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形变热处理对Cu-ni-Si合金组织性能的影响

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材料热处理学报 2024年第1期45卷 95-102页

作者：单运启张彦敏张朝民刘爱奎冯江赵世恒皇保欢宋克兴周延军河南科技大学材料科学与工程学院河南洛阳471023 河南省有色金属材料科学与加工技术重点实验室河南洛阳471023 河南省科学院河南郑州450046 河南省先进导体材料重点实验室河南郑州450046 凯美龙精密铜板带(河南)有限公司河南新乡453700

借助扫描电镜、电子万能试验机、维氏硬度计和数字涡流金属电导仪等研究了冷轧变形量和时效对Cu-ni-Si合金组织与性能的影响。结果表明:冷轧态合金变形量越大,显微组织中晶粒沿着轧制的方向被拉得越长和越扁。当时效温度或时效时间增加... 详细信息

借助扫描电镜、电子万能试验机、维氏硬度计和数字涡流金属电导仪等研究了冷轧变形量和时效对Cu-ni-Si合金组织与性能的影响。结果表明:冷轧态合金变形量越大,显微组织中晶粒沿着轧制的方向被拉得越长和越扁。当时效温度或时效时间增加到一定程度时,冷变形晶粒发生了回复再结晶,时效时间继续延长再结晶晶粒逐渐长大。冷轧态合金主要以脆性断裂为主,时效态合金以韧性断裂为主。当冷轧变形量为80.0%及经500℃×1 h时效后合金的综合性能最佳,电导率为46.37%IACS,显微硬度为236.14 HV0.1,抗拉强度为638.24 MPa,屈服强度为581.55 MPa,伸长率为5.77%。

关键词： Cu-ni-Si合金形变热处理显微组织力学性能

Consensus on diagnostic criteria for Yin deficiency syndrome in hypertension:a modified Delphi study

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Journal of Traditional Chinese Medicine 2023年第1期43卷 181-187页

作者： HE yun HE Jing XU Xiangru LI Haixiao SHI Rongwei LIANG Junya zhou Ying ZHU Yao CHEN xiaohu TANG Shuhua xiao min ZHAN Libin PEI Yinghao JIANG Weimin Department of General Internal Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China Department of Hepatology Jiangsu Province Hospital of Chinese Medicine Affiliated to Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China Department of Emergency Longhua Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Institute of Hypertension Jiangsu Province Hospital of Chinese Medicine Affiliated to Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China Department of Cardiology Jiangsu Province Hospital of Chinese Medicine Affiliated to Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China Department of Cardiology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine&School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Intensive Care Unit Jiangsu Province Hospital of Chinese Medicine Affiliated to Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE:To reach consensus on the diagnostic criteria for Yin deficiency syndrome in hypertension(YDSH)patients by a modified Delphi ***:Our study was consistent with T/CACM *** methodology of RAND/UCLA appropriateness was used to develop consensus guidance statements.A nationwide panel of experienced clinical experts from 19 provinces was *** experts were all prominent in Traditional Chinese Medicine(TCM)of cardiovascular *** consensus process consisted of two rounds of questionnaires and a final round of consultation to analyze the weight score of each ***,the data extraction process is carried out independently by third-party researchers(LIANG Junya,sun Yang,and DU xiaona).When there is disagreement in all three rounds,the expert panel group(odd number)are invited to vote,and the one with more votes *** the questionnaires,participants were asked to rate the appropriateness of each syndrome item using a nine-point Likert *** consensus was defined as a panel median rating 1-3 or 7-9 without *** then the diagnostic criteria of YDSH were formed according to the weight score in the final ***:Twenty-eight experts(84.8%)participated in the first round,and thirty-one(93.9%)finished the second *** two rounds,the consensus of YDSH was reached on 11 items(25.6%),including symptoms,signs,and pulse ***-one experts(63.6%)completed the final round in which they used a grading system for each *** tongue with scanty fur had the highest weighting(22.8%),followed by heat in the palms and soles(20.1%).CONCLUSIONS:The consensus-based diagnostic criteria for YDSH,formed by a modified Delphi method,can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our YDSH criteria.

关键词： Yin deficiency syndrome hypertension consensus Delphi technique weight score

双轨道Hubbard模型的动力学平均场理论研究

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物理学报 2022年第14期71卷 235-245页

作者：倪煜孙健全亚民罗东奇宋筠北京师范大学物理系北京100875 上海科技大学物质科学与技术学院上海201210 中国科学院合肥物质科学研究院固体物理研究所材料物理重点实验室合肥230031

基于以Lanczos方法为杂质求解器的动力学平均场理论,研究了非局域轨道间跃迁对于双轨道强关联体系中轨道选择Mott相变的影响.计算了轨道间跃迁系数不同的双轨道Hubbard模型的准粒子权重和态密度,并构建了它们在相互作用强度U和轨道带宽... 详细信息

基于以Lanczos方法为杂质求解器的动力学平均场理论,研究了非局域轨道间跃迁对于双轨道强关联体系中轨道选择Mott相变的影响.计算了轨道间跃迁系数不同的双轨道Hubbard模型的准粒子权重和态密度,并构建了它们在相互作用强度U和轨道带宽比t_(2)/t_(1)影响下的相图.通过正则变换引入两个有效的退耦和轨道,在一定条件下轨道间跃迁会有利于轨道选择Mott相变的发生.还比较了Bethe晶格和正方晶格的相图,虽然基于两种不同晶格能带结构得到的轨道选择Mott相变的相变点存在一定的差异,但其中关于轨道选择Mott相变的基本物理图像具有一致性.并将方法拓展到半满的Ba_(2)CuO_(4-d)材料的研究中,与根据密度泛函理论得到的能带对比,我们发现各向同性的轨道间跃迁对能带结构影响较大,进一步采用动量空间各向异性的非局域轨道间跃迁项,得到了材料的相图,在半满条件下Ba_(2)CuO_(4-d)应为轨道选择Mott材料.

关键词：动力学平均场理论 Mott 相变双轨道 Hubbard 模型

A collaborative strategy for enhanced reduction of Cr(Ⅵ) by Fe(0) in the presence of oxalate under sunlight:Performance and mechanism

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Journal of Environmental Sciences 2020年第4期32卷 385-394页

作者： Qi zhou Yang Li Heng Yang yun Gao College of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Chengdu Integrated Testing Center of Rocks and Ores Sichuan Geology and Mineral Exploration and Development BureauChengdu 610081China Anhui Electric Power Construction Second Engineering Co.Ltd. China Energy Construction GroupHefei 230000China

Nanometer-size zero-valent iron(NZVI)is an efficient reducing agent,but its surface is easily passivated with an oxide layer,leading to reaction *** our study,oxalate(OA)was introduced into this heterogeneous system of NZVI,which could form ferrioxalate complexes with the NZVI surface-bound Fe3+and dissolved Fe3+in the *** of ferrioxalate complexes can facilitate the generation of Fe2+from Fe3+and CO2·-radical,both species have strong reduction ***,a"photo-oxalate-Fe(0)"system through sunlight induction was established,which not only prohibited the formation of a surface passivation layer,but also displayed a synergetic mechanism of ferrioxalate photolysis to enhance reduction,exhibiting remarkably higher degradation activity(several times faster)toward the model pollutant Cr(Ⅵ)than the mechanism with NZVI *** tests suggested that both NZVI dosage and OA content markedly affected the reduction *** pH was beneficial to the reduction ***,recyclability experiment showed that the reduction rate decreased from 0.21706 to 0.03977 min-1 after three cycles of reuse due to the NZVI losing reaction activity generally,but the system still maintained considerable reduction ***,a mechanism was revealed whereby NZVI would transform to Fe oxides after the exhaustion of its reductive power,and the photolysis of ferrioxalate to promote the cycling of iron species played the predominant role in providing extra reduction *** features confirm that introduction of OA into Cr(Ⅵ)reduction by NZVI through sunlight induction is advantageous and promising.

关键词： Nanometer-size zero-valent iron Oxalate sun irradiation Photolysis of ferrioxalate Cycling of surface iron Synergetic mechanism

Mageb4,a Testis-Specific Gene,is Dispensable for Mouse Spermatogenesis

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Reproductive and Developmental Medicine 2020年第3期4卷 129-136页

作者： Sheng Gao Da-min yun Li-Wei zhou yun-Hao Wu Deng-Feng Lin xiao-Long Wu Fei sun Medical School Institute of Reproductive MedicineNantong UniversityNantong 226001China

Objective:It has recently been shown that the melanoma antigen gene(MAGE)family is expressed in various tumor cell lines but silent in normal tissues,except germ cell ***4,a member of the MAGE family,is highly expressed in the testis and homologous in humans and ***-exome sequencing studies have identifiedMageb4 as a possible X-linked cause of inherited male ***,the function of Mageb4 protein remains largely ***:Using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)9 technology,we generated aMageb4 knockout mouse model(Mageb4^-/Y)to explore the role of this gene in ***:First,immunostaining of testicular cells showed thatMageb4 is localized in the cytoplasm of ***,Mageb4^-/Y male mice displayed significant increases in ***,Mageb4^-/Y male mice showed normal fertility,including normal sperm concentration,sperm motility,and testicular and epididymal ***:These findings suggest that,despite testis-exclusive expression,Mageb4 is dispensable for mouse *** research should focus on the role of this gene in apoptosis,aiming to provide clinical guidance regarding male infertility.

关键词： Clustered Regularly Interspaced Palindromic Repeats/CRISPR-Associated Protein 9 Mageb4 Male Infertility Spermatogenesis

Common mechanism of Citrus Grandis Exocarpium in treatment of chronic obstructive pulmonary disease and lung cancer

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Chinese Herbal Medicines 2021年第4期13卷 525-533页

作者： Wei zhou min dong Hao Wu Hui-lin Li Jia-le Xie Ru-yun Ma Wei-wei Su Jian-ye Dai School of Pharmacy Lanzhou UniversityLanzhou 730000China Department of Pulmonology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM Guangdong Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese *** kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung *** Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based on"syndrome differentiation and treatment"***,the common mechanism for HJH’s treatment of COPD and lung cancer is not ***:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was *** active ingredients and related targets of HJH were integrated from TCMSP,BATMAN-TAM,STP,and Pubchem *** standard names of these targets were united by Uni Prot *** of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)*** the intersection targets of HJH and diseases were *** STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG *** Cytoscape 3.6.1 was used to build"ingredient-target-signal pathway"***,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and ***:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets *** results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,*** through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung can

关键词： chronic obstructive pulmonary disease Citrus Grandis Exocarpium lung cancer mechanism molecular docking network pharmacology same treatment for different diseases

Efficacy of image-enhanced endoscopy for colorectal adenoma detection:A multicenter,randomized trial

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World Journal of Gastrointestinal Oncology 2023年第5期15卷 878-891页

作者： Zhi-Peng Qi En-Pan Xu dong-Li He Yan Wang Bai-Sheng Chen Xue-Si dong Qiang Shi Shi-Lun Cai Qi Guo ni Li Xing Li Hai-Yan Huang Bing Li Di sun Jian-Guang Xu Zhang-Han Chen Ayimukedisi Yalikong Jin-Yi Liu Zhen-Tao Lv Jian-min Xu Ping-Hong zhou yun-Shi Zhong Endoscopy Center Zhongshan Hospital of Fudan UniversityShanghai 200030China Endoscopy Center Shanghai Xuhui Central HospitalShanghai 200030China Endoscopy Center Traditional Chinese Medical HospitalRongcheng 264300Shandong ProvinceChina Department of Endoscopy Center Xiamen Branch of Affiliated Zhongshan Hospital of Fudan UniversityXiamen 361000Fujian ProvinceChina Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Gastroenterology Pingxiang People’s HospitalPingxiang 337000Jiangxi ProvinceChina Department of Clinical Medicine Xiaogang HospitalNingbo 315000Zhejiang ProvinceChina Endoscopy Center Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina Department of General Surgery Zhongshan Hospital of Fudan UniversityShanghai 200030China

BACKGROUND Improved adenoma detection at colonoscopy has decreased the risk of developing colorectal ***,whether image-enhanced endoscopy(IEE)further improves the adenoma detection rate(ADR)is *** To compare IEE with white-light imaging(WLI)endoscopy for the detection and identification of colorectal *** This was a multicenter,randomized,controlled *** were enrolled between September 2019 to April 2021 from 4 hospital in *** were randomly assigned to an IEE group with WLI on entry and IEE on withdrawal(n=2113)or a WLI group with WLI on both entry and withdrawal(n=2098).The primary outcome was the *** secondary endpoints were the polyp detection rate(PDR),adenomas per colonoscopy,adenomas per positive colonoscopy,and factors related to adenoma *** A total of 4211 patients(966 adenomas)were included in the analysis(mean age,56.7 years,47.1%male).There were 2113 patients(508 adenomas)in the IEE group and 2098 patients(458 adenomas)in the WLI *** ADR in two group were not significantly different[24.0%vs 21.8%,1.10,95%confidence interval(CI):0.99-1.23,P=0.09].The PDR was higher with IEE group(41.7%)than with WLI group(36.1%,1.16,95%CI:1.07-1.25,P=0.01).Differences in mean withdrawal time(7.90±3.42 min vs 7.85±3.47 min,P=0.30)and adenomas per colonoscopy(0.33±0.68 vs 0.28±0.62,P=0.06)were not *** analysis found that with narrowband imaging(NBI),between-group differences in the ADR,were not significant(23.7%vs 21.8%,1.09,95%CI:0.97-1.22,P=0.15),but were greater with linked color imaging(30.9%vs 21.8%,1.42,95%CI:1.04-1.93,P=0.04).the second-generation NBI(2G-NBI)had an advantage of ADR than both WLI and the first-generation NBI(27.0%vs 21.8%,P=0.01;27.0%vs 21.2.0%,P=0.01).CONCLUSION This prospective study confirmed that,among Chinese,IEE didn’t increase the ADR compared with WLI,but 2G-NBI increase the ADR.

关键词： Endoscopy Image-enhanced endoscopy Adenoma detection rate White-light imaging Narrowband imaging

Aquaporin 8 expression is reduced and regulated by microRNAs in patients with ulcerative colitis

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Chinese Medical Journal 2013年第8期126卷 1532-1537页

作者： min min PENG Li-hua sun Gang GUO ming-zhou QIU Ze-wu YANG yun-sheng Department of Gastroenterology and Hepatology AffiliatedHospital of Academy of Military Medical Sciences Beijing100071 China Department of Gastroenterology and Hepatology Chinese People'sLiberation Army General Hospital Beijing 100853 China

Background Ulcerative colitis （UC） is associated with differential expression of genes involved in inflammation and tissue remodeling. MicroRNA （miRNA） plays an important role in the pathogenesis of UC by regulating the gene expression at the post-transcriptional level and control crucial physiological processes. This study aimed to identify aquaporin 8 （AQP8） expression and its relationship with miRNA in UC patients. Methods Human colon samples, in this study, were obtained from 20 patients with UC and 16 healthy subjects undergoing diagnostic colonoscopy at the Chinese People＇s Liberation Army General Hospital between December 2009 and June 2010. We screened different genes from UC tissues and healthy subjects using genome-wide microarray, quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blotting. Regulation of gene expression by miRNAs was assessed by luciferase reporter construct assays and transfection of specific miRNA mimics and inhibitor. Results We identified that 1596 genes were increased and 1301 genes were decreased in UC patients compared to healthy subjects. Among them, we focused on the analysis of AQP8 which was decreased three folds in UC tissues （P 〈0.01）. The expression of AQP8 mRNA and protein were decreased in UC tissue and tumor necrosis factor （TNF）-α treated HT29 cells compared with controls （P 〈0.05）. We searched candidate target miRNAs of AQP8 through bioformatics and the luciferase report assay analysis indicated that miR-424, miR-195, miR-330, miR-612, and miR-16 which has complementary site in the 3-untranslated region （3＇UTR） of AQP8 could decrease the relative luciferase activities by 10%-45%. Conclusion AQP8 and its relationship with miRNAs may be involved in the pathogenesis of UC.

关键词： ulcerative colitis aquaporin 8 microRNAs

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精炼渣酸性氧化浸出制备黑铜电解液实验

矿产综合利用 2024年第3期45卷 157-160页

作者：李俊周兆安刘小文毛谙章孙雁军周爱青广东飞南资源利用股份有限公司广东肇庆526233

这是一篇冶金工程领域的文章。研究了双氧水氧化酸性浸出法从高铜高锡阳极炉精炼渣中脱除铜制备黑铜电解液。主要考查了双氧水用量、反应温度、硫酸浓度、固液比和反应时间等因素对铜脱除效果的影响。结果表明,在精炼渣20.0 g,2.0 mol/... 详细信息

这是一篇冶金工程领域的文章。研究了双氧水氧化酸性浸出法从高铜高锡阳极炉精炼渣中脱除铜制备黑铜电解液。主要考查了双氧水用量、反应温度、硫酸浓度、固液比和反应时间等因素对铜脱除效果的影响。结果表明,在精炼渣20.0 g,2.0 mol/L硫酸溶液200 mL,S/L=1/10,浸出温度65℃,双氧水用量10.0 mL,搅拌速度400 r/min和浸出时间60 min时,Cu、As的平均浸出率分别达到88.98%、87.33%,而ni和Sn的浸出率仅为7.72%和1.34%,浸出液中铜离子浓度为48.48 g/L,可用于黑铜电解液的补充液。

关键词：冶金工程精炼渣脱除氧化浸出黑铜电解液