Cucurbitane triterpenoids from Hemsleya penxianensis

作     者：Jian-Chao CHEN Lin ZHOU Yun-Hua WANG Ren-Rong TIAN Yun-Xin YAN Yin NIAN Yun SUN Yong-Tang ZHENG Ming-Hua QIU 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Laboratory of Molecular ImmunopharmacologyKey Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2012年第2卷第4期

页      面：138-144页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Natural Science Foundation of Yunnan Province(2008CD158) the Western Doctoral Foundation of Chinese Academy of Sciences(J.C.Chen) the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences(P2008ZZ23,P2010ZZ14) the Cooperative Project of Guangdong Province and CAS(2009B091300135) 

主　　题：cucurbitane triterpenoid jinfushanencin jinfushanoside Hemsleya penxianensis 

摘      要：Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya *** structures were elucidated on the basis of extensive spectroscopic and chemical *** isolates were tested their anti-HIV-1 activities,and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9μg/mL)with a selectivity index of 13.5.