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Testosterone level and mortality in elderly men wit systolic chronic heart failure

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Asian Journal of Andrology 2011年第5期13卷 759-763页

作者： hai-yun wu Xiao-Fei Wang Jun-Hua Wang Jiang-Yuan Li Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Cardiology the 306th Hospital of Chinese PLA Beijing 100101 China Department of Cardiology Chinese PLA Aifforce General Hospital Beijing 100036 China Department of Endocrinology Chinese PLA General Hospital Beijing 100853 China

Previous studies on the prognostic significance of serum levels of androgens in patients with chronic heart failure （CHF） have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHF. A total of 175 elderly men （age ≥60 years） with CHF were recruited. Total testosterone （TI＇） and sex hormone-binding globulin （SHBG） were measured, and estimated free testosterone （eFT） was calculated. The median follow-up time was 3.46 years. Of these patients, 17 had a TT level below 8 nmol I^-1 （230 ng dI^-1）, 27 had an eFT level below 0.225 nmol I^-1 （65 pg ml^-1） and 12 had both. Using the age-specific tenth percentiles of TT and eFT in healthy men in our laboratory as cutoff points, the prevalences of TT and eFT deficiency was 21.7% （38/175） and 27.4% （48/175）, respectively. Both TT and eFT were inversely associated with left ventricular ejection fraction （LVEF） and N-terminal pro-brain natriuretic peptide （NT-pro-BNP）（all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TT and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations of either TT or eFT levels with survival time （0R=0.97, 95% CI： 0.84-1.12, P=0.28 and 0R=0.92, 95% CI： 0.82-1.06, P=0.14, respectively）. Our study showed that levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, but they are not independent predictors for mortality.

关键词： free testosterone heart failure prognosis total testosterone

Endless passion for excellence： the life and work of Professor Shi-Wen Wang

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Journal of Geriatric Cardiology 2012年第1期9卷 1-2页

作者： hai-yun wu Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road 100853 Beijing China

The 30th of January 2012 was a sad day for thousands of Chinese cardiologists and geriatricians:they lost a respected and admired colleague,an outstanding leader and innovative *** Shi-Wen Wang (1933～2012),founder and director of the Institute of Geriatric Cardiology at Chinese PLA General Hospital,Editor-in-Chie f of Journal of Geriatric Cardiology,passed away on that day. Professor Wang was born in Shandong,China on January 25,*** father was a postmaster in a small county town,who had managed to provide college educations for all his 4 sons and his only daughter,an extraordinary and almost heroic achievement at that time in *** in several missionary and public sehools in Nanjing,Professor Wang in 1950 entered the medical school of Nanjing University,then one of the best universities in China,and obtained her *** in 1955.

关键词：生活激情大学教育心血管病南京大学医学院中国老年

Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China

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World Journal of Clinical Cases 2021年第10期9卷 2205-2217页

作者： Wei Zhang Yuan Ban yun-hai wu Jin-Yang Liu Xing-hai Li Hao wu Huan Li Rui Chen Xiao-Xu Yu Rui Zheng Department of Pulmonary and Critical Care Medicine Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Critical Care Medicine The Sixth People's Hospital of ShenyangShenyang 110006Liaoning ProvinceChina Department of Infectious Diseases The Sixth People's Hospital of ShenyangShenyang 110006Liaoning ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)has spread rapidly to multiple countries through its infectious agent severe acute respiratory syndrome coronavirus *** severity,atypical clinical presentation,and lack of specific anti-viral treatments have posed a challenge for the diagnosis and treatment of *** the epidemiological and clinical characteristics of COVID-19 cases in different geographical areas is essential to improve the prognosis of COVID-19 patients and slow the spread of the *** To investigate the epidemiological and clinical characteristics and main therapeutic strategy for confirmed COVID-19 patients hospitalized in Liaoning Province,*** Adult patients(n=65)with confirmed COVID-19 were enrolled in this retrospective study from January 20 to February 29,2020 in Liaoning Province,*** swabs and sputum specimens were collected from the patients for the detection of severe acute respiratory syndrome coronavirus 2 nucleic *** demographic information and clinical data were collected from the medical *** on the severity of COVID-19,the patients were divided into nonsevere and severe groups. All patients were followed until March 20,*** mean age of 65 COVID-19 patients was 45.5 ± 14.4 years, 56.9% were men,and 24.6% were severe cases. During the 14 d before symptom onset, 25 (38.5%)patients lived or stayed in wuhan, whereas 8 (12.3%) had no clear history ofexposure. Twenty-nine (44.6%) patients had at least one comorbidity;hypertension and diabetes were the most common comorbidities. Compared withnonsevere patients, severe patients had significantly lower lymphocyte counts[median value 1.3 × 10^(9)/L (interquartile range 0.9-1.95) vs 0.82 × 10^(9)/L (0.44-1.08),P < 0.001], elevated levels of lactate dehydrogenase [450 U/L (386-476) vs 707 U/L(592-980), P < 0.001] and C-reactive protein [6.1 mg/L (1.5-7.2) vs 52 mg/L (12.7-100.8), P < 0.001], and a prolonged median duration of

关键词： Coronavirus disease COVID-19 Epidemiology Liaoning SARS-CoV-2 Viral pneumonia

Incidence and in-hospital mortality of acute aortic dissection in China： analysis of China Health Insurance Research （CHIRA） Data 2011

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Journal of Geriatric Cardiology 2015年第5期12卷 502-506页

作者： Lei XIA Jing-Hu LI Kun ZHAO hai-yun wu The Administrating Office Chinese PLA General Hospital Beijing China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing China China Health Insurance Research Association Beijing China Brainpower Phama Consulting Co. Ltd. Beijing China

Objective Acute aortic dissection （AAD） is a catastrophic event with high early mortality rate, but to date, no data on the incidence of AAD in China's Mainland is available. This study aimed to estimate the incidence of AAD in China and characterize the clinical profile, management and in-hospital outcomes of this vascular event. Methods We used the China Health Insurance Research Data （the CHIRA Data） 2011 which comprises all inpatient hospital records （300,886） during the period of Jan. 1st 2011 to Dec. 31 2011 of 3,335,000 randomly sampled beneficiaries （1,718,500 men and 1,616,500 women） from 25 cities and counties in different economic-geographic regions of China's Mainland. Patients with acute aortic dissection were identified according to International Classification of Disease 10m Revision （ICD-10） of I71.0, The estimated incidence of AAD was calculated using the equation： estimated incidence = 2.0 × （40% × hospital admission rate）＋ 60% × hospital admission rate. Results The hospital admission rate was 2.0/100,000 （65/3,325,000, 95% CI： 1.2-2.8）. The estimated annual incidence of AAD was 2.8/100,000 （95% CI： 1.9-3.6） and was higher in male than in female （3.7 vs. 1.5, P 〈 0.001）. The mean age was 58.9 ± 13.4 years. During the mean hospital stay of 23 ±6 days, the overall in-hospital mortality was 13.9% （9/65）. Conclusions Our study showed relatively lower but not negligible incidence and in-hospital mortality of AAD in the mainland of China. The mean age of patients with AAD in Chinese was younger than that reported by researches from west countries, while the male to female incidence ratio is similar to those reported by other studies.

关键词： Acute aortic dissection China health insurance research Incidence rate

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China

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World Journal of Clinical Cases 2020年第21期8卷 5188-5202页

作者： Jing-Bo Wang hai-Tao Wang Lei-Shi Wang Lu-Ping Li Jiao Xv Chun Xv Xing-hai Li yun-hai wu Hong-Yan Liu Bai-Jun Li Hong Yu Xia Tian Zhi-Yu Zhang Yan Wang Rui Zhao Jin-Yang Liu Wei Wang Ye Gu Department of Infectious Disease The Sixth People’s Hospital of ShenyangShenyang 110006Liaoning ProvinceChina Department of General Surgery The Second Affiliated Hospital of Shenyang Medical CollegeShenyang 110002Liaoning ProvinceChina Department of Clinical Laboratory The Sixth People’s Hospital of ShenyangShenyang 110006Liaoning ProvinceChina Department of Intensive Critical Medicine The Sixth People’s Hospital of ShenyangShenyang 110006Liaoning ProvinceChina Department of Infectious Diseases Clinic The Sixth People’s Hospital of ShenyangShenyang 110006Liaoning ProvinceChina

BACKGROUND Pneumonia of uncertain cause has been reported in wuhan,China since the beginning of early December *** early January 2020,a novel strain ofβ-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients,which was recently named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).There is evidence of human-to-human transmission and familial cluster outbreak of SARSCoV-2 *** World Health Organization(WHO)recently declared the SARS-CoV-2 epidemic a global health *** of February 17,2020,71329 laboratory-confirmed cases(in 25 countries,including the United States and Germany)have been reported *** than its rapid transmission,the epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)remain *** December 2019,coronavirus disease(named COVID-19 by the WHO)associated with the SARS-CoV-2 emerged in wuhan,China and spread quickly across the *** To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province,a Chinese region about 1800 km north of *** The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were *** cases originated from eight cities in Liaoning *** The median age of the patients was 45 years,and 57.1%of them were *** patient had been in direct contact with wild *** them,23 patients(41.1%)had resided in or traveled to wuhan,27 cases(48.2%)had been in contact with confirmed COVID-19 patients,5 cases(8.9%)had been in contact with confirmed patients with a contact history to COVID-19 patients,and 1 case(1.8%)had no apparent history of ***(75.0%)and cough(60.7%)were the most common *** typical manifestations in lung computed tomography(CT)included ground-glass opacity and patchy shadows,with 67.8%of them being *** the patients in the cohort,78.6%

关键词： SARS-CoV-2 COVID-19 Epidemiological characteristics Clinical characteristics Hypoxemia Acute respiratory distress syndrome

Metabolic syndrome vs. its components for prediction of cardiovascular mortality： A cohort study in Chinese elderly adults

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Journal of Geriatric Cardiology 2012年第2期9卷 123-129页

作者： Dong-Ling Sun Jian-Hua Wang Bin Jiang Liang-Shou Li Lan-Sun Li Lei wu hai-yun wu Yao He Institute of Geriatrics Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Department of Acupuncture Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Department of Epidemiology the 4th Military Medical University No.17 Changle West Road Xi'an 710032 Shaanxi Province China Department of Cardiology the 4^th Military Medical University No.17 Changle West Road Xi'an 710032 Shaanxi Province China Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective The predictive value of the metabolic syndrome （MetS） for mortality from all-cause and cardiovascular disease （CVD） in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults. Methods A cohort of 1,535 subjects （994 men and 541 women） aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios （HRs） predicted by MetS according to the harmonized defmition and by its individual components. Results The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 （95% confidence interval （CI）： 1.20-1.80） and 1.96 （95%CI： 1.42-2.72）, respectively, compared with those without MetS. Non-significant higher risk of CVD mortality was seen in those with one or two individual components （HR = 1.22, 95%CI： 0.59-2.50; fir = 1.82, 95%CI： 0.91-3.64, respectively）, while a substantially higher risk of CVD mortality only appeared in those with 3, 4, or 5 components （H_R = 2.81-3.72）, compared with those with no components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality. Conclusions The number of positive MetS components seems no more informative than classifying （dichotomous） MetS for CVD risks assessment in this Chinese cohort.

关键词： Cardiovascular disease Metabolic syndrome Cohort study Chinese adults

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Spinal interleukin-10 produces antinociception in neuropathy through microglial β-endorphin expression,separated from antineuroinflammation

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Spinal interleukin-10 produces antinociception in neuropathy...