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Effect of fermented Rosa roxburghii Tratt fruit juice on gut microbiota in a dextran sulfate sodium-induced colitis mouse model

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Food Science and Human Wellness 2024年第4期13卷 2234-2243页

作者： yunyang zuo Haoxiang Xu Dandan Feng Yuanyuan Shi Jiuchang Li Maoyang Wei Ling Wang Yulong Zhang Ping Hu School of Liquor and Food Engineering Guizhou UniversityGuiyang 550025China

This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in *** to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of ***,Desulfovibrio C21_c20,*** and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of *** in ***-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC ***,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ *** with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis *** analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis *** together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition.

关键词： Rosa roxburghii Tratt Lacticaseibacillus paracasei Ulcerative colitis Fermentation characteristics

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冷藏和冻藏方式对刺梨果品质和风味的影响

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食品与发酵工业 2024年第9期50卷 290-297,I0016-I0019页

作者：王令左云洋李久长魏茂洋胡萍贵州大学酿酒与食品工程学院贵州贵阳550025

该研究旨在为探究不同低温方式下刺梨鲜果保藏过程中的品质和风味变化。该研究以刺梨鲜果为原料,探讨不同条件(4℃冷藏、-20℃缓冻、液氮速冻)下保藏过程中刺梨果品质和风味物质的变化规律。实验通过测定刺梨果保藏过程中的色差值、超... 详细信息

该研究旨在为探究不同低温方式下刺梨鲜果保藏过程中的品质和风味变化。该研究以刺梨鲜果为原料,探讨不同条件(4℃冷藏、-20℃缓冻、液氮速冻)下保藏过程中刺梨果品质和风味物质的变化规律。实验通过测定刺梨果保藏过程中的色差值、超氧化物歧化酶(superoxide dismutase,SOD)、维生素C等理化指标,结合顶空固相微萃取-气相色谱-质谱联用(headspace solid phase microextraction-gas chromatography-mass spectrometry,HS-SPME-GC-MS)技术对其风味物质进行检测,并通过电子扫描显微镜对微观结构进行表征。结果表明,刺梨果在4℃冷藏至第45天开始出现腐烂,缓冻和速冻组的刺梨经过365 d的冻藏仍未变质。在冻藏过程中速冻组色差变化显著小于缓冻组(P0.05)。刺梨微观结构和硬度测定结果表明,速冻组刺梨的结构更加完整,硬度更高。GC-MS分析结果表明,3种处理条件在不同保藏时间段共检测出166种风味物质,酯类31种、醇类26种、醛类26种、酮类18种、酸类8种、烃类48种、其他类9种,其中酯类、烃类和醛类是刺梨主要风味物质。冻藏与冷藏相比,损失(E)-3-己烯-1-丁酸酯、2-十一酮、4-环己基苯乙酮风味物质,新增酯类(20种)、烃类(32种)、醛类(24种)、酮类(15种)、醇类(22种)。速冻组总的挥发性物质和特有挥发性物质均显著高于其他组(P<0.05)。冻藏与冷藏相比,刺梨果的品质保持效果较好,适合长期保藏。与缓冻处理相比,速冻处理后冻藏能够更好地保持刺梨果的色泽、细胞结构和风味物质。

关键词：刺梨果低温保藏品质风味

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不同乳酸菌发酵对刺梨汁品质及风味影响

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食品与生物技术学报 2024年第4期43卷 90-97页

作者：魏涛涛左云洋王令魏茂洋胡萍贵州大学酿酒与食品工程学院贵州贵阳550025 贵州极海果蔬饮品工程技术有限公司贵州贵阳550014

以副干酪乳杆菌SR10-1(全文简称SR10-1)、干酪乳杆菌(全文简称H1)、发酵乳杆菌GZSC-1(全文简称GZSC-1)发酵的刺梨汁为研究对象,对发酵前后刺梨汁品质变化进行对比,并采用气相-离子迁移谱(gas chromatography-ion mobility spectroscopy,... 详细信息

以副干酪乳杆菌SR10-1(全文简称SR10-1)、干酪乳杆菌(全文简称H1)、发酵乳杆菌GZSC-1(全文简称GZSC-1)发酵的刺梨汁为研究对象,对发酵前后刺梨汁品质变化进行对比,并采用气相-离子迁移谱(gas chromatography-ion mobility spectroscopy,GC-IMS)和电子鼻技术对不同乳酸菌发酵刺梨汁的挥发性风味物质组成及差异进行分析。结果表明,SR10-1发酵刺梨汁中VC和超氧化物歧化酶(SOD)的损失率最低(P<0.05),H1发酵刺梨汁中单宁降解率最高,达到(41.37±1.08)%。电子鼻分析结果表明,3株乳酸菌发酵的刺梨汁气味轮廓相似,但SR10-1对发酵刺梨汁的气味贡献度最高。采用GC-IMS从3组乳酸菌发酵样品、稀释4倍刺梨原汁和刺梨原汁样品中共分离出54种挥发性成分,鉴定出44种物质,主要有酯类、醛类、醇类和酸类化合物。3株不同乳酸菌发酵样品中共有的挥发性风味物质包括叶醇、乙醇、乙酸丙酯、3-戊酮、乙酸乙酯、丙酮等;二甲基硫、丙酮和丁酸乙酯分别是SR10-1、GZSC-1和H1发酵样品的特征性风味物质;H1和GZSC-1发酵样品的主要风味成分相似,这与电子鼻结果一致。以上结果表明,通过乳酸菌发酵刺梨汁,保留了刺梨汁的主要营养成分,并增加了新的代谢物质,增加了刺梨汁的果香,对改善刺梨汁风味起到了积极作用。

关键词：刺梨汁乳酸菌挥发性风味物质气相-离子迁移谱电子鼻

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副干酪乳杆菌SR10-1发酵刺梨汁对葡聚糖硫酸钠诱导小鼠溃疡性结肠炎的缓解作用

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食品科学 2023年第15期44卷 121-128页

作者：左云洋胡萍许浩翔冯丹丹石媛媛李久长王令魏茂洋贵州大学酿酒与食品工程学院贵州贵阳550025

目的:探讨副干酪乳杆菌(Lactobacillus paracasei)SR10-1发酵刺梨汁(Rosa roxburghii ***,RRTJ)对小鼠溃疡性结肠炎(ulcerativecolitis,UC)的保护效果。方法:实验室自制SR10-1发酵刺梨汁;采用葡聚糖硫酸钠(dextran sulfate sodium,DSS)诱导小鼠溃疡性结肠炎模型,设置空白对照(Control)组、DSS模型组、阳性对照组、乳酸菌发酵刺梨汁(LAB-RRTJ)组和刺梨原汁(RRTJ)组。分析UC小鼠疾病活动指数(disease activity index,DAI)评分、脏器指数、结肠长度、结肠病理改变、炎症因子水平、抗氧化应激水平、髓过氧化物酶(myeloperoxidase,MPO)活力和肠道屏障相关基因表达水平。结果:给药结束时,相较于DSS模型组,LAB-RRTJ组能够显著降低DAI评分(P<0.05),缓解小鼠腹泻、便血、结肠萎缩状态和病理结构。此外,与DSS模型组相比,小鼠结肠长度显著增加(P<0.001);脾脏和肝脏指数显著降低(P<0.001、P<0.05);白细胞介素(interleukin,IL)-1β、IL-6、IL-17A、肿瘤坏死因子α、干扰素γ水平显著降低(P<0.05),而IL-10水平显著升高(P<0.05);丙二醛、MPO水平显著降低(P<0.05);超氧化物歧化酶、谷胱甘肽水平显著升高(P<0.001、P<0.05);肠道屏障相关基因Claudin-3、ZO-1、MUC2表达水平极显著增加(P<0.01)。结论:副干酪乳杆菌SR10-1发酵刺梨汁能够通过改善小鼠UC炎症反应、调节氧化应激水平和肠道屏障功能,减轻小鼠肠道损伤,对小鼠UC有良好的缓解作用。

关键词：乳酸菌刺梨发酵溃疡性结肠炎缓解作用

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乳酸菌发酵刺梨汁体外降血糖、降血脂活性研究

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食品与发酵工业 2022年第8期48卷 212-219页

作者：冯丹丹胡萍许浩翔张珺石媛媛吴文燕李娟左云洋李久长贵州大学酿酒与食品工程学院贵州贵阳550025

为评价乳酸菌发酵刺梨汁的功能特性,对3株乳酸菌(副干酪乳杆菌SR10-1、干酪乳杆菌H1、发酵乳杆菌GZSC-1)的菌悬液、胞外分泌物及其发酵刺梨汁进行体外降血糖、降血脂能力探究。结果表明,降血糖能力上,SR10-1发酵刺梨汁对α-葡萄糖苷酶... 详细信息

为评价乳酸菌发酵刺梨汁的功能特性,对3株乳酸菌(副干酪乳杆菌SR10-1、干酪乳杆菌H1、发酵乳杆菌GZSC-1)的菌悬液、胞外分泌物及其发酵刺梨汁进行体外降血糖、降血脂能力探究。结果表明,降血糖能力上,SR10-1发酵刺梨汁对α-葡萄糖苷酶活性抑制能力最强,IC_(50)值为(3.10±0.34)mg/L;通过葡萄糖透析延迟指数(glucose dialysis retardation index,GDRI)反映样品对葡萄糖在肠胃道延迟吸收的能力,在透析30 min与60 min后,SR10-1发酵刺梨汁的GDRI最高,分别达到(92.62±4.31)%与(71.86±2.11)%,显著高于刺梨汁与H1、GZSC-1发酵刺梨汁(P<0.05);降血脂能力上,SR10-1发酵刺梨汁对牛磺胆酸钠、甘氨胆酸钠与胆固醇胶束的结合能力最强,分别为(1.10±0.03)、(2.57±0.18)mmol/mL与(2.78±0.06)μmol/mL;在抑制胰脂肪酶活性方面,刺梨汁的胰脂肪酶抑制率达到(58.87±3.44)%,强于发酵后的刺梨汁。研究结果表明,经过SR10-1发酵的刺梨汁显著提高了其降血糖和降血脂的活性,为乳酸菌发酵刺梨制品的体外功能性评价和发酵菌种筛选研究提供了依据。

关键词：刺梨汁乳酸菌发酵体外降血糖体外降血脂

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Daily power demand prediction for buildings at a large scale using a hybrid of physics-based model and generative adversarial network

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Building Simulation 2022年第9期15卷 1685-1701页

作者： Chenlu Tian yunyang Ye Yingli Lou Wangda zuo Guiqing Zhang Chengdong Li Shandong Key Laboratory of Intelligent Building Technology School of Information and Electrical EngineeringShandong Jianzhu UniversityJinan 250101China Pacific Northwest National Laboratory RichlandWA 99354USA Department of Civil Environmental and Architectural EngineeringUniversity of Colorado BoulderBoulderCO 80309USA

Power demand prediction for buildings at a large scale is required for power grid *** bottom-up prediction method using physics-based models is popular,but has some limitations such as a heavy workload on model creation and long computing ***-down methods based on data driven models are fast,but less *** the similarity of power demand patterns of single buildings and the superiority of generative adversarial network(GAN),this paper proposes a new method(E-GAN),which combines a physics-based model(EnergyPlus)and a data-driven model(GAN),to predict the daily power demand for buildings at a large *** new E-GAN method selects a small number of typical buildings and utilizes EnergyPlus models to predict their power *** the prediction for those typical buildings,the GAN then is adopted to forecast the power demands of a large number of *** verify the proposed method,the E-GAN is used to predict 24-hour power demands for a set of residential *** results show that(1)4.3%of physics-based models in each building category are required to ensure the prediction accuracy;(2)compared with the physics-based model,the E-GAN can predict power demand accurately with only 5%error(measured by mean absolute percentage error,MAPE)while using only approximately 9%of the computing time;and(3)compared with data-driven models(e.g.,support vector regression,extreme learning machine,and polynomial regression model),E-GAN demonstrates at least 60%reduction in prediction error measured by MAPE.

关键词： large-scale simulation power demand generative adversarial networks building energy model

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Evaluating the energy impact potential of energy efficiency measures for retrofit applications:A case study with *** office buildings

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Building Simulation 2021年第5期14卷 1377-1393页

作者： yunyang Ye Kathryn Hinkelman Yingli Lou Wangda zuo Gang Wang Jian Zhang Pacific Northwest National Laboratory RichlandWA 99354USA Department of Civil Environmental and Architectural EngineeringUniversity of Colorado BoulderBoulderCO 80309USA National Renewable Energy Laboratory GoldenCO 80401USA Civil Architectural and Environmental Engineering DepartmentUniversity of MiamiCoral GablesFL 33146USA

Quantifying the energy savings of various energy efficiency measures(EEMs)for an energy retrofit project often necessitates an energy audit and detailed whole building energy modeling to evaluate the EEMs;however,this is often cost-prohibitive for small and medium *** order to provide a defined guideline for projects with assumed common baseline characteristics,this paper applies a sensitivity analysis method to evaluate the impact of individual EEMs and groups these into packages to produce deep energy savings for a sample prototype medium office building across 15 climate zones in the United *** start with one baseline model for each climate zone and nine candidate EEMs with a range of efficiency levels for each *** energy performance indicators(EPIs)are defined,which are annual electricity use intensity,annual natural gas use intensity,and annual energy ***,a Standard Regression Coefficient(SRC)sensitivity analysis method is applied to determine the sensitivity of each EEM with respect to the three EPIs,and the relative sensitivity of all EEMs are calculated to evaluate their energy *** the selected range of efficiency levels,the results indicate that the EEMs with higher energy impacts(i.e.,higher sensitivity)in most climate zones are high-performance windows,reduced interior lighting power,and reduced interior plug and process ***,the sensitivity of the EEMs also vary by climate zone and EPI;for example,improved opaque envelope insulation and efficiency of cooling and heating systems are found to have a high energy impact in cold and hot climates.

关键词： energy impact evaluation energy efficiency measure medium office energy retrofit

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乳酸菌强化发酵对刺梨果醋风味品质的影响

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食品与发酵科技 2022年第2期58卷 22-30页

作者：石媛媛胡萍张珺冯丹丹李娟吴文燕左云洋李久长贵州大学酿酒与食品工程学院贵州贵阳550025

以刺梨汁为主要原料,通过液态发酵的方式,将酵母菌分别搭配三株不同乳酸菌(鼠李糖乳杆菌H3、副干酪乳杆菌SR10-1、植物乳杆菌LP)进行混菌酒精发酵,再接种巴士醋杆菌进行醋酸发酵制备刺梨果醋。为了探究乳酸菌强化发酵对刺梨果醋风味品... 详细信息

以刺梨汁为主要原料,通过液态发酵的方式,将酵母菌分别搭配三株不同乳酸菌(鼠李糖乳杆菌H3、副干酪乳杆菌SR10-1、植物乳杆菌LP)进行混菌酒精发酵,再接种巴士醋杆菌进行醋酸发酵制备刺梨果醋。为了探究乳酸菌强化发酵对刺梨果醋风味品质的影响,采用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS),分析不同乳酸菌强化发酵刺梨果醋挥发性风味物质组成及理化指标的差异。结果表明,酵母菌发酵组与乳酸菌强化发酵组差异明显。从4组刺梨果醋样品中共检测出49种挥发性风味物质,其中酵母菌组有30种、鼠李糖乳杆菌H3组有41种、副干酪乳杆菌SR10-1组有37种、植物乳杆菌LP组有41种,各组共有挥发性物质22种,分别含有0种、2种、1种和5种特有挥发性物质,挥发性风味物质的总质量浓度高低依次为:鼠李糖乳杆菌H3组>植物乳杆菌LP组>副干酪乳杆菌SR10-1组>酵母菌组,乳酸菌强化组的挥发性风味物质种类和含量明显高于酵母菌组,其醇类、醛类和烃类总质量浓度减少,酸类和酯类总质量浓度有所增加,且乳酸菌强化组中总酸、乳酸、总黄酮、总多酚含量和SOD活力均高于酵母菌组,说明接种乳酸菌强化发酵不仅能有效保留刺梨果醋的营养物质,还有利于促进挥发性风味物质的形成,增加风味物质的种类和含量,提升产品风味品质和营养价值。

关键词：乳酸菌刺梨果醋顶空固相微萃取-气相色谱-质谱联用技术挥发性风味物质品质

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Dynamic changes of HBV DNA in serum and peripheral blood mononuclear cells of chronic hepatitis patients after lamivudine treatment

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World Journal of Gastroenterology 2006年第25期12卷 4061-4063页

作者： Chang-Zheng Ke Yue Chen zuo-Jiong Gong Zhong-Ji Meng Li Liu Ze-Jiu Ren zuo-Hua Zhou Department of Infectious Diseases Taihe Hospital Affiliated to Yunyang Medical College Shiyan 442000 Hubei Province China Department of Infectious Diseases Renmin Hospital Affiliated to Wuhan University Wuhan 430060 Hubei Province China Clinical Laboratory Taihe Hospital Affiliated to Yunyang Medical College Shiyan 442000 Hubei Province China

AIM： To study the dynamic changes of hepatits B virus （HBV） DNA in serum and peripheral blood mononuclear cells （PBMCs） of patients after lamivudine therapy. METHODS： A total of 72 patients with chronic HBV infection were included in this study. All patients were confirmed to have the following conditions： above 16 years of age, elevated serum alanine amonotransferase （ALT）, positive hepatitis B e antigen （HBeAg）, positive HBV DNA in serum and PBMCs, negative antibodies against HAV, HCV, HDV, HEV. Other possible causes of chronic liver damages, such as drugs, alcohol and autoimmune diseases were excluded. Seventy-two cases were randomly divided into lamivudine treatment group （n = 42） and control group （n = 30）. HBV DNA was detected both in serum and in PBMCs by fluorescence quantitative polymerase chain reaction （PCR）, during and after lamivudine treatment. RESULTS： In the treatment group, HBV DNA became negative both in serum and in PBMC, of, 38 and 25 out of 42 cases respectively during the 48 wk oflamivudine treatment, the negative rate was 90.5% and 59.5% respectively. In the control group, the negative rate was 23.3% and 16.7% respectively. It was statistically significant at 12, 24 and 48 wk as compared with the control group （P 〈 0.005）. The average conversion period of HBV DNA was 6 wk （2-8 wk） in serum and 16 wk （8-24 wk） in PBMC.CONCLUSION： Lamivudine has remarkable effects on HBV replication both in serum and The inhibitory effect on HBV DNA in PBMCs than that in serum inhibitory in PBMCs. is weaker

关键词： Lamivudine Hepatitis B virus DNA Peripheral blood mononuclear cells

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A novel myeloma cell line identified for multidrug resistant study

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The Chinese-German Journal of Clinical Oncology 2009年第5期8卷 296-299页

作者： Hui Xiao Qi Xiao Kejian Zhang Xuelan zuo Department of Hematology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Internal Medicine Yanqiao Hospital of Yunyang Medical College Shiyan 442000 China

Objective:To find out how to overcome resistance during multiple myeloma(MM) treatment through establishing a multidrug resistant human multiple myeloma cell line and investigating its biological ***:The parent cell line MOLP-2 was exposed to different concentrations of melphalan and a melphalan-resistant cell line MOLP-2/R was identified by continuous stepwise *** cell morphology and growth curves were *** levels of P-gp, MRP and FANCD2 monoubiquitination were checked by Western *** IC50 of melphalan and resistance index(RI) were detected by MTT ***:A melphalan-resistant cell line MOLP-2/R was finally *** RI of MOLP-2/R cells to melphalan was *** melphalan it was cross resistant to other chemotherapeutic agents, including ADM, CTX, DDP and *** multiplication time was postponed(P < 0.05).Studies showed that FANCD2 protein monoubiquitination was enhanced, but the levels of P-gp and MRP expressions in the MOLP-2/R cells were similar with the parent ***:MOLP-2/R cell line may serve as an ideal model for exploring the mechanism of ***-expression of FANCD2 protein monoubiquitination might contribute to acquired drug resistance in MOLP-2/R cell line.

关键词： multiple myeloma (MM) FANCD2 drug resistance, multiple

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