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Effect of moxibustion at Shenque (CV8) on immune system in rats with different degrees of exhaustive exercise

Journal of Acupuncture and Tuina Science 2019年第2期17卷 74-79页

作者： Zhang Ya-hui zhou xiao-hong Zhang Zhi-fang Liang Yu-lei Gao Fei Wu Jun sun dong-yun sun Hao Hebei University of Chinese Medicine. Shijiazhuang 050200. China Hebei Province Laboratory of Specific Effects of Acupuncture and Moxibustion. Shijiazhuang 050091 China Hebei Bokang Institute of Chinese Medicine Shijiazhuang 050021 China

Objective: To investigate the effect of moxibustion at Shenque (CV8) on the immune system in rats with different levels of exhaustive exercise. Methods: Fifty-six male Sprague-Dawley (SD) rats were randomly divided into a blank group (n=8), an exhaustive group (n=24), and a moxibustion group (n=24). The exhaustive group was randomly divided into a 1-time exhaustive group, a 4-time exhaustive group and a 7-time exhaustive group, with 8 rats in each group. According to the treatment time, the moxibustion group was randomly divided into a 1-time moxibustion group, a 4-time moxibustion group and a 7-time moxibustion group, with 8 rats in each group. Rats in the exhaustive groups and the moxibustion groups were subjected to replicating the exhaustive swimming models. Rats in each moxibustion group received mild moxibustion for 15 min immediately after the exhaustive modeling, once every other day. Twenty-four hours after the corresponding exhaustive exercise, the rats in each group were tested for the levels of serum immunoglobulin (Ig) G, IgA, IgM and acid phosphatase (ACP), and the morphological changes of spleen tissues were observed. The level of IgA was detected by immunoturbidimetric assay, and the levels of IgG, IgM and ACP were detected by en zyme-linked imm uno sorb ent assay (ELISA). Results: Compared with the 1-time exhaustive group, swimming time of rats in the 4-time exhaustive group was significantly proIonged (Pming time of rats in the 7-time exhaustive group was significantly shortened (Pming time of rats in the 7-time moxibustion group was significantly proIonged (Pnificantly decreased (***), and the levels of IgG, IgA and IgM in the 4-time exhaustive group and the 7-time exhaustive group were all sign ifica ntly decreased (P<0.05 or ***), while the ACP level was in creased sign

关键词： Moxibustion Therapy Moxa Stick Moxibustion Point, Shenque (CV8) Exhaustive Exercise Fatigue Immunoglobulins Acid Phosphatase Rats

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定点突变提高γ-谷氨酰转肽酶的pH耐受性及催化活性

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高校化学工程学报 2016年第1期30卷 133-141页

作者：彭清姚忠周治王浩绮肖环倪芳孙芸南京工业大学食品与轻工学院江苏南京211816

γ-谷氨酰转肽酶(GGT)是生物体内谷氨酰循环的关键酶,可广泛应用于多种γ-谷氨酰基化合物的生物合成。但其在体外催化环境下(p H>9.0)极易发生不可逆失活,限制其生物催化领域的实际应用。本实验以枯草芽孢杆菌*** NX-2 GGT(wt_GGT)为对... 详细信息

γ-谷氨酰转肽酶(GGT)是生物体内谷氨酰循环的关键酶,可广泛应用于多种γ-谷氨酰基化合物的生物合成。但其在体外催化环境下(p H>9.0)极易发生不可逆失活,限制其生物催化领域的实际应用。本实验以枯草芽孢杆菌*** NX-2 GGT(wt_GGT)为对象,采用同源建模获得wt_GGT的3D结构预测模型;分析wt_GGT大、小亚基表面氨基酸残基的性质、空间位置和保守性,最终选取Asp46、Thr201、Tyr280、Gln322、Glu502和His543为候选位点;通过定点突变将候选位点分别替换为缬氨酸,以期通过提高wt_GGT大小亚基间的疏水作用,改善其p H耐受性。研究成功实现了6种突变酶(D46V、T201V、Y280V、E502V、Q322V和H543V)的异源表达,并分别研究了其催化活性和稳定性。结果表明:D46V、Y280V、E502V、H543V的Km略小于wt_GGT,且Y280V的kcat较wt_GGT有明显提高;D46V、Y280V和E502V的p H稳定性均较wt_GGT有所改善,其中Y280V的p H稳定性最高;模型分析显示,在<10?范围内,Y280V可与附近4个氨基酸残基(Y-283、W-277、I-501和I-497)产生疏水相互作用,这可能是其p H耐受性较强的主要原因。

关键词： γ-谷氨酰转肽酶定点突变疏水相互作用 pH稳定性催化性质

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An electrodeposition approach to metal/metal oxide heterostructures for active hydrogen evolution catalysts in near-neutral electrolytes

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Nano Research 2019年第6期12卷 1431-1435页

作者： Michael J.Kenney Jianan Erick Huang Yong Zhu Yongtao Meng mingquan Xu Guanzhou Zhu Wei-Hsuan Hung yun Kuang Mengchang Lin xiaoming sun Wu zhou Hongjie Dai Department of Chemistry Stanford UniversityStanfordCA 94305USA School of Physical Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100049China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China Department of Materials Science and Engineering Feng Chia UniversityTaichung 40724TaiwanChina State Key laboratory of Chemical Resource Engineering and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

Neutral water splitting is attractive for its use of non-corrosive and environmentally friendly ***,catalyst development for hydrogen and oxygen evolution remains a challenge under neutral *** we report a simple electrodeposition and reductive annealing procedure to produce a highly active ni-Co-Cr metal/metal oxide heterostructured catalyst directly on ni *** resulting electrocatalyst for hydrogen evolution reaction (HER) requires only 198 mV of overpotential to reach 100 mNcm2 in 1 M potassium phosphate (pH =7.4) and can operate for at least two days without significant performance *** transmission electron microscopy coupled with electron energy loss spectroscopy (STEM-EELS) imaging reveals a ni-Co alloy core decorated with blended oxides layers of niO,CoO and *** metal/metal oxide interfaces are suggested to be responsible for the high HER activity.

关键词： water splitting catalysis nanostructured materials hydrogen evolution chemical mapping

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咳喘固本丸治疗慢性阻塞性肺疾病稳定期肺肾两虚证疗效观察

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江西中医药 2024年第10期55卷 44-48页

作者：倪训庆徐新颖孙浩洋周春丽蒋喜娟张新伟临沂市中医医院呼吸与危重症医学科山东临沂276003 济南市济阳区中医院ICU科济南251400 青岛大学医学院松山医院内科山东青岛266021 临沂市中医医院老年病科山东临沂276003 临沂市人民医院医学影像科山东临沂276003

目的:观察咳喘固本丸治疗慢性阻塞性肺疾病(COPD)稳定期肺肾两虚证的临床疗效。方法:选取2021年6月—2023年1月收治于临沂市中医医院呼吸与危重症医学科的COPD稳定期肺肾两虚证患者80例,利用分层随机分组法分为对照组和观察组,各40例。... 详细信息

目的:观察咳喘固本丸治疗慢性阻塞性肺疾病(COPD)稳定期肺肾两虚证的临床疗效。方法:选取2021年6月—2023年1月收治于临沂市中医医院呼吸与危重症医学科的COPD稳定期肺肾两虚证患者80例,利用分层随机分组法分为对照组和观察组,各40例。对照组给予布地格福吸入,观察组在对照组基础上给予咳喘固本丸口服,3个月为1个疗程,共2个疗程。比较2组临床疗效、中医证候积分、第一秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC百分比(FEV1/FVC%)、呼吸困难指数(mMRC)、6 min步行试验距离(6MWD)、评估测试评分(CAT)等。结果:治疗后,2组总有效率比较观察组(96.97%)高于对照组(82.86%),差异有统计学意义(P<0.05);2组中医证候积分、mMRC、CAT改善情况比较,观察组均优于对照组,差异有统计学意义(P<0.05);2组肺功能指标FEV1、FVC及FEV1/FVC%比较,观察组均优于对照组,差异有统计学意义(P<0.05)。结论:咳喘固本丸能显著改善COPD稳定期肺肾两虚证患者的症状和肺功能。

关键词：咳喘固本丸布地格福吸入气雾剂慢性阻塞性肺疾病肺肾两虚证肺功能

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泡沫铝二次发泡工艺用先驱体中TiH_2发泡剂的分散性

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中国有色金属学报 2008年第1期18卷 78-84页

作者：左孝青梅俊熊恒周芸孙加林昆明理工大学材料与冶金工程学院昆明650093

研究二次发泡泡沫铝工艺用熔体路径发泡先驱体中TiH2的分散性,包括熔体粘度测量、工艺参数对发泡剂分散性影响等。结果表明,610℃是ZLD104合金熔体粘度变化的转折点,低于610℃熔体粘度随温度的变化较大,高于610℃熔体粘度随温度的变化较... 详细信息

研究二次发泡泡沫铝工艺用熔体路径发泡先驱体中TiH2的分散性,包括熔体粘度测量、工艺参数对发泡剂分散性影响等。结果表明,610℃是ZLD104合金熔体粘度变化的转折点,低于610℃熔体粘度随温度的变化较大,高于610℃熔体粘度随温度的变化较小;随分散温度、搅拌速度、分散时间的提高,发泡剂分散均匀性提高,但在3 000 r/min,分散30 s的条件下,发泡剂的团聚现象仍然存在;在粘度?温度非敏感区分散发泡剂,并采用挤压使发泡先驱体致密化,以及采用3 000 r/min以上的搅拌速度分散发泡剂,可提高熔体路径发泡先驱体发泡剂均匀性。

关键词： TiH2发泡剂熔体路径先驱体分散性泡沫铝

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Functional magnetic resonance imaging and immunohistochemical study of hypothalamic function following oral glucose ingestion in rats

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Chinese Medical Journal 2007年第14期120卷 1232-1235页

作者： CHEN min ZHANG Tie-mei LUO Sen-lin zhou Cheng WU xiao-meng zhou ni-na CAI Kui YANG Zhen-han WANG Wen-chao ZHAO Wei-feng LI Sa-ying WANG Zhi ZHANG yun-ting LI Guo-zhen Department of Radiology Beijing Hospital Beijing 100730 China Department of Cytology Beijing Institute of Geriatrics Beijing 100730 China Beijing Institute of Technology Beijing 100034 China Tianjin Medical University Tianjin 300070 China

Background The hypothalamus plays a central role in the regulation of metabolism by sensing metabolic demands and releasing regulatory neurotransmitters. This study investigated the response of the hypothalamus to glucose ingestion in rats by blood oxygen level-dependent functional magnetic resonance imaging （BOLD-fMRI） and immunohistochemical techniques to determine the role of the hypothalamus in glycoregulation during disturbances in carbohydrate metabolism. Methods The signal intensity of the hypothalamus was monitored by fMRI for 60 minutes after oral glucose intake in 48 healthy rats （age 14 months）, which included 24 normal weight rats （weighing （365±76.5） g） and 24 overweight rats （weighing （714±83.5） g）. Then, 12 rats （6 normal, 6 overweight） underwent a repeat fMRI scan after consuming an equivalent amount of water without glucose on a separate day. The procedure for fMRI with water intake was the same as for glucose ingestion, fMRI data was processed using time cluster analysis and intensity averaging method. After fMRI the expression of neuropeptide Y （NPY） and 5-hydroxytryptamine （5-HT） in the hypothalamus of all rats was determined by immunohistochemistry. Positive cells for NPY or 5-HT were counted. Results There was a transient, but significant, decrease in fMRI signal intensity in all rats （mean （3.12±0.78）%） in the hypothalamus within 19.5-25.5 minutes of oral glucose ingestion. In overweight rats, the decrease in signal intensity in response to the glucose ingestion was more markedly attenuated than that observed in normal weight rats （（2.2±1.5）% vs （4.2±0.7）% inhibition, t=2.12, P〈0.05）. There was no significant response in the hypothalamus after oral water ingestion. The percentage of NPY positive cells in obese rats were slightly lower than those in control group （21% vs 23% t=0.71, P〉0.05）; but there was no significant difference between the two groups; the percentage of 5-HT positive cells in obese rats were significantly lower than those

关键词： functional magnetic resonance imaging hypothalamus glucose neuropeptide Y serotonin

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Microstructure and properties of high-strength Cu–ni–Si–(Ti) alloys

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Rare Metals 2021年第11期40卷 3251-3260页

作者： Yi-Hai Yang Sheng-Yao Li Zhen-Shan Cui zhou Li yun-Ping Li Qian Lei State Key Lab for Powder Metallurgy Central South UniversityChangsha 410083China School of Physical and Mathematical Science Nanyang Technological UniversitySingapore 637371Singapore School of Materials Science and Engineering Central South UniversityChangsha 410083China

The tradeoff between the strength and the fracture elongation in the high-strength Cu-ni-Si alloy became a hot research topic ***-ni-Si-(Ti) alloys were fabricated in a vacuum induction melting furnace to study the effects of titanium on the microstructure and mechanical properties of Cu-ni-Si alloys with different thermo-mechanical *** homogenization at 900℃ for 4 h,hot-rolled by 80%,solution treatment at 970℃ for 2 h,cold-rolled by 50%,and finally aged at 450℃ for 180 min,the studied Cu-10 ni-Si-2 Ti alloy achieved the hardness of HV 252.4,electrical conductivity of 23.6% IACS,tensile strength of 764.4 MPa,yield strength of 622.26 MPa,fracture elongation of 10.4%,and strength-elongation product of 7.95 GPa%,which are less than those of the studied Cu-10 ni-2 Si *** addition of Ti contributed to refining the microstructure,suppressing the decreasing trend in mechanical properties after peak hardening,and arousing a primary substructure strengthening mechanism rather than the precipitation strengthening in Cu-ni-Si *** findings provide essential understandings of the effects of the Ti on Cu-ni-Si system alloys,and the designed Cu-ni-Si alloys with highstrength and fracture elongation could fulfill some requirements of the electronic and electrical industry.

关键词： Copper alloy Microstructure Strength Electrical conductivity

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Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3240-3243页

作者： Yi-Hong Ling Meng-ni Liu Yi-Xin Yin Zhong-Guo zhou Jie-Wei Chen Wei Wei Jing-Ping yun Dan Xie Rong-Ping Guo Mu-Yan Cai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Clinical Big Data Research Center Scientific Research CenterThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina

Dear Editor,Hepatocellular carcinoma(HCC)ranks the fourth most lethal cancer worldwide and over 50%of cases are diagnosed as multifocal HCC(mHCC)with dismal prognosis.1 mHCC displays more complicated intratumor hetero... 详细信息

关键词： alterations multifocal clinical

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定向凝固Mg-xGd-0.5Y合金的微观组织及拉伸变形行为

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金属学报 2020年第3期56卷 340-350页

作者：孙衡林小娉周兵赵圣诗唐琴董允东北大学秦皇岛分校资源与材料学院秦皇岛066004

研究了Gd含量(3.0%、4.5%、6.0%,质量分数)对定向凝固Mg-x Gd-0.5Y合金微观组织及室温力学性能的影响,并利用EBSD技术分析其室温拉伸形变行为。结果表明,在抽拉速率为3 mm/min条件下,Mg-x Gd-0.5Y合金获得了纵向晶界与热流方向平行、主... 详细信息

研究了Gd含量(3.0%、4.5%、6.0%,质量分数)对定向凝固Mg-x Gd-0.5Y合金微观组织及室温力学性能的影响,并利用EBSD技术分析其室温拉伸形变行为。结果表明,在抽拉速率为3 mm/min条件下,Mg-x Gd-0.5Y合金获得了纵向晶界与热流方向平行、主要沿■晶面的法线方向择优生长的柱状晶组织,且柱状晶的横截面呈"三角形"或"十"字形花瓣状,二次分枝由3.0%Gd的3个分枝逐渐变为6.0%Gd的4个分枝。室温下,柱状晶晶体生长取向多集中在■的Mg-6.0Gd-0.5Y合金具有较高的抗拉强度(107 MPa)和断后延伸率(32.56%),其形变机制以基面滑移和■拉伸孪生为主。晶体生长取向较为分散(集中在■个取向)的Mg-3.0Gd-0.5Y合金形变时,因晶粒取向不同导致孪生机制不同,既有以■拉伸孪生协调应变的晶粒,也有以■压缩孪生协调应变的晶粒,各柱状晶协同变形能力较差,故其室温塑性较低,断后延伸率仅有14.88%。

关键词： Mg-Gd-Y合金晶体取向孪生机制断后延伸率

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High efficient removal of HCN over porous CuO/CeO2 micro-nano spheres at lower temperature range

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Chinese Journal of Chemical Engineering 2021年第10期34卷 155-164页

作者： Zhihao Yi Jie sun Jigang Li Tian zhou Shouping Wei Hongjia Xie Yulin Yang Department of Chemistry Defense Institute of NBC DefenseBeijing 102205China

The porous CeO2 flowerlike micro-nano spheres based materials were prepared to remove HCN effectively at lower temperature *** CeO2 and a serious of porous flowerlike ceria based materials loaded with metal species including Cu,Ag,ni,Co and Fe were synthesized by hydrothermal method and precipitation method *** physicochemical properties were probed by means of XRD,H2-TPR,BET,SEM and *** removal ability for 130 mg·m﹣3 HCN over CuO/CeO2 showed the highest activity,the breakthrough time of which was more than 70 min at the condition of 30℃,120,000 h-1 and b 5%(volume)H2O,owe to a higher relative atomic ratio of oxygen vacancies and Oβ,the stronger interaction between metal particle and support,the optimum redox *** reaction mechanism was speculated by detecting the reaction products selectivity at different reaction *** was shown that the reaction system for removal of HCN over CuO/CeO2 catalytic material involved chemisorption,catalytic hydrolysis,catalytic oxidation as well as NH3-SCR reactions.

关键词： Rice(Oryza sativa L.) Saline-alkaline stress Abscisic acid(ABA) OsABA8ox1-kd Endogenous ABA levels

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