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Journal of Traditional Chinese Medicine 2024年第4期44卷 688-693页

作者： ZHU Xuan LOU An ZHU Keke ruan Mingyu Department of Science and Technology Hunan University of Chinese MedicineChangsha 410208China Department of prosthodontics Hunan University of Chinese Medicine Affiliated Dental HospitalChangsha 410005China Department of Stomatology the First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021China School of Medicine Hunan University of Chinese MedicineChangsha 410208China

OBJECTIVE:To investigate the protective effect of the Chinese herbal formula of Jiedu Huayu decoction(解毒化瘀汤,JHD)on oral mucosa of rats with oral submucosal fibrosis(OSF)and its potential mechanism of ***:Sprague-Dawley male OSF model rats were constructed by injection of betaine and topical rubbing and were randomly grouped and administered by gavage for 4 *** opening and buccal mucosa scores interleukin levels and the expression of Axin andβ-catenin proteins or genes were measured before and after drug ***:After treatment with JHD the buccal mucosal lesions of rats were significantly reduced Axin protein and mRNA expression were significantly increasedβ-catenin protein and m RNA expression were significantly decreased interleukin-1βand interleukin-6 levels were decreased and interleukin-10 levels were ***:The mechanism of action of JHD can effectively alleviate the pathological damage of buccal mucosa in OSF rats which may be related to the promotion of Axin expression and inhibition ofβ-catenin expression.

关键词：解毒化瘀汤 Axin injection

Efficient V‑Shaped Substrate for Surface and Volume Enhanced Raman Spectroscopic Analysis of Bioaerosol:Prevention from Potential Health Risk

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Environment & Health 2024年第4期2卷 212-220页

作者： Juan Liu Yangyang Liu Yunyun Zhang Xuejun ruan Hanyun Cheng Qiuyue Ge Liwu Zhang Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science&EngineeringFudan UniversityShanghai 200433China Shanghai Institute of Pollution Control and Ecological Security Shangha 200092China Foriin Technology(Shanghai)Co. Ltd.Shanghai 200433China

Bioaerosols pose a great threat to human life and health,and developing highly efficient and accurate identification and analysis methodologies for bioaerosols provides prerequisite knowledge to evaluate their toxicity on human *** this paper,a rapid and economical method is proposed for the detection of bioaerosols based on surface-enhanced Raman scattering(SERS).The SERS substrate was prepared using an anodic aluminum oxide(AAO)template with an inverted conical(V-shaped)nanopore array structure that was subsequently deposited with Ag nanoparticles(AgNPs)through magnetron *** tailored nanostructure essentially enables the differentiated and efficient detection of Escherichia coli and Staphylococcus epidermidis health risks within 10 min,along with corresponding detection limits of 103 cells/mL and 104 cells/mL,***,by comparing the Raman spectrum of the two bacteria obtained from the plain plane deposited with the same AgNPs,the V-shaped nanopore array structure provides a more robust enhancement effect in the Raman signal relative to the ordinary *** importantly,the applicability of developed AgNPs@V-shaped AAO SERS substrate was validated using ambient bioaerosols,thus emphasizing the great potential of the application of SERS-based technique for a cost-effective,rapid label-free and culture-free bioaerosol analysis without experiencing conventional time-consuming and laborious incubation processes.

关键词： SERS V-shaped AAO bacteria bioaerosol

Insight into Lithium–sulfur batteries performance enhancement: from metal nanoparticles to metal nanoclusters to single metal atoms

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Tungsten 2024年第3期6卷 504-521页

作者： Shuang Ma Qing-Ling ruan Xue-Cheng Liu Gui-Jun Zhu Die Yuan Ling-Qiao Hu Yu-Mei Huang Xing-Xing Gu Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and Resources Chongqing Technology and Business University National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University

Lithium-sulfur(Li-S) batteries have attracted much attention and developed rapidly in recent years due to their high energy density,low cost,and ***,its commercialization process still encounters various *** them,the sulfur cathode is easy to dissolve and shuttle,resulting in the loss of active substances and the severe growth of lithium anode dendrites,which is one of the biggest *** the redox conversion kinetics of sulfur cathode is expected to fundamentally alleviate the shuttle phenomenon of poly ***,this paper reviews the effects of metal nanoparticles to metal nanoclusters to metal single-atom catalysts on improving the redox of Li-S batteries,to let researchers better understand the size effect on the kinetics of sulfur cathodes in Li-S batteries,which will provide important guidance for the future large-scale commercialization of Li-S batteries.

关键词： Lithium–sulfur batteries Metal nanoparticles Metal nanoclusters Metal single atoms Size effects

The Maximum and Minimum Value of Exponential RandićIndices of Quasi-Tree Graph

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1804-1818页

作者： Lei Qiu Xijie ruan Yan Zhu School of Mathematics East China University of Science and Technology Shanghai China

The exponential Randić index has important applications in the fields of biology and chemistry. The exponential Randić index of a graph G is defined as the sum of the weights e 1 d( u )d( v ) of all edges uv of G, where d( u ) denotes the degree of a vertex u in G. The paper mainly provides the upper and lower bounds of the exponential Randić index in quasi-tree graphs, and characterizes the extremal graphs when the bounds are achieved.

关键词： Exponential Randić Index Quasi-Tree Graph Extremal Value Extremal Graphs

Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU Jin-yu GUO Hua ZHOU Hai-ying ruan Xia PENG Ying-chun SHEN Xue-fang XIONG Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation

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Oncology Research 2024年第4期32卷 625-641页

作者： WEN GE YA LI YUTING ruan NINGXIA WU PEI MA TONGPENG XU YONGQIAN SHU YINGWEI WANG WEN QIU CHENHUI ZHAO Department of Immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of Immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and *** investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to ***,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and ***,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all ***,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.

关键词： NSCLC cell migration and invasion IL-17 p300 STAT3 MMP19 Acetylation and phosphorylation

Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework

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Science China Chemistry 2024年第6期67卷 1983-1989页

作者： Wen Cui Wei-Wei Wu Ze-Yu ruan Yan-Cong Chen Guang-Jun Zeng Guan-Xi Chen Si-Guo Wu Zhao-Ping Ni Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou510275China

Spin-crossover(SCO)materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple ***,we reported a three-dimensional Hofmann-type metal-organic framework(MOF)[Fe(bpy){Pt(CN)_(4)}]·coumarin(1·coumarin,bpy=4,4′-bipyridine),which exhibits an incomplete and hysteretic SCO *** importantly,the light-induced stepped thermal relaxation(LISTR)with obvious magnetic plateau for a hidden intermediate spin state is firstly *** hidden spin state is also observed for the first time in the thermal relaxation after light-assisted spin state annealing(LASSA).Meanwhile,an extremely rare bi-directional light-induced excited spin-state trapping(LIESST)with the highest reverse-LIESST temperature is ***,five spin states can be captured in 1·coumarin and the tristability can be modulated below 102 K through the excitation-relaxation ***,the light-and temperatureinduced multistability provides a new strategy for developing multistable materials.

关键词： light magnetic multistability iron metal-organic framework spin-crossover

3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li Yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin Yang Xuesong Zhu Changshun ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

Analysis of plant resources and diversity in Balluk Mountain, Xinjiang Uygur Autonomous Region

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Asian Journal of Traditional Medicines 2024年第1期19卷 10-25页

作者： Minli ruan Anhua Wang Jingming Jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China University of Michigan Ann Arbor.930 N University AveAnn ArborMI 48109USA

Balluk Mountain is located between the Tianshan Mountains and the Altai Mountains in Xinjiang *** by the humid air and diverse landforms of Lake Alacuri,the unique climate of Mount Baluk nourishes excellent pastures and supports numerous wildlife,making it rich in plant *** 9th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team conducted field investigations,literature reviews,and specimen identification to study the plant resources and diversity of Balluk Mountain in Xinjiang Province.A total of 235 species of medicinal plants belonging to 59 families and 159 genera were collected during the period from July to August 2015 in this *** dominant families observed were Asteraceae,Caryophyllaceae,Lamiaceae,Ranunculaceae,Rosaceae and Umbelliferae,with 35,11,14,12,27,and 13 species *** families account for over 47.4%of the total species collected,though comprising only 10.2%of the total number of *** the genus level,Artemisia was found to be the most dominant genus with eight species,contributing to 0.63%of the total genera,while representing 3.4%of the total species ***,this study provides an updated analysis of the plant resources and diversity in Balluk *** species have been identified to possess significant medicinal properties and hold potential for various research fields,including natural product chemistry and drug *** study also offers practical and meaningful suggestions for strengthening the protection and utilization of plant resources in the *** implementing these suggestions,we can better preserve the plant diversity in Balluk Mountain and ensure the sustainable use of these valuable resources.

关键词： plant resources diversity medicinal use protection and utilization Balluk Mountain

基于强化学习的混合元启发式暂态电压稳定特征选择方法及可解释性研究

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电网技术 2024年第4期48卷 1519-1531,I0043页

作者：甄永赞阮程新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

新型电力系统发展背景下,使用有效的特征选择方法来提取与暂态电压稳定强相关的关键响应特征,对研究暂态电压失稳机理与系统潜在安全隐患具有重要意义。为此,提出一种基于改进过滤法与混合元启发式包装法的复合框架进行特征选择的新方... 详细信息

新型电力系统发展背景下,使用有效的特征选择方法来提取与暂态电压稳定强相关的关键响应特征,对研究暂态电压失稳机理与系统潜在安全隐患具有重要意义。为此,提出一种基于改进过滤法与混合元启发式包装法的复合框架进行特征选择的新方法。基于对称不确定性值改进的最大相关最小冗余性准则进行特征粗筛;将Q学习强化学习融合至元启发式优化算法中,并采用开发探索折衷策略以增强特征细选能力,获取最优关键响应特征子集。在此基础上,采用沙普利值加性解释归因理论综合分析各筛选特征对暂态电压稳定的影响与系统薄弱环节。新型电力系统算例验证了所提方法的有效性。

关键词：暂态电压稳定特征选择强化学习混合元启发式沙普利值加性解释