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Can near-to-mid Infrared Spectral Energy Distribution Quantitatively Trace Protoplanetary Disk Evolution?

Research in Astronomy and Astrophysics 2024年第7期24卷 34-46页

作者： Mingchao Liu Jinhua He Zhen Guo Jixing Ge yuping tang Yunnan Observatories Chinese Academy of SciencesKunming 650216China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Instituto de Física y Astronomía Universidad de Valparaísoave.Gran Bretaña1111Casilla 5030ValparaísoChile Centre for Astrophysics Research University of HertfordshireHatfield AL109ABUK Millennium Institute of Astrophysics Nuncio Monseñor Sotero Sanz 100Of.104ProvidenciaSantiagoChile Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China

Infrared(IR)spectral energy distribution(SED)is the major tracer of protoplanetary *** was recently proposed to use the near-to-mid IR(or K-24)SED slopeαdefined between 2 and 24μm as a potential quantitative tracer of disk *** critically examine the viability of this idea and confront it with additional statistics of IR luminosities and SED *** point out that,because the statistical properties of most of the complicated physical factors involved in disk evolution are still poorly understood in a quantitative sense,the only viable way is to assume them to be random so that an idealized“average disk”can be defined,which allows theαhistogram to trace its *** confirm that the statistics of the zeroth order(luminosity),first order(slopeα),and second order characteristics(concavity)of the observed K-24 SEDs indeed carry useful information upon the evolutionary processes of the“average disk”.We also stress that intrinsic diversities in K-24 SED shapes and luminosities are always large at the level of individual stars so that the application of the evolutionary path of the“average disk”to individual stars must be done with *** data of most curves in plots are provided on GitHub(Disk-age package https://***/starage/disk-age/).

关键词： stars formation-stars pre-main sequence-stars protostars-infrared stars-protoplanetary disks

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A nitric oxide-triggered hydrolysis reaction to construct controlled self-assemblies with complex topologies

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Science China Chemistry 2024年第4期67卷 1289-1299页

作者： Wenzhuo Chen yuping tang Shuai Chen Zipei Chen Jia He Hongbin Huo Juan Zhang Jiajia Li Fei Yan Wei Tian Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs ResearchCollege of PharmacyShaanxi University of Chinese MedicineXianyang 712046China Shaanxi Key Laboratory of Macromolecular Science and Technology Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic DeviceMOE Key Laboratory of Material Physics and Chemistry under Extraordinary ConditionsSchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural ***,utilizing the proper hydrolysis reactions to construct controlled assemblies with complex topologies is still an arduous challenge in artificial systems and needs to be ***,we report a nitric oxide(NO)-triggered slow hydrolysis strategy for the controlled construction of biomimetic supramolecular toroids(STs),thus realizing their visualization of intermediate structures and regulation of geometry *** presented protocol harnesses hydrolysis reactions to control of non-equilibrium self-assembly processes for the construction of self-assemblies with complex topologies successfully,which sheds light on how the hydrolysis reaction rate can modulate the kinetic pathway of assembly,thus realizing the artificial establishment of bio-inspired hierarchical structures.

关键词： supramolecular toroids controlled self-assembly nitic oxide-triggered hydrolysis pathway regulation

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Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress Author links open overlay panel

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 330-339页

作者： Jiajian Guo Dongxiao Cui yuping tang Sanjiao Wang Cuiyan Ma Wenfu Ma School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an 712046China School of Literature and History Mianyang Teachers'CollegeMianyang 621000China

Objective To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved,specifically focusing on the role of the caspase-3/gasdermin E(GSDME)signaling pathway and the impact of endoplasmic reticulum(ER)stress and *** Necrostatin-1(Nec-1),lactate dehydrogenase release(LDH)assay,and Hoechst/propidium iodide(PI)double staining were employed to validate the mode of cell *** blot was used to detect the cleavage of GSDME and the expression of light chain 3(LC3)and *** Celastrol induced cell swelling with large bubbles,which is consistent with the pyroptotic ***,treatment with celastrol induced GSDME cleavage,indicating the activation of GSDME-mediated *** knockout via CRISPR/Cas9 blocked the pyroptotic morphology of celastrol in HeLa *** addition,cleavage of GSDME was attenuated by a specific caspase-3 inhibitor in celastrol-treated cells,suggesting that GSDME activation was induced by ***,celastrol induced endoplasmic reticulum(ER)stress and autophagy in HeLa cells,and other ER stress inducers produced effects consistent with those of *** These findings suggest that celastrol triggers caspase-3/GSDME-dependent pyroptosis via activation of ER stress,which may shed light on the potential antitumor clinical applications of celastrol.

关键词： Celastrol Tumor cells Pyroptosis GSDME Caspase-3 Endoplasmic reticulum stress stress Cell death Traditional Chinese medicine

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基于GIS的闽江河口国家湿地公园生态敏感性评价与空间格局分析

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Journal of Resources and Ecology 2024年第1期15卷 33-43页

作者：汤雨平舒梦蓉吴元晶宣阳福州工商学院城建学院福州350007 福州外语外贸学院艺术与设计学院福州350000 福建农林大学风景园林与艺术设计学院福州350000 广州博厦建筑设计研究院福建分院福州350000

湿地是地球生态系统中最为复杂的生态系统类型之一,而生态敏感性评价是对湿地公园科学系统规划的重要依据。福建闽江河口湿地位于沿海城市福州,生态系统和生物多样性具有突出的区域特征,其水域是北半球同一纬度最具有丰富的近海海洋物... 详细信息

湿地是地球生态系统中最为复杂的生态系统类型之一,而生态敏感性评价是对湿地公园科学系统规划的重要依据。福建闽江河口湿地位于沿海城市福州,生态系统和生物多样性具有突出的区域特征,其水域是北半球同一纬度最具有丰富的近海海洋物种的水域之一,至少有四项指标符合国际重要湿地的标准。本文在遥感(RS)和地理信息系统(GIS)的技术支撑下,采用层次分析法确定要素权重及指标,通过德尔菲专家评分法,构建湿地公园生态敏感性评价指标体系。然后对闽江河口湿地国家公园进行生态敏感性评价和空间格局分析。将闽江河口国家湿地公园分为极端敏感、高敏感、中敏感、低敏感、不敏感五种生态敏感水平。结果表明,河岸、海滩、水渠、池塘及周边地区均在高、中敏感区范围内,而不敏感区、低敏感区分布在林地、农田、公园等人工景观环境中。

关键词： GIS 闽江河口国家湿地公园生态敏感性滨海城市

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麝香类药用生物资源及其资源化利用研究

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中草药 2024年第19期55卷 6797-6805页

作者：孙何怡萱徐顶巧付瑞嘉晏菲杨洁唐于平陕西中医药大学陕西省中医药管理局中药配伍重点研究室

麝香是我国优良的天然资源，其功效多、适用范围广，为我国道地产区中药材的典型代表之一，但由于生态环境的破坏及对麝的肆意滥杀，麝香的资源状况已十分严峻。通过系统性归纳生产麝香五大麝种的外观、形状等特征，总结了麝香及其活性... 详细信息

麝香是我国优良的天然资源，其功效多、适用范围广，为我国道地产区中药材的典型代表之一，但由于生态环境的破坏及对麝的肆意滥杀，麝香的资源状况已十分严峻。通过系统性归纳生产麝香五大麝种的外观、形状等特征，总结了麝香及其活性成分的药理作用。整合了天然麝香与人工麝香及麝香类似物（麝鼠香、灵猫香、龙涎香）在多方面的异同，为寻找麝香人工或天然替代品研究提供依据。从中药资源化学的角度出发，基于不同提取方法、不同季节、不同产地等因素，对比麝香资源化学成分。进一步分析麝香药用资源价值，并根据进展提出利用策略。为深入研究和开发该类药用植物资源提供参考，并为麝香药用资源综合利用提供理论支撑。

关键词：麝麝香人工麝香名贵中药麝香酮开窍醒神资源化学

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黄芩炒炭过程中主要成分与色度值的变化规律及其止血作用研究

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中草药 2024年第15期55卷 5083-5092页

作者：乔瑞瑞刘硕白亚亚赵重博史亚军张丽唐于平张桥孙静陕西中医药大学药学院陕西西安712046 南京中医药大学翰林学院江苏泰州225300

目的通过分析黄芩Scutellariae Radix炒炭过程中化学成分与色度值的动态变化规律及其止血作用评价,以期为黄芩炒炭过程中的质量控制提供科学依据,同时为黄芩炒炭终点的判断奠定基础。方法制备不同炮制程度的黄芩炭样品(H1~H10),采用紫外... 详细信息

目的通过分析黄芩Scutellariae Radix炒炭过程中化学成分与色度值的动态变化规律及其止血作用评价,以期为黄芩炒炭过程中的质量控制提供科学依据,同时为黄芩炒炭终点的判断奠定基础。方法制备不同炮制程度的黄芩炭样品(H1~H10),采用紫外-可见分光光度法测定不同炮制程度黄芩炭样品的总黄酮含量和炭吸附力;采用HPLC法测定不同炮制程度黄芩炭样品中没食子酸、5-羟甲基糠醛、野黄芩苷、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素及千层纸素A含量;采用分光测色仪测定不同炮制程度黄芩炭样品的L^(*)(亮度值)、a^(*)(红绿色值)、b^(*)(黄蓝色值)、E_(ab)^(*)(总色值);采用SPSS 19.0和SIMCA 14.1软件进行颜色与主要成分的关联分析。最后,采用剪尾法及玻片法进行不同炮制程度黄芩炭样品对正常小鼠止血及凝血时间的药效评价。结果在黄芩炭炮制过程中,随着炭化程度的增加,样品中总黄酮、没食子酸、5-羟甲基糠醛、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、千层纸素A的含量呈先增后降的趋势,野黄芩苷呈下降趋势。样品粉末的L^(*)、b^(*)、E_(ab)^(*)值呈降低趋势,a^(*)值呈先增后降趋势。L^(*)值、b^(*)值和E_(ab)^(*)值与野黄芩苷、黄芩苷、汉黄芩苷呈正相关,a^(*)值与没食子酸、5-羟甲基糠醛、黄芩素、汉黄芩素、千层纸素A呈正相关,总黄酮与L^(*)、a^(*)、b^(*)、E_(ab)^(*)呈正相关。主成分分析(principal component analysis,PCA)结果显示,不同炮制程度黄芩炭样品各自归类成簇,可区分不同程度的炮制品。回归分析显示,仅没食子酸、5-羟甲基糠醛、汉黄芩素可通过色度值结合回归方程来预测含量,其余成分则不能。结合PCA、炭吸附力及药理实验结果表明,黄芩炭炮制前后炭吸附力和止血、凝血作用差异较大,样品H7(180℃、9 min)炭吸附力作用较强,结合止血及凝血时间,H7样品止血作用较好。结论黄芩炒炭过程中的颜色与化学成分的变化存在相关性,可为黄芩炒炭终点判断提供数据支撑。

关键词：黄芩炭化学成分色度值炭吸附力止血作用黄酮没食子酸 5-羟甲基糠醛野黄芩苷黄芩苷汉黄芩苷黄芩素汉黄芩素千层纸素A 主成分分析

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Laboratory Simulation of the Formation Process of Surface Geochemical Anomalies Applied to Hydrocarbon Exploration

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 2149-2162页

作者： WANG Guojian tang yuping CHENG Tongjin tang Junhong FAN Ming LU Li Wuxi Research Institute of Petroleum Geology Research Institute of Petroleum Exploration and ProductionSINOPEC College of Material & Environmental Engineering Hangzhou Dianzi University

The formation mechanisms and processes of geochemical anomalies used as proxies in surface geochemistry exploration （SGE） have not been well understood. Previous studies cannot realize 3D measurement of microseeping hydrocarbons from reservoirs to the surface, which made it difficult to understand the features and pathways of deep hydrocarbon microseepages. Understanding the processes of hydrocarbon microseepages will contribute to the acceptance and effectiveness of surface geochemistry. Based on a simplified geological model of hydrocarbon microseepages, including hydrocarbon reservoir, direct caprock, overlying strata and Quaternary sediments, this work established a 3D experimental system to simulate the mechanisms and processes of deep hydrocarbon microseepes extending to the surface. The dispersive halos of microseeping hydrocarbons in the subsurface were adequately described by using this 3D experimental system. Results indicate that different migration patterns of hydrocarbons above the point gas source within the simulated caprock and overlying strata can be reflected by the ratio of i-butane to n-butane （i-C4/n-C4）, which follow diffusion and infiltration （buoyancy） mechanisms. This is not the case for vertical measurement lines far from the point gas source. A vertical gas flow in the form of a plume was found during hydrocarbon microseepage. For sampling methods, the high-density grid sampling is favorable for delineating prospecting targets. Hydrocarbon infiltration or buoyancy flow occurs in the zones of infiltration clusters, coupling with a diffusion mechanism at the top of the water table and forming surface geochemical anomalies. These results are significant in understanding hydrocarbon microseepage and interpreting SGE data.

关键词： hydrocarbon microseepage surface geochemical anomaly 3D measurement laboratory simulation migration mechanisms and processes

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蓍草防治急性肝损伤的作用机制及量效关系研究

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中国现代应用药学 2024年第15期41卷 2023-2032页

作者：王超付瑞嘉左倩曾晓涛徐顶巧唐于平刘继平陕西中医药大学药学院陕西咸阳712046

目的基于网络药理学和多指标综合指数法,探究蓍草防治急性肝损伤的作用机制,并评价不同剂量蓍草(1.56、3.12、6.24、9.36、12.48、15.60 g·kg^(-1))的肝保护作用。方法运用网络药理学预测蓍草对肝脏损伤可能的作用靶点和与相关疾病的... 详细信息

目的基于网络药理学和多指标综合指数法,探究蓍草防治急性肝损伤的作用机制,并评价不同剂量蓍草(1.56、3.12、6.24、9.36、12.48、15.60 g·kg^(-1))的肝保护作用。方法运用网络药理学预测蓍草对肝脏损伤可能的作用靶点和与相关疾病的潜在关系,并通过分子对接和免疫荧光检测进行验证。采用四氯化碳橄榄油溶液诱导大鼠急性肝损伤,测定了多项指标包括肝指数、ALT、AST、TNF-α、IL-6、IL-1β、CAT、SOD、GSH-px、MDA和GSH。最后采用主成分分析和CRITIC权重分析法综合评价蓍草对肝脏保护效应。结果共获得351个蓍草和急性肝损伤的共同靶点。网络药理学分析发现,AKT1、TNF和ALB为前3个核心靶点,主要涉及PI3K/AKT信号通路。免疫荧光染色显示,蓍草下调了急性肝损伤大鼠肝脏中PI3K、AKT和TNF蛋白的表达,上调了ALB蛋白的表达。与对照组相比,模型组中各指标差异有统计学意义;与模型组比较,蓍草不同剂量给药组能较好地改善急性肝损伤大鼠的各项指标水平,并呈一定的量效关系。综合主成分分析和多指标综合指数法得出,蓍草在浓度为15.60 g·kg^(-1)时的肝保护作用最明显。结论蓍草具有防治急性肝损伤的作用,这可能与蓍草调节PI3K信号通路有关;当蓍草剂量为15.60 g·kg^(-1)时,其药效最好,这为蓍草的合理应用奠定了基础。

关键词：蓍草 PI3K/AKT信号通路 CRITIC权重分析法多指标综合指数法量效关系

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肌筋膜触发点治疗技术在膝关节疼痛的临床应用

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内蒙古中医药 2024年第5期43卷 158-162页

作者：唐玉萍胡运翔梁恩龙广西骨伤医院广西南宁530000

膝关节疼痛治疗的目的是消除疼痛,恢复关节功能。随着肌筋膜触发点(myofascial trigger points,MTrPs)理论的提出及大量的临床应用,发现其在治疗疼痛方面疗效显著。本文就肌筋膜触发点治疗膝关节疼痛的临床应用效果进行综述,旨在为临床... 详细信息

膝关节疼痛治疗的目的是消除疼痛,恢复关节功能。随着肌筋膜触发点(myofascial trigger points,MTrPs)理论的提出及大量的临床应用,发现其在治疗疼痛方面疗效显著。本文就肌筋膜触发点治疗膝关节疼痛的临床应用效果进行综述,旨在为临床治疗膝关节疼痛提供参考。

关键词：肌筋膜触发点膝关节疼痛综述

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Relationship Between Hematoma Expansion Induced by Hypertension and Hyperglycemia and Blood-brain Barrier Disruption in Mice and Its Possible Mechanism:Role of Aquaporin-4 and Connexin43

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Neuroscience Bulletin 2020年第11期36卷 1369-1380页

作者： Heling Chu Zidan Gao Chuyi Huang Jing Dong yuping tang Qiang Dong Department of Neurology Huashan HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200040China Department of Neurology North Huashan HospitalFudan UniversityShanghai 201907China Department of Neurology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Neurology Shanghai East HospitalTongji University School of MedicineShanghai 200120China

We aimed to select an optimized hematoma expansion(HE)model and investigate the possible mechanism of blood-brain barrier(BBB)damage in *** results showed that HE occurred in the group with hypertension combined with hyperglycemia(HH-HE)from3 to 72 h after intracerebral hemorrhage;this was accompanied by neurological deficits and hardly influenced the survival *** receiver operating characteristic curve suggested the criterion for this model was hematoma volume expansion≥45.0%.Meanwhile,HH-HE aggravated BBB disruption.A protector of the BBB reduced HH-HE,while a BBB disruptor induced a further ***-4(AQP4)knock-out led to larger hematoma volume and more severe BBB ***,hematoma volume and BBB disruption were reduced by multiple connexin43(Cx43)inhibitors in the wild-type group but not in the AQP4 knock-out *** conclusion,the optimized HE model is induced by hypertension and hyperglycemia with the criterion of hematoma volume expanding≥45.0%.HH-HE leads to BBB disruption,which is dependent on AQP4 and Cx43.

关键词： Intracerebral hemorrhage Hematoma expansion Animal model Blood-brain barrier Aquaporin-4 Connexin43

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