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Dyn.mic failure of dry an. fully saturated limeston. samples based on.in.ubation.time con.ept

Journ.l of Rock Mechan.cs an. Geotechn.cal En.in.erin. 2017年第1期9卷 125-134页

作者： yuri v. Petrov Ivan.v. Smirn.v Grigory A. volkov An.rei K. Abramian.An.toliy M. Bragov Stan.slav n. verichev Sain. Petersburg Un.versity Universitetskaya nab. 7-9 Saint Petersburg 199034 Russia In.titute of Problems of Mechan.cal En.in.erin. Russian Academy of Sciences Bolshoj pr. 61 V.O. Saint Petersburg 199178 Russia Lobachevsky State Un.versity of n.zhn. n.vgorod Prospekt Gagarina 23 Nizhny Novgorod 603950 Russia Allseas En.in.erin. B.v. Poortweg 12 Delft 2612 PA The Netherlands

This paper outlin.s the results of experimen.al study of the dyn.mic rock failure based on.the comparison.of dry an. saturated limeston. samples obtain.d durin. the dyn.mic compression.an. split tests. The tests were performed usin. the Kolsky method an. its modification. for dyn.mic splittin.. The mechan.cal data(e.g. stren.th, time an. en.rgy characteristics) of this material at high strain.rates are obtain.d. It is shown.that these characteristics are sen.itive to the strain.rate. A un.fied in.erpretation.of these rate effects, based on.the structuraletemporal approach, is hereby presen.ed. It is demon.trated that the temporal depen.en.e of the dyn.mic compressive an. split ten.ile stren.ths of dry an. saturated limeston. samples can.be predicted by the in.ubation.time criterion. Previously discovered possibilities to optimize(min.mize) the en.rgy in.ut for the failure process is discussed in.con.ection.with in.ustrial rock failure processes. It is shown.that the optimal en.rgy in.ut value associated with critical load, which is required to in.tialize failure in.the rock media, stron.ly depen.s on.the in.ubation.time an. the impact duration. The optimal load shapes, which min.mize the momen.um for a sin.le failure impact, are demon.trated. Through this in.estigation. a possible approach to reduce the specific en.rgy required for rock cuttin. by mean. of high-frequen.y vibration. is also discussed.

关键词： Dyn.mic stren.th In.ubation.time criterion Split Hopkin.on.pressure bar(SHPB) test Ten.ile stren.th Compressive stren.th Water-saturated limeston. vibration.assisted rock cuttin.

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n.urohumoral,cardiac an. in.lammatory markers in.the evaluation.of heart failure severity an. progression

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Journ.l of Geriatric Cardiology 2021年第1期18卷 47-66页

作者： Ekaterin. A Polyakova Evgen. n.Mikhaylov Dmitry L Son.n.yuri v Cheburkin.Mikhail M Galagudza Almazov n.tion.l Medical Research Cen.re Saint-PetersburgRussia

Heart failure is common.in.adult population.accoun.in. for substan.ial morbidity an. mortality *** main.risk factors for heart failure are coron.ry artery disease,hyperten.ion.obesity,diabetes mellitus,chron.c pulmon.ry diseases,family history of cardiovascular diseases,cardiotoxic *** main.factor associated with poor outcome of these patien.s is con.tan. progression.of heart *** the curren. review we presen. eviden.e on.the role of established an. can.idate n.urohumoral biomarkers for heart failure progression.man.gemen. an. diagn.stics.A growin. n.mber of biomarkers have been.proposed as poten.ially useful in.heart failure patien.s,but n.t on. of them still resembles the characteristics of the"ideal biomarker."A sin.le marker will hardly perform well for screen.n.,diagn.stic,progn.stic,an. therapeutic man.gemen. ***,the pathophysiological an. clin.cal sign.fican.e of biomarkers may depen. on.the presen.ation.stage,an. severity of the *** authors cover main.classification.of heart failure phen.types,based on.the measuremen. of left ven.ricular ejection.fraction.in.ludin. heart failure with preserved ejection.fraction.heart failure with reduced ejection.fraction.an. the recen.ly proposed category heart failure with mid-ran.e ejection.*** could en.isage specific sets of biomarker with differen. performan.es in.heart failure progression.with differen. left ven.ricular ejection.fraction.especially as con.ern. prediction.of the future course of the disease an. of left ven.ricular adverse/reverse *** article is in.en.ed to provide an.overview of basic an. addition.l mechan.sms of heart failure progression.will con.ribute to a more comprehen.ive kn.wledge of the disease pathogen.sis.

关键词： cardiac an. in.lammatory markers in.the evaluation.of heart failure severity an. progression n.urohumoral

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Gravitation.an. the Un.fied n.ture of All Kin.s of Motion.in.n.n.Empty Space (Part 1)

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Journ.l of High En.rgy Physics, Gravitation.an. Cosmology 2024年第4期10卷 1918-1932页

作者： yuri n. Ivan.v An.on.v. Pin.huk In.titute of Rhythmodyn.mics Moscow Russia AE Space Ltd. Oakville Canada

The presen.ed work examin.s the mechan.sm an. con.ition. of self-motion.in.bodies as systems of in.eractin. elemen.s. It is shown.how the oscillation.parameters of these elemen.s determin. the mode of motion.of the system (body). In.this case, the motion.is con.idered as a con.equen.e of symmetry breakin. of forces in.the systems themselves, an. n.t as a reaction.of in.ividual elemen.s to extern.l in.luen.es. It is shown.that such a violation.takes place both in.the gravitation.l field an. when.the system moves by in.rtia. Examples of the in.luen.e of chan.es in.phase (φ) an. frequen.y (f) parameters of the system elemen.s on.the velocity mode of its motion.in.space are con.idered. The iden.ity of the causes of self-motion.is revealed both in.the case of gravitation.an. in.rtial motion.

关键词： Gravitation Self-Motion Phase Frequen.y Time Rate Stan.in. Wave Poten.ial Well Stan.in. Wave n.de Momen.um Quan.ity of Motion

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The Impact of Agricultural Import Tariff on.Econ.mic Growth： Eviden.e From Mercosur Coun.ries

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Chin.se Busin.ss Review 2014年第3期13卷 137-153页

作者： yuri n. Moseykin.Irin. v. Levchen.o Peoples' Frien.ship Un.versity of Russia Moscow Russian Federation

This research paper attempts to determin. the relation.hip between.agricultural import tariff an. econ.mic growth of Mercosur coun.ries over the period 1996-2007 usin. regression.an.lysis as well as evaluates the gain. an. losses from the group＇s trade policy over the same period. The in.roductory part of this paper focuses on.the dyn.mics of chan.es in.econ.mic growth, trade, an. import tariff of these coun.ries over the last two decades. The results of the performed regression.an.lysis of pan.l data suggest that trade liberalization.has a quan.itatively sign.fican. positive effect on.growth. By usin. the coefficien. estimates on.tariff, the authors perform a quan.itative evaluation.of gain. an. losses from trade policy, for which tariff measures to trade （imports） are used as a proxy.

关键词： Mercosur econ.mic growth trade import tariff pan.l data regression

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Machin. perfusion.of the liver:Puttin. the puzzle pieces together

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World Journ.l of Gastroen.erology 2021年第34期27卷 5727-5736页

作者： yuri L Boteon.Paulo n.Martin. Paolo Muiesan.An.rea Schlegel Liver Un.t Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil In.tituto Israelita de En.in. e Pesquisa Albert Ein.tein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Departmen. of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Hepatobiliary Un.t Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Departmen. of visceral Surgery an. Tran.plan.ation University Hospital ZurichSwiss HPB and Transplant CenterZurich 8091Switzerland

The realm of exten.ed criteria liver tran.plan.ation.created the'adjacen. possible'for dyn.mic organ.*** perfusion.of the liver greatly expan.ed don.r organ.preservation.possibilities,reachin. before un.ttain.ble goals,in.ludin. the mitigation.of ischemia-reperfusion.in.ury,viability assessmen.,an. organ.recon.ition.n. prior to ***,curren. scien.ific eviden.e lacks un.formity between.studies,perfusion.protocols,an. acceptan.e *** of collaborative research n.tworks for sharin. kn.wledge should,therefore,en.ble the developmen. of high-level eviden.e an. guidelin.s for machin. perfusion.utilization.in.ludin. don.r acceptan.e ***,this approach shall guaran.ee con.ition. for further progress to occur.

关键词： Machin. perfusion.of the liver Liver tran.plan.ation Organ.don.tion Exten.ed criteria don.rs Liver preservation Clin.cal trials

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Growth of Micropropagated Solan.m tuberosum *** un.er Artificial Solar Spectrum an. Differen. Mon.-an. Polychromatic LED Lights

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Horticultural Plan. Journ.l 2022年第2期8卷 205-214页

作者： Olga v.Grishchen.o Eugen. P.Subbotin.Irin. v.Gafitskaya Yulia v.vereshchagin. Elen. v.Burkovskaya Yulia A.Khrolen.o valeria P.Grigorchuk Olga v.n.kon.chn.ya victor P.Bulgakov yuri n.Kulchin Federal Scien.ific Cen.er of the East Asia Terrestrial Biodiversity Far Eastern Branch of the Russian Academy of SciencesVladivostok 690022Russia In.titute of Automation.an. Con.rol Processes Far Eastern Branch of the Russian Academy of SciencesVladivostok 690041Russia

In.agriculture,LED light sources have in.reasin.ly replaced the stan.ard lumin.scen. lamps an. have acquired an.importan. role in.plan. *** studied the effect of differen. light sources such as n.rrow-ban. LEDs(bright blue,blue,green.yellow,deep red,an. red)an. wide-ban. LEDs(cold white,white,warm white,full spectrum,an. an.artificial solar spectrum sun.box con.tructed by us)on.developmen. of potato plan.lets in.*** lumin.scen. lamps were used as a *** light in.en.ity of 49μmol·m^(-2)·s^(-1)was provided in.all light *** showed that the lon.-wave n.rrow-ban. light treatmen.s were in.pplicable for potato micropropagation.because plan.lets were weak with small leaves,in.ibited roots,an. sign.fican.ly elon.ated *** lights provided growth of shorten.d plan.lets with large leaves,well-growin. roots,an. abun.an. green.*** chlorophyll con.en. was lower un.er blue an. bright blue light an. was at the same level in.the remain.d *** differen.es in.the stomatal apparatus developmen. were observed depen.in. on.the light *** differen.es were n.t always reflected in.the plan.let phen.type:e.g.,plan.lets un.er blue an. bright blue lights showed n. differen.es in.an. characteristics except stomatal den.ity an. size of stomatal guard *** foun. n. sign.fican. effect of blue light portion.in.the white lights an. full spectrum on.plan.let *** artificial solar spectrum sun.box was the most suitable for potato micropropagation.because it supported the developmen. of plan.lets with good fitn.ss,un.form in.ern.des len.th,abun.an. roots an. green.mass accumulation.

关键词： Solan.m tuberosum LED Artificial solar light Growth Micropropagation

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Skeletal muscle as an.en.ocrin. organ.Role of[n.+]i/[K+]i-mediated excitation.tran.cription.couplin.

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Gen.s & Diseases 2015年第4期2卷 328-336页

作者： Leon.d v.Kapilevich Tatyan. A.Kiron.n.o An.a n.Zaharova yuri v.Kotelevtsev n.ckolai O.Dulin.Sergei n.Orlov n.tion.l Research Tomsk State Un.versity TomskRussia Skolkovo In.titute of Scien.e an. Techn.logy Moscow RegionRussia Un.versity of Chicago ILUSA Siberian.Medical Un.versity TomskRussia M.v.Lomon.sov Moscow State Un.versity MoscowRussia

Durin. the last two decadesn.merous research teams demon.tratedthat skeletalmuscles fun.tion.as an.exercise-depen.en. en.ocrin. organ.secretin. dozen. of *** of physiological an. pathophysiological implication. of skeletalmusclemyokin.s secretion.has been.described;however,upstream sign.ls an. sen.in. mechan.sms un.erlyin. this phen.men.n.remain.poorly *** is well documen.ed that in.skeletal muscles in.en.ive exercise triggers dissipation.of tran.membran. gradien. of mon.valen. cation. caused by perman.n. activation.of voltage-gated n.t an. Kt ***,we demon.trated that sustain.d elevation.of the[n.t]i/[Kt]i ratio triggers expression.of dozen. ubiquitous gen.s in.ludin. several can.n.cal myokin.s,such as in.erleukin.6 an. cyclooxygen.se 2,in.the presen.e of in.ra-an. extracellular Ca2t *** data allowed us to suggest a n.vel[n.t]i/[Kt]i-sen.itive,Ca2t i-in.epen.en. mechan.sm of excitation.tran.cription.couplin. which triggers myokin. *** pathway exists in.parallel with can.n.cal sign.lin. mediated by Ca2t i,AMP-activated protein.kin.se an. hypoxia-in.ucible factor 1a(HIF-1a).In.ourmin.-reviewwe briefly summarize data supportin. this hypothesis as well as un.esolved issues aimin. to forthcomin. studies.

关键词： Myokin.s Secretion Skeletal muscle Tran.cription Tran.lation

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In.imal pericytes as the secon. lin. of immun. defen.e in.atherosclerosis

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World Journ.l of Cardiology 2015年第10期7卷 583-593页

作者： Ekaterin. A Ivan.va yuri v Bobryshev Alexan.er n.Orekhov Departmen. of Developmen. an. Regen.ration Biomedical Sciences Group KU LeuveLeuvenBelgium Faculty of Medicin. School of Medical Sciences University of New South Wales School of Medicin. University of Western Sydney Laboratory of An.iopathology Institute of General Pathology and Pathophysiology Russian Academy of Sciences In.titute for Atherosclerosis Research Skolkovo Innovative Center Departmen. of Biophysics Faculty of Biology Lomonosov Moscow State University

In.lammation.plays an.essen.ial role in.the developmen. of atherosclerosis. The in.tiation.an. growth of atherosclerotic plaques is accompan.ed by recruitmen. of in.lammatory an. precursor cells from the bloodstream an. their differen.iation.towards pro-in.lammatory phen.types. This process is orchestrated by the production.of a n.mber of pro-in.lammatory cytokin.s an. chemokin.s. Human.arterial in.ima con.ists of structurally distin.t leaflets, with a proteoglycan.rich layer lyin. immediately below the en.othelial lin.n.. Recen. studies reveal the importan. role of stellate pericyte-like cells(in.imal pericytes) populatin. the proteoglycan.rich layer in.the developmen. of atherosclerosis. Durin. the pathologic process, in.imal pericytes may participate in.the recruitmen. of in.lammatory cells by producin. sign.llin. molecules an. play a role in.the an.igen.presen.ation. In.imal pericytes are also in.olved in.lipid accumulation.an. the formation.of foam cells. This review focuses on.the role of pericytelike cells in.the developmen. of atherosclerotic lesion..

关键词： Atherosclerosis Arteries In.ima Immun.-in.lammator

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Tun.ble chemical complexity to con.rol atomic diffusion.in.alloys

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n.j Computation.l Materials 2020年第1期6卷 1360-1367页

作者： yuri Osetsky Alexan.er v.Barashev Lauren. K.Bélan. Zhon.wen.Yao Keyvan.Ferasat Yan.en.Zhan. Materials Scien.e an. Techn.logy Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Departmen. of n.clear En.in.erin. an. Radiological Scien.es University of MichiganAnn ArborMI 48109USA Departmen. of Mechan.cal an. Materials En.in.erin. Queen’s UniversityKingstonON K7L 3N6Canada Departmen. of Materials Scien.e an. En.in.erin. University of TennesseeKnoxvilleTN 37996USA

In.this paper we report a n.w fun.amen.al un.erstan.in. of chemically-biased diffusion.in.n.–Fe ran.om alloys that is tun.d/con.rolled by the in.rin.ic quan.ifiable chemical *** of radiation.toleran. alloys has been.a lon.-stan.in. *** we show how in.rin.ic chemical complexity can.be utilized to guide the atomic diffusion.an. suppress radiation.*** in.luen.e of chemical complexity is shown.by the example of in.erstitial atom(IA)diffusion.that is the most importan. defect in.radiation.*** useμs-scale molecular dyn.mics to reveal sluggish diffusion.an. percolation.of IAs in.con.en.rated n.–Fe *** develop a mean.field diffusion.model to take in.o accoun. the effect of migratin. defect en.rgy properties on.diffusion.percolation.which is verified by a n.w kin.tic Mon.e Carlo approach addressin. detailed *** demon.trate that the local variation. in.the groun. state en.rgy of IA con.iguration. in.alloys,reflectin. the chemical differen.e between.alloyin. compon.n.s,drives the percolation.effects for atomic ***,chemically-biased an. sluggish diffusion.are phen.men. that are directly related to the chemical complexity in.rin.ically to multicompon.n. alloys.

关键词： alloys alloyin. diffusion

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Modern.tren.s in.an.mal ven.m research-omics an. n.n.materials

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World Journ.l of Biological Chemistry 2017年第1期8卷 4-12页

作者： yuri n.Utkin Laboratory of Molecular Toxin.logy ShemyakinOvchinnikov Institute of Bioorganic Chemistry117997 MoscowRussia n.tion.l Un.versity of Scien.e an. Techn.logy MISiS 119049 MoscowRussia

An.mal ven.m research is a specialized in.estigation.field, in.which a n.mber of differen. methods are used an. this array is con.tan.ly expan.in.. Thus, recen.ly emerged omics an. n.n.techn.logies have already been.successfully applied to ven.m research. An.mal ven.ms have been.studied for quite a lon. time. The tradition.l reduction.st approach has been.to isolate in.ividual toxin. an. then.study their structure an. fun.tion. Un.ortun.tely, the characterization.of the ven.m as a whole system an. its multiple effects on.an.en.ire organ.sm were n.t possible un.il recen. times. The developmen. of n.w methods in.mass spectrometry an. sequen.in. have allowed such characterization. of ven.m, en.ompassin. the iden.ification.of n.w toxin. presen. in.ven.ms at extremely low con.en.ration. to chan.es in.metabolism of prey organ.sms after en.en.mation. In.particular, this type of comprehen.ive research has become possible due to the developmen. of the various omics techn.logies: Proteomics, peptidomics, tran.criptomics, gen.mics an. metabolomics. As in.other research fields, these omics techn.logies ushered in.a revolution.for ven.m studies, which is n.w en.erin. the era of big data. n.n.techn.logy is a very n.w bran.h of techn.logy an. developin. at an.extremely rapid pace. It has foun. application.in.man. spheres an. has n.t bypassed the ven.m studies. n.n.materials are quite promisin. in.medicin., an. most studies combin.n. ven.ms an. n.n.materials are dedicated to medical application.. Con.ugates of n.n.particles with ven.m compon.n.s have been.proposed for use as drugs or diagn.stics. For example, n.n.particles con.ugated with chlorotoxin. a toxin.in.scorpion.ven.m, which has been.shown.to bin. specifically to glioma cells- are con.idered as poten.ial glioma-targeted drugs, an. con.ugates of n.urotoxin. with fluorescen. semicon.uctor n.n.particles or quan.um dots may be used to detect en.ogen.us targets expressed in.live cells. The data on.application.of omics an. n.n.t

关键词： An.mal ven.m Proteomics Peptidomics Tran.criptomics n.n.techn.logy Gen.mics Quan.um dots n.n.particles Metabolomics

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