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Photonics Research 2024年第1期12卷 70-77页

作者： MENGDI LUO JISEN WEN PENGcHENG MA QIUYUAN SUN XIANMENG XIA GANGYAO ZHAN ZHENYAO YANG liang XU DAZHAO ZHU cUIFANG KUANG XU LIU Research center for Intelligent chips and Devices Zhejiang LabHangzhou 311100China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation center Hangzhou 311200China

Optical singularity is pivotal in nature and has attracted wide interest from many disciplines nowadays,including optical communication,quantum optics,and biomedical *** vortex lines formed by phase singularities and fabricating chiral nanostructures using the evolution of vortex lines are of great *** this paper,we introduce a promising method based on two-photon polymerization direct laser writing(2PP-DLW)to record the morphology of vortex lines generated by tightly focused multi-vortex beams(MVBs)at the *** to Gouy phase,the singularities of the MVBs rotate around the optical axis and move towards each other when approaching the focal *** propagation dynamics of vortex lines are recorded by 2PP-DLW,which explicitly exhibits the evolution of the phase ***,the MVBs are employed to fabricate stable three-dimensional chiral nanostructures due to the spiral-forward property of the vortex *** of the obvious chiral features of the manufactured nanostructures,a strong vortical dichroism is observed when excited by the light carrying orbital angular momentum.A number of applications can be envisioned with these chiral nanostructures,such as optical sensing,chiral separation,and information storage.

关键词： vortex chiral singularity

RAcK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis

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Journal of Integrative Plant Biology 2024年第5期66卷 956-972页

作者： Yajuan Fu Wei Zhu Yeling Zhou Yujing Su Zhiyong Li Dayan Zhang Dong Zhang Jinyu Shen Jiansheng liang Key Laboratory of Molecular Design for Plant cell Factory of Guangdong Higher Education Institutes Department of BiologySchool of Life SciencesInstitute of Plant and Food SciencesSouthern University of Science and TechnologyShenzhen 518055China

Plants deploy versatile scaffold proteins to intricately modulate complex cell *** these,RAcK1A(Receptors for Activated c Kinase 1A)stands out as a multifaceted scaffold protein functioning as a central integrative hub for diverse signaling ***,the precise mechanisms by which RAcK1A orchestrates signal transduction to optimize seedling development remain largely ***,we demonstrate that RAcK1A facilitates hypocotyl elongation by functioning as a flexible platform that connects multiple key components of light signaling ***1A interacts with PHYTOcHROME INTERAcTING FAcTOR(PIF)3,enhances PIF3 binding to the promoter of BBX11 and down-regulates its ***,RAcK1A associates with ELONGATED HYPOcOTYL 5(HY5)to repress HY5 biochemical activity toward target genes,ultimately contributing to hypocotyl *** darkness,RAcK1A is targeted by cONSTITUTIVELY PHOTOMORPHOGENIc(cOP)1 upon phosphorylation and subjected to cOP1-mediated degradation via the 26 S proteasome *** findings provide new insights into how plants utilize scaffold proteins to regulate hypocotyl elongation,ensuring proper skoto-and photo-morphogenic development.

关键词： Arabidopsis hypocotyl development light signaling components RAcK1 scaffoldprotein

Stay in touch with the endoplasmic reticulum

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Science china(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing cai Jose c.Pastor-Pareja liang Ge chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(McSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signals

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Zoological Research 2024年第1期45卷 13-24页

作者： Wei liang Kang Li Haiyou Gao Kunming Li Jiansong Zhang Qian Zhang Xinying Jiao Jialong Yang Xiumei Wei State Key Laboratory of Estuarine and coastal Research School of Life SciencesEast China Normal UniversityShanghai 200241China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China

Mammalian T-cell responses require synergism between the first signal and co-stimulatory ***,whether and how dual signaling regulates the T-cell response in early vertebrates remains *** the present study,we discovered that the Nile tilapia(Oreochromis niloticus)encodes key components of the LAT signalosome,namely,LAT,ITK,GRB2,VAV1,SLP-76,GADS,and PLc-γ*** components are evolutionarily conserved,and cD3εmAb-induced T-cell activation markedly increased their ***,at least ITK,GRB2,and VAV1 were found to interact with LAT for signalosome *** of the first signal,the NF-κB,MAPK/ERK,and PI3K-AKT pathways were activated upon cD3εmAb ***,treatment of lymphocytes with cD28 mAbs triggered the AKT-mTORc1 pathway downstream of the co-stimulatory *** cD3εand cD28 mAb stimulation enhanced ERK1/2 and S6 phosphorylation and elevated NFAT1,c-Fos,IL-2,cD122,and cD44 expression,thereby signifying T-cell ***,rather than relying on the first or co-stimulatory signal alone,both signals were required for T-cell *** T-cell activation was accompanied by marked apoptosis and cytotoxic *** findings suggest that tilapia relies on dual signaling to maintain an optimal T-cell response,providing a novel perspective for understanding the evolution of the adaptive immune system.

关键词： Oreochromis niloticus cD3 cD28 T cells Adaptive immunity Evolution

Insights from TARGET-seq:Inflammation drives TP53-mediated clonal evolution

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The Innovation 2024年第2期5卷 7-8页

作者： Yeqian Zhao Wenxuan Huo Yue liang Xiaodong Mo Shanshan Pei Yanmin Zhao Bone Marrow Transplantation center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Institute of Hematology Zhejiang UniversityHangzhou 311121China Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing 100044China

Approximately 10%–20%myeloproliferative neoplasms(MPNs)can progress into blast-phase MPNs,also termed secondary acute myeloid leukemias(sAMLs),presenting dismal *** exhibits a distinctive clinical and pathological profile compared to de novo AML,marked by a higher incidence of erythroid leukemias and reduced responsive to conventional chemotherapies,resulting in a median survival of approximately 6 ***53 alterations are prevalent adverse events in leukemic transformation(LT),occurring in around one-third of sAML subjects.

关键词： TP53 neoplasms alterations

Estimation of Peanut Maturity Using color Image Analysis

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American Journal of Plant Sciences 2024年第8期15卷 617-635页

作者： Wei-Zhen liang Kendall R. Kirk James S. Thomas Andrew c. Warner Department of Biological Systems Engineering University of Nebraska-Lincoln Lincoln NE USA Panhandle Research and Extension center University of Nebraska-Lincoln Scottsbluff NE USA Department of Plant Environmental Science Clemson University Clemson SC USA Edisto Research and Education center Clemson University Blackville SC USA University of Georgia-Athens cooperative Extension Athens GA USA

Peanuts pods grow underground and mature unevenly, resulting that choosing the correct time to harvest is more complicated than other crops. Pod maturity can be determined by blasting with a pressure washer to remove outer skin of the pod (exocarp) to expose the color of the middle layer (mesocarp). The mesocarp color changes with maturity from white to yellow, orange, brown and finally black. The sum of percentage from orange, brown, and black mesocarp (OBB) color and black color (BL) represents the kernels that are mature enough to harvest. The goal of this research is to identify methodologies to estimate OBB and BL of the pods using RGB images taken in the field and validate the proposed model using other pod images. The Mahalanobis distance classification method was used to process sets of images and calculate pod area (number of pixels) corresponding to two classes (mesocarp and background) with nine different color groups. The results showed a performance of 94% effectiveness for mesocarp using Mahalanobis distance classification. Statistical regression for OBB and BL was developed based on 315 images of peanut pods taken from the field. The R2 and root mean square error of predicted and actual OBB were 0.93 and 4.1%, respectively. The R2 and root mean square error of predicted and actual BL were 0.88 and 1.8%, respectively. The validation of OBB using other images provided reasonable estimation (R2 = 0.98 and RMSE = 2.73%). This study introduces a novel, cost-effective, and non-destructive method for estimating peanut maturity using RGB imagery and Mahalanobis distance classification in the field. This innovative approach addresses the limitations of traditional methods and offers a robust alternative for real-time maturity assessment.

关键词： Peanut Maturity Mesocarp Exocarp Mahalanobis Distance Statistical Regression

computational Screening of Pt1@Ti_(3)c_(2)T_(2)(T=O,S)MXene catalysts for Water-Gas Shift Reaction

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Precision chemistry 2024年第2期2卷 70-80页

作者： Yang Meng Haiyan Wang Jin-Xia liang chun Zhu Jun Li School of chemistry and chemical Engineering Guizhou UniversityGuiyang 550025China Department of chemistry and Guangdong Provincial Key Laboratory of catalytic chemistry Southern University of Science and TechnologyShenzhen 518055China Department of chemistry and Engineering Research center of Advanced Rare-Earth Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

Single-atom catalysts(SAcs)provide an oppor-tunity to elucidate the catalytic mechanism of complex reactions in heterogeneous *** low-temperature water-gas shift(WGS)reaction is an important industrial technology to obtain high purity ***,we study the catalytic activity of Pt1@Ti_(3)c_(2)T_(2)(T=O,S)SAcs,where one subsurface Ti atom with three T vacancies in the functionalized Ti_(3)c_(2)T_(2)(T=O,S)MXene is substituted by one Pt atom,for the low-temperature show that Pt1@Ti_(3)c_(2)T_(2)provides an excellent platform for the WGS reaction by its bowl-shaped vacancy derived from the Pt1 single atom and three T defects surrounding ***,Pt1@Ti_(3)c_(2)S_(2)SAc has higher catalytic performance for the WGS reaction,due to the weaker electronegativity of the S atom than the O atom,which significantly reduces the energy barrier of H*migration in the WGS reaction,which is often the rate-determining *** the most favorable redox mechanism of the WGS reaction on Pt1@Ti_(3)c_(2)S_(2),the rate-determining step is the dissociation of OH*into O*and H*with the energy barrier as low as 1.12 *** results demonstrate that Pt1@Ti_(3)c_(2)S_(2)is promising in the application of MXenes for low-temperature WGS reactions.

关键词： single-atom catalyst(SAc) density functional theory(DFT) water gas shift(WGS)reaction defective MXene thermocatalysis

Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties

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Nano Research 2024年第3期17卷 927-938页

作者： Beibei Zhan Yanling Hao Xiaosi Qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu Gong Yanli chen Qiong Peng Wei Zhong college of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and ***,effective integrating the multiple functions into a single material remains a huge ***,cellular carbon foams(ccFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the *** obtained results revealed that the thermal treated temperature and g-c_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of ccFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the special cellular structure,the designed ccFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the as-prepared ccFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal ***,our findings not only presented a facile approach to produce different porous structures of ccFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional ccFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning thermal insulation

Research progress on the development of hepatocyte growth factor/c-Met signaling pathway in gastric cancer:A review

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3397-3409页

作者： Wu-Jie Wei Ya-Li Hong Yi Deng Guan-liang Wang Jiang-Tao Qiu Fang Pan Department of Oncology People's Hospital of Chongqing HechuanChongqing 401520China Department of cardiovascular People's Hospital of Chongqing HechuanChongqing 401520China Intensive care Unit People's Hospital of Chongqing HechuanChongqing 401520China Department of Gastrointestinal Surgery Beijing Tsinghua Changgung HospitalBeijing 100084China

Hepatocyte growth factor(HGF)and its receptor,c-Met,play important roles in the occurrence,development,and treatment of gastric cancer(Gc).This review explored the function of the HGF/c-Met signaling pathway in Gc and its potential targeted therapeutic *** one of the most common malignant tumors worldwide,Gc has a complex pathogenesis and limited therapeutic ***,a thorough understanding of the molecular mechanism of Gc is very important for the development of new therapeutic *** HGF/c-Met signaling pathway plays an important role in the proliferation,migration,and invasion of Gc cells and has become a new therapeutic *** review summarizes the current research progress on the role of HGF/c-Met in Gc and discusses targeted therapeutic strategies targeting this signaling pathway,providing new ideas and directions for the treatment of Gc.

关键词： Targeted therapy Hepatocyte growth factor c-Met Gastric cancer Prognosis assessment Review

Oriented Generation of Novel Thermo-Sensitive Genic Male Sterile Lines with Improved Grain Shape and Outcrossing Rate in Early-Season Rice

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Rice science 2024年第2期31卷 129-133,I0001-I0016页

作者： ZHANG Huali cHEN Junyu LI Ruiqing WANG Huimei DAI Dongqing liang Minmin WU Mingyue MA liangyong State Key Laboratory of Rice Biology and Breeding/chinese National center for Rice Improvement China National Rice Research InstituteHangzhou 310006China

Two-line hybrid rice with excellent quality is preferred in the chinese ***,there is a trade-off between reducing costs for hybrid seed production and lowering the outcrossing rate of the sterile line,which is largely determined by the stigma exsertion rate(SER).In this study,we constructed mutants of male sterility lines with improved grain length(GL)and SER in three elite early-season indica rice varieties through targeted manipulation of the TMS5 and GS3 genes using cRISPR/cas9-mediated multiplex *** obtained a series of marker-free gs3 single mutants and gs3tms5 double mutants with significantly higher SER,longer grains,and increased 1000-grain weight compared with the wild type(WT).Importantly,the typically thermo-sensitive genic male sterile(TGMS)trait with a higher SER was observed in gs3tms5 mutants,and their F1 hybrids exhibited remarkable improvements in grain shape and yield-related *** findings provided an efficient method to generate new valuable TGMS germplasm with improved SER through the mutagenesis of GS3 and TMS5 synergistically,and demonstrated that GS3 had pleiotropic effects on grain size,SER,and grain quality in early-season indica rice.

关键词： sterile elite season