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载药外泌体在中枢神经系统疾病中的热点问题

中国组织工程研究 2025年第23期29卷 5013-5021页

作者：林慧洁黄云黄志华江丽霞赣南医科大学第一临床医学院江西省赣州市341000 赣南医科大学心脑血管重点实验室江西省赣州市341000 赣南医科大学基础医学院江西省赣州市341000 赣南医科大学第一附属医院检验科江西省赣州市341000

背景:利用外泌体作为药物载体不仅可以精确靶向治疗部位,还能提高局部浓度,为药物进入中枢神经系统开辟了一条新途径。目的:探讨外泌体的生物发生、生物学功能,综述当前有关细胞外囊泡作为药物载体在中枢神经系统疾病治疗中的最新进展... 详细信息

背景:利用外泌体作为药物载体不仅可以精确靶向治疗部位,还能提高局部浓度,为药物进入中枢神经系统开辟了一条新途径。目的:探讨外泌体的生物发生、生物学功能,综述当前有关细胞外囊泡作为药物载体在中枢神经系统疾病治疗中的最新进展。方法:由第一作者检索Web of Science、Pub Med和中国知网数据库1976年1月至2024年1月发表的相关文献,以“exosomes,extracellular vesicles,central nervous system,drug delivery,ischemic stroke,Alzheimer’s disease,Parkinson’s disease,spinal cord injury,brain tumor”为英文检索词,以“外泌体,细胞外囊泡,中枢神经系统疾病,载药,脑卒中,阿尔兹海默病,帕金森病,脊髓损伤、脑肿瘤”为中文检索词,最终纳入94篇文献进行分析。结果与结论:(1)外泌体可以轻易通过血脑屏障输送蛋白质、代谢物和核酸到受体细胞中,调节细胞代谢。由于外泌体是由细胞分泌的小囊泡,具有更低的循环免疫原性,在体内循环中能够更少被巨噬细胞识别清除。(2)外泌体可以被设计为递送不同的治疗成分,包括RNA、蛋白质、化疗药物和免疫调节剂,能够将治疗成分传送至期望的目标。经过工程修饰的外泌体具有更好的靶向性,并且这种外泌体介导的传递免疫原性极低,有望为将来中枢神经系统疾病的精准治疗提供更加安全有效的方法。

关键词：中枢神经系统疾病外泌体药物递送脑卒中阿尔茨海默病帕金森病脊髓损伤脑肿瘤

Challenges in the management of visual and tactile hallucinations in elderly people

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World Journal of Psychiatry 2025年第1期15卷 185-188页

作者： Si-sheng huang Division of Geriatric Psychiatry Department of PsychiatryChanghua Christian HospitalChanghua 500Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan

This letter provides a concise review of the pertinent literature on visual and tactile hallucinations in elderly *** discussion addresses differential diagnoses and potential underlying mechanisms,as well as the psychopathology associated with tactile hallucinations,and emphasizes the necessity for invest-igation into the possibility of coexisting delusional infestation(parasitosis).These symptoms frequently manifest in patients with primary psychotic disorders,organic mental disorders,and substance use *** proposed pathophy-siological mechanisms may involve dopaminergic imbalances and dysfunction of the striatal dopamine transporter.

关键词： Delusional infestation Dementia Haptic hallucination Scratching behavior Tactile hallucination Visual hallucination Alzheimer’s disease

Nonrecursive residual Monte Carlo method for S_(N) transport discretization error estimation

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Nuclear Science and Techniques 2022年第5期33卷 102-112页

作者： yun-huang Zhang Department of Physics Zhejiang UniversityHangzhou 310027China

In this paper,we present a nonrecursive residual Monte Carlo method for estimating discretization errors associated with the S_(N) transport solution to radiation transport *** this technique is general,we applied it to the mono-energetic 1-D S_(N) equation with linear-discontinuous finite element method spatial discretization as a demonstration of the theory for the purpose of this *** angular flux representations:conforming and simplified representations were considered in this analysis,and the results were *** is shown that the simplified representation dramatically reduces the memory footprint and computational complexity of residual source generation and sampling while accurately capturing the error associated with certain types of responses.

关键词： Residual Monte Carlo Discretization error Angular flux representation

The　physical　implication　of　coda　amplitude　ratio　and　its　possible　application

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Acta Seismologica Sinica(English Edition) 1998年第4期11卷 441-448页

作者： Tian-Zhong Zhang (1) yun-sheng Ma (1) Rong-Liang huang (1) 1. Institute of Geophysics China Seismological Bureau 100081 Beijing China

ＴｈｅｐｈｙｓｉｃａｌｉｍｐｌｉｃａｔｉｏｎｏｆｃｏｄａａｍｐｌｉｔｕｄｅｒａｔｉｏａｎｄｉｔｓｐｏｓｓｉｂｌｅａｐｐｌｉｃａｔｉｏｎＴＩＡＮ－ＺＨＯＮＧＺＨＡＮＧ（张天中）ＹＵＮ－ＳＨＥＮＧＭＡ（马支生）ＲＯＮＧ－... 详细信息

ＴｈｅｐｈｙｓｉｃａｌｉｍｐｌｉｃａｔｉｏｎｏｆｃｏｄａａｍｐｌｉｔｕｄｅｒａｔｉｏａｎｄｉｔｓｐｏｓｓｉｂｌｅａｐｐｌｉｃａｔｉｏｎＴＩＡＮ－ＺＨＯＮＧＺＨＡＮＧ（张天中）ＹＵＮ－ＳＨＥＮＧＭＡ（马支生）ＲＯＮＧ－ＬＩＡＮＧＨＵＡＮＧ（黄蓉良）Ｉｎ...

关键词： coda amplitude ratio energy ratio coda Q mean free path seismic precursors

A novel method for radar echo simulation based on fast-constructed database

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Journal of Systems Engineering and Electronics 2022年第1期33卷 72-79页

作者： huang Xiaowei sheng Xinqing Institute of Radio Frequency Technology and Software School of Integrated Circuits and ElectronicsBeijing Institute of TechnologyBeijing 100081China

This paper presents a novel method for fast calculation of radar echo in near-field regions after the equivalent source has been computed by method of moments(MoM).An easy-to-access near-field database(NFDB)is established,which is built on the auxiliary tetrahedral meshes surrounding the nearfield regions of *** near-fields calculation(NFC)of arbitrary observation points can be expressed explicitly via the *** efficient matrix compression scheme named random sampling-based butterfly factorization(RS-BF)is proposed to speed up the construction of *** this approach,each group of O(N)elements in the database can be calculated through one fast matrix-vector multiplication operation that has a computational complexity below O(Nlog~2 N).The proposed method can avoid time-consuming point-by-point NFC of the traditional *** numerical examples are presented to demonstrate the accuracy and efficiency of this *** particular,the echo simulation of a missile-target encounter example is presented to illustrate its capability for practical applications.

关键词： radar echo simulation near-field database(NFDB) butterfly factorization(BF)

LARGE EDDY SIMULATION OF PARTICLE TRANSPORT IN FULLY DEVELOPED VERTICAL TURBULENT CHANNEL FLOW

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Journal of Hydrodynamics 2004年第4期16卷 386-392页

作者： WANGAn LIUNan-sheng LUXi-yun DepartmentofMechanicsandMechanicalEngineering UniversityofScienceandTechnologyofChinaHefei230026China

Fully developed vertical turbulent channel flow with particle transport wasinvestigated by use of Large Eddy Simulation (LES) approach coupled with dynamic the Sub-Grid Scale(SGS) model. It was assumed that the motion of each particle is followed in a Lagrangian frame ofreference driven by the forces exerted by fluid motion and gravity under the condition of one-waycoupling. The goal of this study is to investigate the effectiveness of the LES technique forpredicting particle transport in turbulent flow and the behavior of particle-laden turbulent channelflow for three kinds of particles at different Stokes numbers. To depict the behavior ofparticle-laden turbulent channel flow, statistical quantities including particle fluctuation andfluid-particle velocity correlation, and visualization of the particle number density field wereanalyzed.

关键词： large eddy simulation (LES) turbulent channel flow particle transport particle-laden turbulent flow sub-grid scale (SGS) model

Dislocation Dissociation Strongly Influences on Frank-Read Source Nucleation and Microplasticy of Materials with Low Stacking Fault Energy

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Chinese Physics Letters 2014年第4期31卷 96-99页

作者： huang Min-sheng Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Wuhan 430074

The influence of dislocation dissociation on the evolution of Frank-Read （F-R） sources is studied using a three- dimensional discrete dislocation dynamics simulation （3D-DDD）. The classical Orowan nucleation stress and recently proposed Benzerga nucleation time models for F-R sources are improved. This work shows that it is necessary to introduce the dislocation dissociation scheme into 3D-DDD simulation, especially for simulations on micro-plasticity of small sized materials with low stacking fault energy.

关键词： NUCLEATION MOLECULAR dynamics DISLOCATION loops DISSOCIATION (Chemistry) NICKEL

锯齿形氮化铝纳米带负阻器件电子输运性质研究

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原子与分子物理学报 2025年第2期42卷 85-90页

作者：黄绛雪黄启俊何进王豪常胜武汉大学物理科学与技术学院武汉430072

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输... 详细信息

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输运特性.研究表明:锯齿型氮化铝纳米带可以通过以上手段实现能带结构的半导体-金属转换.计算电子输运特性,我们发现三种边缘修饰的器件均呈现出负微分电阻效应,其中AlN-F器件有最大峰谷电流比(PVCR),达到了1.78×10^(7),是硅烯纳米器件以及黑磷纳米器件的10^(6)倍.值得一提的是,相比于H-AlN-Cove纳米器件,AlN-F器件能够在更小的偏压范围内实现高PVCR.该结果为锯齿形氮化铝纳米带在低功耗纳米器件中的应用提供了广泛的前景.

关键词：锯齿形氮化铝纳米带电子输运负微分电阻效应第一性原理

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超碱NLi_(4)团簇修饰DHQ石墨烯的储氢性能研究

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原子与分子物理学报 2025年第5期42卷 95-101页

作者：戴小乐王允辉黄欣南京邮电大学电子与光学工程学院柔性电子(未来技术)学院南京210023 南京邮电大学理学院南京210023

基于第一性原理计算,系统研究了超碱NLi_(4)团簇修饰在DHQ石墨烯表面上的几何结构及吸附能等性质,并深入探索了其储氢性能.研究结果表明:超碱NLi_(4)团簇可以稳定均匀地吸附在DHQ石墨烯表面,Li原子与N原子的强结合能有效避免了Li原子发... 详细信息

基于第一性原理计算,系统研究了超碱NLi_(4)团簇修饰在DHQ石墨烯表面上的几何结构及吸附能等性质,并深入探索了其储氢性能.研究结果表明:超碱NLi_(4)团簇可以稳定均匀地吸附在DHQ石墨烯表面,Li原子与N原子的强结合能有效避免了Li原子发生团聚.每个NLi_(4)团簇周围最多可吸附11个氢气分子,平均吸附能为0.20 eV,最大储氢容量为12.05 wt%,达到美国能源部制定的2025年储氢目标5.5 wt%.最后,基于相对能量计算,发现当压强大于84 bar时,该储氢体系可以在室温下稳定存在.以上结果表明经超碱NLi_(4)团簇修饰的DHQ石墨烯是一种有潜力的储氢材料.

关键词：多孔材料储氢超碱NLi_(4)团簇 DHQ石墨烯第一性原理计算