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Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 568-580页

作者： Hao ZHANG Xinshu WANG Bo HU Peicheng LI Yierfan ABUDUAINI Hongmei ZHAO Ayinaer JIEENSIHAN Xishuang CHEN Shiyu WANG Nuojin GUO Jian YUAN Yunhui LI Lei LI yuntong yang Zhongmin LIU Zhaosheng TANG Hua WANG Department of Endocrinology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China Research Center for Translational Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China Department of Cardiology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China Department of Biochemistry and Molecular Biology School of MedicineTongji UniversityShanghai 200331China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai East HospitalShanghai 200120China Ji’an Hospital Shanghai East HospitalJi’an 343000China

diabetes mellitus(DM)is a disease syndrome characterized by chronic hyperglycaemia.A long-term high-glucose environment leads to reactive oxygen species(ROS)production and nuclear DNA *** umbilical cord mesenchymal stem cell(HUcMSC)infusion induces significant antidiabetic effects in type 2 diabetes mellitus(T2DM)***-like growth factor 1(IGF1)receptor(IGF1R)is important in promoting glucose metabolism in diabetes;however,the mechanism by which HUcMSC can treat diabetes through IGF1R and DNA damage repair remains *** this study,a DM rat model was induced with high-fat diet feeding and streptozotocin(STZ)administration and rats were infused four times with *** glucose,interleukin-6(IL-6),IL-10,glomerular basement membrane,and renal function were *** that interacted with IGF1R were determined through coimmunoprecipitation *** expression of IGF1R,phosphorylated checkpoint kinase 2(p-CHK2),and phosphorylated protein 53(p-p53)was examined using immunohistochemistry(IHC)and western blot ***-linked immunosorbent assay(ELISA)was used to determine the serum levels of 8-hydroxydeoxyguanosine(8-OHdG).Flow cytometry experiments were used to detect the surface markers of *** identification of the morphology and phenotype of HUcMSC was performed by way of oil red“O”staining and Alizarin red *** rats exhibited abnormal blood glucose and IL-6/10 levels and renal function changes in the glomerular basement membrane,increased the expression of IGF1 and ***1R interacted with CHK2,and the expression of p-CHK2 was significantly decreased in IGF1R-knockdown *** cisplatin was used to induce DNA damage,the expression of p-CHK2 was higher than that in the IGF1R-knockdown group without cisplatin *** infusion ameliorated abnormalities and preserved kidney structure and function in DM *** expression of IGF1,IGF1R,p-CHK2,and p-p53,and the level of 8-OHdG in the DM group increased sign

关键词： Insulin-like growth factor 1 receptor(IGF1R) Checkpoint kinase 2(CHK2) Protein 53(p53) Diabetes mellitus Human umbilical cord mesenchymal stem cell(HUcMSC) DNA damage repair

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低含水油水两相流等效介电常数模型

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测井技术 2024年第3期48卷 308-316页

作者：曲婧慧刘兴斌刘冬梅邓宇恒刘大勇杨韵桐东北石油大学物理与电子工程学院黑龙江大庆163318 中国国际工程咨询有限公司国际业务部北京100048 中国石油集团测井有限公司华北分公司河北沧州016000

电容法测油水两相流含水率在油田的地面油水计量及井中的产出剖面分层测试中都得到广泛应用。持水率(水相体积分数)的测量需要建立油水两相流持水率与传感器电容的关系,为此需要建立混相等效介电常数与持水率的理论模型或经验模型。由... 详细信息

电容法测油水两相流含水率在油田的地面油水计量及井中的产出剖面分层测试中都得到广泛应用。持水率(水相体积分数)的测量需要建立油水两相流持水率与传感器电容的关系,为此需要建立混相等效介电常数与持水率的理论模型或经验模型。由于油井采出的地层水以及地面实验室标定所用的自来水在低频和中频时均具有良好导电性,因此,单纯考虑介电性而不考虑导电性会对持水率测量的准确性产生显著影响。基于电介质极化的有效电场理论,在低含水且油水状态为精细泡状流条件下,将水视为良导体,建立了油水两相流等效介电常数模型。按此模型,油水两相流的等效介电常数只取决于持水率和油相介电常数,与水相介电常数以及水相电导率无关,初步实验验证了模型正确。该研究对于油为连续相时油水两相流的含水率传感器的设计和现场应用具有重要意义。

关键词：油水两相流电容持水率计持水率有效电场等效介电常数

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Rhodium-catalyzed addition reactions of benzylic C–H bonds to cyclic N-sulfonyl ketimines viaπ-coordination

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Chinese Chemical Letters 2024年第3期35卷 287-291页

作者： yuntong Li Hang Shi Department of Chemistry Zhejiang UniversityHangzhou 310027China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and ***,the inclusion of alkylarenes instead of active carbon pronucleophiles such as aldehydes and ketones in these addition reactions has been a challenge due to the inherent difficulty of benzylic *** this study,we present a novel approach for the construction of N-sulfonyl amines via rhodium-catalyzed addition of unbiased benzylic C–H bonds to cyclic N-sulfonyl ketamines throughπ-*** strategy enables the synthesis of a diverse range of N-sulfonyl amines,and subsequent diversification of the addition products showcases the synthetic potential of this protocol.

关键词： Benzylic deprotonation Cyclic N–sulfonyl ketimines π-Coordination Mannich-type addition Rhodium catalysis

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Stability analysis of a liquid crystal elastomer self-oscillator under a linear temperature field

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 337-354页

作者： Haiyang WU Jiangfeng LOU Biao ZHANG yuntong DAI Kai LI School of Civil Engineering Anhui Jianzhu UniversityHefei 230601China

Self-oscillating systems abound in the natural world and offer substantial potential for applications in controllers,micro-motors,medical equipments,and so ***,numerical methods have been widely utilized for obtaining the characteristics of self-oscillation including amplitude and ***,numerical methods are burdened by intricate computations and limited precision,hindering comprehensive investigations into self-oscillating *** this paper,the stability of a liquid crystal elastomer fiber self-oscillating system under a linear temperature field is studied,and analytical solutions for the amplitude and frequency are ***,we establish the governing equations of self-oscillation,elucidate two motion regimes,and reveal the underlying ***,we conduct a stability analysis and employ a multi-scale method to obtain the analytical solutions for the amplitude and *** results show agreement between the multi-scale and numerical *** research contributes to the examination of diverse self-oscillating systems and advances the theoretical analysis of self-oscillating systems rooted in active materials.

关键词： self-oscillation stability analysis multi-scale method liquid crystal elastomer linear temperature field

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An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie Tang Shengjun Sun Xun He Hui Zhang Chaoxin yang Min Zhang Meng Yue Hefeng Wang yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun Huiqing Wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

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An Improved CREAM Model Based on DS Evidence Theory and DEMATEL

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2597-2617页

作者： Zhihui Xu Shuwen Shang yuntong Pu Xiaoyan Su Hong Qian Xiaolei Pan State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen518172China School of Automation Engineering Shanghai University of Electric PowerShanghai200090China School of Safety and Management Engineering Hunan Institute of TechnologyHengyang421002China

Cognitive Reliability and Error Analysis Method(CREAM)is widely used in human reliability analysis(HRA).It defines nine common performance conditions(CPCs),which represent the factors thatmay affect human reliability and are used to modify the cognitive failure probability(CFP).However,the levels of CPCs are usually determined by domain experts,whichmay be subjective and ***’smore,the classicCREAMassumes that the CPCs are independent,which is *** the dependence among CPCs will result in repeated calculations of the influence of the CPCs on CFP and lead to unreasonable reliability *** address the issue of uncertain information modeling and processing,this paper introduces evidence theory to evaluate the CPC levels in specific *** address the issue of dependence modeling,the Decision-Making Trial and Evaluation Laboratory(DEMATEL)method is used to process the dependence among CPCs and calculate the relative weights of each CPC,thus modifying the multiplier of the *** detailed process of the proposed method is illustrated in this paper and the CFP estimated by the proposed method is more reasonable.

关键词： Human reliability analysis CREAM uncertainty modeling dependence Dempster-Shafer evidence theory DEMATEL

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Co-doped Ni_(3)S_(2) nanosheet array: A high-efficiency electrocatalyst for alkaline seawater oxidation

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Nano Research 2024年第3期17卷 1050-1055页

作者： Meng Yue Xun He Shengjun Sun yuntong Sun Mohamed S.Hamdy Mhamed Benaissa Alsamani A.M.Salih Jun Liu Xuping Sun College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemical Engineering College of EngineeringUniversity of Ha’ilP.O.Box 2440Ha’il 81441Saudi Arabia Department of Otolaryngology-Head&Neck Surgery West China HospitalSichuan UniversityChengdu 610041China

Developing efficient and durable oxygen evolution reaction(OER)catalysts holds great promise for green hydrogen production via seawater electrolysis,but remains a ***,we report a Co-doped Ni_(3)S_(2) nanosheet array on Ni foam(Co-Ni_(3)S_(2)/NF)as a high-efficiency OER electrocatalyst for *** alkaline conditions,Co-Ni_(3)S_(2)/NF requires an overpotential of only 368 mV to drive 100 mA·cm^(–2),superior to Ni_(3)S_(2)/NF(385 mV).Besides,it exhibits at least 50-h continuous electrolysis.

关键词： Co doping Ni_(3)S_(2)nanosheet array oxygen evolution reaction seawater electrolysis electrocatalyst

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低产液高含水油气水三相流气液分离装置设计及分离效率研究

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石油管材与仪器 2019年第3期5卷 6-10页

作者：杨韵桐东北石油大学电子科学学院燕山大学信息科学与工程学院

油田开发中油气水三相流共存是普遍存在的现象,由于气相的干扰,使原有测量两相流的仪器不能满足多相流测量精度的要求。为了解决油井井下油气水三相流流量测量精度低的问题,设计了低产液高含水条件下,井下气液分离装置的物理模型。在此... 详细信息

油田开发中油气水三相流共存是普遍存在的现象,由于气相的干扰,使原有测量两相流的仪器不能满足多相流测量精度的要求。为了解决油井井下油气水三相流流量测量精度低的问题,设计了低产液高含水条件下,井下气液分离装置的物理模型。在此基础上,构建了气液分离装置模型。利用Fluent模拟仿真软件对模型进行数值模拟,得到20~60m^3/d流量下气液分离的效率,仿真结果显示该模型气液分离效率高,具有很高的可行性。设计的气液分离装置为整体实验样机设计制作奠定了理论基础。

关键词：气液分离油气水三相流分离效率数值模拟

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重构政治社会:洛克式政府的有限道德责任及其繁荣目标

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江西师范大学学报（哲学社会科学版） 2024年第3期57卷 77-85页

作者：吴允通中共江西省委党校哲学教研部江西南昌330108

洛克的政治理论建立在道德哲学基础之上,他认为个体在自然状态中具有完全道德责任,而进入政治共同体以后只负有限制性道德责任。贯穿这一推理的指导思想是“权利导致权力”,在道德哲学层面则表述为概然性的政治权力基于必然性的道德权... 详细信息

洛克的政治理论建立在道德哲学基础之上,他认为个体在自然状态中具有完全道德责任,而进入政治共同体以后只负有限制性道德责任。贯穿这一推理的指导思想是“权利导致权力”,在道德哲学层面则表述为概然性的政治权力基于必然性的道德权利。这一思想的产生得益于洛克对“社会性”与“政治”同构传统的破除,转而对社会性做道德化理解,对政治做功能化理解。政治自由因此被认为是对道德自由的偶然性限定,它代表的是对某种共同善的追求。财产是这一偶然性限定的表征,它是个体理性与意志主动外化的产物,个体在这一外化过程中成为道德主体。基于此,洛克认为,政治共同体的使命就是保护财产权、促进社会繁荣。

关键词：约翰·洛克道德政治共同体自然法社会性

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基于多属性群决策层次分析的POPs污染处理技术评价模型研究

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计算机与应用化学 2016年第2期33卷 218-222页

作者：张启伦杨韵桐东北石油大学电子科学学院黑龙江大庆163000

为了准确评估POPs污染处理技术优劣程度,提出一种基于多属性群决策层次分析法的POPs污染处理技术优劣评价模型。首先,详细分析了评价POPs污染处理技术优劣的指标因素,建立了综合评价指标体系;其次,通过计算专家评价矩阵间的相似度和差... 详细信息

为了准确评估POPs污染处理技术优劣程度,提出一种基于多属性群决策层次分析法的POPs污染处理技术优劣评价模型。首先,详细分析了评价POPs污染处理技术优劣的指标因素,建立了综合评价指标体系;其次,通过计算专家评价矩阵间的相似度和差异度得到专家信任度,聚合群体专家意见形成共识矩阵并得到各指标权重值;同时,引入最大隶属度原则的有效度,提出采用级别特征值公式和置信度准则确保了POPs污染处理技术优劣评估结果的可靠性。最后以实际案例进行技术优劣评估。结果表明了模型合理可靠,能准确判断优劣级别。

关键词：相似度聚合共识矩阵模糊综合评价群决策层次分析法

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