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Systematic bibliometric analysis of research hotspots and trends on the application of premium IOLs in the past 2 decades

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 736-747页

作者： Liang-Pin Li Li-yun Yuan De-Shen Mao xia Hua xiao-Yong Yuan Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China School of Medicine Nankai UniversityTianjin 300071China Anhui Medical University Hefei 230032Anhui ProvinceChina Tianjin Aier Eye Hospital Tianjin UniversityTianjin 300190China

AIM:To analysis of research hotspots and trends on the application of premium intraocular lens(PIOLs)in the past 2 ***:The literature search was performed on the Web of Science and included PIOLs studies published between January 2000 and December *** retrieved literature was collated and analyzed by R-tool’s Bibliometrix package,CitNetExplorer,CiteSpace and other ***:A total of 1801 articles about PIOLs were obtained,most of which were published in Spain and the United *** organization that published the most articles was the University of Valencia in ***ó JL,and Montés-Micó R,from Spain were the most influential authors in this *** Journal of Cataract and Refractive Surgery and Journal of Refractive Surgery were the core journals for this field;the top 10 cited articles mainly focus on postoperative satisfaction with multifocal intraocular lens(IOLs)and postoperative results of toric *** the keyword analysis,we found that trifocal IOLs,astigmatism and extended depth of focus(EDoF)IOLs are the most discussed topics at present,and the importance of astigmatism and the clinical application of the new generation of PIOLs are the emerging research ***:Bibliometric analysis can effectively help to identify multilevel concerns in PIOLs research and the prevailing research trends in the realm of PIOLs encompass the adoption of EDoF IOLs,trifocal IOLs,and their respective Toric models.

关键词： premium intraocular lens bibliometric H-index cataract surgery global trends

Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

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Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-Wei Chen Jia-Nan Chen Jun Zhang Chao Wang Tian-Yu sun yun-Dong Wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

High-resolution neutronics model for ^(238)Pu production in high-flux reactors

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Nuclear Science and Techniques 2024年第5期35卷 226-236页

作者： Qing-Quan Pan Qing-Fei Zhao Lian-Jie Wang Bang-Yang xia yun Cai Jin-Biao Xiong xiao-Jing Liu School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610200China

We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux *** filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy *** burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme *** three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were *** neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.

关键词： ^(238)Pu Neutronics model High-flux reactor Spectrum resolution Spectrum optimization

Balancing act:The dilemma of rapid hyperglycemia correction in diabetes management

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World Journal of Diabetes 2024年第2期15卷 129-132页

作者： Ke-Xin Zhang Cheng-xia Kan xiao-Dong sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

The global diabetes surge poses a critical public health challenge,emphasizing the need for effective glycemic ***,rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications,necessitating a reevaluation of the speed and intensity of glycemic *** suggest swift blood sugar reductions may cause inflammation,oxidative stress,and neurovascular changes,resulting in *** providers should cautiously approach aggressive glycemic control,especially in long-standing,poorly controlled *** and managing these complications requires a personalized,comprehensive approach with education,monitoring,and interdisciplinary *** management must balance short and longterm goals,prioritizing overall *** editorial underscores the need for a personalized,nuanced approach,focusing on equilibrium between glycemic control and avoiding overcorrection.

关键词： Diabetes Hyperglycemia correction Management Microvascular complications Glucose control

Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer

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Science China(Life Sciences) 2024年第2期67卷 424-427页

作者： Ziting Chen xiangyang Li Qian Zhang Wenjun sun xiaoxuan Song xia Zhang Xingxu Huang Bo sun School of Life Science and Technology and Gene Editing Center ShanghaiTech UniversityShanghai 201210China Zhejiang Lab HangzhouZhejiang 311121China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Base editing has been developed to be one of the effective CRISPR-based gene editing techniques(Rees and Liu,2018).Base editors(BEs)take advantage of DNAmodifying enzymes fused with a catalytically impaired CRISPR protein to install base *** BE,DNA-modifying enzymes often process nontarget singlestranded DNA(NTS)generated by Cas proteins.

关键词： install base winding

The Boundedness of the Pullback Attractor for a 2D Micropolar Fluid Flows

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Acta Mathematicae Applicatae Sinica 2024年

作者： Wen-long sun Chun-lin LAI yun-yun LIANG School of information and mathematics Yangtze University

The purpose of this work is to investigate the boundedness of the pullback attractors for the micropolar fluid flows in two-dimensional unbounded domains. Exactly, the H1-boundedness and H2-boundedness of the pullback attractors are established when the external force F (t, x) has different regularity with respect to time variable, respectively.

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Modeling Reynolds stress anisotropy invariants via machine learning

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Acta Mechanica Sinica 2024年第6期40卷 50-63页

作者： xianglin Shan Xuxiang sun Wenbo Cao Weiwei Zhang Zhenhua xia School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China

The presentation and modeling of turbulence anisotropy are crucial for studying large-scale turbulence structures and constructing turbulence ***,accurately capturing anisotropic Reynolds stresses often relies on expensive direct numerical simulations(DNS).Recently,a hot topic in data-driven turbulence modeling is how to acquire accurate Reynolds stresses by the Reynolds-averaged Navier-Stokes(RANS)simulation and a limited amount of data from *** existing studies use mean flow characteristics as the input features of machine learning models to predict high-fidelity Reynolds stresses,but these approaches still lack robust generalization *** this paper,a deep neural network(DNN)is employed to build a model,mapping from tensor invariants of RANS mean flow features to the anisotropy invariants of high-fidelity Reynolds *** the aspects of tensor analysis and input-output feature design,we try to enhance the generalization of the model while preserving invariance.A functional framework of Reynolds stress anisotropy invariants is derived *** irreducible invariants are then constructed from a tensor group,serving as alternative input features for ***,we propose a feature selection method based on the Fourier transform of periodic *** results demonstrate that the data-driven model achieves a high level of accuracy in predicting turbulence anisotropy of flows over periodic hills and converging-diverging ***,the well-trained model exhibits strong generalization capabilities concerning various shapes and higher Reynolds *** approach can also provide valuable insights for feature selection and data generation for data-driven turbulence models.

关键词： Reynolds stress Anisotropy invariant Tensor analysis Machine learning

Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization

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Nano Research 2024年第4期17卷 2908-2918页

作者： Guanting Li Fengli xia Hongying xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin sun Zhonggui He Bingjun sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics College of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Emergency Department The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery ***,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies,which are highly unfavorable for sterilization through filtration,and may cause capillary blockage upon intravenous *** rational design of camptothecins-based prodrug nanoassemblies remains a ***,we propose that branched aliphatic alcohol(BAA)functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug ***,four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin(SN38)with BAAs of varying lengths via a tumor redox-responsive disulfide bond,which self-assemble into uniform spherical *** length of BAA was found to significant impact the multiple drug delivery process,including colloidal stability,drug release profiles and ***,SN38-C21 NPs(SN38-11-heneicosanol nanoparticles),featuring the longest BAA,showcased multiple therapeutic advantages,ultimately culminating the optimal antitumor efficacy and *** findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies,and provide valuable insights for developing translational camptothecins-based nanomedicines.

关键词： prodrug nanoassembly self-assembly antitumor efficacy tolerance 7-ethyl-10-hydroxycamptothecin(SN_(3)8)

Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： Zeng-Mei sun Yuan-Ze Du Su-Yuan Wang Shu-Yao sun Yan Ye Xue-Ping sun Ming-xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 *** accuracy of the FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude