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One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo

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Neural Regeneration Research 2024年第2期19卷 458-464页

作者： Lin Feng Da Li Yao Tian Chengshun Zhao yun Sun Xiaolong Kou Jun Wu Liu wang qi Gu Wei Li Jie Hao Baoyang Hu Yukai wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Institute for Stem Cell and Regenerative Medicine Chinese Academy of SciencesBeijingChina National Stem Cell Resource Center Chinese Academy of SciencesBeijingChina Savaid Medical School University of Chinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina

Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s *** of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s ***,transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation ***,we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor *** beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion,effectively maintaining axonal integrity in ***,midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell ***,our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation.

关键词： axonal integrity cell cryopreservation cellular environment cellular niche cell replacement therapy dopaminergic progenitors human pluripotent stem cell mechanical damage neuronal cell delivery Parkinson’s disease small-aperture gelatin microcarriers

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-yun Guo Jia-qi Yang Xun-Xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： Jia-qi Peng Yuan-Yuan Wei Dong-Ming Liu yun Li Bin Hu Bin Huang Jian-Wen Yang Shun-Hua Xiao Ren-Heng wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

Mixing states and secondary formation processes of organic nitrogen-containing single particles in Guangzhou,China

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Journal of Environmental Sciences 2024年第4期138卷 62-73页

作者： Lijun yun Chunlei Cheng Suxia Yang Zaihua wang Mei Li qi En Zhong LiyuanMao Sulin Liu Xiaoya Cheng Duanying Chen Fan Yang Zhen Zhou Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for on-line source apportionment system of air pollutionJinan UniversityGuangzhou 510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 510632China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy ScienceXi’an 710061China Institute for Environment and Climate Research Jinan UniversityGuangzhou 510632China Guangdong Academy of Sciences Institute of Resources Utilization and Rare Earth DevelopmentGuangzhou 510650China Environmental Monitoring Station of Pudong New District Shanghai 201200China

Organic nitrogen(ON)compounds play a significant role in the light absorption of brown carbon and the formation of organic aerosols,however,the mixing state,secondary formation processes,and influencing factors of ON compounds are still *** paper reports on the mixing state of ON-containing particles based on measurements obtained using a highperformance single particle aerosol mass spectrometer in January 2020 in *** ON-containing particles accounted for 21% of the total detected single particles,and the particle count and number fraction of the ON-containing particles were two times higher at night than during the *** prominent increase in the content of ON-containing particles with the enhancement of NO_xmainly occurred at night,and accompanied by high relative humidity and nitrate,which were associated with heterogeneous reactions between organics and gaseous NO_(x)and/or NO_(3)*** synchronous decreases in ON-containing particles and the mass absorption coefficient of water-soluble extracts at 365 nm in the afternoon may be associated with photo-bleaching of the ON species in the *** addition,the positive matrix factorization analysis found five factors dominated the formation processes of ON particles,and the nitrate factor(33%)mainly contributed to the production of ON particles at *** results of this study provide unique insights into the mixing states and secondary formation processes of the ON-containing particles.

关键词： Organic nitrogen compounds Single particles Mixing state Secondary formation Nighttime chemistry

FLNB haploinsufficiency-related short stature:a new syndrome or an expanded spectrum of Larsen syndrome

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World Journal of Pediatrics 2024年第9期20卷 976-980页

作者： qing wang Hong-Ying wang Shui-Yan Wu Xue-qian wang Hai-Ying Wu Rong-Rong Xie Feng-yun wang Xiu-Li Chen Lin-qi Chen Hai-Tao Lv Ting Chen Department of Endocrinology Genetics and MetabolismChildren’s Hospital of Soochow UniversitySuzhouChina Suzhou Clinical Center for Rare Diseases in Children Children’s Hospital of Soochow UniversitySuzhouChina Intensive Care Unit Children’s Hospital of Soochow UniversitySuzhouChina Department of Cardiology Children’s Hospital of Soochow UniversitySuzhouChina Department of Pediatrics Kunshan Sixth People’s HospitalSuzhouJiangsuChina

FLNB encodes the protein filamin B(FLNB),which is expressed in chondrocytes of the human growth plate[1].To date,pathogenic mutations in the FLNB gene have solely been found to cause skeletal deformities,indicating th... 详细信息

关键词： insufficiency skeletal expanded

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

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World Journal of Psychiatry 2024年第5期14卷 686-694页

作者： Xia Ding Ling-Xia qi Dong-yun Sun Department of Gangzha General Medical Center The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmic Surgery Room The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Insomnia is among the most common sleep disorders *** in older adults is a social and public health *** affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical *** subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent *** To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized *** One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this ***-reported symptoms were assessed using the Athens Insomnia Scale(AIS),Generalized Anxiety Disorder Scale-7(GAD-7),Geriatric Depression Scale-15(GDS-15),Memorial University of Newfoundland Scale of Happiness(MUNSH),Barthel Index Evaluation(BI),Morse Fall Scale(MFS),Mini-Mental State Examination,and the Short Form 36 Health Survey Questionnaire(SF-36).Correlation coefficients were used to analyze the correlation between sleep quality and self-reported *** of insomnia was analyzed using Logistic regression *** Nineteen patients with AIS≥6 were included in the insomnia group,and the incidence of insomnia was 19%(19/100).The remaining 81 patients were assigned to the non-insomnia *** were significant differences between the two groups in the GDA-7,GDS-15,MUNSH,BI,MFS,and SF-36 items(P<0.05).Patients in the insomnia group were more likely to experience anxiety,depression,and other mental illnesses,as well as difficulties with everyday tasks and a greater risk of falling(P<0.05).Subjective well-being and quality of life were poorer in the insomnia group than in the control *** AIS scores positively correlated with the GAD-7,GDS-15,and MFS scores in elderly hospitalized patients with insomnia(P<0.05).Logistic regression analysis showed that GDS-15≥5 was an independent risk factor for ins

关键词： Elderly hospitalized patients Insomnia Self-reported outcomes Symptoms Subjective feelings Correlation

Mating behaviors in ovoviviparous black rockfish(Sebastes schlegelii):molecular function of prostaglandin E2 as both a hormone and pheromone

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Marine Life Science & Technology 2024年第1期6卷 15-30页

作者： Likang Lyu Yijia Yao Songyang Xie Xiaojie wang Haishen Wen yun Li Jianshuang Li Chenpeng Zuo Shaojing Yan Jingyi Dong Xin qi Key Laboratory of Mariculture(Ocean University of China) Ministry of EducationOcean University of ChinaQingdao 266003China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

Prostaglandins(PGs)are profound hormones in teleost sexual behavior,especially in *** act as pheromones that affect the olfactory sensory neurons of males,inducing the initiation of a series of mating ***,the molecular mechanism by which PGs trigger mating behavior in ovoviviparous teleosts is still *** the present study,we employed the ovoviviparous black rockfish(Sebastes schlegelii),an economically important marine species whose reproductive production is limited by incomplete fertilization,as a model *** results showed that when the dose of PGE2 was higher than 10 nmol/L,a significant(P<0.05)increase in mating behaviors was ***-fluorescence in situ hybridization indicated that PGE2 could fire specific neurons in different brain regions and receptor cells in the olfactory *** combining with specific neurons in the central nervous system(CNS),a series of genes related to reproduction are *** intracerebroventricular administration of PGE_(2) significantly increased lhb levels(P<0.05)in both ***,steroidogenesis in gonads was also affected,inducing an increase(P<0.05)in E_(2) levels in males and T levels in ***_(2) levels were also increased significantly(P<0.05)in both *** present study revealed that PGE2 can activate mating behavior in black rockfish in both hormone and pheromone pathways,leading to variations in sex steroid levels and activation of reproductive *** results provide not only novel insight into the onset of mating behaviors in ovoviviparous teleosts but also solutions for the incomplete fertilization caused by natural mating in cage aquaculture.

关键词： Black rockfish Mating behavior Ovoviviparity Prostaglandin E2

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-qi wang Bing-Hai Lou Jun He Cui-yun Lei Lin Cong Hao-qiang Liu Xue-Feng wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

Effect of crystal morphology of ultrahigh-nickel cathode materials on high temperature electrochemical stability of lithium ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 327-335,I0008页

作者： Bi Luo Hui Li Haoyu qi yun Liu Chuanbo Zheng Weitong Du Jiafeng Zhang Lai Chen School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600JiangsuChina National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina School of Materials Science and Engineering Beijing Key Laboratory of Environmental Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Higher nickel content endows Ni-rich cathode materials LiNi_(x)Co_yMn_(1-x-y)O_(2)(x>0.6)with higher specific capacity and high energy density,which is regarded as the most promising cathode materials for Li-ion ***,the deterioration of structural stability hinders its practical application,especially under harsh working conditions such as high-temperature *** these circumstances,it becomes particularly critical to clarify the impact of the crystal morphology on the structure and high-temperature performance as for the ultrahigh-nickel ***,we conducted a comprehensive comparison in terms of microstructure,high-temperature long-cycle phase evolution,and high-temperature electrochemical stability,revealing the differences and the working mechanisms among polycrystalline(PC),single-crystalline(SC)and Al doped SC ultrahigh-nickel *** results show that the PC sample suffers a severe irreversible phase transition along with the appearance of microcracks,resulting a serious decay of both average voltage and the energy *** the Al doped SC sample exhibits superior cycling stability with intact layered ***-situ XRD and intraparticle structural evolution characterization reveal that Al doping can significantly alleviate the irreversible phase transition,thus inhibiting microcracks generation and enabling enhanced ***,it exhibits excellent cycling performance in pouch-type full-cell with a high capacity retention of 91.8%after 500 cycles at 55℃.This work promotes the fundamental understanding on the correlation between the crystalline morphology and high-temperature electrochemical stability and provides a guide for optimization the Ni-rich cathode materials.

关键词： Single-crystalline Ultrahigh-nickel cathode High-temperature performance Phase evolution