Integrating transcriptomes and somatic mutations to identify RNA methylation regulators as a prognostic marker in hepatocellular carcinoma

作     者：Yue Yan Yun-Hai Luo Dao-Feng Zheng Tong Mu Zhong-Jun Wu Yue Yan;Yun-Hai Luo;Dao-Feng Zheng;Tong Mu;Zhong-Jun Wu

作者机构：Department of Hepatobiliary SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2021年第20卷第1期

页      面：34-45页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the R project for statistical computing (including the Rtools) 

主　　题：RNA methylation Hepatocellular carcinoma Prognostic marker Epigenetics 

摘      要：Background:RNA methylation modifying plays an important role in the occurrence and progression of a range of human cancers including hepatocellular carcinoma(HCC),which is characterized by a mass of genetic and epigenetic ***,the treatment targeting these alterations is ***:We used comprehensive bioinformatics analysis to analyze the correlation between cancerassociated RNA methylation regulators and HCC malignant features in network ***:We identified two HCC subgroups(cluster 1 and 2),which had clearly distinct clinicopathological,biofunctional and prognostic characteristics,by consensus *** cluster 2 subgroup correlated with malignancy of the primary tumor,higher tumor stage,higher histopathological grade and higher frequency of TP53 mutation,as well as with shorter survival when compared with cluster *** enrichment indicated that the cluster 2 correlated to the tumor malignancy signaling and biological *** on these findings,an 11-gene risk signature was built,which not only was an independent prognostic marker but also had an excellent power to predict the tumor ***:Our study indicated that RNA methylation regulators are vital for HCC malignant progression and provide an important evidence for RNA methylation,methylation regulators are actionable targets for anticancer drug discovery.