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MicroRNA-184 promotes proliferation ability of glioma cells by regulating FOXO3

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 776-779页

作者： Qing-Ke Cui Wei-Dong Liu Jian-Xin Zhu yun-hua wang Zhi-Gang wang Department of Neurosurgery The Qilu Hospital of Shandong University Liaocheng People's Hospital

Objective:To investigate the effect of microRNA(miR-184)on regulating the *** and prolifration of glioma ***:Lipidosome was used to transfect miR-184 mimic and inhibitor to glioma cell ling,and the cell proliferation ability changes were determined by MTT and plate cloning experiment after the *** test was used to measure the levels of cyclinD1,p27 and *** was used to detect miR-184expression in glioma cell *** tissues and adjacent *** experiment was used to test 3'UTR gene targeting regulation of miR-184 and ***:QPCR results showed a significaat lower miR-184 expression level in glioma cell line and glioma tissues than that in juxtacancerous *** and plate cloning experiments have shown that after overexpressing of miR-184,the cell proliferation capacity of glioma U87 and T98G was signifieantly increased,which was significantly inhibited after the inhibition of *** results showed a lower expression level of p27 in U87 and T98G cells,and a higher expression level of cyclind1after over-expressing of miR-184 wss ***.a lower expression level of eyelinD1and a higher expression level of p27 after the inhibition of *** luciferase activity was inhibited after the over-expressing of ***:MiR-184 can affect the proliferation abilities of glioma cells and regulate the cell cycle related *** plays an important role in the occurrence and development of gliomas.

关键词： miR-184 Glioma Cell proliferation FOXO3

Cucurbitane triterpenoids from Hemsleya penxianensis

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Natural Products and Bioprospecting 2012年第4期2卷 138-144页

作者： Jian-Chao CHEN Lin ZHOU yun-hua wang Ren-Rong TIAN yun-Xin YAN Yin NIAN yun SUN Yong-Tang ZHENG Ming-hua QIU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Laboratory of Molecular Immunopharmacology Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya *** structures were elucidated on the basis of extensive spectroscopic and chemical *** isolates were tested their anti-HIV-1 activities,and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9μg/mL)with a selectivity index of 13.5.

关键词： cucurbitane triterpenoid jinfushanencin jinfushanoside Hemsleya penxianensis

Dermatopathic Lymphadenitis

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Chinese Medical Journal 2015年第22期128卷 3121-3122页

作者： Na Hu Yan-Lin Tan Zhen Cheng yun-hua wang PET/CT Center of The Second Xiangya Hospital Central South University Changsha Hunan 410011 China Department of Radiology and Bio-X Program Canary Centerat Staniord for Cancer Early Detection Stanford University Stanford California CA 94305 USA

To the Editor： Dermatopathic lymphadenitis （DL） represents a rare benign lymphatic hyperplasia commonly associated with exfoliative or eczematoid dermatitis. DL was also reported to be a potential mimicker of lymphoma. Here, we report the ^18F-fluorodeoxyglucose （^18F-FDG） positron emission tomography/ computer tomograpby （PET/CT） results and the histological findings of a 40-year-old female patient with DL.

关键词：氟脱氧葡萄糖F18 淋巴结炎淋巴瘤皮炎体层摄影术体层摄影术 X线计算机体层摄影术发射型计算机血气分析女(雌)性

18F-fluorodeoxyglucose Uptake with Expression of Excision Repair Cross-complementary Group I and Ribonucleotide Reductase Subunit M1 in Non-small Cell Lung Cancer

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Chinese Medical Journal 2017年第17期130卷 2117-2118页

作者： Na Hu yun-hua wang Dai-Qiang Li Xiao-huang Yang Yan-Lin Tan PET/CT Center The Second Xiangya Hospital Central South University Changsha Hunan 410011 China Department of Pathology The Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Fluorodeoxyglucose positron emission tomography/conlputed tomography （FDG PET/CT） is widely applied in non-small cell lung cancer （NSCLC）. The standardized uptake value （SUV）, a semi-quantitative index, plays an essential role in NSCLC tbr diagnosis, staging, and efficacy evaklation. It has been px3posed that the SUV of tumors may correlate with the presence or absence of chemotherapy resistance-associated biomarkers based on studies that have displayed a close correlation between SUV and the expression levels of excision repair cross-complementary Group 1 （ERCC 1 ）1~1 and Tp53-induced glycolysis and apoptosis regulator.121 FDG avidity of NSCLC and ERCC 1 and ribonucleotide reductase subunit M 1 （RRM 1 ） levels have not been as extensively investigated. Based on these findings, we looked tbr correlations among metabolic parameters （SUVm,,. metabolic tumor volume [MTV], and total lesion glycolysis [TLG]） and ERCC1 and RRM1 expression in patients with NSCLC, to investigate whether FDG uptake reflects the presence or absence ofchemoresistance proteins （ERCC1 and RRM 1 ） within tumor cells.

关键词： Computed Tomography: Excision Repair Cross-complementary Group 1: Non-small Cell Lung Cancer: Positron-emission Tomography Ribonucleotide Reductase Subunit M 1

A Simplified Algorithm of PLS Regression

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Systems Science and Systems Engineering 2000年第4期10卷 414-419页

作者： ZHU yun\|hua,\ wang Hui\|wen,\ YANG Xiang\|long School of Management, Beijing University of Aeronautics and Astronautics, Beijing 100083, China

This paper describes a simplified algorithm of PLS regression, which can obviously reduce the computation of some parameters and simplify the computing procedure. Moreover, the new optimistic rule of this method provi... 详细信息

关键词： PLS regression simplified algorithm

METAL　ION　SUBSTIUTION　OF　Cd_5Zn_2－METALLOTHIONEINEIN　WITR　CUPROUS　ION　MONITORED　BY￣1HNMR

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Chinese Chemical Letters 1994年第11期5卷 953-954页

作者： Wei Qiang GU Ming FENG yun hua wang ZhongXian huaNG(Department of Chemistry.Fudan University,Shanghai 200433)

Rat Liver Cd5Zn2-metallothionein isoforms were titrated with cuprous ion and monitored by 1H NMR Initial replacement occurred in β-domain followed by α-*** exhibited well-defined structure under 10 mole equivalents ... 详细信息

关键词： SUBSTIUTION OF BY METAL MONITORED HNMR Cd5Zn2 Zn

Status and Development of Foundry Industry in Liaoning Province of China

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China Foundry 2006年第3期3卷 219-223页

作者： GE Hou-yan, Shenyang Foundry Association ZHANG yun-hua, wang Bo, Shenyang Research Institute of Foundry Shenyang Foundry Association Shenyang Research Institute of Foundry

1 General situation The Liaoning province is famous for the machine building industry and the iron-steel industry in China. The foundry industry also has fully been developed in Liaoning. There are about 3 000 foundries and (1.1-1.2) ×105 employees in Liaoning’s foundry industry and the total yield of castings is 2.4 million tons. Foundry plants mainly concentrate in Dalian, Shenyang, Dandong, Anshan, Chaoyang, Fushun, Benxi and other places. The industry enterprises of Liaoning take state-run system as main body. In the process of converting from the plan economy to the market economy, a lot of contradiction has been appearing continuously, which makes the structure of enterprises to occur great changes, at the same time the product’s structure is renewed quickly, and the mode of the foundry production and the types of the castings have also been adjusting. For the foundry enterprises, it will be a huge challenges to face the rigorous situation of sudden change in market. Since the reform and opening in China more than 20 years ago, great changes have occurred in Liaoning’s foundry industry whether in the yield and varieties of castings or production processes, equipment level, people’s quality consciousness and manage character aspect. The foundry industry has entered into a period of very good development and has been recongnized by more and more customers.

关键词： In Status and Development of Foundry Industry in Liaoning Province of China

单次肌内注射用甲磺酸齐拉西酮在中国健康志愿者中的药动学研究

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中国药学杂志 2017年第9期52卷 767-771页

作者：王韵葛庆华王慧芳李华芳上海市精神卫生中心上海200030 药物制剂国家工程研究中心上海201203

目的评价单次肌内注射用抗精神病药甲磺酸齐拉西酮的药动学特点,评价该药对于健康志愿者的安全性。方法 12名中国健康志愿者(男、女各6例)单剂量肌内注射用甲磺酸齐拉西酮10 mg后在规定的时间点采血。采用LC-MS/MS检测齐拉西酮的血药浓... 详细信息

目的评价单次肌内注射用抗精神病药甲磺酸齐拉西酮的药动学特点,评价该药对于健康志愿者的安全性。方法 12名中国健康志愿者(男、女各6例)单剂量肌内注射用甲磺酸齐拉西酮10 mg后在规定的时间点采血。采用LC-MS/MS检测齐拉西酮的血药浓度。根据血药浓度计算药动学参数。另外通过体检、实验室和心电图检查等项初步评估注射用甲磺酸齐拉西酮的安全性。结果血药浓度-时间曲线为二室模型。药动学参数ρ_(max)为(97.85±29.24)ng·mL^(-1);t_(max)为(0.56±0.30)h;MRT为(5.35±0.96)h;t_(1/2)为(4.29±0.88)h;AUC_(0→t)为(405.6±98.68)ng·h·mL^(-1),AUC_(0→∞)为(413.3±100.69)ng·h·mL^(-1);CL为(25.50±6.10)L·h^(-1);Vd为(157.48±47.60)L;Kel为(0.168±0.035)h。男、女比较各参数的差异均无统计学意义。常见的不良事件为嗜睡、恶心和乏力,程度均为轻至中度。结论 12名健康受试者肌肉注射甲磺酸齐拉西酮注射液10mg后药动学参数与国外文献报道结果基本一致。通过药物不良事件说明该药物的镇静作用较强,比较适用于兴奋躁动状态的精神障碍。

关键词：甲磺酸齐拉西酮药动学液相色谱串联质谱法健康志愿者安全性

房地产投资信托与房地产私募股权基金的辨析与应用初探

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特区经济 2011年第12期 274-276页

作者：花蕴汪红艳王烨哈尔滨工业大学深圳研究生院城市规划与管理学院广东深圳518000 花样年集团(中国)有限公司

近年来房地产面临更加严峻的信贷政策,传统融资渠道受限。房地产投资信托(REITs)及房地产私募股权基金(REPE)成为关注的新型融资渠道。本文详细辨析了REITs与REPE的概念,探讨了REITs与REPE在国内应用的可行性,分析其在国内应用存在的障... 详细信息

近年来房地产面临更加严峻的信贷政策,传统融资渠道受限。房地产投资信托(REITs)及房地产私募股权基金(REPE)成为关注的新型融资渠道。本文详细辨析了REITs与REPE的概念,探讨了REITs与REPE在国内应用的可行性,分析其在国内应用存在的障碍并提出建议。

关键词：房地产投资信托私募股权 REITs