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Phenotypic changes of Schwann cells on the proximal stump of injured peripheral nerve during repair using small gap conduit tube

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Neural Regeneration Research 2017年第9期12卷 1538-1543页

作者： Shi-jun Zhang Wen-liang wu Kai-yun Yang yun-zhen Chen hai-chun Liu Department of Orthopedics Qilu Hospital of Shandong University Laboratory of Ears Nose and Throat Oral and Maxillofacial Surgery Qilu Hospital of Shandong University

Dedifferentiation of Schwann cells is an important feature of the response to peripheral nerve injury and specific negative myelination reg- ulators are considered to have a major role in this process. However, most experiments have focused on the distal nerve stump, where the Notch signaling pathway is strongly associated with Schwann cell dedifferentiation and repair of the nerve. We observed the phenotypic changes of Schwann cells and changes of active Notch signaling on the proximal stump during peripheral nerve repair using small gap conduit tubulization. Eighty rats, with right sciatic nerve section of 4 mm, were randomly assigned to conduit bridging group and control group （epineurium suture）. Glial fibrillary acidic protein expression, in myelinating Schwann cells on the proximal stump, began to up-reg- ulate at 1 day after injury and was still evident at 5 days. Compared with the control group, Notchl mRNA was expressed at a higher level in the conduit bridging group during the first week on the proximal stump. Hesl mRNA levels in the conduit bridging group significantly increased compared with the control group at 3, 5, 7 and 14 days post-surgery. The change of the Notch intracellular domain shared a simi- lar trend as Hesl mRNA expression. Our results confirmed that phenotypic changes of Schwann cells occurred in the proximal stump. The differences in these changes between the conduit tubulization and epineurium suture groups correlate with changes in Notch signaling. This suggests that active Notch signaling might be a key mechanism during the early stage of neural regeneration in the proximal nerve stump.

关键词： nerve regeneration Schwann cells nerve injury small gap conduit therapy chitin peripheral nerve injury Notch signaling Notch 1 Hes1 glial fibrillary acidic protein S100 neural regeneration

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Integrating transcriptomes and somatic mutations to identify RNA methylation regulators as a prognostic marker in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 34-45页

作者： Yue Yan yun-hai Luo Dao-Feng Zheng Tong Mu Zhong-Jun wu Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Background:RNA methylation modifying plays an important role in the occurrence and progression of a range of human cancers including hepatocellular carcinoma(HCC),which is characterized by a mass of genetic and epigenetic ***,the treatment targeting these alterations is ***:We used comprehensive bioinformatics analysis to analyze the correlation between cancerassociated RNA methylation regulators and HCC malignant features in network ***:We identified two HCC subgroups(cluster 1 and 2),which had clearly distinct clinicopathological,biofunctional and prognostic characteristics,by consensus *** cluster 2 subgroup correlated with malignancy of the primary tumor,higher tumor stage,higher histopathological grade and higher frequency of TP53 mutation,as well as with shorter survival when compared with cluster *** enrichment indicated that the cluster 2 correlated to the tumor malignancy signaling and biological *** on these findings,an 11-gene risk signature was built,which not only was an independent prognostic marker but also had an excellent power to predict the tumor ***:Our study indicated that RNA methylation regulators are vital for HCC malignant progression and provide an important evidence for RNA methylation,methylation regulators are actionable targets for anticancer drug discovery.

关键词： RNA methylation Hepatocellular carcinoma Prognostic marker Epigenetics

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Mixture of Electromagnetically Induced Transparency and Autler–Townes Splitting in a Five-Level Atomic System

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Communications in Theoretical Physics 2017年第2期67卷 217-221页

作者： Xiao-yun Zhang Shan wu hai-Chao Li College of Physics and Electronic Science Hubei Normal University Huangshi 435002 China Institute for Interdisciplinary Research Jianghan University Wuhan 430056 China College of Science China Three Gorges University Yichang 443002 China

Discerning electromagnetically induced transparency(EIT) from Autler–Townes splitting(ATS) is a significant issue in quantum optics and has attracted wide attention in various three-level configurations. Here we present a detailed study of EIT and ATS in a five-level atomic system considered to be composed of a four-level Y-type subsystem and a three-level Λ-type subsystem. In our theoretical calculations with standard density matrix formalism and steadystate approximation, we obtain the general analytical expression of the first-order matrix element responsible for the probe-field absorption. In light of the well-known three-level EIT and ATS criteria, we numerically show an intersection of EIT with ATS for the Y-type subsystem. Furthermore, we show that an EIT dip is sandwiched between two ATS dips(i.e., multi-dip mixture of EIT and ATS) in the absorption line for the five-level system, which can be explained by the dressed-state theory and Fano interference.

关键词： electromagnetically induced transparency Autler–Townes splitting five-level atomic systems

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Investigation of migration of pollutant at the base of Suzhou Qizishan landfill without a liner system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 439-449页

作者： hai-jian XIE yun-min CHEN Liang-tong ZHAN Ren-peng CHEN Xiao-wu TANG Ru-hai CHEN Han KE MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Hangzhou 310058 China College of Civil Engineering and Architeeture Zhejiang University Hangzhou 310058 China

We investigated migration of pollutant at the base of the Suzhou landfill after it had been operated for 13 years. The investigation was carried out by performing chemical analyses on the soil samples taken from the silty clay deposit. Concentrations of chloride, chemical oxygen demand （COD） and the heavy metals in the soil samples were determined using the standard methods. The experimental data showed that the maximum migration depth of chloride was more than 10 m, while the maximum migration depth of COD varied between 1 and 3.5 m. It is believed that the difference is attributed to the variation in diffusion rate and leachate-soil interaction. The chloride profiles also indicated that adveetion may be the dominant contaminant transport mechanism at this site. The total contents ofCu, Pb and Cr are very close to the background levels and the concentration values of these metals mainly are lower than the threshold values specified by the Chinese soil quality standard and the European one. The water-extractable concentrations of COD in the surface of the silty clay generally exceed the limit value specified by the Chinese standard. The concentrations of copper and chromium in pore water are 1-2 orders of magnitude less than the total concentrations of these heavy metals within the soils, implying that heavy metals are mainly adsorbed by the soil particles. Finally, remediation methods were suggested for this landfill site.

关键词： Uncontrolled landfill Field investigation Contaminant migration Soil contamination Heavy metals Organic contaminants Chloride

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Phase Sensitive Photonic Flash

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Communications in Theoretical Physics 2018年第8期69卷 215-219页

作者： Xin-yun Cui Zhi-hai Wang Jin-Hui wu Center for Quantum Sciences and School of Physics Northeast Normal UniversityChangchun 130024China

We theoretically propose a photonic flash based on a linearly coupled cavity system. Via driving the two side cavities by external fields, it forms a cyclic energy-level diagram and therefore the phase difference between the driving fields acts as a controller of the steady state due to the quantum interference effect. In the optical trimer structure,we show that the perfect photonic flash can be realized in the situation of resonant driving. The perfect photonic flash scheme is furthermore generalized to multiple coupled cavity system, where the cavities with odd and even number turn bright and dark alternatively. Our proposal may be applied for designing the quantum neon and realizing a controllable photonic localization.

关键词： phase control photonic flash coupled cavity system

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全膝关节置换术围手术期复合镇痛疗效观察

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实用骨科杂志 2009年第2期15卷 86-88页

作者：祝云利吴海山吴宇黎符培亮李晓华钱齐荣赵辉上海长征医院骨科关节外科上海200003

目的评价全膝置换围手术期复合镇痛效果,探讨最佳镇痛方案。方法将2006年1月至2008年1月我院收治的90例单侧全膝关节置换(totalknee arthroplasty,TKA)手术患者随机分成两组,采用不同镇痛方案进行围手术期镇痛治疗,对术后疼痛情况进行... 详细信息

目的评价全膝置换围手术期复合镇痛效果,探讨最佳镇痛方案。方法将2006年1月至2008年1月我院收治的90例单侧全膝关节置换(totalknee arthroplasty,TKA)手术患者随机分成两组,采用不同镇痛方案进行围手术期镇痛治疗,对术后疼痛情况进行积分分析并观察并发症。结果积极持续的镇痛方法具有明显的镇痛效果,患者满意率及功能康复效果取得明显改善。结论TKA术围手术期采用积极、持续、综合的镇痛措施具有重要意义。

关键词：全膝置换疼痛复合镇痛

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Newly onset indirect traumatic optic neuropathy-surgical treatment first versus steroid treatment first

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 124-128页

作者： Bo Yu Ying-Jie Ma yun-hai Tu Wen-Can wu Department of Orbital & Oculoplastic Surgery Eye Hospital of Wenzhou Medical University

AIM: To investigate the efficacy and safety of the treatment of endoscopic trans-ethmosphenoid optic canal decompression(ETOCD) with combination of steroid in patients with newly onset indirect traumatic optic neuropathy(ITON) and compare the outcome between immediate ETOCD treatment and ETOCD with preoperative steroid treatment. METHODS: Patients presented as newly onset ITON(suffered trauma within 3 d) at a tertiary medical center between Mar 1 st, 2016 and Mar 1 st, 2018 were enrolled in this study. All patients were equally and randomly divided into 2 groups. Cases in group A were performed ETOCD immediately after admition while cases in group B were prescribed by methylprednisolone(20 mg/kg · d) for 3 d before ETOCD. Methylprednisolone(20 mg/kg · d) was used after surgery for 6 d in group A and 3 d in group B. Follow-up was up to 3 mo in all cases. Visual acuity(VA) before and after treatment between the two groups were taken into comparison. RESULTS: Complete postoperative data were acquired from 34 patients in group A and from 32 patients in group B. Group A had significantly higher effective rate in VA than group B(χ~2 =4.905, P=0.027).CONCLUSION: For patients with newly onset ITON, combination treatment of ETOCD with high-dose steroid is an effective and safe way. Immediate surgery will lead to better prognosis for these cases.

关键词： indirect traumatic optic neuropathy endoscopic trans-ethmosphenoid optic canal decompression steroid visual acuity newly onset

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Finite element analysis of stress distribution of obturator prostheses for acquired unilateral maxillary defects

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Journal of Central South University of Technology 2005年第z1期12卷 365-368页

作者： FENG yun-zhi FENG hai-lan wu Han-jiang Department of Stomatology the Second Xiangya Hospital Central South University Changsha 410011 China Department of Prosthodontics School of Stomatology Peking University Beijing 100081 China Department of Stomatology the Second Xiangya Hospital Central South University Changsha 410011 China

Objective To assess stresses produced by different obturator prostheses. Methods Three-dimensional finite clement models of unilateral maxillary defects rehabilitated with different obturators were constructed. The different stresses were analyzed by three-dimensional finite element method under different load angle. Results The Von Mises stress values obtained for the remaining tissues adjacent to defect cavity were higher when rehabilitated by inferior hollow obturator in comparison with by superior hollow obturator. The maximum of Von Mises were higher when rehabilitated by resilient hollow obturator than by rigid hollow obturator. It was also observed that in the rigid type stress distribution contours formed in the remaining tissues adjacent to defect cavity, while in resilient hollow obturator prostheses the stress distributed mainly in the prosthesis itself. The oblique load shows the most maximum of Von Mises among all types of obturator prostheses. Conclusions A high lateral wall of an obturator may be more better in preserving the remaining structures than a shorter prosthesis lateral wall. A soft liner may be incorporated to reduce the pain of the residual maxillary structures and mucosa. When load on defect, higher stress would be generated to the residual maxillary structures. The adjustment of occlusual relationship is very important.

关键词： maxillary defect obturator prosthesis 3-dimention finite element stress

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中老年膝内侧半月板后角放射裂的临床研究

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实用骨科杂志 2009年第9期15卷 670-672页

作者：陈宜祝云利吴海山吴宇黎符培亮上海解放军第八五医院上海200052

目的讨论膝内侧半月板后角放射状撕裂的临床特点和关节镜下半月板部分切除术后的随访结果。方法自2000年6月至2006年6月对386例(418膝)关节镜下治疗的膝内侧半月板撕裂患者进行回顾性研究,其中后角放射状撕裂93膝(22.2%),全部行半月板... 详细信息

目的讨论膝内侧半月板后角放射状撕裂的临床特点和关节镜下半月板部分切除术后的随访结果。方法自2000年6月至2006年6月对386例(418膝)关节镜下治疗的膝内侧半月板撕裂患者进行回顾性研究,其中后角放射状撕裂93膝(22.2%),全部行半月板部分切除术。在详细的手术记录和关节镜图像资料基础上,分析患者术前体征、M R I结果、术中所见和术后Lysho lm膝关节评分。结果中老年患者中膝内侧半月板后角放射状撕裂有较高的发生率,大多数患者表现出机械卡压或撞击症状,M R I很难发现这种撕裂,有特点的疼痛症状和物理检查有助于诊断。虽然大多数患者年龄较大,关节软骨已发生退变,但关节镜下半月板部分切除术后,症状会明显改善。结论膝内侧半月板放射状撕裂比较常见,但因为多数患者同时伴有骨关节炎症状,且M R I上假阴性率较高,诊断比较困难。在严格掌握手术指征下,关节镜下半月板部分切除术有助于改善症状。

关键词：内侧半月板后角放射状撕裂

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Nanofiltration Membranes via Layer-by-layer Assembly and Cross-linking of Polyethyleneimine/Sodium Lignosulfonate for Heavy Metal Removal

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Chinese Journal of Polymer Science 2020年第9期38卷 965-972,I0006页

作者： Meng-yun Xie Jiang Wang Qing-yun wu Faculty of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

Layer-by-layer(LbL)assembly technology is a facile method for constructing thin film composite ***,a novel nanofiltration(NF)membrane was prepared by LbL assembly of polyethyleneimine(PEI)and sodium lignosulfonate(LS)followed by *** surface composition,morphology,and property of PEI/LS bilayer were detailedly investigated by FTIR/ATR,XPS,SEM,AFM,and water contact angle *** PEI/LS bilayer full of amino and hydroxyl groups presents increased roughness and improved ***,the NF performance of PEI/LS LbL assembly membranes can be modulated by bilayer number,polyelectrolyte concentration,and salt *** water flux reduced while the salt rejection greatly improved as increasing the bilayer numbers,PEI concentration,or NaCl *** than 95%MgSO4 and MgCl2,as well as 80%NaCl can be rejected by a NF membrane prepared by 6 PEI/LS bilayers,1 wt%PEI,0.5 wt%LS,and 1 mol/L ***,this NF membrane can be used to remove more than 95%heavy metal ions(Cd2+,Zn2+,Mn2+,Cr2+,Cu2+,and Ni2+).This work proposed a promising NF membrane by using PEI/LS as low cost polyelectrolytes and facile LbL assembly method,which should receive much attention in water purification.

关键词： Desalination Nanofiltration Sodium lignosulfonate Layer-by-layer Heavy metal

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