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Semi-Markovian Model of Control of Restorable System with Latent Failures

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Applied Mathematics 2011年第3期2卷 383-388页

作者： yuriy E. Obzherin Aleksey I. Peschansky Yelena G. Boyko 不详

Mathematical model of control of restorable system with latent failures has been built. Failures are assumed to be detected after control execution only. Stationary characteristics of system operation reliability and efficiency have been defined. The problem of control execution periodicity optimization has been solved. The model of control has been built by means of apparatus of semi-Markovian processes with a discrete-contin- uous field of states.

关键词： Control Latent Failure Semi-Markovian Process System Stationary Characteristics

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

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Nano Research 2017年第2期10卷 652-671页

作者： Svitlana Prylutska Rostyslav Panchuk Grzegorz Golunski Larysa Skivka yuriy Prylutskyy Vasyl Hurmach Nadya Skorohyd Agnieszka Borowik Anna Woziwodzka Jacek Piosik Olena Kyzyma Vasil Garamus Leonid Bulavin Maxim Evstigneev Anatoly Buchelnikov Rostyslav Stoika Walter Berger Uwe Ritter Peter Scharff Taras Shevchenko National University of Kyiv 64 Volodymyrska Str. 01601 Kyiv Ukraine Institute of Cell Biology NAS of Ukraine 14-16 Drahomanov 5tr. 79005 Lviv Ukraine Laboratory of Biophysics Intercollegiate Faculty ofBiotechnology UG-MUG Abrahama 58 80-307 Gdansk Poland Joint Institute for Nuclear Research 6 Joliot-Curie Str. 141980 Dubna Moscow reg. Russia Helmholtz-Zentrum Geesthacht: Centre for Materials and Coastal Research 1 Max-Planck Str. 21502 Geesthacht Germany Belgorod State University 85 Pobedy Str. 308015 Belgorod Russia Institute of Cancer Research and Comprehensive Cancer Center Medical University Vienna 1090 8A Borschkegasse Vienna Austria Institute of Chemistry and Biotechnology Technical University ofllmenau 25 Weimarer Str. 98693 Ilmenau Germany

We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin （Cis） with C60 fullerene （C60＋Cis complex） and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. The highest toxicity of the complex was observed in HL-60/adr and HL-60/vinc chemotherapy- resistant human leukemia cell sublines （resistant to Adriamycin and Vinculin, respectively）. We discovered that the action of the C60＋Cis complex is associated with overcoming the drug resistance of the tumor cell lines through observing an increased number of apoptotic cells in the Annexin V/PI assay. Moreover, in vivo assays with Lewis lung carcinoma （LLC） C57BL/6J male mice showed that the C60＋Cis complex increases tumor growth inhibition, when compared to Cis or C60 fullerenes alone. Simultaneously, we conducted a molecular docking study and performed an Ames test. Molecular docking specifies the capability of a C60 fullerene to form van der Waals interactions with potential binding sites on P-glycoprotein （P-gp）, multidrug resistance protein 1 （MRP-1）, and multidrug resistance protein 2 （MRP-2） molecules. The observed phenomenon revealed a possible mechanism to bypass tumor cell drug resistance by the C60＋Cis complex. Additionally, the results of the Ames test show that the formation of such a complex diminishes the Cis mutagenic activity and may reduce the probability of secondary neoplasm formation. In conclusion, the C60＋Cis complex effectively induced tumor cell death in vitro and inhibited tumor growth in vivo, overcoming drug resistance likely by the potential of the C60 fullerene to interact with P-gp, MRP-1, and MRP-2 molecules. Thus, the C60＋Cis complex might be a potential novel chemotherapy modification.

关键词： molecular docking,small-angle X-ray scattering,apoptosis,mutagenic activity lung carcinoma (LLC),cytotoxicity

Effects of differently polarized microwave radiation on the microscopic structure of the nuclei in human fibroblasts

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 801-805页

作者： yuriy G.SHCKORBATOV Vladimir N.PASIUGA Elena I.GONCHARUK Tatiana Ph.PETRENKO Valentin A.GRABINA Nicolay N.KOLCHIGIN Dmitry D.IVANCHENKO Victor N.BYKOV Oleksandr M.DUMIN Kharkiv National University Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine

To investigate the influence of microwave radiation on the human fibroblast nuclei,the effects of three variants of electromagnetic wave polarization,linear and left-handed and right-handed elliptically polarized,were *** conditions were:frequency(f) 36.65 GHz,power density(P) at the surface of exposed object 1,10,30,and 100 μW/cm2,exposure time 10 *** fibroblasts growing in a monolayer on a cover slide were exposed to microwave electromagnetic *** layer of medium that covered cells during microwave exposure was about 1 mm *** were stained immediately after irradiation by 2%(w/v) orcein solution in 45%(w/v) acetic *** were made at room temperature(25 °C),and control cell samples were processed in the same *** assessed heterochromatin granule quantity(HGQ) at 600× *** irradiation at the intensity of 1 μW/cm2 produced no effect,and irradiation at the intensities of 10 and 100 μW/cm2 induced an increase in *** intense irradiation induced more chromatin *** right-handed elliptically polarized radiation revealed more biological activity than the left-handed polarized one.

关键词： Human cells Chromatin Heterochromatin Electromagnetic field Elliptical polarization

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乌克兰供热系统的主要技术和经济指标

农业与技术 2013年第1期33卷 208-210页

作者： KHARYTONOV yuriy 乌克兰动力工程应用研究中心国立马卡罗夫船舶大学乌克兰尼古拉耶夫市54025

目前发展乌克兰电力综合设施的最热门话题是现代化建设和改造市政供热系统。电力综合设施的各个环节现代化建设是一件急迫的事情(热源设施,供热网络,和热用户),在满足功效、稳定性、环境影响和热损失等方面这些环节产生一些矛盾问题。... 详细信息

目前发展乌克兰电力综合设施的最热门话题是现代化建设和改造市政供热系统。电力综合设施的各个环节现代化建设是一件急迫的事情(热源设施,供热网络,和热用户),在满足功效、稳定性、环境影响和热损失等方面这些环节产生一些矛盾问题。通过分析主要技术和经济指标,明确在乌克兰启动改造供热系统项目的必要性。

关键词：乌克兰供热系统主要技术经济指标

Synthesis of Iron Nanoparticles by Thermal Decomposition of Diironnonacarbonyl in Ionic Liquid and Their Potential Use as Nanotracers for Mixer Studies in Liquids Feeds

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Advances in Chemical Engineering and Science 2020年第3期10卷 201-209页

作者： Irina Irgibaeva Nikolay Barashkov Tamara Sakhno Artur Mantel Svetlana Mendigaliyeva Irina Barashkova yuriy Sakhno Eurasian National University Nur-Sultan Kazakhstan Micro-Tracers Inc. San Francisco CA USA Poltava University of Economics and Trade Poltava Ukraine Institute of Chemical Physics Russian Academy of Sciences Moscow Russia University of Delaware Newark DE USA

Iron nanoparticles with dynamic light scattering median diameter around 10 nm have been prepared by thermal decomposition under a nitrogen atmosphere from diironnonacarbonyl (DINC) dissolved in n-butyl-3-methylimidazolium tetrafluoroborate (BMIMBF). The effect of temperature changes in the range of 170°C - 200°C and changes in concentration of DINC in BMIMBF in the range of 0.1% - 0.9% on the properties of obtained iron nanoparticles has been investigated. The stable dispersion of iron nanoparticle in ethanol has been prepared after separation of nanoparticles from ionic liquid by centrifugation following by their re-dispersion in ethanol. The possibility of quantitative analysis of iron content in ethanol dispersion by deposition of ferromagnetic nanoparticles on the surface of plastic-protected neodymium magnet, dissolution of iron in hydrochloric acid and addition of ammonium thiocyanate solution following by spectrophotometric determination of iron cations at wavelength of 490 nm has been investigated. The feasibility of using the same approach in case of addition of ethanol dispersion of iron nanoparticles to the liquid animal feeds for evaluation of efficiency of their mixing has been discussed.

关键词： Ionic Liquids Magnetic Nanoparticles Surfactant Mixing Performance Ani-mal Feed

The influences of meteorological factors on the health and functional state of human

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Health 2013年第12期5卷 2068-2076页

作者： Reza Sharafi Volodymyr B. Bogdanov Dmytro S. Gorlov yuriy P. Gorgo Kyiv Polytechnic Institute Kiev Ukraine Taras Shevchenko National University of Kyiv Kiev Ukraine University of Liege Liege Belgium

The influence of fluctuations of atmospheric pressure on the functional state of the humans was studied during spring, autumn and winter seasons. Sensory-motor reaction time and selfreported wellbeing, activity and mood were used for evaluation of functional state. The inter-individual variations of those parameters were compared to meteorological parameters using rank order correlation and general linear model. It was found that atmospheric pressure fluctuations have a stronger negative effect with periods of 120-1200 s and 20-120 s on psychological self-assessment and with periods of 10-20 s and 5-10 s on sensory-motor reaction time than the fluctuations with other periods.

关键词： Weather Functional State Reaction Time Task Wellbeing Activity Mood

Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury

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Open Journal of Molecular and Integrative Physiology 2013年第1期3卷 36-41页

作者： yuriy Slyvka Felicia V. Nowak Tracey M. Hayes Sharon R. Inman Department of Biomedical Sciences Ohio University Athens USA Program in Molecular and Cellular Biology Ohio University Athens USA

Objectives: The process of transplantation is associated with exposure to both long and short cold and warm ischemic times that result in ischemia/reperfusion injury. Oxidative stress contributes to tissue fibrosis, renal dysfunction, and/or rejection. Treatments that scavenge oxygen free radicals and have antioxidant properties can ameliorate the damaging results in renal grafts following ischemia/reperfusion injury. The present study tests the hypothesis that an antioxidant-fortified diet given to rats before and after renal ischemia/reperfusion injury will reduce the kidney damage that results and improve renal function. Endothelial and inducible nitric oxide synthases may change with tissue injury, including ischemia/ reperfusion. Materials and Methods: Male Wistar rats were subjected to ischemia/reperfusion injury at 7 or 19 weeks of age with or without dietary antioxidant supplementation. One week later, glomerular filtration rate, mean arterial pressure and urinary nitric oxide were measured, and renal endothelial and inducible nitric oxide synthases examined. Results: The glomerular filtration rate was elevated more than two-fold above the normal range? at 8 weeks in animals on the regular diet exposed to ischemia/reperfu- sion, while in the 8 week antioxidant-fortified diet group the glomerular filtration rate was normal. Also, in 8 week rats, levels of endothelial nitric oxide synthase protein in cortex were higher on the regular than on the antioxidant-fortified diet. Conclusion: Early after ischemia/reperfusion injury renal endothelial nitric oxide synthase levels rise, possibly contributing to vascular dilation and hyperperfusion, and an antioxidant-fortified diet can ameliorate these changes in the younger age group.

关键词： Antioxidants Ischemia/Reperfusion Kidney Nitric Oxide Synthase

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基于散射计波浪参数反演模型的改进算法实验

遥感技术与应用 2016年第5期31卷 907-911页

作者：过杰何宜军张彪 Vladimir Yurjevich Karaev M.A.Panfilova yuriy Titchenko 中国科学院烟台海岸带研究所山东省海岸带环境过程重点实验室山东烟台264003 南京信息工程大学海洋科学学院江苏南京210044 Department of Hydrophysics Institute of Applied PhysicsRussian Academy of Science Nizhny NovgorodRussia46603950

一种新的利用散射计(ERS1/2)数据反演有效波高和平均周期的模式被提出。通过俄罗斯学者利用浮标数据建立完全成长风浪条件下有效波高与风速之间的关系,与匹配浮标观测的有效波高数据对比,区分完全成长风浪、成长风浪和涌浪3种海况下的... 详细信息

一种新的利用散射计(ERS1/2)数据反演有效波高和平均周期的模式被提出。通过俄罗斯学者利用浮标数据建立完全成长风浪条件下有效波高与风速之间的关系,与匹配浮标观测的有效波高数据对比,区分完全成长风浪、成长风浪和涌浪3种海况下的匹配数据;利用BP神经网络建立模式反演3种海况下的有效波高,均方根误差分别为0.53、0.57和0.86m,反演平均周期均方根误差分别为0.69、1.04和1.36s。这种反演方法在完全成长风浪海况下最好,依次是成长风浪和涌浪海况。该研究为散射计数据反演波浪参数提供了依据,使大面积反演波浪参数成为可能。

关键词：有效波高平均周期 BP神经网络散射计(ERS1/2)数据浮标数据

Accurate, First-Principle Study of Electronic and Related Properties of the Ground State of Li<sub>2</sub>Se

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Journal of Modern Physics 2019年第8期10卷 909-921页

作者： Abdoulaye Goita Feng Gao Ifeanyi H. Nwigboji yuriy Malozovsky Lashounda Franklin Diola Bagayoko Department of Physics Southern University and A&M College Baton Rouge LA USA

We present results from ab-initio, self-consistent calculations of electronic and related properties for the ground state of cubic lithium selenide (Li2Se). We employed a local density approximation (LDA) potential and performed computations following the Bagayoko, Zhao, and Williams (BZW) method, as enhanced by Ekuma and Franklin (BZW-EF). This method verifiably leads to the ground state of materials without employing over-complete basis sets. We present the calculated electronic energies, total and partial densities of states, effective masses, and the bulk modulus. The present calculated band structures show clearly that cubic Li2Se has a direct fundamental energy band gap of 4.065 eV at the Γpoint for the room temperature experimental lattice constant of 6.017 Å. This result is different from findings of previous density functional theory (DFT) calculations that uniformly reported an indirect band gap, from Γto X, for Li2Se. We predicted a direct band gap of 4.363 eV, at the computationally determined equilibrium lattice constant of 5.882 Å, and a bulk modulus of 35.4 GPa. For the first time known to us, we report calculated electron and hole effective masses for Li2Se. The experimental confirmation of the large, direct gap we found will point to a potential importance of this material for ultraviolet technologies and applications. Due to a lack of experimental results, most of our calculated ones in this paper are predictions for Li2Se.

关键词： Density Functional Theory BZW-EF Method Electronic Properties Bulk Modulus