease to include hepatic steatosis along with other factors such as diabetes,obesity,overweight,or meeting the criteria for metabolic dysfunction.

关键词： NAFLD liver MAF

Metabolic-associated Fatty Liver Disease(MAFLD):A Multi-systemic Disease Beyond the Liver

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 329-338页

作者： Eda Kaya yusuf yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochumGermany Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Liver Research Unit Institute of GastroenterologyMarmara UniversityIstanbulTurkey

Nonalcoholic fatty liver disease(NAFLD)is a multisystemic clinical condition that presents with a wide spectrum of extrahepatic manifestations,such as obesity,type 2 diabetes mellitus,metabolic syndrome,cardiovascular diseases,chronic kidney disease,extrahepatic malignancies,cogni-tive disorders,and polycystic ovarian *** NAFLD patients,the most common mortality etiology is cardiovascular disorders,followed by extrahepatic malignancies,diabetes mellitus,and liver-related ***,the severity of extrahepatic diseases is parallel to the severity of *** clinical practice,awareness of the associations of concomitant diseases is of major importance for initiating prompt and timely screening and multidisciplinary management of the disease *** 2020,a consensus from 22 countries redefined the disease as metabolic(dysfunction)-associated fatty liver disease(MAFLD),which resulted in the redefinition of the corre-sponding *** the patients diagnosed with MAFLD and NAFLD mostly overlap,the MAFLD and NAFLD populations are not *** this review,we compared the associations of key extrahepatic diseases between NAFLD and MAFLD.

关键词： Metabolic diseases Fatty liver Liver fibrosis Diabetes mellitus,type 2 Cardiometabolic risk factors

Thermodynamic Performance Analysis of a Low-Cost,Recycled and Energy-Efficient Solar Air Heater with Waste Beverage Cans:An Experimental Research

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Journal of Thermal Science 2023年第4期32卷 1657-1670页

作者： Pinar Mert CUCE Abhishek SAXENA Erdem CUCE yusuf Nadir yilmaz Saboor SHAIK GUO Shaopeng Department of Architecture Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Pinar Mert Cuce Low/Zero Carbon Energy Technologies Laboratory Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Mechanical Engineering Department School of EngineeringDev Bhoomi Uttarakhand UniversityDehradunIndia Solar Energy Research Lab PandharpurMaharashtraIndia Department of Mechanical Engineering Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey School of Mechanical Engineering Vellore Institute of Technology VelloreVelloreTamil Nadu632014India School of Energy and Environment Inner Mongolia University of Science and TechnologyBaotou014010China

Solar air heaters are at the centre of interest owing to their widespread use for various *** the study,thermal performance analysis of a solar air heater that can be easily produced from daily waste materials is *** system has a low-cost structure with both waste material use and a simple *** proposed system is tested under different climatic conditions,and the energetic and the exergetic performance figures are obtained for the first time in *** is observed from the experimental tests that the results are stable and coherent as well as in good accordance with the similar attempts in literature with some cost reductions and performance *** performance analyses indicate that the maximum energy efficiency of the system is about 21%,whereas the exergy efficiency is 1.8%.The energetic and exergetic outputs of the system are also determined to be 27 W and 3 W,respectively,which is promising.

关键词： solar air heaters absorber design waste beverage cans energy and exergy efficiency

Biomarkers for noninvasive biochemical diagnosis of nonalcoholic steatohepatitis:Tools or decorations?

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World Journal of Gastroenterology 2009年第34期15卷 4346-4347页

作者： yusuf yilmaz Enver Dolar Department of Gastroenterology Marmara UniversitySchool of Medicine Department of Gastroenterology Uludag University Medical School

In light of the growing epidemics of nonalcoholic fatty liver disease(NAFLD),identification and validation of the novel biochemical surrogate markers for nonalcoholic steatohepatitis(NASH)are paramount to reduce the necessity for liver *** availability of such markers has tremendous potential to radically alter the management strategies of NAFLD patients and to monitor the disease *** current biomarkers do not entirely fulfill the many requirements for the identification of patients with NASH,they should not discourage our quest,but remind us that we need to cognize the challenges ahead.

关键词：生物标志物酒精性肝炎生化脂肪装饰品侵入性工具

Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2009年第35期15卷 4387-4391页

作者： yusuf yilmaz Alla Eldeen Kedrah Osman Ozdogan Department of Gastroenterology Marmara UniversitySchool of Medicine

Nonalcoholic fatty liver disease(NAFLD)remains a leading cause of chronic liver *** the context of NAFLD,the presence of nonalcoholic steatohepatitis (NASH)portends an adverse prognosis with greater risk of liver fibrosis and *** liver biopsy is the keystone of patient management in NAFLD,it is also increasingly clear that such evaluation has its *** availability of biochemical markers of NAFLD and NASH has tremendous potential to radically alter management strategies for these conditions,as well as to monitor disease *** article provides an overview of biomarker discovery and selection in the setting of NAFLD and highlights future directions in the field.

关键词：脂肪肝病生物标志物酒精性代谢综合征细胞角蛋白肝纤维化 NASH 生化指标

Real-life experience of ranibizumab therapy for neovascular age-related macular degeneration from Turkey

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 267-273页

作者： Zafer Cebeci yusuf Cem yilmaz Nur Kir Department of Ophthalmology Istanbul Faculty of Medicine Istanbul University

AIM： To report the real-life experience and clinical results of intravitreal ranibizumab injections to neovascular agerelated macular degeneration（nAMD） in a single institution in ***： A total of 101 eyes of 89 patients with nAMD treated with intravitreal ranibizumab injection, followed up for at least 24 mo between 2009 and June 2014, which were evaluated retrospectively. A pro re nata（PRN） treatment protocol was performed after the patients had received three, monthly loading injections. Best corrected visual acuity（BCVA） and central macular thickness measurements were evaluated at baseline and 3, 6, 12, 18, and 24 mo. Number of injections and visits were also ***： Of the 89 patients, 34（38.2%） were male and 55（61.8%） were female and the mean age was 74.0±9.5（52-91）y. The mean follow-up period was 24.82±4.4（24-29）mo. Mean number of visits was 8.4±1.12（7-12） in the first year and 6.6±1.33（4-12） in the second year. The mean number of injections was 5.8±1.6（3-10） and 4.2±2.2（0-9） in the first and second year, respectively. The mean BCVA was 59±15.8 letters at baseline by the Early Treatment Diabetic Retinopathy Study（ETDRS） chart. The mean BCVA at 3, 12, and 24 mo was 70.3±15.9, 67.9±14.3 and 67.3±16.9 letters, respectively. Improvement in visual acuity for each of the visits from baseline was found to be statistically significant（P〈0.01）. Visual acuity in 9 eyes at month 3, 7 eyes at month 12, and 13 eyes at month 24 did not change. The mean central macular thickness（CMT） was 437.99±164.78 μm at baseline. The mean CMT was 348.05±138.47 μm, 349.27±139.79 μm, and 344.13±146.30 μm at months 3, 12, and 24, respectively. The decrease in CMT for each of the visits from baseline was found to be statistically significant（P〈0.01）.CONCLUSION： Anatomical and functional achievement are obtained in our study, but the mean number of injections and visits are found to be lower than the findings reported in randomized controlled clinical trials in the litera

Reinforcing effects of polypropylene on energy absorption and fracturing of cement-based tailings backfill under impact loading

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 650-664页

作者： Jiajian Li Shuai Cao Erol yilmaz School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of High-Efficient Mining and Safety of Metal Mines of Ministry of Education University of Science and Technology BeijingBeijing 100083China Department of Civil Engineering Geotechnical DivisionRecep Tayyip Erdogan UniversityFenerRize TR53100Turkey

Polypropylene(PP)fiber-reinforced cement-based tailings backfill(FRCTB)is a green compound material with superior crack resistance and has good prospects for application in underground ***,FRCTB exhibits susceptibility to dynamic events,such as impact ground pressure and blast *** paper investigates the energy and crack distribution behavior of FRCTB under dynamic impact,considering the height/diameter(H/D)*** Hopkinson pressure bar,industrial computed tomography scan,and scanning electron microscopy(SEM)experiments were carried out on six types of *** outcomes confirmed fiber aggregation at the bottom of *** H/D was less than 0.8,the proportion of PP fibers distributed along theθangle direction of80°-90°*** the total energy,all samples presented similar energy absorption,reflectance,and ***,a rise in H/D may cause a rise in the energy absorption rate of FRCTB during the peak phase.A positive correlation existed between the average strain rate and absorbed energy per unit *** increase in H/D resulted in a decreased crack volume fraction of *** the H/D was greater than or equal to 0.7,the maximum crack volume fraction of FRCTB was observed close to the incidence *** cracks were present only in the FRCTB with an H/D ratio of *** with H/D ratios of 0.5 and 0.6 showed similar distributions of weakly and heavily damaged *** fibers can limit the emergence and expansion of cracks by influencing their *** observations revealed considerable differences in the bonding strengths between fibers and the *** that adhered particularly well to the substrate were attracted together with the hydration products adhering to *** results show that FRCTB is promising as a sustainable and green backfill for determining the design properties of mining with backfill.

关键词： cement-based tailings fiber-reinforced backfills fracture energy absorption impact loading

The use of fluoroscopy for detecting hypertensive lung edema due to prosthetic valve dysfunction: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 313-315页

作者： yusuf Kantar Necmi Baykan Emergency Department Akçaabat Haçkalibaba State HospitalTrabzon 61060Turkiye Emergency Department Kayseri City HospitalKayseri 38080Turkiye

Heart valve diseases affect more than one hundred million people around the world,which are a serious cause of illness and mortality.[1]Among the valve diseases,mitral valve insufficiency ranks second in the list of valve diseases requiring surgical repair in Europe.[2]Prosthetic valve replacement is the standard treatment in cases where repair is not sufficient for valve diseases.[3]Mechanical and bioprosthetic valves can be preferred for replacement,mechanical valves are more durable and require lifelong use of *** disadvantage of bioprosthetic valves is early degeneration,and infective reoperation is required due to the formation of endocarditis.[4-5]The risk of thromboembolism,lifetime anticoagulant use and complications related to anticoagulation remain disadvantages of valve surgery.[3]The most important complication requiring urgent intervention is valve dysfunction due to *** usually occurs due to inappropriate use of the anticoagulants.[6]Surgical treatment is used for severe obstructions,such as thrombi larger than 10 *** therapy can be applied in small thrombi and in cases where surgical intervention is risky.

关键词： valve disadvantage lifetime

Metabologenomics and network pharmacology to understand the molecular mechanism of cancer research

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World Journal of Clinical Cases 2024年第3期12卷 474-478页

作者： yusuf Tutar Department of Basic Pharmaceutical Sciences Faculty of PharmacyDivision of BiochemistryUniversity of Health SciencesIstanbul 34668Turkey Health Sciences Faculty Recep Tayyip Erdogan UniversityRize 53350Turkey Molecular Oncology Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey Molecular Medicine Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey

In this editorial I comment on the article“Network pharmacological and molecular docking study of the effect of Liu-Wei-Bu-Qi capsule on lung cancer”published in the recent issue of the World Journal of Clinical Cases 2023 November 6;11(31):*** all living forms are able to manufacture particular chemicals-metabolites that enable them to differentiate themselves from one another and to overcome the unique obstacles they encounter in their natural *** methods for chemical warfare,communication,nutrition acquisition,and stress prevention are made possible by these specialized *** is a popular technique for collecting direct mea-surements of metabolic activity from many biological ***,con-fusing metabolite identification is a typical issue,and biochemical interpretation is frequently constrained by imprecise and erroneous genome-based estimates of enzyme *** annotation and gene integration uses a biochemical reaction network to obtain a metabolite-gene association so called *** network uses an approach that emphasizes metabolite-gene consensus via biochemical *** metabolomics and genomics data is ***,computer networking proposes that using meta-bolomics data may improve annotations in sequenced species and provide testable hypotheses for specific biochemical *** The genome and metabolites of biological organisms are not fully characterized with current ***,increasing high-throughput metabolomics and genomics data provide promising generation of paired data sets to understand the molecular mechanism of biochemical processes as well as determining targets for pharmaceutical drug *** network infrastructures to integrate omics analysis can provide molecular mechanism of biochemical ***,clinical data may be integrated to gene expression–metabolite expression by system genetics appr

关键词： Network pharmacology Metabologenomics Genome Pathways Cancer

A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1039-1094页

作者： Elif Varol Altay Osman Altay yusuf Ovik Department of Software Engineering Manisa Celal Bayar UniversityManisa45400Turkey

Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to *** design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary ***,there are established optimization techniques that have shown effectiveness in addressing these types of *** research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design *** algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering ***,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged *** research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions.

关键词： Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems