检索结果-南通市图书馆

Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer:a clinical and translational study

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第2期18卷 357-374页

作者： Haoyu Wang Zhengyuan Wang Zheng Wang Xiaoyang li yuntong li Ni Yan lili Wu Ying liang Jiale Wu Huaxin Song Qing Qu Jiahui Huang Chunkang Chang Kunwei Shen Xiaosong Chen Min Lu Department of General Surgery Comprehensive Breast Health CenterRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200025China

p53 is mutated in half of cancer ***,no p53-targeting drugs have been ***,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor *** a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV *** the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type *** a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type *** the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with *** integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

基于数学物理模拟和高温测速的拉速对吹氩结晶器流场行为的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

炼钢 2024年第5期40卷 69-80页

作者：杨泽宇杨健李贇通林芷清上海大学材料科学与工程学院省部共建高品质特殊钢冶金与制备国家重点实验室上海200444

通过结晶器的流场优化可以降低连铸坯的炼钢缺陷,从而提高汽车外板的表面质量。结合数值模拟、水模拟和高温定量测速3种手段研究了拉速对结晶器流场的影响。研究结果表明,随着拉速提高,结晶器1/4宽度附近的表面流速增大,数值模拟、水模... 详细信息

通过结晶器的流场优化可以降低连铸坯的炼钢缺陷,从而提高汽车外板的表面质量。结合数值模拟、水模拟和高温定量测速3种手段研究了拉速对结晶器流场的影响。研究结果表明,随着拉速提高,结晶器1/4宽度附近的表面流速增大,数值模拟、水模拟和高温定量测速的结果吻合良好。在结晶器断面尺寸为1190 mm×230 mm,氩气流量为8 L/min,水口浸入深度为170 mm时,随着拉速从1.2 m/min增加至1.3、1.4、1.5、1.6 m/min,结晶器流场的流动形态均为双循环流,结晶器窄面附近和1/4宽度附近的钢液从窄面向水口方向流动,水口附近的钢液从水口向外流动。随着拉速增大,窄面附近和1/4宽度附近的表面流速逐渐增大,水口附近的表面流速逐渐减小。此外,窄面附近和1/4宽度附近的液面波动都逐渐增大,容易形成气泡卷渣。因此应根据连铸生产中汽车外板的质量要求,将拉速控制在一个合理的范围内。

关键词：连铸结晶器流场数值模拟水模拟高温定量测速

同方期刊数据库

石化行业烧焦过程二氧化碳排放量核算方法研究

在线全文

学校读者我要写书评

暂无评论

环境影响评价 2024年第2期46卷 14-18,36页

作者：牛皓李昀潼范娜吴健超宋骞生态环境部环境工程评估中心北京100041 中石化广州工程有限公司广东广州510360 中国寰球工程有限公司北京分公司北京100029 北京飞燕石化环保科技发展有限公司北京102500

石化行业作为高耗能高排放行业,其碳排放量约占工业行业总碳排放量的五分之一,核算石化行业的碳排放量对整个工业行业的碳减排具有举足轻重的作用。基于催化装置和重整装置烧焦过程的碳排放情况,采用现行的多种碳排放量核算方法进行数... 详细信息

石化行业作为高耗能高排放行业,其碳排放量约占工业行业总碳排放量的五分之一,核算石化行业的碳排放量对整个工业行业的碳减排具有举足轻重的作用。基于催化装置和重整装置烧焦过程的碳排放情况,采用现行的多种碳排放量核算方法进行数据对比,分析结果表明:在建设项目设计阶段,催化剂质量平衡法与装置碳质量平衡法计算出的碳排放量基本一致,排放因子法计算结果差别较大;运行阶段,催化剂质量平衡法和烟气监测法计算出的碳排放量误差范围为3%~17%。另外,建议后续技术成熟阶段,开展催化裂化装置再生烟气中CO_(2)在线监测试点工作,并作为其排放量的核算依据。最后,提出建立建设项目和现有企业“双时空”催化剂烧焦过程CO_(2)排放核算体系,建设项目设计阶段CO_(2)排放量作为减污降碳管控、碳排放水平核算及对标的参考,现有企业CO_(2)排放量作为碳排放配额发放和碳市场履约的依据的建议。

关键词：石化行业烧焦过程碳排放量核算方法

工科类院校高等数学教学改革探索——基于工程案例与数学文化视角

在线全文

学校读者我要写书评

暂无评论

镇江高专学报 2024年第1期37卷 112-114,124页

作者：赵增逊孙文青李兵方李运通陕西铁路工程职业技术学院(学生处) 陕西渭南714000 陕西铁路工程职业技术学院基础课部陕西渭南714000 陕西铁路工程职业技术学院国有资产管理处陕西渭南714000 陕西铁路工程职业技术学院信息化与网络安全处陕西渭南714000

工科类院校高等数学教学存在专业衔接有空缺、教材内容不完善、学生基础不均衡、课堂效果不理想等问题,结合学校特点,融合工程案例、数学文化、数学建模等教学内容,体现高等数学的应用、文化、思维、思想价值,推行应用性考核模式,可以... 详细信息

工科类院校高等数学教学存在专业衔接有空缺、教材内容不完善、学生基础不均衡、课堂效果不理想等问题,结合学校特点,融合工程案例、数学文化、数学建模等教学内容,体现高等数学的应用、文化、思维、思想价值,推行应用性考核模式,可以提升专业服务水平。

关键词：高等数学工程案例数学文化

Stability analysis of a liquid crystal elastomer self-oscillator under a linear temperature field

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 337-354页

作者： Haiyang WU Jiangfeng LOU Biao ZHANG yuntong DAI Kai li School of Civil Engineering Anhui Jianzhu UniversityHefei 230601China

Self-oscillating systems abound in the natural world and offer substantial potential for applications in controllers,micro-motors,medical equipments,and so ***,numerical methods have been widely utilized for obtaining the characteristics of self-oscillation including amplitude and ***,numerical methods are burdened by intricate computations and limited precision,hindering comprehensive investigations into self-oscillating *** this paper,the stability of a liquid crystal elastomer fiber self-oscillating system under a linear temperature field is studied,and analytical solutions for the amplitude and frequency are ***,we establish the governing equations of self-oscillation,elucidate two motion regimes,and reveal the underlying ***,we conduct a stability analysis and employ a multi-scale method to obtain the analytical solutions for the amplitude and *** results show agreement between the multi-scale and numerical *** research contributes to the examination of diverse self-oscillating systems and advances the theoretical analysis of self-oscillating systems rooted in active materials.

关键词： self-oscillation stability analysis multi-scale method liquid crystal elastomer linear temperature field

Transcriptome Sequencing and de novo Analysis for Oviductus Ranae of Rana chensinensis Using Illumina RNA-Seq Technology

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2013年第3期40卷 137-140页

作者： Mei Zhang yuntong li Baojin Yao Minying Sun Zhiwu Wang Yu Zhao Center for New Medicine Research Changchun University of Chinese Medicine School of Public Health Jilin University

Oviductus Ranae is the dried oviduct of female Rana tem-poraria chensinensis （David）, distributed mainly in North- eastern China. Oviductus Ranae is one of the best-known and highly valued oriental foods and medicines. Traditional Chinese medicine holds that Oviductus Ranae can nourish yin, moisten lung and replenish the kidney essence. Meanwhile, activities of Oviductus Ranae such as anti-aging, anti-lipemic, anti-oxidation and anti-fatigue have also been demonstrated by modern phar-macological studies. Previous studies have shown that Oviductus Ranae is mainly composed of proteins, which are up to 50% or more.

关键词： Transcriptome Sequencing and de novo Analysis for Oviductus Ranae of Rana chensinensis Using Illumina RNA-Seq Technology RNA

Value of Non-tumoral liver Volume in the Prognosis of Large Hepatocellular Carcinoma Patients After R0 Resection

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第3期11卷 560-571页

作者： Dongliang Zuo yuntong li Hongzhi liu Dongxu liu Qinliang Fang Pengtao li liang Tu Yu Xiong Yongyi Zeng Pingguo liu Department of Zhongshan Hospital of Xiamen University School of MedicineXiamen UniversityXiamenFujianChina Department of Hepatobiliary Surgery Zhongshan Hospital Xiamen UniversityXiamenFujianChina Department of Hepatobiliary Surgery Mengchao Hepatobiliary Surgery Hospital of Fujian Medical UniversityFuzhouFujianChina Public Health Clinical Center of Chengdu ChengduSichuanChina

Background and Aims:Hepatectomy is an effective treatment for selected patients with large hepatocellular carcinoma(HCC).This study aimed to develop a nomogram in-corporating non-tumoral liver volume(non-TLV)and liver function markers to predict the patients’overall survival(OS)and disease-free survival(DFS).Methods:Data of 198 consecutive large HCC patients who underwent hepa-tectomy at the Zhongshan Hospital Xiamen University were *** 68 patients from the Mengchao Hepatobil-iary Surgery Hospital served as an external validation *** nomograms were developed based on the independent prognostic factors screened by multivariate Cox regression *** index(C-index),calibration curves,and time-dependent receiver operating characteristic(ROC)curves were used to measure the discrimination and predic-tive accuracy of the ***:High HBV DNA level,low non-TLV/ICG,vascular invasion,and a poorly differenti-ated tumor were confirmed as independent risk factors for both OS and *** model established in this study pre-dicted 5-year post-operative survival and DFS in good agree-ment with the actual observation confirmed by the calibra-tion *** C-indexes of the nomograms in predicting OS and DFS were 0.812 and 0.823 in the training cohort,0.821 and 0.846 in the internal validation cohort,and 0.724 and 0.755 in the external validation *** areas under the ROC curves(AUCs)of nomograms for predicted OS and DFS at 1,3,and 5 year were 0.85,0.86,0.83 and 0.76,0.76,0.63,***:Nomograms with non-TLV/ICG predicted the prognosis of single large HCC patients ac-curately and effectively.

关键词： Hepatocellular carcinoma Hepatectomy Prognosis Nomogram

LRC渐进协作教学体系在眼科培训中的设计与实践

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

眼科学报 2024年第5期39卷 259-265页

作者：胡安娣娜赵秀娟余曦灵李云彤魏雁涛丁小燕中山大学中山眼科中心眼病防治全国重点实验室广东省眼科视觉科学重点实验室广州510060

目的:以提升进行住院医师规范化培训(住培)的眼科医生临床诊疗思维能力为导向,建立LRC渐进协作教学体系(LRC Stepwise Collaborative Learning Model)。方法:2023年7月—2023年12月,以26名进行眼科住培的医生为试验组的研究对象,采用小... 详细信息

目的:以提升进行住院医师规范化培训(住培)的眼科医生临床诊疗思维能力为导向,建立LRC渐进协作教学体系(LRC Stepwise Collaborative Learning Model)。方法:2023年7月—2023年12月,以26名进行眼科住培的医生为试验组的研究对象,采用小讲课(Lecture)、教学查房(Rounds)及病例讨论(Case discussion)的LRC渐进协作教学体系,通过定量分析方法评估教学效果。结果:实施LRC渐进协作教学模式后,住培医生平均成绩由培训前的50.00(40,50)分提高至培训后的90.00(80,100)分,差异具有统计学意义(P<0.001)。问卷调查满分5分,小讲课、教学查房和病例讨论三种教学形式的满意度满分比例分别为92.3%(24/26),84.6%(22/26)、76.9%(20/26),三种教学形式的满意评分分别为5.00(5.00,5.00)、5.00(5.00,5.00)、5.00(4.75,5.00)分。结论:LRC渐进协作教学体系作为住培教学新体系,得到眼科住培医生的认可,促进临床诊疗思维的整体提升,有助于岗位胜任力的培养,为未来教学模式的设计与实施提供了重要参考。

关键词：眼科学眼底病 LRC渐进协作教学体系住院医师规范化培训

Integrative analysis of transcriptome reveals the possible mechanism of delayed leaf senescence in pak choi(Brassica rapa ***)following melatonin treatment

在线全文

学校读者我要写书评

暂无评论

Food Quality and Safety 2023年第1期7卷 87-99页

作者：刘雪松李韫同朱俊臻李鹏霞 Institute of Agricultural Facilities and Equipment Jiangsu Academy of Agricultural SciencesNanjingChina Key Laboratory of Cold Chain Logistics Technology for Agro-Products Ministry of Agriculture and Rural AffairsChina Department of Food Science Shenyang Agricultural UniversityShenyangChina School of Food and Biological Engineering Jiangsu UniversityZhenjiangChina Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement NanjingChina

Melatonin(MT)is a low molecular weight compound with a wide variety of biological functions in *** is known to delay senescence in various fruits and *** study demonstrates that MT(100μmol/L)delayed the senescence of pak choi stored at 20°C.A total of 1121 differentially expressed genes(DEGs)were identified in an MT-treated group in comparison to untreated pak *** of DEGs revealed that MT-induced delay in senescence involved reduction in the expression of chlorophyll metabolism genes and regulation of the expression of hormone-related genes and leaf senescence-related transcription *** decreased the activity of chlorophyll metabolism-related enzymes Mg-dechelatase,pheophytinase,and pheide a oxygenase,decreased the concentrations of abscisic acid and jasmonic acid,and increased auxin *** delayed the impact of senescence-related transcription factors BcNAC41 and BcNAC87 on tobacco leaf *** study provides an insight into the molecular mechanisms of MT-induced delay of postharvest senescence in pak choi and confirms its potential as a preservation technique.

关键词： Pak choi melatonin transcriptome postharvest senescence