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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

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Frontiers of Medicine 2024年第1期18卷 109-127页

作者： Guoqiang Li Peng Pu Mengqiao pan Xiaoling Weng Shimei Qiu Yiming Li Sk Jahir Abbas Lu Zou Ke Liu Zheng Wang Ziyu Shao Lin Jiang Wenguang Wu yun Liu Rong Shao Fatao Liu Yingbin Liu Department of Biliary-pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteShanghai200127China Shanghai Key Laboratory of Biliary Tract Disease Shanghai200082China Department of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai200082China Shanghai Tenth People’s Hospital of Tongji University Shanghai200072China Department of General Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200082China Department of Pharmacology Shanghai Jiao Tong University School of MedicineShanghai200025China

Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human ***,knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely ***,by taking advantage of in situ Hi-C,RNA-sequencing,and chromatin immunoprecipitation sequencing(ChIP-seq),we investigated structural reorganization and functional changes in chromosomal compartments,topologically associated domains(TADs),and CCCTC binding factor(CTCF)-mediated loops in gallbladder cancer(GBC)tissues and cell *** observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and gene expression *** inter-TAD interactions with weaker TAD boundaries were identified in cancer cell lines relative to normal ***,the chromatin short loops and cancer unique loops associated with chromatin remodeling and epithelial–mesenchymal transition activation were enriched in cancer compared with their control ***-specific enhancer–promoter loops,which contain multiple transcription factor binding motifs,acted as a central element to regulate aberrant gene *** of individual enhancers in each loop anchor that connects with promoters led to the inhibition of their corresponding gene ***,our data offer the landscape of hierarchical layers of cancer genome and functional alterations that contribute to the development of GBC.

关键词： 3D genome cancer TADs loop gene regulation

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-Qi Wang Bing-Hai Lou Jun He Cui-yun Lei Lin Cong Hao-Qiang Liu Xue-Feng Wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

Applying Hybrid Clustering in Pulsar Candidate Sifting with Multi-modality for FAST Survey

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Research in Astronomy and Astrophysics 2024年第3期24卷 283-296页

作者： Zi-Yi You yun-Rong pan Zhi Ma Li Zhang Shuo Xiao Dan-Dan Zhang Shi-Jun Dang Ru-Shuang Zhao Pei Wang Ai-Jun Dong Jia-Tao Jiang Ji-Bing Leng Wei-An Li Si-Yao Li School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550025China College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Information and Computing Guizhou Province Guizhou Normal UniversityGuiyang 550001China School of Big data and Computer Science Guizhou Normal UniversityGuiyang 550025China Guizhou Software Engineering Research Center Guiyang 550000China

Pulsar search is always the basis of pulsar navigation,gravitational wave detection and other research ***,the volume of pulsar candidates collected by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)shows an explosive growth rate that has brought challenges for its pulsar candidate filtering ***,the multi-view heterogeneous data and class imbalance between true pulsars and non-pulsar candidates have negative effects on traditional single-modal supervised classification *** this study,a multi-modal and semi-supervised learning based on a pulsar candidate sifting algorithm is presented,which adopts a hybrid ensemble clustering scheme of density-based and partition-based methods combined with a feature-level fusion strategy for input data and a data partition strategy for *** on both High Time Resolution Universe SurveyⅡ(HTRU2)and actual FAST observation data demonstrate that the proposed algorithm could excellently identify pulsars:On HTRU2,the precision and recall rates of its parallel mode reach0.981 and 0.988 *** FAST data,those of its parallel mode reach 0.891 and 0.961,meanwhile,the running time also significantly decreases with the increment of parallel nodes within ***,we can conclude that our algorithm could be a feasible idea for large scale pulsar candidate sifting for FAST drift scan observation.

关键词： methods data analysis-surveys-methods numerical

Evaluation of the efficacy of neoadjuvant chemotherapy for intermediate and advanced breast cancer by 3.0T MR and ultrasound combined with tumour markers

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Clinical Research Communications 2024年第3期7卷 53-60页

作者： bao-Jun pan Chun-Lei Sun Yu-Hua Liu Guo-Zheng Tan Chun-yun Liu Hai-Jie Xu Qing-Yu Meng Ji-Xuan Liu Xiang-Dong Wei Wen-Ming Cao Thyroid and mammary department Shandong Changle People’s HospitalWeifang 262400China. Gynecology Department Pingshan District Central HospitalShenzhen 518122China.

Objective:To evaluate the efficacy of neoadjuvant chemotherapy before and after neoadjuvant chemotherapy for intermediate and advanced breast cancer using 3.0T MR and ultrasound in combination with tumour markers(CEA,CA-153,CA125),and to provide therapeutic references for the clinicians,so as to better satisfy the needs of treatment for intermediate and advanced breast cancer ***:The team collected 30 patients who were diagnosed with intermediate and advanced breast cancer by biopsy and received neoadjuvant chemotherapy,and divided them into sensitive and insensitive groups according to the MP grading of postoperative pathological *** team retrospectively analysed the changes in the values of serum CEA,CA-153,and CA 125 before and after the neoadjuvant chemotherapy,the changes in the average ADC of the lesions before and after the observation by MRI,and the changes in the volume and size of lesions before and after the observation by ultrasonography to assess the effects of neoadjuvant chemotherapy individually,and the results of neoadjuvant chemotherapy were evaluated *** effect of neoadjuvant chemotherapy was assessed *** of the above was evaluated independently,and the accuracy of each item was calculated by comparing the evaluation results with the pathological examination results,and the accuracy of the single item was compared with the accuracy of the three combined tests to determine whether the combined evaluation was more ***:All three examination and testing methods can achieve high accuracy,and the combined evaluation of the three is more accurate than the evaluation of the single way,and the difference is statistically significant(P<0.05).Conclusion:In neoadjuvant chemotherapy for breast cancer patients,the combined assessment of MR,CDFI and tumour markers can more comprehensively and accurately assess the effect of ADC,and more accurately guide the clinical treatment and determine the progn

关键词： breast cancer neoadjuvant chemotherapy MR ultrasound tumour markers

鼠妇内生真菌Talaromyces malicola的次生代谢产物研究

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中国中药杂志 2024年第16期49卷 4470-4476页

作者：杨晨宇陈科良刘洋易诚贾兴宝刘云宝中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室

对节肢动物鼠妇内生真菌Talaromyces malicola的次生代谢产物进行研究,采用硅胶柱色谱、凝胶柱色谱、半制备液相色谱等进行分离纯化,共从鼠妇内生真菌T. malicola发酵物的乙酸乙酯部位中分离鉴定出11个化合物。结合核磁共振波谱、高分... 详细信息

对节肢动物鼠妇内生真菌Talaromyces malicola的次生代谢产物进行研究,采用硅胶柱色谱、凝胶柱色谱、半制备液相色谱等进行分离纯化,共从鼠妇内生真菌T. malicola发酵物的乙酸乙酯部位中分离鉴定出11个化合物。结合核磁共振波谱、高分辨质谱、紫外、红外以及圆二色谱等分析方法确定了化合物的结构,分别为talarosesquiterpene A(1)、(3β,5α,6α,15α,22E)-5,6-epoxyergosta-8(14),22-diene-3,7,15-triol (2)、vermistatin(3)、hydroxyvermistatin(4)、bercheminol A(5)、penicillide(6)、lunatinin(7)、penipurdin A(8)、emodin(9)、BE-25327(10)、(-)-regiolone(11)。化合物1为新的diaporol型倍半萜类化合物,化合物2、4～5、7～11为首次从篮状菌属真菌中分离得到。

关键词：鼠妇内生真菌 Talaromyces malicola 次生代谢产物

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基于界面本构模型的砂土中单桩荷载−沉降响应预测方法

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岩土力学 2024年第6期45卷 1686-1698页

作者：周攀李镜培李盼盼刘耕云张超哲同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092 东南大学岩土工程研究所江苏南京211189

基于界面本构模型提出了一种新的砂土中单桩荷载沉降响应的预测方法。首先,从土−结构界面本构模型出发推导了严格的桩−土界面非线性荷载传递模型,该模型承继了界面本构模型特征,能够模拟桩−土界面上发生的应变硬化/软化、剪胀与应力路... 详细信息

基于界面本构模型提出了一种新的砂土中单桩荷载沉降响应的预测方法。首先,从土−结构界面本构模型出发推导了严格的桩−土界面非线性荷载传递模型,该模型承继了界面本构模型特征,能够模拟桩−土界面上发生的应变硬化/软化、剪胀与应力路径依赖性等行为。此外,采用双曲线荷载传递模型模拟桩端−土相互作用的非线性应力−位移关系。上述荷载传递模型所需参数可以通过室内界面剪切试验和土工试验进行校准。继而,基于荷载传递法,提出了单桩荷载沉降响应分析的一维计算模型,并采用迭代算法进行数值求解。最后,将理论解答与已报道的模型试验、自主开展的模型桩试验以及数值模拟结果进行比较,以验证所提出的理论方法的正确性。试验结果表明,预测值与实测值吻合较好,且该方法能够很好地预测非位移桩与位移桩的荷载沉降响应。提出了一个基于界面本构模型的单桩荷载沉降响应分析框架,为竖向荷载下砂土中单桩优化设计提供了理论参考。

关键词：单桩砂土荷载-沉降响应桩-土相互作用界面本构模型模型试验

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立方对角面开孔人工鱼礁流场效应的数值模拟

水产学报 2024年第3期48卷 184-195页

作者：薛大文庞聪利潘昀浙江海洋大学船舶与海运学院

人工鱼礁是建设现代化海洋牧场的基础设施，为了研究在不同海域流速下，迎流角度对人工鱼礁的影响，实验基于Ansys-Fluent平台，采用RNG k-ε的湍流模型，进行数值水槽模拟，对结构边长为3 m的立方对角面开孔鱼礁在3种来流速度(0.5、1.0... 详细信息

人工鱼礁是建设现代化海洋牧场的基础设施，为了研究在不同海域流速下，迎流角度对人工鱼礁的影响，实验基于Ansys-Fluent平台，采用RNG k-ε的湍流模型，进行数值水槽模拟，对结构边长为3 m的立方对角面开孔鱼礁在3种来流速度(0.5、1.0和1.5 m/s)、4种迎流角度(0°、15°、30°和45°)下的上升流体积、背涡流体积、阻力、倾覆力矩等水动力特性进行比较分析。结果显示，人工鱼礁内部和周围存在具有显著特征的上升流区域和背涡流区域；流场规模的大小基本不受来流速度的影响；流速是影响立方对角面开孔人工稳定性的主要因素，流速越大，作用在礁体上的阻力和倾覆力矩相应变大，礁体的稳定性越差；迎流角度是影响人工鱼礁流场效应的主要因素，鱼礁的流场效应规模在迎流角度为30°～45°时达到最优，礁体为45°迎流时上升流体积和背涡流体积都达到最大值。利用权重赋值法，引入人工鱼礁建设效果综合评价模型，通过综合评价分析，在不考虑海底底质淤积、风浪等条件下，投放人工鱼礁时宜选取最大流速不超过1 m/s的海域，且迎流角在30°至45°范围内，鱼礁的建设效果最佳。

关键词：人工鱼礁海洋牧场流场效应数值模拟稳定性迎流角度

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基于人口动态演化的碳排放问题研究

辽宁工程技术大学学报（自然科学版） 2024年第1期43卷 119-128页

作者：包攀高雷阜辽宁工程技术大学工商管理学院辽宁葫芦岛125105 辽宁工程技术大学运筹与优化研究院辽宁阜新123000

为实现数据信息有限约束下碳排放的模型构建与策略选择,在系统分析人口因素及其导致社会环境与物质水平发生变化的基础上,从人口自然增长、受到环境等条件约束的阻滞性人口变化、考虑年龄结构的人口变化,以及偏微分方程形式的人口发展... 详细信息

为实现数据信息有限约束下碳排放的模型构建与策略选择,在系统分析人口因素及其导致社会环境与物质水平发生变化的基础上,从人口自然增长、受到环境等条件约束的阻滞性人口变化、考虑年龄结构的人口变化,以及偏微分方程形式的人口发展角度探究不同人口模型演化蕴含的内在规律,并根据拓扑学中同伦变换思想得到一个等效替代函数,使问题能够统一化处理。研究结果表明:所得扩展的STIRPAT模型拟合效果更优,利用Markov过程对人口演化模型预测的影响因素进行反向误差调节与修正,得到更精准的预测结果,基于人口变化解析碳排放问题的思想也为处理相关问题提供了有效方法。

关键词：碳排放人口变化同伦变换 Markov过程扩展的STIRPAT模型

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不同养护方式对铁尾矿砂制备的再生粗骨料性能影响

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哈尔滨工程大学学报 2024年第6期45卷 1217-1224页

作者：刘宝潘钢华高敏蒙海宁陆军工程大学国防工程学院江苏南京210007 东南大学材料科学与工程学院江苏南京211189 东南大学江苏省土木工程材料重点实验室江苏南京211189 江苏镇江建筑科学研究院有限公司江苏镇江212004

为了提高铁尾矿沙的利用率,本文采用成球技术使用铁尾矿沙制备粗骨料,将经过界面预处理后的铁尾矿砂采用喷洒预处理液水雾,同时撒入胶凝材料的方式生成骨料颗粒,最后将骨料颗粒进行养护得到再生粗骨料。探究不同的养护方式对再生粗骨料... 详细信息

为了提高铁尾矿沙的利用率,本文采用成球技术使用铁尾矿沙制备粗骨料,将经过界面预处理后的铁尾矿砂采用喷洒预处理液水雾,同时撒入胶凝材料的方式生成骨料颗粒,最后将骨料颗粒进行养护得到再生粗骨料。探究不同的养护方式对再生粗骨料的性能的影响,结合SEM和MIP探究养护方式对再生粗骨料微观形貌和孔结构的影响。结果表明:改进的成球技术制备铁尾矿沙再生粗骨料具有一定的可行性。另外,自然养护条件骨料的性能表现最差,蒸汽养护骨料的压碎指标最小,碳化养护骨料的吸水率最小。从微观结构来看碳化养护的骨料体系结构致密,孔隙和微裂缝含量相对较少,因此骨料吸水率最小;蒸汽养护水化产物含有大量的凝胶状和网状结构的水化硅酸钙、针状钙矾石和少量的氢氧化钙晶体,这是压碎指标小的原因。这些研究结果为铁尾矿沙制备再生粗骨料应用于混凝土的后期服役过程中提供了指导意义。

关键词：铁尾矿沙再生粗骨料养护方式利用率微观结构压碎指标吸水率混凝土