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Regenerative Biomaterials 2020年第3期7卷 313-320页

作者： Yan Dai Xiao-Hui Han Li-Hua Hu Hai-Wei Wu sheng-yun huang Yu-Peng Lu Department of Oral and Maxillofacial Surgery Central Hospital of ZiboShandong UniversityZibo 255036China Department of Oral and Maxillofacial Surgery Department of Prosthodontics Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China School of Materials Science and Engineering Shandong UniversityJinan 250061China

To evaluate the clinical efficacy of concentrated growth factors(CGFs)combined with mineralized collagen(MC)in guided bone regeneration(GBR).A retrospective study involving 29 patients treated with GBR technique,which was performed either CGF and MC complexes or MC *** were inserted simultaneously and cone-beam computed tomography was taken immediately,at 3 and 6 months *** were completed by all patients so as to evaluate the main symptoms and daily activities during the first week after *** outcomes of the two groups were statistically *** implants healed *** in both groups suffered from different levels of discomfort for the reason of swelling,pain and chewing impairment on 1-2 ***,swelling of the Trial group was weaker than the Control *** compared with the Control group,pain levels in Trial group were more rapidly reduced and patients took fewer analgesics from Day ***,the reconstitution mean value of the graft was thicker at 3 and 6 months in Trial *** complex with MC were beneficial to relieve the clinical symptoms,promote the peri-implant bone regeneration and shorten the healing time.

关键词： concentrated growth factors mineralized collagen guided bone regeneration bone augmentation osseointegration

Study on the characteristics of grout permeation based on cylindrical diffusion

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Journal of Coal Science & Engineering(China) 2013年第1期19卷 57-62页

作者： Shen-gang LI Wen ZHA01 yun-sheng huang yun-xia LEI Long-mei Yu College of Resources and Engineering Northeastern University Shenyang 110819 China China Overseas Property Co. Ltd. Shenyang 110014 China Shenyang Urban-Rural Construction Committee Shenyang 110002 China Dalian Port Construction Supervision & Consultation CO. Ltd Dalian 116015 China

Permeation grouting is widely applied for its low grouting pressure and minor disturbance to the stratum in grouting engineering, especially in engineering with strict requirements on ground settlement. However, permeation grouting theory lags behind compared with other engineering disciplines, and the theoretical formulas now available cannot accurately be used to guide grouting engineering design and predict the cost and effects of grouting due to many factors affecting grout permeation in stratum. In this study, permeation grouting experiment devices were independently manufactured with the characteristics of easily controlling grouting pressure, simulating sandy strata grout, and detecting grouting effect. Using a uniform design, the sand consolidation agent, as grouting material, its spread in Shenyang sandy strata was tested with these experiment devices. The quantitative relations between grouting factors （grouting pressure, strata parameters, water-sand consolidation agent ratio） and grouting effects （grout spread radius, gell strength, grout amount） are obtained with regression analysis, and the influence degree of grouting factors on grouting effects is studied.

关键词： permeation grouting cylindrical diffusion grout amount slurry spreading radius gell strength

SYNTHESIS OF NEW ESTRONE DERIVATIVES OF AMINO ACIDS AND PEPTIDES

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Chinese Chemical Letters 1991年第2期2卷 99-100页

作者： yun sheng huang yun Hua YE Department of Chemistry,Peking University,Beijing,100871

A series of estrone derivatives of amino acids and peptides haze been synthesized by different coupling reagents and the binding affinity of deblocked derivatives to the estrogen receptor of rats uteri have been measu... 详细信息

关键词： BOP SYNTHESIS OF NEW ESTRONE DERIVATIVES OF AMINO ACIDS AND PEPTIDES

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： yun FANG Jingchen huang Yujun WU Jiaqi DONG Weichao GUO Xinjun sheng State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

基于旋转变压器及AD2S83的位置检测单元

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微特电机 2004年第8期32卷 33-35页

作者：韩军周理兵马志云黄声华华中科技大学湖北武汉430074

介绍了永磁无刷电动机中由旋转变压器和AD2S83构成的位置检测单元,在分析AD2S83工作原理的基础上,总结了它的外围电路参数选取问题。

关键词：永磁无刷电动机旋转变压器 AD2S83 位置检测单元自动控制系统

硬实时内核智能变电站继电保护实时数字闭环仿真系统

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云南电力技术 2017年第1期45卷 24-27页

作者：李非非韩振峰李昀黄胜国电南瑞科技股份有限公司南京211100 国网山东省电力公司检修公司济南250000

以RTDS为例分析目前实时数字闭环仿真系统性能要求,提出了基于改进的Linux硬实时内核与智能保护装置的实时数字闭环仿真系统,分别探讨了系统实时性和闭环的实现原理。该系统以传统PC机为硬件,以改进Linux硬实时系统为软件平台,以智能保... 详细信息

以RTDS为例分析目前实时数字闭环仿真系统性能要求,提出了基于改进的Linux硬实时内核与智能保护装置的实时数字闭环仿真系统,分别探讨了系统实时性和闭环的实现原理。该系统以传统PC机为硬件,以改进Linux硬实时系统为软件平台,以智能保护装置为试验对象,搭建实时数字闭环仿真系统。

关键词： RTDS Linux硬实时内核实时数字闭环仿真 SV采样报文 goose报文

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-yun Zhou Xiao huang Xin-Yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Relative difficulty distillation for semantic segmentation

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Science China(Information Sciences) 2024年第9期67卷 126-145页

作者： Dong LIANG Yue SUN yun DU Songcan CHEN sheng-Jun huang MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Shenzhen Research Institute Nanjing University of Aeronautics and Astronautics

Current knowledge distillation(KD) methods primarily focus on transferring various structured knowledge and designing corresponding optimization goals to encourage the student network to imitate the output of the teacher network. However, introducing too many additional optimization objectives may lead to unstable training, such as gradient conflicts. Moreover, these methods ignored the guidelines of relative learning difficulty between the teacher and student networks. Inspired by human cognitive science, in this paper, we redefine knowledge from a new perspective — the student and teacher networks' relative difficulty of samples, and propose a pixel-level KD paradigm for semantic segmentation named relative difficulty distillation(RDD). We propose a two-stage RDD framework: teacher-full evaluated RDD(TFE-RDD) and teacher-student evaluated RDD(TSE-RDD). RDD allows the teacher network to provide effective guidance on learning focus without additional optimization goals, thus avoiding adjusting learning weights for multiple losses. Extensive experimental evaluations using a general distillation loss function on popular datasets such as Cityscapes, Cam Vid, Pascal VOC, and ADE20k demonstrate the effectiveness of RDD against state-ofthe-art KD methods. Additionally, our research showcases that RDD can integrate with existing KD methods to improve their upper performance bound. Codes are available at https://***/sunyueue/***.

关键词： knowledge distillation semantic segmentation relative difficulty sample weighting prediction discrepancy