Metabolic syndrome vs. its components for prediction of cardiovascular mortality： A cohort study in Chinese elderly adults
Metabolic syndrome vs. its components for prediction of cardiovascular mortality： A cohort study in Chinese elderly adults作者机构：Institute of Geriatrics Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Department of Acupuncture Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Department of Epidemiology the 4th Military Medical University No.17 Changle West Road Xi'an 710032 Shaanxi Province China Department of Cardiology the 4^th Military Medical University No.17 Changle West Road Xi'an 710032 Shaanxi Province China Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China
出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)
年 卷 期：2012年第9卷第2期
页 面：123-129页
核心收录：
学科分类：0710[理学-生物学] 02[经济学] 0202[经济学-应用经济学] 020208[经济学-统计学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0714[理学-统计学（可授理学、经济学学位）] 070103[理学-概率论与数理统计] 0701[理学-数学]
基 金：This study was supported by the National Natural Science Foundation of China Ministry of Science and Technology of China National Department Public Benefit Research Foundation by Ministry of Health of China
主 题：Cardiovascular disease Metabolic syndrome Cohort study Chinese adults
摘 要：Objective The predictive value of the metabolic syndrome （MetS） for mortality from all-cause and cardiovascular disease （CVD） in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults. Methods A cohort of 1,535 subjects （994 men and 541 women） aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios （HRs） predicted by MetS according to the harmonized defmition and by its individual components. Results The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 （95% confidence interval （CI）： 1.20-1.80） and 1.96 （95%CI： 1.42-2.72）, respectively, compared with those without MetS. Non-significant higher risk of CVD mortality was seen in those with one or two individual components （HR = 1.22, 95%CI： 0.59-2.50; fir = 1.82, 95%CI： 0.91-3.64, respectively）, while a substantially higher risk of CVD mortality only appeared in those with 3, 4, or 5 components （H_R = 2.81-3.72）, compared with those with no components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality. Conclusions The number of positive MetS components seems no more informative than classifying （dichotomous） MetS for CVD risks assessment in this Chinese cohort.
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