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Chapter 1 LHAASO Instruments and Detector technology

Chinese Physics C 2022年第3期46卷 1-35页

作者： Xin-Hua Ma Yu-Jiang Bi Zhen Cao Ming-Jun Chen Song-Zhan Chen Yao-Dong Cheng Guang-Hua Gong Min-Hao Gu Hui-Hai He Chao Hou Wen-Hao Huang Xing-Tao Huang Cheng Liu Oleg Shchegolev Xiang-Dong Sheng yuri Stenkin Chao-Yong Wu Han-Rong Wu Sha Wu Gang Xiao Zhi-Guo Yao Shou-Shan Zhang Yi Zhang Xiong Zuo Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China TIAnFU Cosmic Ray Research Center ChengduSichuanChina University of Chinese Academy of Sciences Beijing 100049China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina Institute for nuclear Research of Russian Academy of Sciences Moscow 117312Russia Moscow Institute of Physics and Technology Moscow 141700Russia Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina

The Large High Altitude Air Shower Observatory(LHAASO)(Fig.1)is located at ***(4410 m a.s.l.,600 g/cm^(2),29°21'27.56"n,100°08'19.66"E)in Daocheng,Sichuan province,*** consists of 1.3 km^(2) array(KM2A)of electromagnetic particle detectors(ED)and muon detectors(MD),a water Cherenkov detector array(WCDA)with a total active area of 78,000 m^(2),18 wide field-of-view air Cherenkov telescopes(WFCTA)and a newly proposed electron-neutron detector array(EnDA)covering 10,000 m^(2).Each detector is synchronized with all the other through a clock synchronization network based on the White Rabbit *** observatory includes an IT center which comprises the data acquisition system and trigger system,the data analysis *** this Chapter,all the above-mentioned components of LHAASO as well as infrastructure are described.

关键词： LHAASO gamma ray astronomy cosmic ray physics

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利用埃洛石负载防老剂制备耐老化橡胶

利用埃洛石负载防老剂制备耐老化橡胶

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中国化学会第30届学术年会

作者：付烨杨春王文才 yuri Lvov 北京化工大学有机无机纳米复合材料国家重点实验室北京化工大学先进弹性体材料研究中心 Institute for Micromanufacturing Louisiana Tech University

利用埃洛石粘土纳米管内部负载防老剂n-异丙基-n’-苯基对苯二胺（4010nA）作为填料制备新型耐老化丁苯橡胶（SBR）复合材料。负载在埃洛石内部的防老剂在橡胶基体中的缓释时间能够达到9个月,并且能够在不引起喷霜的前提下提高防老剂的... 详细信息

利用埃洛石粘土纳米管内部负载防老剂n-异丙基-n’-苯基对苯二胺（4010nA）作为填料制备新型耐老化丁苯橡胶（SBR）复合材料。负载在埃洛石内部的防老剂在橡胶基体中的缓释时间能够达到9个月,并且能够在不引起喷霜的前提下提高防老剂的用量到传统配方的三倍。另外,可通过对埃洛石表面进行硅烷偶联剂改性来提高其与橡胶基体中的相容性。通过对比热氧老化前后的机械性能研究了所得丁苯胶埃洛石复合材料的耐老化性能,经过90oC老化七天后机械性能保持稳定而且即使一个月后都没有产生喷霜。填充27wt.%埃洛石负载防老剂4010nA的丁苯胶耐老化性能显著提升充分体现埃洛石作为功能性橡胶填料的发展前景。

关键词：耐老化弹性体缓释纳米管埃洛石

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人3型腺病毒六邻体基底区重组蛋白的克隆表达和纯化

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哈尔滨医科大学学报 2017年第3期51卷 191-194页

作者：崔奇董妥王迎晨李宇齐彬彬 Vladimir I.Zlobin yuri P.Dzhioev Oleg n.Reva 曲章义哈尔滨医科大学公共卫生学院卫生微生物学教研室黑龙江哈尔滨150081 俄罗斯伊尔库茨克国立医科大学生物医学技术研究所俄罗斯伊尔库茨克664003 比勒陀利亚大学生物信息学与计算生物学部生物化学系南非比勒陀利亚市0002

目的克隆、表达人腺病毒六邻体蛋白基底区片段,为后续研究六邻体蛋白的抗原性及蛋白结构,进而研发腺病毒的基因工程疫苗及诊断试剂奠定基础。方法以3型人腺病毒核酸为模板,用PCR法扩增六邻体基底区片段,将该片段定向克隆至p QE32质粒,... 详细信息

目的克隆、表达人腺病毒六邻体蛋白基底区片段,为后续研究六邻体蛋白的抗原性及蛋白结构,进而研发腺病毒的基因工程疫苗及诊断试剂奠定基础。方法以3型人腺病毒核酸为模板,用PCR法扩增六邻体基底区片段,将该片段定向克隆至p QE32质粒,在大肠杆菌表达系统中表达带有组氨酸标签的重组蛋白片段,利用镍亲和层析法对重组蛋白进行纯化。结果构建出重组表达质粒,通过测序验证了克隆结果的正确性;在大肠杆菌表达体系中获得了高效表达。结论成功表达并获得了纯化的人3型腺病毒六邻体基底区重组蛋白片段。

关键词：腺病毒六邻体蛋白表达蛋白纯化

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Coseismic Effects of the 2011 Magnitude 9.0 Tohoku-Oki Earthquake Measured at Far East Russia Continental Coast by Gravity and GPS Methods

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International Journal of Geosciences 2013年第2期4卷 362-370页

作者： Vladimir Timofeev Ruslan Kulinich Maxim Valitov yuri Stus Eugeniy Kalish Bernard Ducarme Pavel Gornov Dmitriy Ardyukov Igor Sizikov Anton Timofeev Gulshat Gil’manova Tatyana Kolpashikova Zoya Proshkina Institute of Petroleum Geology and Geophysics Siberian Branch of Russian Academy of SciencesNovosibirskRussia V.I.Il’ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of ScienceVladivostokRussia Institute of Automatic and Electrometry Siberian Branch of Russian Academy of SciencesNovosibirskRussia Georges Lemaitre Centre for Earth and Climate Research Catholic University of LouvainLeuvenBelgium Institute of Tectonics and Geophysics Far Eastern Branch of Russian Academy of SciencesKhabarovskRussia

This work presents the results of complex gravity observation performed at Shults Cape, Gamov peninsula (42.58°n, 131.15°E), Russia. Absolute laser gravimeter GABL type and Scintrex type relative gravimeter were used for measurement. To investigate the accuracy of tidal corrections we compared the observed tidal parameters of the main tidal waves O1 and M2 with modeled ones computed from 6 different ocean tidal models: CSR4, FES02, FES04, GOT00, nAO99 and TPX06. After discussion a theoretical model based on TPX06 ocean tides model and DDW99 non hydrostatic body tides model was used for tidal correction of absolute gravity data. Preliminary estimate of gravity effect induced by the Tohoku-Oki earthquake of11 March 2011Mw = 9.0 at Primorye territory (Russia) was found to be 5.1 ± 2.0 μGal. Co-seismic crustal displacements revealed by GPS data at Far EastRussiacontinental coast are also investigated. Volumetric dilatation of this area is observed at +1.7 × 10-8 level.

关键词： Absolute Gravimetry GPS Tidal Gravity Modeling and Observation Scintrex Gravimeter Co-Seismic Effect for Tohoku-Oki Earthquake

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Application of the Distance to natural (D2n) Index and Statistical Analysis of Different Anthropic Uses of the Río Grande De Comitán Watershed, Chiapas, México

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Journal of Geoscience and Environment Protection 2022年第11期10卷 225-235页

作者： Flor Magali Aguilar López Dayana Almeida yuri Tavares Rocha Eliziane Carla Scariot Waldir José Gaspar Roberto Bonifaz Alfonzo Elisabete Maria Zanin Alberto Carvalho Peret José Eduardo Dos Santos Universidade Federal de Sã o Carlos S&#227 o Carlos Brazil Universidade de Sã o Paulo S&#227 o Paulo Brazil InstitutoFederal de Sã o Paulo Mat&#227 o Brazil Universidade Federal do Mato Grosso Cuiabá Brazil Universidad nacional Autónoma de México México City México Universidade Regional Integrada do Alto Uruguai e das Missõ es Erechim Brazil

The intensification of anthropic uses (i.e., increase of the hemerobic condition) threatens the remnants of native vegetation due to the reduction of its self-regulation capacity. In this research, the Distance to nature (D2n) index for land use and land cover was applied in the Río Grande de Comitán watershed (Southern Mexico) to answer the following questions: 1) What were the land use dynamics observed in the Rio Grande de Comitán watershed in the trajectory through 1999, 2009 and 2019? 2) Does the subcategorization of the D2n allow one to identify which anthropic uses influence more the territorial expression of the watershed? To answer these questions, we performed a supervised classification of land use and land cover was performed in this watershed, and for the D2n index, the classification was simplified to three-category scale for the subcategorization of the anthropic component. Through Principal Component Analysis (PCA), we identified that agricultural anthropogenic use had the greatest influence on territorial expression. The reported scenario indicates a trend of gradual and continuous reduction of naturalness over the last 20 years. Additionally, the D2n index proved to be a useful tool to demonstrate both the anthropic impact, with the simplified scale, and the component that most influences the territory, by subcategorizing the anthropic scale.

关键词： Anthropic Land-Use Pressures Spatio-Temporal Principal Component Analysis (PCA) Environmental Planning nature Conservation

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Azithromycin in a triple therapy for *** eradication in active duodenal ulcer

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World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： Vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya Petr Va.Grigoriev yuri V.Vasiliev Emilia P.Yakovenko Pavel V.Gulyaev Valeri I.Fedchenko V.Vasilenko Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia Pathology Department of the Moscow Sechenov Medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health Ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing active duodenal ulcer and *** eradication. METHODS:100 patients with active duodenal ulcer were included in the open,multicentre,randomized study with comparative *** were randomly assigned to one of the following one-week triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAM,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was given after the eradication course as a monotherapy for three *** control endoscopy was performed 8 weeks after the *** was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAM group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in 48 patients of the OAM group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAM(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (Pn and metronidazole failed to eradicate ***'vc\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. Macrolide with amoxicillin are preferable to achieve higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple PPI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Ulcer Agents Azithromycin Comparative Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole Penicillins Research Support, non-U.S. Gov't Treatment Outcome

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Transient GUS and GFP Expression in Spanish Red Cedar(Cedrela odorata L.)Somatic *** of Bombardment Conditions and Evaluation of Selective Agent Lethal Dose

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Open Journal of Forestry 2012年第2期2卷 54-58页

作者： yuri J.Pena-Ramírez Max M.Apolinar-Hernández Oscar A.Gomez-y-Gomez Luisa A.Lopez-Ochoa Aileen O’Connor-Sánchez Instituto Tecnologico Superior de Acayucan AcayucanMexico Centro de Investigacion Científica de Yucatán MéridaMexico

Cedrela odorata is a tropical tree widely appreciated for its wood. Commercial plantations are frequently hampered by the attack of the meliacea borer, Hypsipyla grandella, and the lack of resistant varieties. C. odorata traditional breeding would consume very long periods of time, thus direct transfer of entomotoxic coding genes to generate resistant varieties is a promising alternative. There are two prerequisites for gene manipulation of this species: 1) to set the conditions for transgene delivery and 2) to have a way to select regenerating transformed plants. In this paper, we report the optimal biolistics conditions for transient expression of uidA and gfp reporter genes in C. odorata somatic embryos and the selective doses for kanamycin, spectinomycin, phosphinotrycin and hygromycin to screen transformed cells.

关键词： Biolistics Genetic Transformation Tree Genetic Modification Tropical Wood

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Energy spectrum of an electron confined in the hexagon-shaped quantum well

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Science China(Technological Sciences) 2009年第1期52卷 15-18页

作者： Yu.V.VOROBIEV V.R.VIEIRA P.P.HORLEY P.n.GORLEY J.GOnZALEZ-HERnAnDEZ CInVESTAV Unidad Querétaro Libramiento Norponiente#2000 Centro de Física das Interaccoes Fundamentais Av.Rovisco Pais yuri Fedkovych Chernivtsi national University 2 Kotsyubynsky str. CIMAV 120 Miguel de Cervantes

Considering the hexagonal-shaped quantum-scale formations on the surface of thin semiconductor films, a methodology was developed to obtain the analytical solution of the Schrdinger equation when impenetrable walls of a quantum well are treated as mirrors. The results obtained allowed the calculation of the space probability distributions and the energy spectrum of the particle confined in a hex-agonal-shaped well.

关键词： quantum well Schrodinger equation wave function hexagon reflection boundary conditions impenetrable walls

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Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil

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Infectious Diseases of Poverty 2020年第1期9卷 36-45页

作者： Luciana Regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição Souza yuri Scheidegger de Castro Letícia Silva nascimento Juliana Azevedo da Silva Edilbert Pellegrini nahn Junior Wilmar Dias da Silva Alba Lucínia Peixoto-Rangel Laboratory of Recognition Biology Center of Biosciences and BiotechnologyState University of Northern Rio de JaneiroCampos dos GoytacazesRJBrazil Campos Medical School Campos dos GoytacazesRJBrazil Laboratory of Immunochemistry Butantan InstituteSão PauloSPBrazil

Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in *** with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of *** we investigated the possible influence of ***/*** co-parasitism on the manifestation of leprosy and its clinical ***:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de Janeiro state,southeast Brazil,from August 2015 to December 2019 and clinically diagnosed for *** were selected based on the presence(patients)or absence(healthy controls)of the leprosy *** of patients were also recruited for this *** samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ***,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ***-PGL-1 IgG and IgM levels were compared using one-way AnOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for *** *** risk of *** infection for leprosy disease was assessed using Fisher’s ***:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous *** serologic prevalence for *** infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this *** leprosy risk increase in *** seropositive individuals was two-fold(odds ratio[OR]=2.055;95% c

关键词： Leprosy Toxoplasmosis Coinfection Co-immunomodulation Immunoglobulins Immune response

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利用埃洛石负载防污剂制备抗污弹性体

利用埃洛石负载防污剂制备抗污弹性体

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第十四届中国橡胶基础研究研讨会

作者：付烨公聪聪王文才 yuri MLvov 张立群有机无机复合材料重点实验室北京化工大学先进弹性体材料研究中心北京化工大学 Institute for Micromanufacturing Louisiana Tech University

埃洛石纳米管是一种天然的硅酸盐管状材料,内径15-20 nm,外径50-70 nm,可在内部负载药物、催化剂等小分子或低分子量物质来达到缓释的效果。利用埃洛石纳米管负载防污剂n-（2,4,6-三氯苯基）马来酰亚胺（TCPM）制备具有防污性能的乙烯-... 详细信息

埃洛石纳米管是一种天然的硅酸盐管状材料,内径15-20 nm,外径50-70 nm,可在内部负载药物、催化剂等小分子或低分子量物质来达到缓释的效果。利用埃洛石纳米管负载防污剂n-（2,4,6-三氯苯基）马来酰亚胺（TCPM）制备具有防污性能的乙烯-醋酸乙烯酯共聚物（EVA）复合材料。通过将防污剂负载到埃洛石管腔内达到缓慢释放的效果,大大延长防污剂的作用时间。实验证明,负载在埃洛石内部的防污剂在EVA基体中的缓释时间超过12个月,远大于将防污剂直接添加到EVA中。此外,埃洛石作为填料可以提高EVA的机械性能及结晶度,使该复合材料具有良好的海洋防污应用前景。

关键词：防污埃洛石弹性体缓释

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