Common mechanism of Citrus Grandis Exocarpium in treatment of chronic obstructive pulmonary disease and lung cancer

作     者：Wei Zhou Min Dong Hao Wu Hui-lin Li Jia-le Xie Ru-yun Ma Wei-wei Su Jian-ye Dai Wei Zhou;Min Dong;Hao Wu;Hui-lin Li;Jia-le Xie;Ru-yun Ma;Wei-wei Su;Jian-ye Dai

作者机构：School of PharmacyLanzhou UniversityLanzhou 730000China Department of PulmonologyGansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCMGuangdong Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2021年第13卷第4期

页      面：525-533页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the National Key Research and Development Program of China (2018YFC1706300 and 2018YFC17063005) the Science and Technology Planning Project of Gansu Province (20JR10RA586) the Fundamental Research Funds for the Central Universities (lzujbky-2021-kb40) the Project for Longyuan Youth Innovation and Entrepreneurship Talent the Science and Technology Planning Project of Guangdong Province of China (2019B090905002) 

主　　题：chronic obstructive pulmonary disease Citrus Grandis Exocarpium lung cancer mechanism molecular docking network pharmacology same treatment for different diseases 

摘      要：Objective:Same treatment for different diseasesis a unique treatment strategy in traditional Chinese *** kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung *** Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based onsyndrome differentiation and treatment***,the common mechanism for HJH’s treatment of COPD and lung cancer is not ***:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was *** active ingredients and related targets of HJH were integrated from TCMSP,BATMAN-TAM,STP,and Pubchem *** standard names of these targets were united by Uni Prot *** of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)*** the intersection targets of HJH and diseases were *** STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG *** Cytoscape 3.6.1 was used to buildingredient-target-signal pathway***,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and ***:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets *** results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,*** through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung can