Effect of moxibustion at Shenque (CV8) on immune system in rats with different degrees of exhaustive exercise
艾灸神阙穴对不同程度力竭运动大鼠免疫系统的影响作者机构：Hebei University of Chinese Medicine. Shijiazhuang 050200. China Hebei Province Laboratory of Specific Effects of Acupuncture and Moxibustion. Shijiazhuang 050091China Hebei Bokang Institute of Chinese Medicine Shijiazhuang 050021 China
出 版 物：《Journal of Acupuncture and Tuina Science》 (针灸推拿医学（英文版）)
年 卷 期：2019年第17卷第2期
页 面：74-79页
核心收录：
学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：河北省教育厅青年自然科学基金项目(No.QN2016021, No. Z2017074) 河北省中医药管理局科技支撑项目(No.2017011) 河北中医学院大学生创新创业训练计划项目(No.201814432023)
主 题：Moxibustion Therapy Moxa Stick Moxibustion Point, Shenque (CV8) Exhaustive Exercise Fatigue Immunoglobulins Acid Phosphatase Rats
摘 要：Objective: To investigate the effect of moxibustion at Shenque (CV8) on the immune system in rats with different levels of exhaustive exercise. Methods: Fifty-six male Sprague-Dawley (SD) rats were randomly divided into a blank group (n=8), an exhaustive group (n=24), and a moxibustion group (n=24). The exhaustive group was randomly divided into a 1-time exhaustive group, a 4-time exhaustive group and a 7-time exhaustive group, with 8 rats in each group. According to the treatment time, the moxibustion group was randomly divided into a 1-time moxibustion group, a 4-time moxibustion group and a 7-time moxibustion group, with 8 rats in each group. Rats in the exhaustive groups and the moxibustion groups were subjected to replicating the exhaustive swimming models. Rats in each moxibustion group received mild moxibustion for 15 min immediately after the exhaustive modeling, once every other day. Twenty-four hours after the corresponding exhaustive exercise, the rats in each group were tested for the levels of serum immunoglobulin (Ig) G, IgA, IgM and acid phosphatase (ACP), and the morphological changes of spleen tissues were observed. The level of IgA was detected by immunoturbidimetric assay, and the levels of IgG, IgM and ACP were detected by en zyme-linked imm uno sorb ent assay (ELISA). Results: Compared with the 1-time exhaustive group, swimming time of rats in the 4-time exhaustive group was significantly proIonged (P0.01), and swimming time of rats in the 7-time exhaustive group was significantly shortened (P0.01). Compared with the 7-time exhaustive group, exhaustive swimming time of rats in the 7-time moxibustion group was significantly proIonged (P0.01). Compared with the blank group, the IgG level in the 1-time exhaustive group was significantly decreased (***), and the levels of IgG, IgA and IgM in the 4-time exhaustive group and the 7-time exhaustive group were all sign ifica ntly decreased (P0.05 or ***), while the ACP level was in creased sign
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